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      • Teneligliptin versus sitagliptin in Korean patients with type 2 diabetes inadequately controlled with metformin and glimepiride: A randomized, double‐blind, non‐inferiority trial

        Kim, Yonghyun,Kang, Eun Seok,Jang, Hak Chul,Kim, Dong Jun,Oh, Taekeun,Kim, Eun Sook,Kim, Nan‐,Hee,Choi, Kyung Mook,Kim, Sung‐,Rae,You, JiYoung,Kim, Se‐,Jin,Lee, Moon‐,Kyu Blackwell Publishing Ltd 2019 Diabetes, obesity & metabolism Vol.21 No.3

        <P><B>Aim</B></P><P>To assess the efficacy and safety of add‐on therapy with the dipeptidyl peptidase‐4 inhibitor teneligliptin compared with sitagliptin in patients with type 2 diabetes (T2DM) inadequately controlled with metformin and glimepiride.</P><P><B>Materials and Methods</B></P><P>This was a phase 3, randomized, double‐blind, non‐inferiority study of adult Korean subjects with T2DM (n = 201), with HbA1c ranging from 7.0% to 11.0%, on stable doses of metformin plus glimepiride. Subjects were randomized in a 1:1 fashion to receive either oral teneligliptin 20 mg or sitagliptin 100 mg for 24 weeks. The primary endpoint was change from baseline in HbA1c.</P><P><B>Results</B></P><P>At baseline, mean age was 60.56 ± 9.41 years, body mass index was 25.23 ± 2.85 kg/m<SUP>2</SUP> and HbA1c was 8.11% ± 0.79%. At 24 weeks, both groups achieved significant reductions from baseline in HbA1c (teneligliptin, −1.03% ± 0.10% [<I>P</I> < 0.0001]; sitagliptin, −1.02% ± 0.10% [<I>P</I> < 0.0001]). The inter‐group difference was −0.01% (95% confidence interval [CI]: −0.28, 0.26; <I>P</I> = 0.9497); the upper limit of the 95% CI was within the preset limit for non‐inferiority (0.4%). There were no significant differences between groups in the proportion of patients achieving HbA1c targets, or changes from baseline in fasting plasma glucose, body weight or lipid levels at 24 weeks. Rates of adverse events (teneligliptin, n = 63 [61.76%]; sitagliptin, n = 61 [62.24%]; <I>P</I> = 0.9442) and hypoglycaemia (teneligliptin, n = 32 [31.37%]; sitagliptin, n = 28 [28.57%]; <I>P</I> = 0.6656) were similar.</P><P><B>Conclusion</B></P><P>Teneligliptin was non‐inferior to sitagliptin in the context of triple therapy for T2DM and is an important option in this setting.</P>

      • KCI등재

        Template-free Synthesis and Characterization of Spherical Y3Al5O12:Ce3+ (YAG:Ce) Nanoparticles

        Taekeun Kim,이진규 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

        Cerium-activated yttrium aluminate (Y3Al5O12:Ce3+) exhibiting a garnet structure has been widely utilized in the production of light emitting diodes (LEDs) as a yellow emitting phosphor. The commercialized yttrium aluminum garnet (YAG) phosphor is typically synthesized by a solid-state reaction, which produces irregular shape particles with a size of several tens of micrometers by using the top-down method. To control the shape and size of particles, which had been the primary disadvantage of top-down synthetic methods, we synthesized YAG:Ce nanoparticles with a diameter of 500 nm using a coprecipitation method under the atmospheric pressure without the use of template or special equipment. The precursor particles were formed by refluxing an aqueous solution of the nitrate salts of Y, Al, and Ce, urea, and polyvinylpyrrolidone (55 K) at 100 °C for 12 h. YAG:Ce nanoparticles were formed by the calcination of precursor particles at 1100 °C for 10 h under atmospheric conditions. The phase identification, microstructure, and photoluminescent properties of the products were evaluated by X-ray powder diffraction, scanning electron microscopy, absorption spectrum and photoluminescence analyses.

