http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Song, Myeong-Sub,Sekhon, Simranjeet Singh,Shin, Woo-Ri,Rhee, Sung-Keun,Ko, Jung Ho,Kim, Sang Yong,Min, Jiho,Ahn, Ji-Young,Kim, Yang-Hoon American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.5
<P>Shigella sonnei isolate invasion plasmid antigen protein, IpaH, was successfully expressed in recombinant overexpression bacterial system. The soluble expression IpaH was enhanced with molecular chaperon co-expressed environment. Specific aptamer IpaH17 was isolated through the SELEX process and showed fM binding affinity. IpaH17-SPR biosensor platform was involved to verify the binding sensitivity and specificity. The IpaH concentration dependent IpaH17-SPR sensor response was highly linear with a linear regression constant of 99.4% in the range between 0 and 100 ng/mL. In addition, S. sonnei revealed the specific RU value and detected in a real-time manner within 1 hour. Our study indicated that IpaH17-SPR sensor can allow for rapid, sensitive and specific determination of Shigella sonnei virulent factor.</P>
OH, Jae Sub,CHOI, Kwang Il,KIM, Young Su,KANG, Min Ho,SONG, Myeong Ho,LIM, Sung Kyu,YOO, Dong Eun,PARK, Jeong Gyu,LEE, Hi Deok,LEE, Ga Won The Institute of Electronics, Information and Comm 2010 IEICE transactions on electronics Vol.93 No.5
<P>A HfO<SUB>2</SUB> as the charge-storage layer with the physical thickness thinner than 4nm in silicon-oxide-high-<I>k</I> oxide-oxide-silicon (SOHOS) flash memory was investigated. Compared to the conventional silicon-oxide-nitride-oxide-silicon (SONOS) flash memory, the SOHOS shows the slow operational speed and exhibits the poorer retention characteristics. These are attributed to the thin physical thickness below 4nm and the crystallization of the HfO<SUB>2</SUB> to contribute the lateral migration of the trapped charge in the trapping layer during high temperature annealing process.</P>
( Jin Hyoung Kim ),( Ae-rin Baek ),( Song-i Lee ),( Won-young Kim ),( Yong Sub Na ),( Bo Young Lee ),( Gil Myeong Seong ),( Moon Seong Baek ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background ROX index after high-flow nasal cannula (HFNC) initiation can be helpful to identify low-risk patients of HFNC failure in patients with acute hypoxemic respiratory failure. However, it remains unknown which variables are useful for predicting HFNC failure in coronavirus disease 2019 (COVID-19) receiving HFNC. This study aims to determine the discrimination ability of the ROX index and SpO2/FiO2 ratio in COVID-19 patients after HFNC initiation. Methods This multicenter study was conducted at seven university-affiliated hospitals in Korea. We retrospectively reviewed the hospitalized patients diagnosed with COVID-19 between February 10, 2020 and February 28, 2021. The ROX index and SpO2/ FiO2 ratio were calculated at 1 hour and 4 hours after HFNC initiation. The primary outcome was HFNC failure, defined as the subsequent use of mechanical ventilation despite using HFNC. Discrimination of prediction for HFNC failure was evaluated by receiver operating characteristic (ROC) curve analysis. Results During the study period, 1,565 patients with COVID-19 were hospitalized and eligible 133 patients who received HFNC were analyzed. Among them, 63 (47.4%) were successfully weaned from HFNC, and 70 (52.6%) were intubated. SpO2/FiO2 ratio at 1 hour after HFNC initiation was a more accurate predictor of HFNC failure compared to ROX index (AUC 0.762; 95% CI: 0.679- 0.846 vs. 0.733; 95% CI: 0.640-0.826) (Figure 1). In the multivariable analysis, patients older than 70 years old had 3.4 times of HFNC failure compared to younger patients (AUC 3.367 [95% CI: 1.358-8.349], p=0.009), and SpO2/FiO2 at 1 hour (AUC 0.983 [95% CI: 0.972-0.994], p=0.003) were associated with HFNC failure. Conclusions SpO2/FiO2 ratio at 1 hour after HFNC initiation demonstrated a useful predictive ability for HFNC failure. SpO2/FiO2 could be a bedside tool to identify the need for mechanical ventilation in COVID-19 patients receiving HFNC.
