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( Ji Yong Kim ),( Jai Sung Lee ),( Yong Seok Han ),( Jun Hee Lee ),( Inhyu Bae ),( Yeo Min Yoon ),( Sang Mo Kwon ),( Sang Hun Lee ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although H2O2 (200 mM) increased intracellular ROS levels in human MSCs, lycopene (10 μmM) pretreatment suppressed H2O2-induced ROS generation and increased survival. H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
Kim, Ji Yong,Lee, Jai-Sung,Han, Yong-Seok,Lee, Jun Hee,Bae, Inhyu,Yoon, Yeo Min,Kwon, Sang Mo,Lee, Sang Hun The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although $H_2O_2$ ($200{\mu}M$) increased intracellular ROS levels in human MSCs, lycopene ($10{\mu}M$) pretreatment suppressed $H_2O_2$-induced ROS generation and increased survival. $H_2O_2$-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by $H_2O_2$ treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.
S-344 : The Role of Skeletal Muscle Mass in Development of Metabolic Syndrome
( Byung Sam Park ),( Jun Sung Moon ),( Ji Sung Yoon ),( Kyu Chang Won ),( Hyoung Woo Lee ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Introduction: It has been well known that abdominal adiposity is related with insulin resistance and greater risk of metabolic disorder. Skeletal muscle plays central role in insulin mediated glucose disposal of whole body, but we only know a little about the association between skeletal muscle mass and MetS (MetS). The aim of this study is to clarify the clinical role of skeletal muscle mass in developing MetS through using skeletal muscle parameters by body impedance analysis (BIA). Methods: 1,042 healthy adults aged from 20 to 75 years who visited Yeungnam university health promotion center from Jun. 2008 to Jun. 2010 were enrolled. 204 subjects who had prior MetS or chronic disease that can affect to skeletal muscle mass were excluded. After 24 months from baseline, the metabolic parameters were assessed and the development of MetS was diagnosed using modified NCEP-ATP III criteria. From the BIA (Inbody 720), we obtained skeletal muscle mass (SMM, Kg), body fat mass (BFM, Kg), and visceral fat area (VFA, cm2). Then, we had defined as follows; percent of skeletal muscle mass (SMM%, %): SMM (kg)/weight (Kg), skeletal muscle index (SMI, Kg/m2): SMM (Kg)/height (m)2, skeletal muscle to body fat ratio (MFR): SMM (kg)/BFM (Kg) and skeletal muscle to visceral fat ratio (SVR, Kg/cm2): SMM (Kg)/VFA (cm2) Results: Mean follow up periods were 28.7±5.4 months. Among total 838 subjects (46.9±9.9 years, M:F=477:361), 88 (10.5%) were newly diagnosed MetS. 5th quintile of the SMM%, MFR and SVR was associated with decreased risk of development of MetS after adjusting for confounding factors. Conclusion: Decreased skeletal muscle mass may play critical role in development of the MetS and not absolute amount of skeletal muscle mass but relative ratio to body composition may be more important.
Changes in volatile flavor compounds in steam-dried Allium hookeri root
Jun, Hyun-Il,Yang, Jae-Heon,Choi, Ji Yeon,Lee, Sung-Hyen,Song, Geun-Seoup,Kim, Kyong Su,Kim, Young-Soo Korean Society of Food Science and Technology 2016 Food Science and Biotechnology Vol.25 No.5
This study was carried out to identify volatile flavor compounds in Allium hookeri root (AHR) and steam-dried AHR. The volatile compounds were extracted using a simultaneous steam distillation and extraction (SDE) method and identified by gas chromatography/mass spectrometry (GC/MS) analysis. Forty volatile compounds, present at a concentration of 76.10 mg/kg, were identified in AHR, with sulfur-containing compounds (96.8%) as the major volatile compounds. On the other hand, in two and four times steam-dried AHR, 34 volatile compounds present at 5.96 mg/kg and 28 compounds present at 4.23 mg/kg were identified, respectively. This two and four times steam-dried AHR respectively contained sulfur-containing compounds (64.1 and 37.4%) and aldehydes (19.3 and 45.4%) as the dominant compounds. The sulfur-containing compounds decreased, whereas the aldehydes increased relative to levels in AHR with increased steam-drying time. This is the first report on volatile flavor compounds in AHR and steam-dried AHR.
( Sang Jung Park ),( Yeon Seok Seo ),( Seung Woon Park ),( Han Ah Lee ),( Tae Hyung Kim ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( S 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Practice guidelines recommend endoscopic band ligation (EBL) for the treatment of bleeding from cardiac varices on lesser curvature side of the stomach (CVs). However, endoscopic variceal obturation (EVO) using cyanoacrylate has been reported more effective than EBL for fundal variceal bleeding and considering that the mucosa covering cardiac varices is more thickened than esophageal varices and being exposed to gastric acids or food materials continuously, EVO could be more effective than EBL for the treatment of bleeding from CVs. This study was performed to compare the efficacy between EVO and EBL for the treatment of bleeding from CVs. Methods: All patients who were treated EBL or EVO for bleeding from CVs were enrolled. The patients diagnosed with hepatocellular carcinoma or treated with endoscopic injection therapy were excluded. Results: A total of 77 patients treated with bleeding from CVs were enrolled. Age was 56.4±10.6 years and 67 patients (87.0%) were men. Fifty-one and 26 patients were treated with EBL and EVO, respectively. Hemostasis were achieved in 73 patients (94.8%). Hemostasis rates did not differ between EBL (47 patients, 92.2%) and EVO (26 patients, 100%) groups. Varices rebled in 13 patients during follow-up. Rebleeding rate was significantly higher in EBL group compared to EVO group (P=0.044). During follow-up, 12 patients died (10 in EBL group, 2 in EVO group). Mean survival time was 310.4±13.5 days, which did not differ between two groups (P=0.142). Conclusions: Hemostasis success rate and survival did not differ between the EBL and EVO groups. However, rebleeding rate was significantly lower in EVO group compared to EBL group. EVO could be better option for the treatment of bleeding from CVs on lesser curvature side of the stomach.
Acute respiratory distress syndrome caused by gadolinium: a case report
( Sung Jun Chung ),( Ho Joo Yoon ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Acute respiratory distress syndrome (ARDS) is a serious parenchymal lung disease characterized by acute respiratory failure. While various factors can lead to the development of ARDS, many drugs are also suggested to cause ARDS. Gadolinium is a chemical agent, which is used as contrast agents for magnetic resonance imaging (MRI). Here we report a case of gadolinium induced ARDS in a young male adult. A 25-year-old male patient presented to the emergency department of a tertiary university hospital with acute onset dyspnea. On the day of dyspnea onset, he underwent a brain MRI for evaluation of his headache which lasted for three months. Previously, he was healthy and had not taken any medications. Twenty minutes after administration of gadobutrol, a gadolinium- based contrast agent during MRI, he felt short of breath. As dyspnea aggravated over hours, he visited the emergency department of a tertiary university hospital. On physical examination, the respiratory rate was thirty per minute and the breath sound was decreased over the chest. Chest radiographs and CT scan showed bilateral diffuse infiltration of both lungs without cardiomegaly or pleural effusion. Arterial partial pressure of oxygen (PaO<sub>2</sub>) was decreased below 60/ mmHg and the ratio of PaO<sub>2</sub> over the fraction of inspired oxygen was 220 mmHg. He was admitted to the intensive care unit for the treatment of ARDS. As initial therapy, oxygen was administered with a highflow nasal cannula and systemic corticosteroids were given. Over a week of hospitalization and treatment, chest infiltration was recovered and acute respiratory failure was resolved.