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Su-Zi Yoo,Mi-Hyun No,Jun-won Heo,Dae-Yun Seo,Su-Jeen Jung,Hyo-Bum Kwak 한국운동재활학회 2019 한국운동재활학회 학술대회 Vol.2019 No.05
The purpose of this study was to determine the effects of in vivo atorvastatin, L-carnosine, and resistance exercise training on mitochondria-mediated apoptotic signaling in the rat skeletal muscle. Male Wistar rats were randomly assigned to control (CON), 5 mg atorvastatin treated group (STAT), 5 mg atorvastatin plus resistance (ladder climbing) exercise training group (STAT + EX), 5 mg atorvastatin plus L-carnosine treatment group (STAT + CAR), and 5 mg atorvastatin treatment plus resistance exercise training plus L-carnosine treatment group (STAT + EX + CAR) (n=12 rats/group). Animals were administered via oral gavage with a vehicle, 5 mg/kg/day atorvastatin, and 250 mg/kg/day L-carnosine dissolved in 0.25 % w/v hydroxypropyl methylcellulose for 12 weeks. Also, animals were trained for 12 weeks on a ladder with a gradient of about 80 degrees. Mitochondria-mediated apoptotic signaling (e.g., Bax, Bcl-2, mPTP opening, cytochrome c, cleaved caspase-3) were measured in skeletal muscles (e.g., soleus, white gastocnemius). Bax , pro-apoptotic protein, was increased in STAT in both soleus and white gastrocnemius and decreased in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius. In contrast, Bcl-2, anti-apoptotic protein, was elevated in STAT + EX, STAT + CAR, and STAT + EX + CAR in both soleus and white gastrocnemius and reduced in STAT in both soleus and white gastrocnemius. Also, mPTP opening, cytochrome c, and cleaved caspase-3 showed the same patterns like Bax in both soleus and white gastrocnemius. These data demonstrated that skeletal muscle mitochondria-mediated apoptotic signaling was impaired by atorvastatin treatment for 12 weeks. However, L-carnosine and resistance exercise training protected against statin-induced mitochondria-mediated apoptotic signaling in the rat skeletal muscle, suggesting that both L-carnosine and resistance exercise training play a pivotal role in ameliorating apoptosis in statin-induced myopathy.
Heo, Soon Chul,Jeon, Eun Su,Lee, Il Hwan,Kim, Hoon Soo,Kim, Moon Bum,Kim, Jae Ho The Society for Investigative Dermatology, Inc 2011 The Journal of investigative dermatology Vol.131 No.7
Human adipose tissue–derived mesenchymal stem cells (ASCs) stimulate regeneration of injured tissues by secretion of various cytokines and chemokines. Wound healing is mediated by multiple steps including inflammation, epithelialization, neoangiogenesis, and proliferation. To explore the paracrine functions of ASCs on regeneration of injured tissues, cells were treated with tumor necrosis factor-α (TNF-α), a key inflammatory cytokine, and the effects of TNF-α-conditioned medium (CM) on tissue regeneration were determined using a rat excisional wound model. We demonstrated that TNF-α CM accelerated wound closure, angiogenesis, proliferation, and infiltration of immune cells into the cutaneous wound in vivo. To assess the role of proinflammatory cytokines IL-6 and IL-8, which are included in TNF-α CM, IL-6 and IL-8 were depleted from TNF-α CM using immunoprecipitation. Depletion of IL-6 or IL-8 largely attenuated TNF-α CM-stimulated wound closure, angiogenesis, proliferation, and infiltration of immune cells. These results suggest that TNF-α-activated ASCs accelerate cutaneous wound healing through paracrine mechanisms involving IL-6 and IL-8.
Effects of acute exercise on mitochondrial dynamics and mitophagy in the rat skeletal muscles
Su-Zi Yoo,Jun-Won Heo,Mi-Hyun No,Dong-Ho Park,Ju-Hee Kang,Hyo-Bum Kwak 한국운동재활학회 2018 한국운동재활학회 학술대회 Vol.2018 No.10
The current study aims to investigate how mitochondrial dynamics and mitophagy are changed by a single bout aerobic exercise. Four month Fischer 344 rats were divided into 2 groups: sedentary group (SED, n=6) and acute exercise group (AEX, n=6). Rats were performed in a single bout treadmill exercise for 60 minutes. Mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, BNIP3, LC3) were measured in the permeabilized skeletal muscles (e.g., soleus, white gastrocnemius). Mitochondrial fusion-related protein (Opa1) was decreased in soleus of AEX compared with SED. Also, mitochondrial fission-related protein (Drp1) was reduced in soleus of AEX compared with SED. Similarly, in soleus muscle of AEX, mitochondrial autophagy-related protein (LC3) was decreased compared with SED. However, other proteins of mitochondrial dynamics and mitophagy didn’t show significant difference in soleus and white gastrocnemius. A single bout aerobic exercise showed tissue-specific results in mitochondrial dynamics and mitophagy. It demonstrates that acute aerobic exercise may improve mitochondrial function predominantly in soleus muscle (type I fiber). However, further research is needed to understand the cellular and molecular mechanism by which acute aerobic exercise affects mitochondrial dynamics and mitophagy in different types of muscle fibers.
박범진(Bum-Jin Park),허진녕(Jin-Nyung Heo),강원의(Weon-eui Kang),원영수(Young-Su Weon) 한국콘텐츠학회 2012 한국콘텐츠학회논문지 Vol.12 No.9
국내 도로는 지형적 특성상 대부분 산간 혹은 천변을 경유하여 건설되어 있고 다양한 연결로와 복잡한 네트워크로 구성되어 있다. 따라서, 강우, 강설에 취약함은 물론 주행 중 네트워크 미인지로 안전사고가 발생할 수 있다. 이에, 본 연구의 목적은 도로면에 도로교통 정보를 투사할 수 있는 정보제공 장치 원천기술을 확보하고 그에 따른 콘텐츠 개발을 목적으로 한다. 정보제공 장치는 LED와 광학기술을 이용하였으며, 콘텐츠는 현재 도로를 운영하고 있는 관ㆍ산ㆍ학ㆍ연 전문가 53인을 대상으로 설문조사를 실시하였다. 정보제공 장치 실험결과 LCD 패널의 투과율 문제로 인한 광 손실이 발생함을 확인 할 수 있었으며, 설문조사 결과 본 노면시향장치에 대해서 향후 수용할 의지가 있음을 확인하였고 콘텐츠의 경우, 전문가들의 요구가 많은 콘텐츠에 대한 메시지 운영방안을 제시하였다. Most roads in Korea are constructed through a riverside or among the mountains due to geographical characteristics, and composed of various connection roads and complex networks, which makes it susceptible to a fog, rainfall and snowfall and causes serious negligent accidents due to misperception of network while driving. This study amis at securing original technology to provide traffic information, utilizing the road surface by grafting LED and optical technology highly recognized in terms of energy efficiency recently onto ITS, thereby developing next-generation ITS service .To support the research development, H/W was developed and field test was conducted. In addition, the customer satisfaction survey towards equipment, an end product of this research development was also carried out to find out what it means to customers potentially.