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Four different ways of alternative transcripts generation mechanism in <i>ADRA1A</i> gene
Huh, Jae-Won,Kim, Young-Hyun,Lee, Sang-Rae,Kim, Dae-Soo,Park, Sang-Je,Kim, Hyoungwoo,Kim, Ji-Su,Song, Bong-Seok,Kim, Heui-Soo,Chang, Kyu-Tae The Genetics Society of Japan 2010 Genes & genetic systems Vol.85 No.1
<P>The <I>ADRA1A</I> (Alpha-1-adrenergic receptor) gene is one of the members of G protein-coupled receptor superfamily. Alternative splicing of this gene was known to generate four transcript variants which code four isoforms with various C-terminal regions. In this study, we conducted expression analysis and evolutionary characterization of alternative transcripts of the <I>ADRA1A</I> gene. In total, 10 alternative transcripts were identified using experimental approaches and <I>in silico</I> analysis. Among them, 6 alternative transcripts (T1, T2, T3, T4, T4-1, and T8) were validated by RT-PCR approaches and sequencing procedures. From the alternative splicing analysis, it could be assumed that there were three different alternative transcripts generation mechanisms and unknown mechanism. First one is the integration event of three different TEs (<I>AluSc</I>, L1MC5, and MIR3) as seen on the last exons of T3, T4, T4-1, T5, T6, and T7 transcripts. The second mechanism is a differential promoter usage on T8. The third one is a substitution event of the 3’ splicing site during the primate evolution on T3. The last one is an unknown mechanism which was identified in the T4-1 transcript. Therefore, alternative transcripts of human <I>ADRA1A</I> gene occurred by four different ways, such as integration of TEs, differential promoter usage, substitution of splicing sites, and unknown mechanism.</P>
A STUDY ON THE TRIBOLOGICAL CHARACTERISTICS OF FeCrSi/A366.0 ALLOY COMPOSITES
Tae-Hoon Song,Yong-Bum Choi,Sung-Ho Park,Sun-Chul Huh,Won-Jo Park 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
In this paper, we study about wear properties for the metal matrix composites fabricated by low pressure infiltration process. Metal fiber preform reinforced aluminum alloy composite were fabricated by low pressure casting process under 0.4㎫. Infiltration condition was changed the pressure infiltration time of 1 s, 2 s and 5 s under a constant pressure of 0.4㎫. The molten alloy completely infiltrated the FeCrSi metal perform regardless of the increase in the pressure acceleration time. However, the infiltration time at the pressure acceleration time of 1s was shorter than at the pressure acceleration time of 2s or 5s. The FeCrSi/A366.0 composite was investigated the porosity. The porosity is reducing as the pressure acceleration time compared with the pressure acceleration time of 2s and 5s. The FeCrSi/A366.0 composites were investigated the wear resistance. FeCrSi/A366.0 composite at pressure acceleration time of 1s has excellent wear resistance.
A simple and effective treatment for nasal telangiectasia: Needle-assisted electrocoagulation
( Sang Young Byun ),( Bo Ri Kim ),( Jung Tae Park ),( Je Byeong Chae ),( Kyoung Chan Park ),( Sang Woong Youn ),( Changhun Huh ),( Jung Im Na ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Nasal telangiectasia is a common phenomenon in elderly and can cause significant cosmetic and psychological problem. Although there are various lasers and chemical treatment for nasal telangiectasia, insufficient effect and side effects such as purpura and postinflammatory hyperpigmentation are common. We used needle-assisted electrocoagulation for the treatment of nasal telangiectasia with success. A male aged 72 years visited dermatologic department complaining of heavy nasal telangiectasia occurred about 10 years ago. After local anesthesia with EMLA® cream, 30G needle tip was placed in the telangiectactic vessel lumen and electric current was delivered through it. Immediate disappearance of blood vessels was observed. Downtime was minimal because only needle marks exist after procedure. There was no purpura. He showed dramatic improvement of telangiectasia after one session, and after four sessions, almost complete clearance was obtained. Needle-assisted electrocoagulation is a simple and effective treatment for nasal telangiectasia with minimal downtime and minimal adverse effects.
