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( Taehyun Nam ),( Se-hee Kim ),( Jeong-woong Park ),( Sung Hwan Jeong ),( Eun Suk Son ),( Young Eun Lee ),( Sung Young Kyung ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Epithelial-mesenchymal transition (EMT), a process by which epithelial cells undergo a phenotypic conversion that gives rise to myofibroblasts, plays a pivotal role in the development of lung diseases such as pulmonary fibrosis. Recent studies revealed that hypoxia induces EMT of alveolar epithelial cells and that histone deacetylases (HDACs) are aberrantly overexpressed in basal cells of idiopathic pulmonary fibrosis (IPF) lungs. Previously, we found that HDAC3 promotes transition of alveolar epithelial cells to mesenchymal cells and fibroblast migration under hypoxic conditions, thereby accelerating the pulmonary fibrosis. In this study, we aimed to discover the microRNAs (miRNAs) that are controlled by HDAC3 in hypoxic conditions and also identify their target genes. In doing so, we planned to elucidate the mechanism by which HDAC3 accelerates the pulmonary fibrosis process. To identify the miRNAs that are regulated by the HDAC3, we performed a new-generation sequencing analysis using HDAC3-overexpressing A549 cells and found that miR-224 is upregulated by HDAC3 overexpression. MiR-224 expression was found to be increased in lungs from bleomycin-induced mice; it also induced the migration and invasion of hypoxia-exposed fibroblast cells. In addition, we analyzed the target genes of miR-224 using the TargetScan database and selected from these the genes that are associated with EMT for further study. Of these genes, Forkhead Box A1 (FOXA1) was found to be increased by HDAC3 siRNA and miR-224 inhibitor in hypoxia-exposed alveolar cells. Additionally, FOXA1 regulated the expression of mesenchymal markers in HDAC3 siRNA-transfected alveolar cells. FOXA1 also controlled the migration and invasion of HDAC3 siRNA-transfected fibroblast cells under hypoxia. Furthermore, the expression of FOXA1 was downregulated in lungs of bleomycin-induced mice and IPF patients. Therefore, we suggest that HDAC3 induces miR-224 expression to drive alveolar EMT through FOXA1 downregulation in hypoxic conditions, which may accelerate the pulmonary fibrosis.
Measurement of Fractional Exhaled Nitric Oxide in Adults: Comparison of Two Different Analyzers
( Sung-yoon Kang ),( Sang Pyo Lee ),( Taehyun Nam ),( Ui Won Ko ),( Sang Min Lee ),( Sun Young Kyung ),( Shin Myung Kang ),( Jeong-woong Park ),( Sung Hwan Jeong ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Fractional exhaled nitric oxide (FeNO) is a recognized marker for eosinophilic airway inflammation and treatment decisions for responses to corticosteroids. Our study evaluated the differences between two FeNO analyzers and derived a correction equation for adults. Methods A total of 99 participants with the chief complaint of cough and dyspnea, who attended the outpatient clinics, were selected. They underwent concurrent FeNO measurement in a random order using NIOX VERO<sup>®</sup> (Circassia AB, Solna, Sweden) and NObreath<sup>®</sup> (Bedfont, Kent, UK). Agreement between the devices was evaluated by Wilcoxon tests, Spearman’s tests, and Bland-Altman plots. Results: Of the recruited 99 participants, they had a middle-aged female predominant feature (mean age: 51.2 ± 17.1 years and female 58.6%). Patients with asthma were found in 58.6 % of all participants. The median FENO level measured with the NIOX VERO<sup>®</sup> (27, interquartile range, 15-45) was significantly lower than that measured with NObreath<sup>®</sup> (38, 22-58, p < 0.001 ). There was a strong positive correlation in the measurement of FENO level between the devices (r= 0.787, p < 0.001). Bland- Altman plots confirmed this agreement. The following conversion equation was derived using linear regression: Ln (NObreath<sup>®</sup>) = 0.728 × Ln (NIOX VERO<sup>®</sup>) + 1.244. Conclusions The present study demonstrated that the values of two FeNO analyzers were in good agreement and had positive correlations. The correction equation that we provided could help assess the data obtained by these two analyzers.
