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Tahara, M.,Kim, H.Y.,Hosoda, H.,Nam, T.h.,Miyazaki, S. Elsevier Sequoia 2010 Materials science & engineering. properties, micro Vol.527 No.26
The composition dependence of the mechanical properties and martensitic transformation behavior of Ti-Nb-4Zr-2Ta-N alloys is investigated. The effect of annealing temperature on the microstructural evolution and superelastic properties in the N-added and N-free alloys is compared. The addition of N decreases M<SUB>s</SUB> of Ti-Nb-4Zr-2Ta alloys by about 200K per 1at.%N and improves the superelastic properties of Ti-Nb-4Zr-2Ta alloys. The dissolution of α phase increases the martensitic transformation start temperature and decreases the superelastic recovery strain for the N-free alloy, whereas it causes opposite effects for the N-added alloy. The different annealing temperature dependences of superelastic properties are discussed on the basis of microstructure observation.
Lattice modulation and superelasticity in oxygen-added β-Ti alloys
Tahara, M.,Kim, H.Y.,Inamura, T.,Hosoda, H.,Miyazaki, S. Elsevier Science 2011 ACTA MATERIALIA Vol.59 No.16
The microstructure and martensitic transformation behavior of (Ti-23Nb)-1.0O (at.%) alloy have been closely and systematically investigated by transmission electron microscopy (TEM). Diffuse streaks along the <110><SUB>β</SUB><SUP>*</SUP> directions with intensity maxima at ½ positions between basal spots are observed in selected area diffraction patterns obtained from the β phase. The streaks correspond to six variants of {110}<SUB>β</SUB><11@?0><SUB>β</SUB> transverse lattice modulation caused by randomly distributed oxygen atoms and their local strain fields. Nanosized modulated domains (nanodomains) in the β phase are confirmed in dark field micrographs. These nanodomains act as local barriers to martensitic transformation, thereby suppressing long-range martensitic transformation in the (Ti-23Nb)-1.0O alloy. We suggest a new mechanism for superelasticity in oxygen-containing β-Ti-Nb alloys based on the results of in situ X-ray diffraction measurements and in situ TEM observations.
Atsuo Tahara,Toshiyuki Takasu,Masanori Yokono,Masakazu Imamura,Eiji Kurosaki 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.2
The sodium-glucose cotransporter 2 (SGLT2) is responsible for most glucose reabsorption in the kidney and has been proposed as a novel therapeutic target for the treatment of type 2 diabetes. In the present study, the combinatory effects of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice were investigated. Ipragliflozin dose-dependently increased urinary glucose excretion and improved glucose tolerance. In addition, each antidiabetic drug (mitiglinide, glibenclamide, sitagliptin, insulin, metformin, voglibose, or rosiglitazone) also significantly improved glucose tolerance without affecting urinary glucose excretion. Combination treatment of ipragliflozin with each antidiabetic drug additively improved glucose tolerance. In these experiments, ipragliflozin-induced increases in urinary glucose excretion were not influenced by combination treatment with antidiabetic drugs. Further, ipragliflozin did not affect antidiabetic drug-induced insulinotropic action (mitiglinide and glibenclamide), increases in plasma glucagon-like peptide-1 and insulin levels via inhibition of dipeptidyl peptidase 4 activity (sitagliptin), increases in plasma insulin level (insulin), decreases in hepatic phosphoenolpyruvate carboxykinase activity (metformin), inhibition of small intestinal disaccharidase activity (voglibose), or improvement of impaired insulin secretion (rosiglitazone). These results suggest that combination treatment of ipragliflozin with various antidiabetic drugs additively enhances the improvement in glucose tolerance without affecting each drug’s unique pharmacological effects. Ipragliflozin may therefore be expected to be effective when administered as part of a combination regimen in the treatment of type 2 diabetes.
Curvature Tensors of Quaternionic Kähler Structures on the Tangent Bundle of a Complex Space Form
Manabu Tahara KYUNGPOOK UNIVERSITY 2001 Kyungpook mathematical journal Vol.41 No.2
We calculate the curvature tensors of the quaternionic Kähler structures, given in [10], on the tangent bundle of a complex space form of real dimension 2n(n > 2). It is shown that all of their Ricci tensors are flat.
K. Tahara,Y. Fukuda,G. Wakabayashi,H. Ban,Y. Morimoto,M. Yoshioka,K. Kiyohara,Y. Koba,H. Iwamoto,Y. Uozumi,N. Matsufuji 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We measured proton-production double differential cross sections (DDXs) by 290 MeV/u carbon beams on carbon, copper, lead targets at forward angles. The proton energies were measured with the spectrometer which consisted of GSO(Ce) crystals and plastic scintillators. The measured DDXs were compared with the calculated ones with PHITS code. The simulation results generally agreed with the measured ones. The measured results will be useful as the benchmark of existing simulation codes and for the future improvements.