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Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Chae, Weon-Sik,Im, Sung-Jae,Lee, Jin-Kyu,Kim, Yong-Rok Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.3
Free-standing nanoporous alumina membrane microtubes with different shapes (rectangular and cylindrical tubes) and variable dimensions were easily fabricated by direct anodization of the aluminum templates of the specified shapes (strip and wire) and dimensions during the electrochemical reaction.
Chae, Heejung,Kim, Deokhoon,Yoo, Changhoon,Kim, Kyu-pyo,Jeong, Jae Ho,Chang, Heung-Moon,Lee, Sang Soo,Park, Do Hyun,Song, Tae Jun,Hwang, Shin,Kim, Ki-Hun,Song, Gi-Won,Ahn, Chul Soo,Lee, Jae Hoon,Hwang Elsevier 2019 European journal of cancer Vol.120 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>In biliary tract cancer (BTC), standard chemotherapy has limited benefit and no molecular targeted agents have been approved. This study investigated the genetic profile of BTC to identify potential new therapeutic targets and predictive biomarkers.</P> <P><B>Methods</B></P> <P>Targeted exome sequencing was performed for 124 patients with BTC [gallbladder cancer (GBC), 25; intrahepatic cholangiocarcinoma (ICC), 55; extrahepatic cholangiocarcinoma (ECC), 44]. Survival analysis was performed in 112 patients who received palliative chemotherapy for locally unresectable or metastatic disease.</P> <P><B>Results</B></P> <P>Genetic alterations were observed in 104 patients (83.8%); the most commonly mutated genes were <I>TP53</I> (44.4%), <I>KRAS</I> (29.0%), <I>ARID1A</I> (12.1%) and <I>IDH1</I> (9.7%). <I>IDH1/2</I> mutations appeared more frequently in ICC (23.6%, P = 0.0002) than in GBC (4.0%) or ECC (2.3%), while <I>ERBB2</I>/<I>3</I> mutations were found only in GBC (20.0%) and ECC (11.4%). Patients harbouring <I>TP53</I> mutations had shorter overall survival (OS; median 15.2 vs. 37.8 months, <I>P</I> = 0.018), while <I>IDH1</I> mutations showed a tendency for longer progression-free survival (PFS; 10.6 vs. 6.1 months, <I>P</I> = 0.124). Potentially actionable genetic alterations were found in 54.8%, and 7.1% received appropriate molecular targeted therapy in the clinical trial setting. Germline or somatic mutations in DNA damage repair (DDR) genes were found in 63.5% of patients and were significantly associated with longer PFS (6.9 vs. 5.7 months, <I>P</I> = 0.013) and OS (21.0 vs. 13.3 months, <I>P</I> = 0.009) in patients who received first-line platinum-containing chemotherapies (n = 88).</P> <P><B>Conclusions</B></P> <P>A subgroup of patients with BTC may benefit from targeted therapy by the aid of genetic information. In particular, DDR alterations may be a predictive biomarker for response to platinum-containing chemotherapy in patients with BTC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examined genetic landscape of biliary tract cancer with targeted sequencing. </LI> <LI> Certain genetic mutations were associated with clinical outcomes. </LI> <LI> More than half of patients harboured at least one potentially actionable alteration. </LI> <LI> DNA damage repair gene alterations were associated with a better response to platinum-based treatment. </LI> </UL> </P>
Chae, Dong-Ryeol,Kim, Yu-Il,Kee, Seung-Jung,Kim, Yoon-Hee,Chi, Su-Young,Ban, Hee-Jung,Kwon, Yong-Soo,Oh, In-Jae,Kim, Kyu-Sik,Kim, Soo-Ock,Kim, Young-Chul,Lim, Sung-Chul S. Karger AG 2011 Respiration Vol.82 No.2
<P>Abstract</P><P><I>Background:</I> In 2007, the American Thoracic Society (ATS) and Infectious Disease Society of America (IDSA) published new diagnostic guidelines for nontuberculous mycobacterial (NTM) disease. Bacteriological criteria have become simpler compared to the 1997 ATS diagnostic criteria. <I>Objective:</I> For assessing the impact of the 2007 ATS/IDSA diagnostic criteria, we compared the diagnosis rate and time to diagnosis of NTM lung disease using the 1997 and 2007 ATS guidelines. <I>Methods:</I> Sixty-four patients who had excreted <I>Mycobacterium intracellulare</I>, <I>M. avium</I>, <I>M. abscessus</I> or <I>M. kansasii</I> at least one time in their respiratory specimens at Chonnam National University Hospital were reviewed. The 1997 ATS and 2007 ATS/IDSA guidelines were applied to these patients. <I>Results:</I> Thirty-seven of 64 patients (57.8%) were diagnosed with NTM lung disease by the 1997 ATS criteria. When the 2007 ATS/IDSA criteria were applied, 6 patients were newly diagnosed with NTM lung disease. The diagnosis rate significantly increased from 57.8 to 67.2% (p < 0.001). The time to diagnosis in the 1997 ATS and 2007 ATS/IDSA guidelines was 46.4 ± 53.0 and 36.2 ± 38.5 days, respectively (p = 0.002). <I>Conclusion:</I> These data suggest that we can shorten the time to diagnose NTM lung disease and diagnose more simply by using the 2007 ATS/IDSA guidelines. Further study will be needed to assess that these changes affect the management of NTM disease.</P><P>Copyright © 2010 S. Karger AG, Basel</P>
Chae, Tong Un,Ko, Yoo-Sung,Hwang, Kyu-Sang,Lee, Sang Yup Elsevier 2017 Metabolic engineering Vol.41 No.-