Jin-Woo Han,Seong-Wan Ryu,Chung-Jin Kim,Sung-Jin Choi,Sungho Kim,Jae-Hyuk Ahn,Dong-Hyun Kim,Kyu Jin Choi,Byung Jin Cho,Jin-Soo Kim,Kwang Hee Kim,Gi-Sung Lee,Jae-Sub Oh,Myeong-Ho Song,Yun Chang Park,Je IEEE 2009 IEEE transactions on electron devices Vol.56 No.4
<P>A band-offset-based unified-RAM (URAM) cell fabricated on a Si/Si<SUB>1-y</SUB>C<SUB>y</SUB> substrate is presented for the fusion of a nonvolatile memory (NVM) and a capacitorless 1T-DRAM. An oxide/nitride/oxide (O/N/O) gate dielectric and a floating-body are combined in a FinFET structure to perform URAM operation in a single transistor. The O/N/O layer is utilized as a charge trap layer for NVM, and the floating-body is used as an excess hole storage node for capacitorless 1T-DRAM. The introduction of a pseudomorphic SiC-based heteroepitaxial layer into the Si substrate provides band offset in a valence band. The FinFET fabricated on the energy-band-engineered Si<SUB>1-y</SUB>C<SUB>y</SUB> substrate allows hole accumulation in the channel for 1T-DRAM. The band-engineered URAM yields a cost-effective process that is compatible with a conventional body-tied FinFET SONOS. The fabricated URAM shows highly reliable NVM and high-speed 1T-DRAM operations in a single memory cell.</P>
Song, Jeong Young,Seo, Mun Won,Kim, Sun Ick,Nam, Myeong Hyeon,Lim, Hyoun Sub,Kim, Hong Gi The Korean Society of Mycology 2014 Mycobiology Vol.42 No.2
We analyzed the genetic diversity of Cylindrocarpon destructans isolates obtained from Korean ginseng (i.e., Panax ginseng) roots by performing virulence tests and nuclear ribosomal gene internal transcribed spacer (ITS) and mitochondrial small subunit (mt SSU) rDNA sequence analysis. The phylogenetic relationship analysis performed using ITS DNA sequences and isolates from other hosts helped confirm that all the Korean C. destructans isolates belonged to Nectria/Neonectria radicicola complex. The results of in vivo and ex vivo virulence tests showed that the C. destructans isolates could be divided into two groups according to their distinctive difference in virulence and the genetic diversity. The highly virulent Korean isolates in pathogenicity group II (PG II), together with foreign isolates from P. ginseng and P. quinquefolius, formed a single group. The weakly virulent isolates in pathogenicity group I, together with the foreign isolates from other host plants, formed another group and exhibited a greater genetic diversity than the isolates of PG II, as confirmed by the mt SSU rDNA sequence analysis. In addition, as the weakly virulent Korean isolates were genetically very similar to the foreign isolates from other hosts, they were likely to originate from hosts other than the ginseng plants.