Sang-Rae Lee,Kang-Jin Jeong,Sang-Hyun Kim,Keun-Su Kim,Sung-Jin Kim,Young-Hyun Kim,Jae-Won Huh,Ekyune Kim,Myeong-Su Kim,Jun-Gyo Suh,Kyu-Tae Chang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
A low endotoxic Outer membrane vesicles (OMVs) vaccine platform was established with an msbB genedeleted (ΔmsbB) Salmonella enteritidis mutant. The Salmonella ΔmsbB mutant displayed lipopolysaccharide phenotypic changes showing faster migration of the lipid A-core region in an SDS-PAGE analysis and the increased amount of penta-acyl lipid A due to the MsbB deficiency. In an endotoxicity assay, BALB/c mice injected intraperitoneally with the Salmonella ΔmsbB mutant survived for 10 days, whereas mice injected intraperitoneally with the wild type survived for 5 days. Also, all mice inoculated orally with the ΔmsbB mutant survived for 30 days but 70% of mice inoculated orally with wild type survived. Electron microscopically, the Salmonella ΔmsbB mutant produced a larger amount of OMVs than the wild type. In immunogenicity tests, all sera from mice groups immunized with the wild type, ΔmsbB mutant, and their OMVs, showed significantly higher IgG levels. This result was consistent with higher bactericidal activities against wild type S. enteritidis, compared to the negative control. However, there were no significant differences in serum IgG levels and the bactericidal activities of the immune sera between the four mice groups. The viable counts of S. enteritidis recovered from the spleen and liver of four preimmunized mice groups after 5 days of the bacterial challenge showed significant reductions of the live bacteria. Conclusively, the ΔmsbB mutant of S. enteritidis produced relatively low endotoxic OMVs, which was verified in this study for its potential to be a non-replicating Salmonella vaccine candidate.
( Sung Pil Hong ),( Tae Il Kim ),( Hyun Gun Kim ),( Hyun Soo Kim ),( Seong Eun Kim ),( Kyu Chan Huh ),( Jeong Eun Shin ),( Jae Myung Cha ),( Suck Ho Lee ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Background/Aims: Recent guidelines strongly recommend that the interval of surveillance colonoscopy be determined according to the risk stratification obtained at index colonoscopy. However, because of the differences in perception of the classification of colorectal intraepithelial neoplasia between Asian and Western countries, there is some confusion about surveillance colonoscopy. The aim of the present study was to evaluate the clinicopathological characteristics and the interval of surveillance colonoscopy between patients with high-grade dysplasia/carcinoma in situ and those with intramucosal carcinoma. Methods: From January 2003 to June 2010, 727 patients were included from 8 tertiary centers. Four hundred fifteen patients (57.1%) had high-grade dysplasia /carcinoma in situ (group A), and 312 (43.9%) had intramucosal carcinoma (group B). Clinicopathological data were reviewed retrospectively. Results: Group A had a significantly more frequent family history of colorectal cancer (3.1% vs. 0.6%, P<0.001), smaller polyp size (12 mm vs. 15 mm, P=0.001), and more proximal location (31.1% vs. 21.8%, P=0.005) than did group B. Among 727 patients, surveillance colonoscopy was performed within 6 months in 55.8% of patients and within 12 months in 77.8%. Group B had a significantly shorter interval of surveillance colonoscopy than did group A (P<0.001). There was no difference in detection of advanced neoplasia at surveillance colonoscopy between the 2 groups (6.6% vs. 5.4%, P=0.638). Conclusions: The recommended interval of surveillance colonoscopy is not followed in Korea. More education about post-polypectomy surveillance guidelines is required. (Intest Res 2013;11:276-282)
Huh, Gyu-Won,Lee, Dae-Young,In, Suh-Ji,Lee, Don-Gil,Park, Sang Yong,Yi, Tae-Hoo,Kang, Hee Cheol,Seo, Woo-Duck,Baek, Nam-In The Korean Society for Applied Biological Chemistr 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.4
Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.