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진행성 치매와 반복되는 뇌졸중을 보인 뇌 아밀로이드 혈관병증 1예
유봉구,곽강호,김태유,김광수,유경무 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1
Cerebral amyloid angiopathy can cause intracerebral hemorrhage, progressive dementia, seizure and transient ischemic attacks. Dementia is a relatively common manifestation and associated with the presence of recurrent strokes and leukoencephalopathy. A 66-year-old right-handed man with hypertension and recurrent strokes presented with rapidly progressive dementia and sudden onset of dysarthria and dizziness. He showed memory impairment, personality and behavioral changes, and executive dysfunction for one and an half years. These symptoms developed insidiously and quite rapidly without fluctuation. Brain CT showed a small hemorrhage in the right cerebellum. Brain MRI, especially gradient-echo images revealed multiple cortical and cortico-subcortical microbleeds. Four weeks later, right hemiparesis suddenly developed and a repeated MRI showed a new left corona radiata infarction. We learn from this case that gradient-echo MR images should be performed in patients with rapidly progressive dementia and recurrent strokes.
김태환,원유흥,김웅,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
갑상선기능항진증 환자는 선택수술시 마취전에 장기적으로 항갑상선 약물과 베타-수용체 차단제를 사용하여 정상갑상선기능으로 만들어, 적어도 맥박수가 분당 85회이하로 되었을 때 마취를 하여야한다. 정상갑상선기능으로 만들지 않은 환자를 수술을 하였을 때, 수술중이나 후에 갑상선 호르몬이 과량으로 분비하여 합병증을 유발할 수 있다. 그러나 응급수술시에는 수술을 하지 않았을 때의 생명의 위험도와 마취와 수술을 하였을 때의 위험도를 비교하여 결정하여야 한다. 저자들은 심부전을 동반한 조절되지 않은 갑상선기능항진증을 가진 38세의 여자환자를 응급으로 전신 마취하여 성공적으로 난관난소적출술을 시행한 경우를 보고하는 바이다. Elective surgery should never be considered until hyperthyroid patients have been rendered euthyroid and controlled by antithyroid drugs and beta-adrenergic blockades, as evidenced by resting bean rates less than 85 beets/min. Patients who cannot be rendered euthyroid before surgery may develop adverse responses related to excessive release of thyroid honnones during the perioperative period. But in the emergency case, it must be considered the severity between life and risk We described the case of the 38-year-old woman with uncontrolled hyperthyroidism accompanying the congestive heart failure, who was successfully carried out a salpingoophorectomy under general anesthesia.
Yoo, Changhee,Oh, Cheol Young,Cho, Jin Seon,Song, Cheryn,Seo, Seong Il,Ahn, Hanjong,Hwang, Tae-Kon,Cheon, Jun,Lee, Kang Hyun,Kwon, Tae Gyun,Jung, Tae Young,Chung, Moon Kee,Lee, Sang Eun,Lee, Hyun Moo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.4
<P>We investigated the clinical significance of large difference (≥ 2 points) between biopsy-derived (bGS) and post-prostatectomy Gleason scores (pGS). At 14 medical centers in Korea, 1,582 men who underwent radical prostatectomy for prostate cancer were included. According to the difference between bGS and pGS, the patients were divided into three groups: A (decreased in pGS ≥ 2, n = 30), B (changed in pGS ≤ 1, n = 1,361; control group), and C (increased in pGS ≥ 2, n = 55). We evaluated various clinicopathological factors of prostate cancer and hazards for biochemical failure. Group A showed significantly higher mean maximal percentage of cancer in the positive cores (max%) and pathological T stage than control. In group C, the number of biopsy core was significantly smaller, however, tumor volume and max% were significantly higher and more positive biopsy cores were presented than control. Worse pathological stage and more margin-positive were observed in group A and C than in control. Hazard ratio for biochemical failure was also higher in group A and C (<I>P</I> = 0.001). However, the groups were not independent factors in multivariate analysis. In conclusion, large difference between bGS and pGS shows poor prognosis even in the decreased group. However it is not an independent prognostic factor for biochemical failure.</P>
