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( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche
Yoon, Je Moon,Shin, Dong Hoon,Kim, Sang Jin,Ham, Don-Il,Kang, Se Woong,Chang, Yun Sil,Park, Won Soon Lippincott 2017 Retina Vol.37 No.1
<P>Conclusion: In Type 1 retinopathy of prematurity in Zone I, intravitreal bevacizumab with concomitant or deferred laser therapy yielded a better anatomical outcome than conventional laser therapy alone. Moreover, intravitreal bevacizumab with deferred laser treatment resulted in less myopic refractive error.</P>
The Effects of Nitrogen Bonding on Hardness of AlN/CrN Multilayer Hard Coatings
Yoon, Sang-Won,Seo, Jong-Hyun,Chae, Keun-Hwa,Park, Jong-Keuk,Song, Jong-Han,Jayaram, Vickram,Lee, Kon-Bae,Seong, Tae-Yeon,Hoon-Kwon, .,Ahn, Jae-Pyoung American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.2
Large-area, scalable fabrication of conical TiN/GST/TiN nanoarray for low-power phase change memory
Yoon, Jong Moon,Jeong, Hu Young,Hong, Sung Hoon,Yin, You,Moon, Hyoung Seok,Jeong, Seong-Jun,Han, Jun Hee,Kim, Yong In,Kim, Yong Tae,Lee, Heon,Kim, Sang Ouk,Lee, Jeong Yong The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.4
<P>We demonstrate the fabrication and phase change memory performance of a conical TiN/Ge<SUB>2</SUB>Sb<SUB>2</SUB>Te<SUB>5</SUB> (GST)/TiN nanoarray prepared <I>via</I> block copolymer lithography and straightforward two-step etching. The created 30 nm scale phase change memory cell (aerial array density: ∼207 Gbit inch<SUP>−2</SUP>) showed a threshold switching voltage of 1.1 V, a value compatible to conventional phase change memory cells. More significantly, the cell could be amorphized by a reset pulse of 1.8 V height and 100 ns width, where the reset current was 100 μA. Such a low reset current, presumably caused by nanoscale small cell dimension, is greatly beneficial for low power consumption device operation. Reversibly, the set operation was accomplished by crystallization with a set pulse of 1.2 V height, 100 ns width, and 100 ns trailing. This work provides a significant step for low power consumption and ultra-high density storage based on phase change materials.</P> <P>Graphic Abstract</P><P>Ultra-high density and low power phase-change memory (aerial array density: ~207 Gbit inch<SUP>−2</SUP>) was fabricated <I>via</I> block copolymer lithography and straightforward two-step ICP-RIE etching. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm14190b'> </P>
Hoon Seok Yoon,Won Beom Koh,You-Sung Oh,In-Jung Kim 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.5
Petalonia binghamiae extracts (PBE) suppressed melanin synthesis in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-treated B16/F10 murine melanoma cells. Specifically, the cell tyrosinase activity and melanin content were inhibited by 72% and 48%, respectively, in response to treatment with 100 µg/mL of PBE. The results of western blot analysis suggest that PBE induced the inhibition of tyrosinase and TRP-1 protein expression through suppression of α- MSH induced p38 and ERK activation.
Cyberknife Dosimetric Planning Using a Dose-Limiting Shell Method for Brain Metastases
Yoon, Kyoung Jun,Cho, Byungchul,Kwak, Jung Won,Lee, Doheui,Kwon, Do Hoon,Ahn, Seung Do,Lee, Sang-Wook,Kim, Chang Jin,Roh, Sung Woo,Cho, Young Hyun The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.6
Objective : We investigated the effect of optimization in dose-limiting shell method on the dosimetric quality of CyberKnife (CK) plans in treating brain metastases (BMs). Methods : We selected 19 BMs previously treated using CK between 2014 and 2015. The original CK plans ($CK_{original}$) had been produced using 1 to 3 dose-limiting shells : one at the prescription isodose level (PIDL) for dose conformity and the others at low-isodose levels (10-30% of prescription dose) for dose spillage. In each case, a modified CK plan ($CK_{modified}$) was generated using 5 dose-limiting shells : one at the PIDL, another at intermediate isodose level (50% of prescription dose) for steeper dose fall-off, and the others at low-isodose levels, with an optimized shell-dilation size based on our experience. A Gamma Knife (GK) plan was also produced using the original contour set. Thus, three data sets of dosimetric parameters were generated and compared. Results : There were no differences in the conformity indices among the $CK_{original}$, $CK_{modified}$, and GK plans (mean 1.22, 1.18, and 1.24, respectively; p=0.079) and tumor coverage (mean 99.5%, 99.5%, and 99.4%, respectively; p=0.177), whereas the $CK_{modified}$ plans produced significantly smaller normal tissue volumes receiving 50% of prescription dose than those produced by the $CK_{original}$ plans (p<0.001), with no statistical differences in those volumes compared with GK plans (p=0.345). Conclusion : These results indicate that significantly steeper dose fall-off is able to be achieved in the CK system by optimizing the shell function while maintaining high conformity of dose to tumor.
Recurrent Massive Subcutaneous Hemorrhage in NeurofibromatosisType 1: A Case Report
Sung Hoon Baek,Ji Hye Kim,김준식,한승백,Jung Soo Cho,Yong Han Yoon,Lucia Kim 대한의학회 2007 Journal of Korean medical science Vol.22 No.4
Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder that has three major features: multiple neural tumors, cafe-au-lait spots, and pigmented iris hamartomas (Lisch nodules). The purpose of this case report is to advise physicians of the danger associated with the progression of fast-onset massive hemorrhage to hemodynamic instability, which mandates rapid treatment to prevent the development of a life-threatening condition. A 64-yr-old woman with NF-1 was admitted to the Emergency Department (ED) because of a rapidly growing, 10×5×3 cm-sized mass on the left back area. She had previously undergone surgery for a large subcutaneous hematoma, which had developed on her right back area 30 yr before. She became hemodynamically unstable with hypotension during the next 3 hr after admission to ED. Resuscitation and blood transfusion were done, and the hematoma was surgically removed. The mass presented as a subcutaneous, massive hematoma with pathologic findings of neurofibroma. We report a case of NF-1 that presented as recurrent, massive, subcutaneous hemorrhage on the back region combined with hypovolemic shock.