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( Sungsik Shin ),( Jung U Shin ),( Youngin Lee ),( Woong Youn Chung ),( Kee-hyun Nam ),( Tae Gwang Kwon ),( Ju Hee Lee ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.3
Background: Growth factors play important roles in wound healing. However, the evidence for the effects of growth factors on post-thyroidectomy scars is limited. Objective: We performed a prospective study to assess the preventive and therapeutic effect of a multi-growth factor (MGF)-containing cream on post-thyroidectomy scars. Methods: Twenty-one patients with thyroidectomy scars applied MGF cream twice a day. We assessed the changes in erythema, pigmentation, skin elasticity, and skin hydration status using the erythema index, melanin index, cutometer, and corneometer, respectively. In addition, Vancouver scar scale (VSS) and patient satisfaction were assessed at 10 days after surgery (baseline), 2 weeks, 6 weeks, and 12 weeks after baseline. Results: The mean total VSS scores were significantly lower at 6 weeks (3.24±1.51 vs. 1.91±1.38) and 12 weeks (3.24±1.51 vs. 1.71±1.59) compared to the baseline. The degree of pigmentation was significantly lower at 12 weeks compared to the baseline, and the skin elasticity, and the skin hydration status were significantly higher at 12 weeks compared to the baseline. Over 85% of the patients were satisfied with the use of MGF cream without any adverse effect. Conclusion: MGF cream might have additive or supportive effect for scar formation after thyroidectomy. (Ann Dermatol 29(3) 314∼320, 2017)
Seungsoo Jung,Youngho Lee,Sungsik Han,Youngwhan Kim,Taiksang Nam,Ducksun Ahn 대한생리학회-대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.1
Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase A<sub>2</sub>, has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. Ca<sup>2+</sup> influx was shown to be augmented in atherosclerotic artery which might be responsible for abnormal vascular reactivity. However, the mechanism underlying Ca<sup>2+</sup> influx change in atherosclerotic artery remains undetermined. The purpose of the present study was to examine the effects of LPC on L-type Ca<sup>2+</sup> current (I<sub>Ca(L)</sub>) activity and to elucidate the mechanism of LPC-induced change of I<sub>Ca(L)</sub> in rabbit portal vein smooth muscle cells using whole cell patch clamp. Extracellular application of LPC increased I<sub>Ca(L)</sub> through whole test potentials, and this effect was readily reversed by washout. Steady state voltage dependency of activation or inactivation properties of I<sub>Ca(L)</sub> was not significantly changed by LPC. Staurosporine (100 nM) or chelerythrine (3ՌM), which is a potent inhibitor of PKC, significantly decreased basal I<sub>Ca(L)</sub>, and LPC-induced increase of I<sub>Ca(L)</sub> was significantly suppressed in the presence of PKC inhibitors. On the other hand, application of PMA, an activator of PKC, increased basal I<sub>Ca(L)</sub> significantly, and LPC-induced enhancement of I<sub>Ca(L)</sub> was abolished by pretreatment of the cells with PMA. These findings suggest that LPC increased I<sub>Ca(L)</sub> in vascular smooth muscle cells by a pathway that involves PKC, and that LPC-induced increase of I<sub>Ca(L)</sub> might be, at least in part, responsible for increased Ca<sup>2+</sup> influx in atherosclerotic artery.
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이경호,남병욱,남성식,Kyoungho Lee,Byounguk Nam,Sungsik Nam 한국군사과학기술학회 2023 한국군사과학기술학회지 Vol.26 No.3
An optimal design of a simple beam-shaped flexure hinge mount supporting an optical mirror is presented. An optical mirror assembly is an opto-mechanically coupled system as the optical and mechanical behaviors interact. This side-supporting mount is flexible in the radial direction and rigid for the remaining degrees of freedom to support the mirror without transferring thermal load. Through thermo-elastic, optical and eigenvalue analysis, opto-mechanical performance was predicted to establish the objective functions for optimization. The key design parameters for this flexure are the thickness and length. To find the optimal values of design parameters, response surface analysis was performed using the design of experiment based on nested FCD. Optimal design candidates were derived from the response surface analysis, and the optimal design shape was confirmed through Opto-mechanical performance validation analysis.