P206 : Integral hair lipid based barrier in human hair follicle

( Long Quan Pi ),( Sungjoo Tommy Hwang ),( Won Soo Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Integral hair lipid (IHL) plays an important role in all compartments of hair and skin substructures and also in involvement of hair development and function. Objectives: In this study, we described the IHL based barrier in human hair follicle according to the hair keratinization. Methods: The techniques of immunofluorescence and of transmission electron microscopy were performed to observe the ultrastructure of the hair lipid. Hair follicles were cut and observed longitudinally along the hair axis. For revealing IHL with electron microscopy, Lee’s fixative, composed of OsO4 and RuO4 was designed and used. Results: Ultrastructure of anagen hair follicle at the level where Henle layers are keratinizing, showed the intercellular lipid layer (IL) and lamellar structure (LS). Ultrastructure of anagen hair follicle at the level where the inner root sheath (IRS) is completely keratinized showed multiple LS and lamellar granules (LG). Multitudes of LS and IL are observed between the keratinized cells in IRS. Conclusion: The IHL in the hair follicle may be regarded as hair barrier to be similar to the epidermal lipid layer functioning as skin barrier.

Recent Discoveries in Silla Settlement Archaeology

( Lee Sungjoo ) 서울대학교 규장각한국학연구원 2016 Seoul journal of Korean studies Vol.29 No.1

In Silla history, the Maripkan period saw the Kyŏngju-centered Saro polity subjugate peripheral regional polities and towns and develop into an ancient state. Archaeologically, this period saw the construction of large and small Silla-style tombs within the Silla area of authority. In the past, Silla archaeology has tended to study tomb material, especially high tombs constructed in Kyŏngju and the central regions of peripheral regional polities, to understand the political relationship between the Silla central government and local leaders. Silla villages, roads, fortresses, small-tomb cemeteries, and other features dating to the fourth through sixth centuries exposed by recent excavations in the Silla sphere give us a new understanding of Maripkan-period Silla society. The early records of the Silla Annals as contained in the Samguk sagi depict Silla as already having developed to the level of an ancient state, but this does not accord with the reality of the period. Nevertheless, it is true that Maripkan-period records do describe events that are generally accurate. Consequently, there are many details in the Silla Annals’ records of this period that are worth comparing with recently excavated archaeological data of the Maripkan period.

Formation of the Silla and Gaya Ceramic Styles

( Lee Sungjoo ) 국립중앙박물관 2012 Journal of Korean Art and Archaeology (JKAA) Vol.6 No.0

Symmetrical Emission Transparent Organic Light-Emitting Diodes With Ultrathin Ag Electrodes

Lee, Illhwan,Kim, Sungjun,Park, Jae Yong,Kim, Sungjoo,Cho, Hyung Won,Ham, Juyoung,Gim, Seungo,Kim, Kisoo,Hong, Kihyon,Lee, Jong-Lam IEEE 2018 IEEE photonics journal Vol.10 No.3

<P>This paper describes a way to implement a transparent electrode for symmetrical emission from the bottom and top sides of transparent organic light-emitting diodes (TOLEDs). An ultrathin (∼6 nm) and smooth Ag film was achieved by using the pretreatment of using oxygen plasma prior to deposition of a nanoscale-thin Ag film on glass. The treatment increased the surface energy, thereby enhancing the wettability of the Ag on glass substrate and consequently leading to the formation of thin and unifrom Ag film with high optical transmittance <I>T</I> ∼ 76% and low sheet resistance <I>R</I><SUB>S</SUB> < 15 Ω □<SUP>−1</SUP>. Using this scheme, a highly transparent glass/Ag/WO<SUB>3</SUB> structure with <I>T</I> = 85.6%, and <I>R</I><SUB>S</SUB> = 9.3 Ω □<SUP>−1</SUP> was designed (ITO: 83.1%, 10 Ω □<SUP>−1</SUP>). We conducted finite-domain time-difference simulation for this glass/Ag/WO<SUB>3</SUB> electrode to design a weak microcavity structure that retained the transparency and emitting properties. This optimized structure of TOLEDs (Ag = 6 nm) showed higher <I>T</I> = 73.84% than those of ITO devices (<I>T</I> = 73.19%), and can induce the weak microcavity effect, resuting in improved electroluminescent properties and increased the luminance value from 38.25 to 56.25 cd A<SUP>−1</SUP> at 25 mA cm<SUP>–2</SUP>.</P>

A Long Non-Coding RNA snaR Contributes to 5-Fluorouracil Resistance in Human Colon Cancer Cells

Lee, Heejin,Kim, Chongtae,Ku, Ja-Lok,Kim, Wook,Kim Yoon, Sungjoo,Kuh, Hyo-Jeong,Lee, Jeong-Hwa,Nam, Suk Woo,Lee, Eun Kyung Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.7

Several types of genetic and epigenetic regulation have been implicated in the development of drug resistance, one significant challenge for cancer therapy. Although changes in the expression of non-coding RNA are also responsible for drug resistance, the specific identities and roles of them remain to be elucidated. Long non-coding RNAs (lncRNAs) are a type of ncRNA (> 200 nt) that influence the regulation of gene expression in various ways. In this study, we aimed to identify differentially expressed lncRNAs in 5-fluorouracil-resistant colon cancer cells. Using two pairs of 5-FU-resistant cells derived from the human colon cancer cell lines SNU-C4 and SNU-C5, we analyzed the expression of 90 lncRNAs by qPCR-based profiling and found that 19 and 23 lncRNAs were differentially expressed in SNU-C4R and SNU-C5R cells, respectively. We confirmed that snaR and BACE1AS were down-regulated in resistant cells. To further investigate the effects of snaR on cell growth, cell viability and cell cycle were analyzed after transfection of siRNAs targeting snaR. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. Our results provide an important insight into the involvement of lncRNAs in 5-FU resistance in colon cancer cells.