      • SCOPUSKCI등재

        Template-free Synthesis and Characterization of Spherical Y<sub>3</sub>Al<sub>5</sub>O<sub>12</sub>:Ce<sup>3+</sup> (YAG:Ce) Nanoparticles

        Kim, Taekeun,Lee, Jin-Kyu Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

        Cerium-activated yttrium aluminate ($Y_3Al_5O_{12}:Ce^{3+}$) exhibiting a garnet structure has been widely utilized in the production of light emitting diodes (LEDs) as a yellow emitting phosphor. The commercialized yttrium aluminum garnet (YAG) phosphor is typically synthesized by a solid-state reaction, which produces irregular shape particles with a size of several tens of micrometers by using the top-down method. To control the shape and size of particles, which had been the primary disadvantage of top-down synthetic methods, we synthesized YAG:Ce nanoparticles with a diameter of 500 nm using a coprecipitation method under the atmospheric pressure without the use of template or special equipment. The precursor particles were formed by refluxing an aqueous solution of the nitrate salts of Y, Al, and Ce, urea, and polyvinylpyrrolidone (55 K) at $100^{\circ}C$ for 12 h. YAG:Ce nanoparticles were formed by the calcination of precursor particles at $1100^{\circ}C$ for 10 h under atmospheric conditions. The phase identification, microstructure, and photoluminescent properties of the products were evaluated by X-ray powder diffraction, scanning electron microscopy, absorption spectrum and photoluminescence analyses.

      • Biogeochemical properties of sinking particles in the southwestern part of the East Sea (Japan Sea)

        Kim, Minkyoung,Hwang, Jeomshik,Rho, TaeKeun,Lee, Tongsup,Kang, Dong-Jin,Chang, Kyung-Il,Noh, Suyun,Joo, HuiTae,Kwak, Jung Hyun,Kang, Chang-Keun,Kim, Kyung-Ryul Elsevier 2017 Journal of marine systems Vol.167 No.-

        <P><B>Abstract</B></P> <P>This study investigates the biological pump system in the East Sea (Japan Sea) by conducting an analysis of the total particle flux, biogenic material composition, and carbon isotope ratios of sinking particles. The samples were collected for one year starting from March 2011 using time-series sediment traps deployed at depths of 1040m and 2280m on bottom-tethered mooring at Station EC1 (37.33°N, 131.45°E; 2300m water depth) in the Ulleung Basin (UB), southwestern part of the East Sea. The temporal variation in the particulate organic carbon (POC) flux at 1000m shows a good relationship with the primary production in the corresponding surface water. The ratio of POC flux at 1000m to satellite-based primary production in the corresponding region in the UB was ~3%, which is comparable to the values of 2 to 5% estimated from previous studies of other part of the East Sea. The lithogenic material accounted for >17% of the sinking particles at 1000m and for a larger fraction of 40 to 60% at 2280m. The radiocarbon contents of the sinking POC at both trap depths imply the additional supply of aged POC, with a much greater contribution at 2280m. Overall, the particle flux in the deep interior of the East Sea appears to be controlled by the supply of complex sources, including aeolian input, the lateral supply of resuspended sediments, and biological production in the surface water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> POC flux variation at 1000m shows a good relationship with the primary production. </LI> <LI> The ratio of POC flux at 1000m to primary production was ~3% in the UB. </LI> <LI> The particle flux in the East Sea appears to be controlled by complex sources. </LI> </UL> </P>

      • KCI등재

        영상인식 기반 인터랙티브 디지털 콘텐츠 구현 및 사용 편의성 분석

        김태완(Kim Taiwan),김승훈(Kim Seunghoon),조흥목(Jo Heungmok),박태근(Park Taekeun) 한국디지털디자인학회 2011 디지털디자인학연구 Vol.11 No.1

