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Shuo Huang,Shuying Wang,Changjie Xu,Yufeng Shi,Fei Ye 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.11
To avoid water spewing out of the screw conveyor, foam is often used to reduce the permeability coefficient of the soil during earth pressure balance (EPB) shield tunneling. Whether foam can effectively reduce the permeability or not strongly depends on soil gradation characteristics. A series of permeability tests were carried out on foam-conditioned soil with changing effective grain size (d10), curvature coefficient (Cc), and uniformity coefficient (Cu), further, three characteristic times were defined to evaluate the permeation safety of the conditioned soil, including critical time (tc), flow rate safety time (ta) and flow quantity safety time (ts). The test results show that with an increase in d10, the initial permeability coefficient of the conditioned soil increased greatly, however, it only changed slightly with increases in Cc and Cu. In addition, permeability coefficient was still much lower than that of the unconditioned soil, even though entered the slow growth period for a long time. It is shown that as the Cc and Cu increased, the ta and ts changed slightly, however, as the d10 increased, the ta and ts decreased significantly. The results indicate that d10 can greatly affect the permeability characteristics of conditioned soil, more specifically, the initial permeability coefficient and the permeation safety. By contrast, Cc and Cu have less effects. In addition, it is not reasonable to consider that the permeability coefficient of the conditioned soil will reach or be close to that of unconditioned soil when most, or all, of foam in the foam-conditioned soil dissipates.
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Tian, Shuo,Huang, Yan,Lai, Dong,Wang, Hanfeng,Du, Songliang,Shen, Donglai,Chen, Weihao,Xuan, Yundong,Lu, Yongliang,Feng, Huayi,Zhang, Xiangyi,Zhao, Wenlei,Wang, Chenfeng,Wang, Tao,Wu, Shengpan,Huang, Techno-Press 2022 Advances in nano research Vol.12 No.6
The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.
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A Dual-scale Network with Spatial-temporal Attention for 12-lead ECG Classification
Shuo Xiao,Yiting Xu,Chaogang Tang,Zhenzhen Huang 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.9
The electrocardiogram (ECG) signal is commonly used to screen and diagnose cardiovascular diseases. In recent years, deep neural networks have been regarded as an effective way for automatic ECG disease diagnosis. The convolutional neural network is widely used for ECG signal extraction because it can obtain different levels of information. However, most previous studies adopt single scale convolution filters to extract ECG signal features, ignoring the complementarity between ECG signal features of different scales. In the paper, we propose a dual-scale network with convolution filters of different sizes for 12-lead ECG classification. Our model can extract and fuse ECG signal features of different scales. In addition, different spatial and time periods of the feature map obtained from the 12-lead ECG may have different contributions to ECG classification. Therefore, we add a spatial-temporal attention to each scale sub-network to emphasize the representative local spatial and temporal features. Our approach is evaluated on PTB-XL dataset and achieves 0.9307, 0.8152, and 89.11 on macro-averaged ROC-AUC score, a maximum F1 score, and mean accuracy, respectively. The experiment results have proven that our approach outperforms the baselines.
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A Hierarchical Model for Mobile Ad Hoc Network Performability Assessment
( Shuo Zhang ),( Ning Huang ),( Xiaolei Sun ),( Yue Zhang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.8
Dynamic topology is one of the main influence factors on network performability. However, it was always ignored by the traditional network performability assessment methods when analyzing large-scale mobile ad hoc networks (MANETs) because of the state explosion problem. In this paper, we address this problem from the perspective of complex network. A two-layer hierarchical modeling approach is proposed for MANETs performability assessment, which can take both the dynamic topology and multi-state nodes into consideration. The lower level is described by Markov reward chains (MRC) to capture the multiple states of the nodes. The upper level is modeled as a small-world network to capture the characteristic path length based on different mobility and propagation models. The hierarchical model can promote the MRC of nodes into a state matrix of the whole network, which can avoid the state explosion in large-scale networks assessment from the perspective of complex network. Through the contrast experiments with OPNET simulation based on specific cases, the method proposed in this paper shows satisfactory performance on accuracy and efficiency.
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Shuo Li,Lizhou Sun,Guohua Zhou,Huan Huang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.6
Early detection of abnormal expression levels of cancer-related genes is crucial for reducing cancer mortality. Here, we describe a dye-free multiplex bioassay for simultaneous and quantitative analysis of the expression levels of multiple genes from one sample in a single assay, based on Sequence-tagged Multiplex ligationdependent probe Amplification (MLPA) coupled with pyrosequencing (termed as “SMAP”). Each pair of MLPA probes, containing a designed barcode, represents a gene of interest; thus, the use of various dyes to label different genes was avoided. The unique three-base barcode design on the probes, which can be decoded by pyrosequencing, enables individual quantification of the expression levels of six genes. Moreover, a new carryover contamination prevention system based on the use of restriction endonucleases was developed for PCR-based diagnostic screening assays. SMAP analysis revealed significant differences between the expression levels of CRC-related genes in the tumor tissues and normal tissues from a CRC patient. For PCR-based diagnostic screening assays, 0.5 U of the FokI restriction endonuclease was sufficient for the removal 0.01 pmol of PCR contamination. The ability to analyze the expression levels of a greater number of cancer-related genes would improve diagnostic sensitivity and efficacy. SMAP is amenable to the detection of an increased number of genes by lengthening the artificially designed barcodes; thus our method provides a promising means for cancer diagnostics and improving the treatment options available to cancer patients.