Technology clustering based on evolutionary patterns: The case of information and communications technologies

Lee, Hyoung-joo,Lee, Sungjoo,Yoon, Byungun Elsevier 2011 TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE Vol.78 No.6

<P><B>Abstract</B></P><P>Technology trend analysis anticipates the direction and rate of technology changes, and thus supports strategic decision-making for innovation. As technological convergence and diversification are regarded as emerging trends, it is important to compare the growth patterns of various technologies in a particular industry to help understand the industry characteristics and analyse the technology innovation process. However, despite the potential value of this approach, conventional approaches have focused on individual technologies and paid little attention to synthesising and comparing multiple technologies. We therefore propose a new approach for clustering technologies based on their growth patterns. After technologies with similar patterns are identified, the underlying factors that lead to the patterns can be analysed. For that purpose, we analysed patent data using a Hidden Markov model, followed by clustering analysis, and tested the validity of the proposed approach by applying it to the ICT industry. Our approach provides insights into the basic nature of technologies in an industry, and facilitates the analysis and forecasting of their evolution.</P> <P><B>Research Highlights</B></P><P>►We propose an approach to clustering technologies based on their growth patterns. ►Patent data were analysed using a Hidden Markov model, followed by clustering. ►The validity of the proposed approach was verified by applying it to the ICT industry. ►The approach facilitates the analysis and forecasting of technology evolution.</P>

Hypoesthesia after IAN block anesthesia with lidocaine : management of mild to moderate nerve injury

Sungjoo Moon,Seung-Jong Lee,Euiseong Kim,Chan-Young Lee 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.4

Hypoesthesia after an inferior alveolar nerve (IAN) block does not commonly occur, but some cases are reported. The causes of hypoesthesia include a needle injury or toxicity of local anesthetic agents, and the incidence itself can cause stress to both dentists and patients. This case presents a hypoesthesia on mental nerve area followed by IAN block anesthesia with 2% lidocaine. Prescription of steroids for a week was performed and periodic follow up was done. After 1 wk, the symptoms got much better and after 4 mon, hypoesthesia completely disappeared. During this healing period, only early steroid medication was prescribed. In most cases, hypoesthesia is resolved within 6 mon, but being aware of etiology and the treatment options of hypoesthesia is important. Because the hypoesthesia caused by IAN block anesthesia is a mild to moderate nerve injury, early detection of symptom and prescription of steroids could be helpful for improvement of the hypoesthesia.

Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother–neonate pairs

Lee, Jangwoo,Choi, Kyungho,Park, Jeongim,Moon, Hyo-Bang,Choi, Gyuyeon,Lee, Jeong Jae,Suh, Eunsook,Kim, Hai-Joong,Eun, So-Hee,Kim, Gun-Ha,Cho, Geum Joon,Kim, Sung Koo,Kim, Sungjoo,Kim, Su Young,Kim, Se Elsevier 2018 Science of the Total Environment Vol.626 No.-

<P><B>Abstract</B></P> <P>Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios in mother–neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318 mother–neonate pairs at six university hospitals in Korea. BPA levels were detected using liquid chromatography tandem mass spectrometry. The ratios of the BPA levels in the other sample types to the levels in maternal serum were calculated. BPA was detected in 79.5–100% of the maternal and fetal samples. The median BPA concentration in the samples decreased in the order of neonatal urine (4.75ng/mL), maternal urine (2.86ng/mL), cord serum (1.71ng/mL), maternal serum (1.56ng/mL), breast milk (0.74ng/mL), and the placenta (0.53ng/g). We estimated the ratios of BPA levels in the other sample types to those in maternal serum. The median (95th percentile) cord serum-to-maternal serum ratio was 1.12 (15.2) for 160 mother–fetal pairs, in which BPA was detected in both samples. The placenta-, maternal urine-, neonatal urine-, and breast milk-to-maternal serum ratios were 0.28 (5.31), 1.79 (29.9), 1.98 (28.2), and 0.51 (10.5), respectively. In addition, the median (95th percentile) cord serum-to-placenta ratio was 4.03 (45.8), and the neonatal urine-to-cord serum ratio was 1.95 (25.6). The 95th percentile values were 14–20-fold greater than the medians. Urine contained the highest BPA concentrations, followed by serum, breast milk, and the placenta. The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Not enough data on tissue distribution of BPA in mother‑neonate (or fetus) pair </LI> <LI> The order of BPA concentrations in examined tissue or bio-samples are urine in mother and neonates>cord serum>maternal serum>breast milk>placenta. </LI> <LI> BPA in cord serum, significantly associated with in maternal serum and urine but not in others. </LI> <LI> The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Reducing Mobile Storage Writes : Non-Volatile Write Buffer and PRAM-based Journaling

Sungjoo Yoo(유승주),Mungyu Son(손문규),Sungkwang Lee(이성광),Taemin Lee(이태민),Hyunsun Park(박현선),Sunggu Lee(이승구) 한국정보과학회 2015 정보과학회지 Vol.33 No.2

A Study on Fake Iris Detection based on the Reflectance of the Iris to the Sclera for Iris Recognition

Sungjoo Lee,Kang Ryoung Park,Jaihie Kim 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.4