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Sung Hee Yoon,Sun Ok Yun,Jung Yong Park,Hee Yeun Won,Eun-Kyung Kim,Hyun-Jung Sohn,Hyun-Il Cho,김태규 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.3
Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy. Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy.
Sung Hoon Chung,Il Sohn 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6
The effect of NaF and CaO/SiO2 mass pct. ratio (C/S) on the hydrogen solubility in terms of the hydroxyl capacity of theCaO–SiO2–NaF welding flux system was investigated at 1823 K. As a cost-effective alternative to CaF2in welding fluxes,NaF can potentially increase the fluidity, electrical conductivity, and hydroxyl capacity of welding fluxes in advanced highstrengthsteels. Additions of 1.9 to 5.9 mass pct. of NaF was found to depolymerize the structural units in the flux system. Depending on the flux composition, the dominant hydrogen dissolution mechanism varied. At C/S values less than 1.06, theincorporated-hydroxyl dissolution mechanism was dominant in the present flux system, in which SiO2-based complex structuralunits were pronounced. At C/S values above 1.06, the free-hydroxyl dissolution mechanism was pronounced due to thestrong network-modifying CaO content supplemented by NaF. A combination of Fourier transformed infrared, Raman, X-rayphotoelectron spectroscopy and time of flight secondary ion mass spectrometry analysis was used to determine the structuralimplications of NaF additions and C/S, which were correlated to the hydroxyl capacity of the flux. High NaF contents andC/S values were found to depolymerize the complex structural units of the molten flux by supplying greater amounts ofnetwork-modifying free oxygen (O2−) and fluorine (F−) anions to the flux system in the compositional range of this work.
러시아측 동해 북서부 해역과 한국측 동해 남서부 해역 트롤 조사에 어획된 어류의 종조성 및 양적변동
SOHN, Myoung Ho,YOON, Sang Chul,LEE, Sung Il,YOON, Byung Sun,CHA, Hyung Kee,KIM, Jong Bin,Kalchugin, Pavel,Solomatov, Sergey 한국수산해양기술학회 2015 수산해양기술연구 Vol.51 No.3
To examine species composition, abundance and biomass of fishes in the northwestern East Sea of Russian EEZ, trawl survey were conducted at 31 sampling stations from 2006 to 2008. Also, trawl survey were conducted at 21 sampling stations in the southwestern East Sea of Korean EEZ from 2006 to 2008. A total of 67 fishes were collected in the northwestern East Sea of Russian EEZ, a total of 39 fishes were collected in the southwestern East Sea of Korean EEZ. Among them, a total of 53 fishes were collected in the northwestern East Sea of Russian EEZ only, and a total of 25 fishes were collected in the southwestern East Sea of Korean EEZ only. Mean abundance per area which caught by trawl survey in the northwestern East Sea ranged from a high of $116,478inds./km^2$ in 2008 to a low of $19,737inds./km^2$ in 2006. And mean abundance per area in the southwestern East Sea ranged from a high of $89,129inds./km^2$ in 2006 to a low of $8,234inds./km^2$ in 2008. Mean biomass per area which caught by trawl survey in the northwestern East Sea ranged from a high of $11,333kg/km^2$ in 2008 to a low of $2,439kg/km^2$ in 2006. And mean biomass per area in the southwestern East Sea ranged from a high of $6,273kg/km^2$ in 2006 to a low of $1,062 kg/km^2$ in 2008. Cluster analysis, based on a Bray-Curtis similarity matrix of fourth root transformed data of number of species and individuals per area, showed division into three different groups by depth in the northwestern and southwestern East Sea.
Examination of Genetic Relationships of Silkworm Stocks in Korea by Additive Isozyme Analysis
Sohn, Bong-Hee,Kim, Hyun-Su,Kang, Pil-Don,Lee, Sang-Uk,Seong, Su-Il Korean Society of Sericultural Science 2002 International Journal of Industrial Entomology Vol.5 No.2
Previously, genetic relationships among 321 silkworm races preserved in the Department of Sericulture and Entomology, NIAST, RDA were studied using six isozymes comprising 20 loci. As a part of additional studies, three additional isozymes with 7 loci [phos-phoglucomutase (PGM), glucose phosphate isomerase (GPI), malete dehydrogenase (MDH)] from hemolymphs, midgets, and eggs were employed to reevaluate the previous dendrogram (UPGMA method). Although the current study supported the recognition of the previously identified major groups, some minor changes were apparent among the selected 47 forms. The current study showed that the polymorphic loci of GPI from eggs and MDH from hemolymph appear to be responsible characters for generating a new major group in the genetic relationship. Interpreting the data with current additive isozymes may represent more robust genetic relatioships among 321 silkworm races preserved in Korea, until further evidence is available.
Acidic and Catalytic Properties of Modified Silica Catalyst with Benzenesulfo Groups
Sohn, Jong-Rack,Ryu, Sam-Gon,Pae, Young-Il,Choi, Sang-June Korean Chemical Society 1990 Bulletin of the Korean Chemical Society Vol.11 No.5
Two types of new silica catalysts modified with benzenesulfonic acid derivatives were prepared by esterification or phenylation followed by sulfonation. Both catalysts thus prepared were tested as acid catalysts for 2-propanol dehydration and cumene dealkylation reactions. B catalyst () were more active than A catalyst (). Highter catalytic activity for B catalyst may be accounted for by higher resistance to water, higher acid strength, more acidity, and better thermal stability as compared with A catalyst.
A Case of High-degree Atrioventricular Block in a Patient with Ankylosing Spondylitis
( Sang Rok Lee ),( Hyung Wook Park ),( Sang Yub Lim ),( Seo Na Hong ),( Kye Hun Kim ),( Il Suk Sohn ),( Young Joon Hong ),( Ju Han Kim ),( Weon Kim ),( Young Keun Ahn ),( Myung Ho Jeong ),( Jeong Gwan 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10