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Eco RI Restriction Fragment Length Polymorphism of L - myc gene has arisen by a single base change
Na, Doe Sun,Susumu Nishimura,Kazuko Kawashima 한국유전학회 1988 Genes & Genomics Vol.10 No.4
Human genomic DNA shows an EcoRI restriction fragment length polymorphism (RFLP) of L-myc. defined by 10 and 6 kilobase EcoRI fragments. Recently, it has been found that the RFLP of L-myc gene was closely correlated with the progression of human lung cancer to the metastasis. To investigate the differences of the genetic information between two ECoRI fragments, we have isolated clones of these genes from a genomic library. The genomic library was prepared using the DNA isolated from the tumor tissue of a lung cancer patient. The 10Kb and 6Kb L-myc genes were mapped using several restriction enzymes. Comparison of the restriction map of 10Kb L-myc gene to that of 6Kb gene showed that the 6Kb gene may have arisen by the mutation of the 10Kb gene leading to the creation of a EcoRI site. Nucleotide sequence analysis of both genes in this region revealed that a single base change from C to A in 10Kb gene resulted in a creation of a ECoRI site.
민경덕,엄정기,김동욱,최용훈,이윤수,니시무라 스스무,Min, Kyung Duck,Um, Jeong-Gi,Kim, Dong Wook,Choi, Yong Hoon,Lee, Youn Soo,Nishimura, Susumu 대한자원환경지질학회 1992 자원환경지질 Vol.25 No.1
Paleomagnetic study on the sedimentary rocks in the Choongnam Coal Field has been carried out to determine the direction of declination and inclination of NRM and position of paleomagnetic pole, and to investigate the geotectonism and geomagnetic stratigraphy of the sedimentary rocks in the Daedong Group. As a result of paleomagnetic study, the study area can be divided tectonically into two blocks by Baegunsa fault, namely northwestern and southeastern blocks. Site mean declination and inclination of Baegunsa and Seoungjuri Formations in the northwestern block are $23.2^{\circ}$ and $54.9^{\circ}$, respectively. Those of Amisan, Jogyeri, Baegunsa and Seoungjuri Formations in the southeastern block show normal direction with declination and inclination of $-22.1^{\circ}$ and $11.2^{\circ}$, and reversed direction with those of $158.5^{\circ}$ and $-12.6^{\circ}$, respectively. Average paleomagnetic pole position in the northwestern block is located at $212.9^{\circ}E$ and $71.1^{\circ}N$, and that in the southeastern block at $345.7^{\circ}E$ and $53.3^{\circ}N$. This difference suggests relative rotation of about $45^{\circ}$ between two blocks. The paleolatitude of Daedong Group at the time of sedimentation is $5.6^{\circ}N$ much lower than present latitude of $37.7^{\circ}N$. Compared with worldwide Mesozoic paleomagnetic polarity stratigraphy, Amisan Formation is correlated with the lower boundary of Nuanetsi reversal zone in Graham interval, and Baegunsa and Seoungjuri Formations are correlated with just upper part of the upper boundary of Nuanetsi reversal zone, and their geologic ages are Late Triassic to Early Jurassic. The position of paleomagnetic pole acquired from Daedong Group in the study area is different from those in other places. This may be attributed to the different tectonic movement by Daebo Orogeny occurred after the deposition of Daedong Group.