        기술의 발전과 더불어 사용자들은 키보드 마우스 조이스틱과 같은 전통적인 인터페이스 장치에서 벗어나 디지털 콘텐츠와의 다양한 인터랙션을 가능하게 하는 인터페이스 장치를 요구하기 시작하였다. 이러한 사용자의 요구를 충족시키기 위하여 최근에는 사용자의 움직임을 인식하여 디지털 콘텐츠와의 인터랙션을 가능하게 하는 인터페이스 장치 또는 인터랙션 방법들이 연구되고 있다. 사용자의 움직임인식을 기반으로 한 인터랙션 방법은 장치기반 방법과 영상인식 기반 방법으로 분류할 수있다. 고가의 장비를 필요로 하는 장치기반 방법과 달리 영상인식 기반 방식에서는 카메라를 통해 입력된 영상에서 색상과 특장점 등을 추출하여 사용자의 움직임을 인식한다. 따라서 영상인식 기반 방식은 장치기반 방법에 비하여 정밀한 움직임 측정은 어렵지만 저사양의 컴퓨터에서도 동작할 뿐만 아니라 고가의 장비가 필요 없다는 장점을 가진다. 본 논문은 영상인식 기반 방식을 사용하여 인터랙티브 디지털 콘텐츠인 "가상 윈도우"를 구현한다. "가상 윈도우"는 사용자의 얼굴 움직임에 따라 1인칭 시점으로 디스플레이 화면전체에 보이는 3D가 상현실과 인터랙션하는 디지털 콘텐츠이다. 영상인식 기반 인터랙티브 디지털 콘텐츠의 사용 편의성을 알아보기 위해 기존 연구의 사례를 통하여 사용 편의성 평가 항목을 도출한다. 도출된 평가항목을 "가상 윈도우"에 적용하여 영상인식 기반 방법을 사용한 인터랙티브 디지털 콘텐츠의 사용 편의성을 분석한다. Together with technical development users began to require interface devices that enable various interactions with digital contents beyond the traditional interface devices such as keyboards mouse and joy sticks. To satisfy such demands of users interface devices or interaction methods have been recently studied which enable the interaction with digital contents by recognizing the movement of users. Interaction methods based on recognition of movement of users can be classified into the device based method and image recognition based method. Different from device based method requiring expensive equipment image recognition based method recognizes the movement of users by extracting colors features and advantages from the images input through camera. Accordingly image recognition based method is difficult to measure movement precisely than device based method butit has advantage in that it not only operates in computers with low specification but also require no expensive equipment. This thesis implements "Virtual Window" an interactive digital contents using the image recognition based method.'Virtual window' is the digital contents that interact with 3D virtual reality shown in full display screen from the viewpoint of first person according to movement of user's face. This study identifies the items of evaluation of convenient use through the cases of existing studies to examine the convenient use of interactive digital contents based on imagerecognition using the'Virtual Window'. By applying the items of evaluation drawn this study analyzes the convenient use of interactive digital contents using the image recognition based method

      • 단계적 조명변화에 강인한 지역적 스테레오 매칭 기법

        김대근(Taekeun Kim),신광무(Kwangmu Shin),정기동(Kidong Chung) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.1A

        최근 3D영화의 흥행과 더불어 3D 영상제작 기술들이 높은 관심을 받고 있다. 변이 정보를 획득하기 위한, 스테레오 매칭에 관한 분야는 꾸준히 연구가 되고 있는 분야이다. 그 중에서도 지역적 방법은 구현의 용이성과 낮은 계산복잡도로 인하여 많은 연구가 진행되고 있다. 하지만 대부분의 지역적 방법들은 영상이 외부환경에 변형되었을 때의 경우를 고려하지 않고 있기 때문에, 외부환경에 의해 많이 변형된 영상에 대해서는 제대로 된 변이 정보를 추출해내지 못한다. 본 논문에서는 양쪽 영상에서 픽셀간의 차이를 이용하여 서로 대응되는 영역을 찾는 스테레오 매칭 기법을 제안한다. 제안하는 기법은 조명과 같은 외부요소에 강인한 특징을 가진다. 이 기법은 전 처리나 후처리 과정에서 부가적인 작업의 수행 없이 기법 자체만으로 외부요소에 대한 보상을 실행한다는 면에서 장점을 가진다. 다양한 영상에서 변이를 추출하는 실험 결과, 단계적 조명 변화에 대해서도 대조군 방법과 비교하여 균일한 변이 영상을 획득할 수 있었다.

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