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An Sunho,Vo Tam Thuy Lu,Son Taekwon,Choi Hoon,Kim Jinyoung,Lee Juyeon,Kim Byung Hoon,Choe Misun,Ha Eunyoung,Surh Young-Joon,Kim Kyu-Won,Seo Ji Hae 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Human sterile α motif and HD domain-containing protein 1 (SAMHD1) has deoxyribonucleoside triphosphohydrolase (dNTPase) activity that allows it to defend against human immunodeficiency virus type I (HIV-1) infections and regulate the cell cycle. Although SAMHD1 mutations have been identified in various cancer types, their role in cancer is unclear. Here, we aimed to investigate the oncogenic role of SAMHD1 in human clear cell renal cell carcinoma (ccRCC), particularly as a core molecule promoting cancer cell migration. We found that SAMHD1 participated in endocytosis and lamellipodia formation. Mechanistically, SAMHD1 contributed to the formation of the endosomal complex by binding to cortactin. Thereafter, SAMHD1-stimulated endosomal focal adhesion kinase (FAK) signaling activated Rac1, which promoted lamellipodia formation on the plasma membrane and enhanced the motility of ccRCC cells. Finally, we observed a strong correlation between SAMHD1 expression and the activation of FAK and cortactin in tumor tissues obtained from patients with ccRCC. In brief, these findings reveal that SAMHD1 is an oncogene that plays a pivotal role in ccRCC cell migration through the endosomal FAK-Rac1 signaling pathway.
Kim, Sunho,Kim, Royoung,Nam, Hee-Jo,Kim, Ryeo-Gyeong,Ko, Enjin,Kim, Han-Su,Shin, Jihye,Cho, Daeun,Jin, Yurhee,Bae, Soyeon,Jo, Ye Won,Jeong, San Ah,Kim, Yena,Ahn, Seoyeon,Jang, Bomi,Seong, Jiheyon,Lee, Korea Genome Organization 2020 Genomics & informatics Vol.18 No.3
This paper describes a community effort to improve earlier versions of the full-text corpus of Genomics & Informatics by semi-automatically detecting and correcting PDF-to-text conversion errors and optical character recognition errors during the first hackathon of Genomics & Informatics Annotation Hackathon (GIAH) event. Extracting text from multi-column biomedical documents such as Genomics & Informatics is known to be notoriously difficult. The hackathon was piloted as part of a coding competition of the ELTEC College of Engineering at Ewha Womans University in order to enable researchers and students to create or annotate their own versions of the Genomics & Informatics corpus, to gain and create knowledge about corpus linguistics, and simultaneously to acquire tangible and transferable skills. The proposed projects during the hackathon harness an internal database containing different versions of the corpus and annotations.
( Sunho Park ),( Hyun-ha Park ),( Yonghyun Gwon ),( Sujin Kim ),( Daun Kim ),( Hoon Eui Jeong ),( Jangho Kim ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.2
Nanoengineering offers great opportunities for advanced applications in agricultural and biological fields. Here, we proposed a bio-instructive nanospike patch with the precisely controlled sizes using a sophisticated nanoengineering (e.g., capillary force lithography). To investigate the effect of a developed nanospike, the various types of cells including the mammalian cells and bacterial were cultured. Interestingly, the nanospike can both promote the behaviors including proliferation, differentiation, and cytokine excretion of the mammalian cells and prevent the bacterial biofilm formation by the designed feature sized of the nanospike. More specifically, the mammalian cells with relatively large size were received the proper structural stimulation from the nanopske, while the bacterial membrane were damaged by the structure of the nanospike. Our finding reveal the importance of the nanoscale sizes of the spikes to regulate the behaviors of cells, and the proposed nanospike could be used as new bio-instructive platforms such as food packaging and cell therapy platforms in agricultural and biological fields.
Nano-enabled Biosystems Engineering for Future Agriculture
( Sunho Park ),( Yonghyun Gwon ),( Woochan Kim ),( Hyoseong Kim ),( Jangho Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
Despite progress in agricultural prosperity, agriculture faces some problems such as the drop in profitability and the reduction in deforestation, necessitating development of an effective and productive agricultural system. To encourage a productive agricultural system, biosystems engineering have a important role in the impending agri-tech revolution to promote the proper regulatory arrangement. Recently, nanotechnology regards as emerged technology to support biosystems engineering for sustainable agriculture incorporating food security and human health. In this study, we proposed nano-enabled biosystems engineering for future advanced agriculture. Specifically, we reveal that nanomaterials (i.e., graphene) can promote the plant and crop growth, showing the enhanced florescence and the increased sugar content. In addition, biocompatible nanoparticles can improve the pesticide performance and plant growth without cytotoxicity. In addition, nanotopography inspired by extracellular matrix can induce the animal tissue regeneration. Using nano-enabled biosystems engineering, we can confirm their potential use for improving functions of biosystems in the near future.