<P><B>Abstract</B></P> <P>Microbial production of chemicals and materials from renewable sources is becoming increasingly important for sustainable chemical industry. Here, we report construction of a new and efficient platform metabolic pathway for the production of four-carbon (butyrolactam), five-carbon (valerolactam) and six-carbon (caprolactam) lactams. This pathway uses ω-amino acids as precursors and comprises two steps. Activation of ω-amino acids catalyzed by the <I>Clostridium propionicum</I> β-alanine CoA transferase (Act) followed by spontaneous cyclization. The pathway operation was validated both <I>in vitro</I> and <I>in vivo</I>. Three metabolically engineered <I>Escherichia coli</I> strains were developed by introducing the newly constructed metabolic pathway followed by systems-level optimization, which resulted in the production of butyrolactam, valerolactam and caprolactam from renewable carbon source. In particular, fed-batch fermentation of the final engineered <I>E. coli</I> strain produced 54.14g/L of butyrolactam in a glucose minimal medium. These results demonstrate the high efficiency of the novel lactam pathway developed in this study.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Lactams are important chemicals having a wide range of industrial applications. </LI> <LI> Novel metabolic pathways for four-, five- and six-carbon lactams are constructed. </LI> <LI> β-Alanine CoA transferase is a key enzyme for the novel pathway. </LI> <LI> Production of C4, C5 and C6 lactams from renewable carbon sources are demonstrated. </LI> <LI> Fed-batch fermentation allowed production of 54g/L butyrolactam. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Chae, Dong-Kyu,Lee, Sang-Chul,Lee, Si-Yong,Kim, Sang-Wook Elsevier 2018 Neurocomputing Vol.278 No.-
<P>Neighborhood models (NBMs) are the methods widely used for collaborative filtering in recommender systems. Given a target user and a target item, NBM s find k most similar users or items (i.e., k-nearest neighbors) and make a prediction of a target user on an item based on the rating patterns of those neighbors on the item. In NBMs, however, we have a difficulty in satisfying both the performance and accuracy together. In order to pursue an accurate recommendation, NBMs may find the k-nearest neighbors at every recommendation request to exploit the latest ratings, which requires a huge amount of computation time. Alternatively, NBM s may search for the k-nearest neighbors offline, which consequently results in inaccurate recommendation as time goes by, or even may not able to deal with new users or new items, because they cannot exploit the latest ratings generated after the k-nearest neighbors are determined. In this paper, we propose a novel approach that finds the k-nearest neighbors efficiently by identifying only those users and items necessary in computing the similarity. The proposed approach enables NBM s not to require any offline similarity computations but to exploit the latest ratings, thereby resolving speedaccuracy tradeoffsuccessfully. We demonstrate the effectiveness of the proposed approach through extensive experiments. (C) 2017 Elsevier B.V. All rights reserved.</P>
Sung-Kyu Chae,Hyo-Jin Park,Jin-Woo Kim,Jae-Hyun Ahn,Soo-Yong Park,Jae-Young Park,Seul-Gi Yang,Deog-Bon Koo 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.4
Gangliosides exist in glycosphingolipid-enriched domains on the cell membrane and regulate various functions such as adhesion, differentiation, and receptor signaling. Ganglioside GM3 by ST3GAL5 enzyme provides an essential function in the biosynthesis of more complex ganglio-series gangliosides. However, the role of gangliosides GM3 in porcine oocytes during in vitro maturation and early embryo development stage has not yet understood clear. Therefore, we examined ganglioside GM3 expression patterns under apoptosis stress during maturation and preimplantation development of porcine oocytes and embryos. First, porcine oocytes cultured in the NCSU-23 medium for 44 h after H2O2 treated groups (0.01, 0.1, 1 mM). After completion of meiotic maturation, the proportion MII (44 h) was significantly different among control and the H2O2 treated groups (76.8±0.3 vs 69.1±0.4; 0.01 mM, 55.7±1.0; 0.1 mM, 38.2±1.6%; 1 mM, P<0.05). The expressions of ST3GAL5 in H2O2 treated groups were gradually decreased compared with control group. Next, changes of ST3GAL5 expression patterns were detected by using immunofluorescene (IF) staining during preimplantation development until blastocyst. As a result, we confirmed that the expressions of ST3GAL5 in cleaving embryos were gradually decreased (P<0.05) according to the early embryo development progress. Based on these results, we suggest that the ganglioside GM3 was used to the marker as pro-apoptotic factor in porcine oocyte of maturation and early embryo production in vitro, respectively. Furthermore, our findings will be helpful for better understanding the basic mechanism of gangliosides GM3 regulating in oocyte maturation and early embryonic development of porcine in vitro.