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Zhenghao Huang,Fan Shen,Jingwen Chen,Bumin Xie,Xi Chen,Yang Zhao,Shuo Chen 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2
Objective: Endometrial carcinoma (EC) is one of the most common gynecological malignanttumors. Our study showed that long non-coding RNA (lncRNA) linc01194 plays an importantrole in EC. We explored the mechanism of lncRNA linc01194 in EC. Methods: The expression of lncRNA linc01194 was detected in The Cancer Genome Atlasdatabase and starBase database. The potential targeted protein of linc01194 was predictedthrough the starBase database. To determine the role of linc01194 in EC, we downregulatedor upregulated the level of linc01194 in EC cell lines and analyzed the cell behaviors and thechanges of its potential target proteins. Results: The expression of linc01194 in EC tissues is higher than that in normal endometrialtissues. The knockdown of linc01194 inhibited the cell proliferation, invasion and migrationand promoted the apoptosis of EC cells, while overexpression of linc01194 promoted cellproliferation, invasion and migration and inhibited the apoptosis of EC cells. The starBasedatabase revealed that linc01194 could bind to insulin-like growth factor 2 binding protein 1(IGF2BP1). Previous results showed that in EC, IGF2BP1 could promote the expression of sex-determining region Y-box 2 (SOX2) by promoting the stability of SOX2 mRNA. Our resultsshowed that linc01194 regulate the expression of IGF2BP1 and SOX2. Conclusion: Linc01194 can promote the expression of downstream protein SOX2 throughbinding to IGF2BP1, thus promoting the occurrence and development of EC.
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How much information can soil solute profiles reveal about groundwater recharge?
Tianming Huang,Shuo Yang,Jilai Liu,Zhi Li 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.4
The unsaturated zone is an important link between groundwater and the land surface, and can provide storage capacity for both water and contaminants. Consequently, the solute profile of the unsaturated zone can provide much information on groundwater recharge using tracers. This study takes a rain-fed agricultural area (Luochuan loess plain) in the Chinese Loess Plateau as an example to demonstrate how much recharge information in the thick unsaturated zone can be obtained from the solute profile. The results show that the recharge rate is 36–67 mm yr–1 and infiltration rate is 0.19 to 0.30 m yr–1, as obtained using three methods, i.e., evaluating the Cl-peak, chloride mass balance, and nitrate levels. The amount of time needed for annual precipitation to reach the water table is 133–316 years, and the groundwater is tritium free. The nitrate introduced by human activities is mainly distributed in the upper unsaturated zone (above 6 m), and the groundwater nitrate content (3.7 to 9.6 mg l–1 as NO3) remains at baseline level. The storage capacity of the unsaturated zone is found to delay the entrance of pollutants into the aquifer.
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Tian, Fengyuan,Huang, Shuo,Xu, Wangda,Chen, Lan,Su, Jianming,Ni, Haixiang,Feng, Xiaohong,Chen, Jie,Wang, Xi,Huang, Qi The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6
Background: Incretin impairment, characterized by insufficient secretion of L-cell-derived glucagon-like peptide-1 (GLP-1), is a defining step of type 2 diabetes mellitus (T2DM). Ginsenoside compound K (CK) can stimulate GLP-1 secretion; however, the potential mechanism underlying this effect has not been established. Methods: CK (40 mg/kg) was administered orally to male db/db mice for 4 weeks. The body weight, oral glucose tolerance, GLP-1 secretion, gut microbiota sequencing, bile acid (BA) profiles, and BA synthesis markers of each subject were then analyzed. Moreover, TGR5 expression was evaluated by immunoblotting and immunofluorescence, and L-cell lineage markers involved in L-cell abundance were analyzed. Results: CK ameliorated obesity and impaired glucose tolerance in db/db mice by altering the gut microbiota, especially Ruminococcaceae family, and this changed microbe was positively correlated with secondary BA synthesis. Additionally, CK treatment resulted in the up-regulation of CYP7B1 and CYP27A1 and the down-regulation of CYP8B1, thereby shifting BA biosynthesis from the classical pathway to the alternative pathway. CK altered the BA pool by mainly increasing LCA and DCA. Furthermore, CK induced L-cell number expansion leading to enhanced GLP-1 release through TGR5 activation. These increases were supported by the upregulation of genes governing GLP-1 secretion and L-cell differentiation. Conclusions: The results indicate that CK improves glucose homeostasis by increasing L-cell numbers, which enhances GLP-1 release through a mechanism partially mediated by the gut microbiota-BA-TGR5 pathway. Therefore, that therapeutic attempts with CK might be useful for patients with T2DM.
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