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( Sang Wook Son ),( Dae Young Yu ),( Youngdoe Kim ),( Hyo Hyun Ahn ),( Yong Hyun Jang ),( Joo Young Roh ),( Young Bok Lee ),( Ji Yeoun Lee ),( Myung Hwa Kim ),( Youngja Lee ),( Gyeong-hun Park ),( Hyu 대한피부과학회 2022 Annals of Dermatology Vol.34 No.1
Background: In psoriasis treatment, not all body regions improve simultaneously after clinical interventions. Objective: This study was aimed at evaluating clinical responses across body regions, which may differentially influence patient treatment plans. Methods: This prospective, observational, and multi-center study was conducted in Koreans who adhered to ustekinumab treatment based on criteria per local label and reimbursement guidelines. A total of 581 were included in this analysis. Results: The mean (±standard deviation) psoriasis area severity index (PASI) score at baseline, age, disease duration, and body surface area (%) were 18.9±9.69, 44.2±13.29 years, 11.3±9.65 years, and 27.8±17.83, respectively. Across the head and neck, upper extremities, trunk, and lower extremities, the correlation between the PASI sub-scores for the upper and lower extremities was the highest (r=0.680). The mean PASI sub-score for the lower extremities was the highest at baseline. PASI90 and PASI100 scores were the highest for the head and neck region, indicating the highest response rates, while those for the lower extremities were consistently low at all visits. Conclusion: We found differences in regional ustekinumab responses, with the lower extremities being the most difficult to treat. These findings should be considered in psoriasis treatment.
제주도에서 브루셀라에 의해 발생한 특발성 세균성 복막염
허상택,조유경,김영리,이근화,윤지완,고관수,박미연,최영실 대한감염학회 2007 감염과 화학요법 Vol.39 No.1
Spontaneous bacterial peritonitis is the common infectious disease in liver cirrhosis patients with a fever. Brucellosis is a rare cause of bacterial peritonitis. A case indigenous to a citizen of Jeju, he ate a raw veal of cow four times in last 2 months prior to admission. The gram-negative bacilli were isolated from blood and peritoneal fluid cultures. He was confirmed brucellosis by serologic work- ups. This isolate was confirmed as Brucella abortus by using PCR amplification of 16S ribosomal RNA (rRNA) and omp2. This is the first case of bruellosis that was diagnosed spontaneous bacterial peritonitis in liver cirrhosis patient among native korean citizens. Successful treatment was obtained by using a regimen of doxycycline and gentamicin. Brucella should be suspected as a cause of spontaneous bacterial peritonitis in cirrhotic patients with no response to standard spontaneous bacterial peritonitis treatments. 브루셀라증은 전 세계적으로 발생하는 인수공통 전염병중의 하나로, 국내에서도 해마다 환자가 증가하고 있는 상황이다. 본 증례는 간경화 환자에서 환자의 잘못된 지식을 바탕으로 소 태아 육회를 섭취한 이후 복수와 발열을 주소로 내원한 환자이다. 상기 과거력이 환자의 질환과의 직접적인 연관성을 밝히기는 어려우나 환자의 진단을 추정하는데 도움이 되었으며, 이러한 가능성을 배제하기 위해서라도 국내 유통에 있어서 좀더 적극적인 대체가 필요하다 하겠다. 상기 환자는 브루셀라에 의해 발생한 특발성 세균성 복막염 환자로 제주도에서 발생한 내국인의 첫 증례이기에 문헌 고찰과 함께 보고하는 바이다.
김명희 ( Myeung Hee Kim ),이상화 ( Sang Hwa Lee ),송주연 ( Ju Yeoun Song ),유지형 ( Ji Hyoung Yu ),윤지향 ( Ji Hyang Youn ) 부산대학교 간호과학연구소 2014 글로벌 건강과 간호 Vol.4 No.2
Purpose: This study was conducted to investigate the clear concept of nurses` emotional labor. Methods: The research was conducted using Walker & Avant`s conceptual analysis process. Results: Nurses` emotional labor is defined as the empathy by expressing, the patient-centered emotion control, and the role conflict as nurse. Antecedents were found to be bracketing, capacity of emotional exchange, work ethic, expert knowledge. Consequences were found to be emotional dissonance. Conclusion: Nurses` emotional labor as defined by the results of this study will contribute to the nurse`s work environment. The results of this study accurately define the vague concept of nurses` emotional labor and help to manage emotional labor. Further research needs to develop nurses` emotional labor measurements.