EARLY SCIENCE WITH THE KOREAN VLBI NETWORK: EVALUATION OF SYSTEM PERFORMANCE
Lee, Sang-Sung,Petrov, Leonid,Byun, Do-Young,Kim, Jongsoo,Jung, Taehyun,Song, Min-Gyu,Oh, Chung Sik,Roh, Duk-Gyoo,Je, Do-Heung,Wi, Seog-Oh,Sohn, Bong Won,Oh, Se-Jin,Kim, Kee-Tae,Yeom, Jae-Hwan,Chung, American Institute of Physics 2014 The Astronomical journal Vol.147 No.4
<P>We report the very long baseline interferometry (VLBI) observing performance of the Korean VLBI Network (KVN). The KVN is the first millimeter-dedicated VLBI network in East Asia. The KVN consists of three 21 m radio telescopes with baseline lengths in a range of 305-476 km. The quasi-optical system equipped on the antennas allows simultaneous observations at 22, 43, 86, and 129 GHz. The first fringes of the KVN were obtained at 22 GHz on 2010 June 8. Test observations at 22 and 43 GHz on 2010 September 30 and 2011 April 4 confirmed that the full cycle of VLBI observations works according to specification: scheduling, antenna control system, data recording, correlation, post-correlation data processing, astrometry, geodesy, and imaging analysis. We found that decorrelation due to instability in the hardware at times up to 600 s is negligible. The atmosphere fluctuations at KVN baseline are partly coherent, which allows us to extend integration time under good winter weather conditions up to 600 s without significant loss of coherence. The post-fit residuals at KVN baselines do not exhibit systematic patterns, and the weighted rms of the residuals is 14.8 ps. The KVN is ready to image compact radio sources both in snapshot and full-track modes with residual noise in calibrated phases of less than 2 deg at 22 and 43 GHz and with dynamic ranges of ~300 for snapshot mode and ~1000 for full-track mode. With simultaneous multi-frequency observations, the KVN can be used to make parsec-scale spectral index maps of compact radio sources.</P>
풍속 변화에 따른 발전기 온도 및 전력변환장치 효율에 관한 연구
송영상(Young-Sang Song),한운기(Woon-Ki Han),정진수(Jin-Soo Jung),임현성(Hyun-Sung Lim),조성구(Sung-Koo Cho),전태현(Taehyun Jeon) 한국조명·전기설비학회 2015 조명·전기설비학회논문지 Vol.29 No.7
Recently, because a renewable power source must operate as a constant rate in accordance with RPS(Renewable Portfolio Standard), the study of the renewable power sources has been ongoing. Especially because of noise of wind turbine, troubleshooting, and urban greening business, research related with small wind turbine are underway. The economics and reliability are important parts for the activation of small wind turbine, such as solar energy. In this paper, by analyzing the temperature variations for each location and efficiency of power conversion devices in accordance with short period wind speed changes in simulation test, we reviewed the safety about temperature variations of wind generator and the method of selection of power converter.
Nano-Precision Tweezers for Mechanosensitive Proteins and Beyond
Taehyun Yang,Celine Park,Sang-Hyun Rah,손민주 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.1
Mechanical forces play pivotal roles in regulating cell shape, function, and fate. Key players that govern the mechanobiological interplay are the mechanosensitive proteins found on cell membranes and in cytoskeleton. Their unique nanomechanics can be interrogated using single-molecule tweezers, which can apply controlled forces to the proteins and simultaneously measure the ensuing structural changes. Breakthroughs in high-resolution tweezers have enabled the routine monitoring of nanometer-scale, millisecond dynamics as a function of force. Undoubtedly, the advancement of structural biology will be further fueled by integrating static atomic-resolution structures and their dynamic changes and interactions observed with the force application techniques. In this minireview, we will introduce the general principles of single-molecule tweezers and their recent applications to the studies of force-bearing proteins, including the synaptic proteins that need to be categorized as mechanosensitive in a broad sense. We anticipate that the impact of nano-precision approaches in mechanobiology research will continue to grow in the future.