Directional Matrix Nanotopography with Varied Sizes for Engineering Wound Healing
Kim, Jangho,Bae, Won-Gyu,Kim, Yeon Ju,Seonwoo, Hoon,Choung, Han-Wool,Jang, Kyoung-Je,Park, Sunho,Kim, Bog Hee,Kim, Hong-Nam,Choi, Kyoung Soon,Kim, Myung-Sun,Choung, Pill-Hoon,Choung, Yun-Hoon,Chung, J Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.19
Narrative Review of Clinical Impact of Head-Hip Offset Following Adult Spinal Deformity Surgery
Sunho Kim,Seung-Jae Hyun,Jae-Koo Lee,Ki-Jeong Kim 대한신경외과학회 2024 Journal of Korean neurosurgical society Vol.67 No.2
In adult spinal deformity (ASD) surgery, mechanical failure (MF) has been a significant concern for spine surgeons as well as patients. Despite earnest endeavors to prevent MF, the absence of a definitive consensus persists, owing to the intricate interplay of multifarious factors associated with this complication. Previous approaches centered around global spinal alignment have yielded limited success in entirely forestalling MF. These methodologies, albeit valuable, exhibited limitations by neglecting to encompass global balance and compensatory mechanisms within their purview. In response to this concern, an in-depth comprehension of global balance and compensatory mechanisms emerges as imperative. In this discourse, the center of gravity and the gravity line are gaining attention in recent investigations pertaining to global balance. This narrative review aims to provide an overview of the global balance and a comprehensive understanding of related concepts and knowledge. Moreover, it delves into the clinical ramifications of the contemporary optimal correction paradigm to furnish an encompassing understanding of global balance and the current optimal correction strategies within the context of ASD surgery. By doing so, it endeavors to furnish spine surgeons with a guiding compass, enriching their decision-making process as they navigate the intricate terrain of ASD surgical interventions.
( Sunho Park ),( Sujin Kim ),( Yonghyun Gwan ),( Woochan Kim ),( Daun Kim ),( Sungmin Park ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.2
Graphene, one of carbon nanomaterials, has unique properties such as high electrical conductivity, surface area, and carrier mobility, which is currently regarded as emerging engineering platforms in various fields including agriculture and biological applications. Here, we present graphene oxide (GO) that can provide a positive influence on plant growth. To this end, we approached two methods with indirect and direct stimulation to provide unique structural, mechanical, chemical cues of graphene to plants including Arabidopsis thaliana and watermelon. The GO injected Arabidopsis thaliana showed the enhanced growth such as increased root length, leaf number, leaf area, and flower number. In addition, it was confirmed that the GO injected watermelon showed the enhanced sugar concentration. Our findings suggest that graphene with suitable concentration may provide positive effects on the plant growth as a new tool for rational design of plant growth-assisted agents for future agriculture.
Engineering Eggshell Membranes for Manipulation of Nanotopographically-defined Functional Platforms
( Sunho Park ),( Daun Kim ),( Woochan Kim ),( Dohyeon Lee ),( Sungmin Park ),( Sujin Kim ),( Jangho Kim ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Eggshell membrane (ESM), one of the agricultural bioresources, is being recognized as emerging engineering platforms in various fields including agriculture and biological engineering. Eggshell membrane is the protein-rich membrane between the eggshell and egg white, having interesting characteristics such as structural, chemical, and physical properties. However, the raw ESM has many limitations (e.g., low electric capability and mechanical property), which raised some problems for its wide use as commercial engineering platforms. Here, we present new ESM-based engineering platforms based on nanotechnology. To develop the nanotopographically-enhanced ESM platforms, we used graphene, one of the carbon-based nanomaterials, that provides unique nanotopographically-defined cues to the raw ESM. The graphene-ESM hybrid platforms showed hierarchically micro- and nanoscale structures (i.g., microfibers from ESM and nanosheets from graphene). It is also found that the graphene-ESM hybrid platforms could enhance the electrical and mechanical property compared to the raw ESM. Our approach can enable the design and manipulation of ESM-based functional engineering platforms for various applications such as agricultural, biological, environmental, and biomedical platforms (e.g., biomaterials, electric devices, sensors, air purification systems).
Kim, Byung Soo,Kim, Inyoung,Lee, Sunho,Kim, Sangcheol,Rha, Sun Young,Chung, Hyun Cheol Oxford University Press 2005 Bioinformatics Vol.21 No.4
<P> <B>Motivation:</B> It is a common practice in cancer microarray experiments that a normal tissue is collected from the same individual from whom the tumor tissue was taken. The indirect design is usually adopted for the experiment that uses a common reference RNA hybridized both to normal and tumor tissues. However, it is often the case that the test material is not large enough for the experimenter to extract enough RNA to conduct the microarray experiment. Hence, collecting <I>n</I>cases does not necessarily end up with a matched pair sample of size <I>n</I>. Instead we usually have a matched pair sample of size <I>n</I> <SUB>1</SUB>, and two independent samples of sizes <I>n</I> <SUB>2</SUB> and <I>n</I> <SUB>3</SUB>, respectively, for ‘reference versus normal tissue only’ and ‘reference versus tumor tissue only’ hybridizations (<I>n</I>=<I>n</I> <SUB>1</SUB> + <I>n</I> <SUB>2</SUB> + <I>n</I> <SUB>3</SUB>). Standard statistical methods need to be modified and new statistical procedures are developed for analyzing this mixed dataset.</P><P> <B>Results:</B> We propose a new test statistic, <I>t</I> <SUB>3</SUB>, as a means of combining all the information in the mixed dataset for detecting differentially expressed (DE) genes between normal and tumor tissues. We employed the extended receiver operating characteristic approach to the mixed dataset. We devised a measure of disagreement between a RT–PCR experiment and a microarray experiment. Hotelling's <I>T</I> <SUP>2</SUP> statistic is employed to detect a set of DE genes and its prediction rate is compared with the prediction rate of a univariate procedure. We observe that Hotelling's <I>T</I> <SUP>2</SUP> statistic detects DE genes more efficiently than a univariate procedure and that further research is warranted on the formal test procedure using Hotelling's <I>T</I> <SUP>2</SUP> statistic.</P><P> <B>Contact:</B> bskim@yonsei.ac.kr </P>