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Shin-ya Watanabe,Jun-ichi Iga,Shusuke Numata,Masahito Nakataki,Toshihito Tanahashi,Mitsuo Itakura,Tetsuro Ohmori 대한정신약물학회 2012 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.10 No.3
Objective: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects. Methods: Three hundred fifty one patients with schizophrenia and 342 age- and sex- matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays. Results: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects. Conclusion: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects,but might not have same impacts on the BMI of patients with schizophrenia.
Shin, Jonghan,Gireesh, Gangadharan,Kim, Seong-Wook,Kim, Duk-Soo,Lee, Sukyung,Kim, Yeon-Soo,Watanabe, Masahiko,Shin, Hee-Sup The Society 2009 The Journal of neuroscience Vol.29 No.49
<P>Anxiety is among the most prevalent and costly diseases of the CNS, but its underlying mechanisms are not fully understood. Although attenuated theta rhythms have been observed in human subjects with increased anxiety, no study has been done on the possible physiological link between these two manifestations. We found that the mutant mouse for phospholipase C beta 4 (PLC-beta 4(-/-)) showed attenuated theta rhythm and increased anxiety, presenting the first animal model for the human condition. PLC-beta 4 is abundantly expressed in the medial septum, a region implicated in anxiety behavior. RNA interference-mediated PLC-beta 4 knockdown in the medial septum produced a phenotype similar to that of PLC-beta 4(-/-) mice. Furthermore, increasing cholinergic signaling by administering an acetylcholinesterase inhibitor cured the anomalies in both cholinergic theta rhythm and anxiety behavior observed in PLC-beta 4(-/-) mice. These findings suggest that (1) PLC-beta 4 in the medial septum is involved in controlling cholinergic theta oscillation and (2) cholinergic theta rhythm plays a critical role in suppressing anxiety. We propose that defining the cholinergic theta rhythm profile may provide guidance in subtyping anxiety disorders in humans for more effective diagnosis and treatments.</P>
Writer Identification using Wii Remote Controller
Watanabe, Takashi,Shin, Jung-Pil,Chong, Ui-Pil The Korea Institute of Convergence Signal Processi 2013 융합신호처리학회 논문지 (JISPS) Vol.14 No.1
The objective of this study was to develop a system for handwriting recognition in three dimensions (3D) to authenticate users. While previous studies have used a stylus pen for two-dimensional input on a tablet, this study uses the Wii Remote controller because it can capture 3D human motion and could therefore be more effective means of recognition. The information obtained from a Wii Remote controller included x and y coordinates, acceleration (x, y, z), angular velocity (pitch, yaw, roll), twelve input buttons, and time. The proposed system calculates distances using six features extracted after preprocessing the data. In an experiment where 15 subjects wrote "AIZU" 10 times, we obtained a 94.8% identification rate using a combination of writing velocity, the peak value of pitch, and the peak value of yaw. This suggests that this system holds promise for handwriting-based authentication in the future.
Takashi Watanabe,Shin Ishiguro,Akiko Aoki,Mikito Ueda,Yuki Hayashi,Kazufumi Akiyama,Kazuko Kato,Kazutaka Shimoda1 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. Methods-In this age-and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD. Results-No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047). Conclusion-In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
Kazuyuki Watanabe,Koji Otani,Takuya Nikaido,Kinshi Kato,Hiroshi Kobayashi,Shoji Yabuki,Shin-ichi Kikuchi,Shinichi Konno 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.6
Study Design: Observational cohort study. Purpose: To assess the surgical outcomes of posterior decompression and fusion for cervical myelopathy in patients with athetoid cerebral palsy. Overview of Literature: Patients with athetoid cerebral palsy demonstrate involuntary movements and develop severe cervical spondylosis with kyphosis. In these patients, surgery is often performed at an early age because of myelopathy. A few studies have reported about the long-term outcomes of surgical treatment; however, they contain insufficient information. Methods: From 2003 to 2008, 13 patients with cervical myelopathy due to athetoid cerebral palsy underwent posterior fusion surgery and were included in this study. The Japanese Orthopaedic Association (JOA) score, neck disability index (NDI), C2–7 angle on radiography, and need for additional surgical treatment were examined at 1 and 5 years postoperatively. Results: The mean C2–7 angle was −10.5°±21.1° preoperatively and was corrected to −2.9°±13.5° immediately postoperatively. This improvement was maintained for 5 years. The JOA score was 9.5±2.5 preoperatively and 12.2±1.7 at the 5-year follow-up. NDI was 17±6.9 preoperatively and 16±7.5 at the 5-year follow-up. Patient satisfaction with surgery on a 100-point scale was 62.2±22.5 at the 5-year follow-up. Three patients needed additional surgery for loosening of screws. These results demonstrate good surgical outcomes for posterior fusion at 5 years. Conclusions: Posterior decompression and fusion should be considered a viable option for cervical myelopathy in patients with athetoid cerebral palsy.