Sous vide Cook-Chill법으로 생산된 삼치 데리야끼 조림의 레몬즙과 생강즙 첨가에 따른 품질 평가 -이화학적 및 관능적 품질을 중심으로-
김혜영 ( Heh Young Kim ),고성희 ( Sung Hee Ko ),이경연 ( Kyung Yeoun Lee ),박화연 ( Hwa Yyun Park ) 한국식품영양학회 2009 韓國食品營養學會誌 Vol.22 No.3
In this study, we evaluated the physicochemical and sensory quality of Glazed Spanish Mackerel in Teriyaki sauce containing added lemon juice and ginger juice using a Sous vide Cook-Chill method. The products were stored at below 3℃ and then its physicochemical and sensory quality was estimated after varous storage periods(0, 5, 10, 15 days). Measured extent of 40.91~52.04% in extent and reheating after of 42.35~54.40% when moisture content and did not significant by storage period in all sample are until save 15 days. The VBN was increased as the storage period increased. A similar trend was observed after reheating, and while lemon juice additions was significantly low on 15 days(p<0.01). Based on the results of the sensory evaluation, the Teriyaki sauces containing the added lemon juice additions were evaluated that had a better sensory quality is excellent in external appearance, flavor, taste, texture, and acceptability than the control group, and while were the evaluated excellently in overall flavor and taste in occasion of were found to be excellent after the addition of ginger juice.
명간보(明肝補) 추출물의 Acetaminophen 유도 간 손상에 대한 보호효과
김홍준 ( Hong Jun Kim ),목지예 ( Ji Ye Mok ),박광현 ( Kwang Hyun Park ),전인화 ( In Hwa Jeon ),김현수 ( Hyeon Soo Kim ),황성연 ( Sung Yeoun Hwang ),장선일 ( Seon Il Jang ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.2
Objective:Myeongganbo (MGB) composited with Hovenia Semen, Puerariae Radix and Dioscoreae Rhizoma is the prescription for protection of liver function. The purpose of this study was to investigate the effects of MGB extract against acetaminophen (APAP)-induced liver injury in mice. Methods:MGB extract was prepared by extracting with hot distilled water. The extract was freeze-dried following filtration through vacuum distillation system. Mice fasted for overnight were orally administrated with or without MGB extract of different doses (25-200 mg/kg/day). After 30 min, APAP was orally applied with a single dose (400 mg/kg). The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in plasmas of mice. Glutathione (GSH), glutathione peroxidase GSH-px), cyclooxygenase-2 (COX-2) activity and tumor necrosis factor-a (TNF-a) level were investigated in liver homogenates. Liver sections were stained with haematoxylin & eosin, anti-TNF-a and anti-mouse COX-2 antibodies. Results:APAP treatment remarkably increased AST and ALT activities in plasma but inhibited GSH and GSH-px levels in liver homogenates. Also, liver injury was significantly accelerated by APAP treatment. Furthermore, APAP remarkably elevated COX-2 activity and TNF-a levels in liver homogenates. However, administration of MGB extract was able to counteract these effects. Histological studies provided supportive evidence for biochemical and molecular analysis Conclusions:These results suggest that MGB extract has potent hepatoprotective effect against APAP-induced liver injury, these properties may contribute to liver disease care.
Sae Woong Choi,Seung Hwan Jeon,Eun Bi Kwon,Guan Qun Zhu,Kyu Won Lee,Jin Bong Choi,Hyun Cheol Jeong,Kang Sup Kim,Sang Rak Bae,Woong Jin Bae,Su Jin Kim,Hyuk Jin Cho,U-Syn Ha,Sung Hoo Hong,Sung Yeoun Hwa 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.1
Purpose: Testosterone replacement therapy is an effective treatment for late-onset hypogonadism (LOH) despite a few con-traindications and side-effects. The aim of this study was to determine whether modified Ojayeonjonghwan (KH-204, Korean herbal formula) improved LOH. KH-204 is a strong antioxidant herbal formula. We evaluated the effect of Korean herbal pre-scription on androgen receptor (AR) expression in an aged rat model of LOH. Materials and Methods: Eighteen-month-old rats were used as aged LOH rat models. Eighteen Sprague-Dawley rats were ran-domly divided into three equal groups of six animals each and treated with one of the following: 1) normal control group (oral administration with distilled water, n=6), 2) KH-204 200 group (oral administration with 200 mg/kg of KH-204, n=6), and 3) KH-204 400 group (oral administration with 400 mg/kg of KH-204, n=6). After four weeks of treatment (once daily, distilled water or KH-204), serum testosterone levels, changes in testicular and epididymal weight, Western blotting analysis of AR ex-pression and measurement of oxidative stress were examined. Results: Treatment with the herbal formulation KH-204 200 mg/kg and 400 mg/kg (1) increased the weights of testis and epi-didymis; (2) increased the level of serum testosterone; (3) increased the level of superoxide dismutase and reduced the level of 8-hydroxy-20-deoxyguanosine; and (4) upregulated AR expression in testicular tissue. Conclusions: KH-204 might be an effective alternative for LOH. It improves antioxidant mechanisms and increases testicular AR expression without side-effects.