생쥐 췌조직내 Protein Methylase에 대한 자율신경계약물의 영향
유태무(Tae Moo Yoo),박선미(Sun Mee Park),이향우(Hyang Woo Lee) 대한약학회 1991 약학회지 Vol.35 No.4
It was reported that protein carboxymethylation is involved in amylase secretion of parotid gland by isoproterenol. It was also suggested that a small part of the total cellular protein carboxymethylation is directly involved in pancreatic enzyme secretion. On the contrary, other authors reported that there is no relationship between protein carboxymethylation and secretion in pancreas and parotid gland. In recent study, it was proposed that a methyl acceptor protein plays a limited modulatory role in the coupling of cytosolic Ca++ accumulate on and exocytosis. In this study, the effects of cholinergic and adrenergic agents on the activities of protein methylase II in pancreatic tissues were examined to test the relationship between protein methylation and pancreatic secretion. The results are as follows. The activity of amylase was slightly increased at the concentration of 10-5M of isoproterenol and norepinephrine. The activities of protein methylase I and II were decreased by isoproterenol and norepinephrine, but the activities of protein methylase III were hardly changed. The cholinergic stimulants acetylcholine and carbachol at a concentration of 10-5M increased the activities of protein methylase I and decreased the activities of protein methylase III compared with control.
닭 췌장 Protein Methylase II의 분리정제 및 성질
유태무(Tae Moo Yoo),남궁석민(Suck Min Namkoong),홍성렬(Sung Youl Hong),이향우(Hyang Woo Lee) 대한약학회 1991 약학회지 Vol.35 No.6
Protein methylase II (S-adenosyl-L-methionine:protein carboxyl-0-methyltransferase; EC 2.1.1.24., PM II) was purified from chicken pancreas by subcellular fractionation, DEAE-cellulose chromatography, QAE-Sephadex A-50 chromatography, Sephadex G-75 chromatography, and Sephadex G-75 rechromatography. The purified PM II gave a single band upon polyarcrylamide gel electrophoresis both in the presence of SDS and in Tris glycine buffer without SDS. The pI value of purified PM II was identified as 5.7 on isoelectric focusing gel. Properties and activities of PM II were studied and the following results were obtained. 1) PM II from chicken pancreas was purified approximately 221-fold with a yield of 1.3%. 2) The purified PM II appear constituted of a single polypeptide chain of a molecular weight 46,800 daltons. 3) Hemoglobin exhibited the highest of methyl-accepting activity among the substrates tested. 4) The purified PM II has a Km of 4.67 X 10-6M and a Vmax of 37.5 pmoles of methyl-14C/min/mg enzyme for SAM-14CH3 as methyl donor in the presence of histone type II-As. 5) It is found that S-adenosyl-L-homocysteine is a competitive inhibitor for PM II with KI value of 3.23 X 10-5M.
Development of a Novel Anti-TNFα Monoclonal Antibody for Rheumatoid arthritis treatment
( Moo Young Song ),( Sang Koo Park ),( Tae Hyoung Yoo ),( Seung Hoon Kim ),( Kyung Mi Park ),( Hyung Jin Moon ),( Hyun Ho Choi ),( Bong Tae Kim ),( Kyoung Kyu Ahn ),( Won Jae Kwag ),( Byuing Kyu Lee ) 한국응용약물학회 2008 학술대회 Vol.2008 No.1
Yoo, Ki-Yeon,Hwang, In Koo,Lim, Beong Ou,Kang, Tae-Cheon,Kim, Dong-Woo,Kim, Sang Moo,Lee, Hyeon Yong,Kim, Jong Dai,Won, Moo Ho Pharmaceutical Society of Japan 2006 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.29 No.4
<P>In the present study, we studied the neuroprotective effects of berberry extract (BE) against ischemic damage and the temporal and spatial alterations of <I>N</I>-methyl-<SMALL>D</SMALL>-aspartate receptor type 1 (NR1) and NR2A/2B immunoreactivities in the gerbil hippocampal CA1 region after transient ischemia to examine anti-ischemic effects and its role in transient forebrain ischemia. In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60—75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage <I>via</I> the reduction of NR1 activity.</P>