Yong Sub Na,Ae-Rin Baek,Moon Seong Baek,Won-Young Kim,Jin Hyoung Kim,Bo young Lee,Gil Myeong Seong,Song-I Lee 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.1
Background/Aims: Secondary infection with influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, there is limited information about it in patients with severe coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical outcomes of and risk factors for secondary infections in patients with severe COVID-19. Methods: This study included patients with severe COVID-19 who were admitted to seven hospitals in South Korea between February 2020 to February 2021. Multivariate logistic regression analyses were performed to assess factors associated with the risk of secondary infections. Results: Of the 348 included patients, 104 (29.9%) had at least one infection. There was no statistically significant difference in the 28-day mortality (17.3% vs. 12.3%, p = 0.214), but in-hospital mortality was higher (29.8% vs. 15.2%, p = 0.002) in the infected group than in the non-infected group. The risk factors for secondary infection were a high frailty scale (odds ratio [OR], 1.314; 95% confidence interval [CI], 1.123 to 1.538; p = 0.001), steroid use (OR, 3.110; 95% CI, 1.164 to 8.309; p = 0.024), and the application of mechanical ventilation (OR, 4.653; 95% CI, 2.533 to 8.547; p < 0.001). Conclusions: In-hospital mortality was more than doubled in patients with severe COVID-19 and secondary infections. A high frailty scale, the use of steroids and application of mechanical ventilation were risk factors for secondary infection.
( Yong Sub Na ),( Ae-rin Baek ),( Moon Seong Baek ),( Won-young Kim ),( Jin Hyoung Kim ),( Bo Young Lee ),( Gil Myeong Seong ),( Song-i Lee ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background and objective Secondary infection with the influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, information remains limited about it in patients with severe COVID-19. Thus, we investigated the clinical outcomes and risk factors of secondary infections in patients with severe COVID-19. Methods This multicentre retrospective cohort study included patients with severe COVID-19 who were admitted to seven tertiary or referral hospitals in South Korea from February 2, 2020, to February 28, 2021. Multivariate logistic regression analyses were performed to assess factors associated with the risk of secondary infections. Results Of the 348 included patients, 120 (34.5%) had at least one infection and 228 (65.5%) had no infection. The most common pathogens of hospital-acquired or ventilator-associated pneumonia were Acinetobacter baumannii (24/92, 26.1%), and of bloodstream infections or central line-associated bloodstream infections were coagulase-negative staphylococci (9/36, 25.0%), and of catheter-associated urinary tract infections were Escherichia coli (9/17, 52.9%) (Figure 1). The time of diagnosis of infection was 16.0 ± 13.7 days from symptom onset and 10.6 ± 12.9 days from hospital admission. There was no statistically significant difference in the 28-day mortality (Table 1). However, in-hospital mortality was higher in the infected group. The risk factors for secondary infection were APACHE II, frailty scale, and corticosteroid use (Table 2). Conclusions In patients with severe COVID-19 and secondary infections, in-hospital mortality was more than doubled. A higher APACHE II score, frailty scale, and use of steroids were risk factors for secondary infection.
( Jeong Young Song ),( Mun Won Seo ),( Sun Ick Kim ),( Myeong Hyeon Nam ),( Hyoun Sub Lim ),( Hong Gi Kim ) 한국균학회 2014 韓國菌學會誌 Vol.42 No.2
We analyzed the genetic diversity of Cylindrocarpon destructans isolates obtained from Korean ginseng (i.e., Panax ginseng) roots by performing virulence tests and nuclear ribosomal gene internal transcribed spacer (ITS) and mitochondrial small subunit (mt SSU) rDNA sequence analysis. The phylogenetic relationship analysis performed using ITS DNA sequences and isolates from other hosts helped confirm that all the Korean C. destructans isolates belonged to Nectria/Neonectria radicicola complex. The results of in vivo and ex vivo virulence tests showed that the C. destructans isolates could be divided into two groups according to their distinctive difference in virulence and the genetic diversity. The highly virulent Korean isolates in pathogenicity group II (PG II), together with foreign isolates from P. ginseng and P. quinquefolius, formed a single group. The weakly virulent isolates in pathogenicity group I, together with the foreign isolates from other host plants, formed another group and exhibited a greater genetic diversity than the isolates of PG II, as confirmed by the mt SSU rDNA sequence analysis. In addition, as the weakly virulent Korean isolates were genetically very similar to the foreign isolates from other hosts, they were likely to originate from hosts other than the ginseng plants.