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Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
Kim Minji,An Jangeun,Shin Seong-Ah,Moon Sun Young,Kim Moonsu,Choi Seyeon,Kim Huiji,Phi Kim-Hoa,Lee Jun Hyuck,Youn Ui Joung,Park Hyun Ho,Lee Chang Sup 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-
Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the patho physiology of several chronic diseases. Although anti‑inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activi ties, including anti‑inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti‑inflammatory effects and molecular mechanisms of 2,5,6‑trimethoxy‑p‑terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS‑stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro‑inflammatory cytokines (IL‑1β, TNF‑α, IL‑6) and the mRNA and protein levels of the pro‑inflammatory enzymes (inducible nitric oxide synthase and cyclooxyge nase‑2). Moreover, TP1 suppressed lipopolysaccharide‑induced phosphorylation of the NF‑κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by sup pressing the expression of pro‑inflammatory cytokines, making it a potential anti‑inflammatory drug for the treatment of severe inflammatory diseases.
Kim, Ha Na,Kim, Hyemin,Kong, Joo Myung,Bae, Seyeon,Kim, Yong Sung,Lee, Naeun,Cho, Byung Joo,Lee, Seung Koo,Kim, Hang‐,Rae,Hwang, Young‐,il,Kang, Jae Seung,Lee, Wang Jae Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.3
<P><B>Abstract</B></P><P>It is known that vitamin C induces apoptosis in several kinds of tumor cells, but its effect on the regulation of the angiogenic process of tumors is not completely studied. Vascular endothelial growth factor (VEGF) is the most well‐known angiogenic factor, and it has a potent function as a stimulator of endothelial survival, migration, as well as vascular permeability. Therefore, we have investigated whether vitamin C can regulate the angiogenic process through the modulation of VEGF production from B16F10 melanoma cells. VEGF mRNA expression and VEGF production at protein levels were suppressed by vitamin C. In addition, we found that vitamin C suppressed the expression of cyclooxygenase (COX)‐2 and that decreased VEGF production by vitamin C was also restored by the administration of prostaglandin E2 which is a product of COX‐2. These results suggest that vitamin C suppresses VEGF expression via the regulation of COX‐2 expression. Mitogen‐activated protein kinases are generally known as key mediators in the signaling pathway for VEGF production. In the presence of vitamin C, the activation of p42/44 MAPK was completely inhibited. Taken together, our data suggest that vitamin C can down‐regulate VEGF production via the modulation of COX‐2 expression and that p42/44 MAPK acts as an important signaling mediator in this process. J. Cell. Biochem. 112: 894–901, 2011. © 2010 Wiley‐Liss, Inc.</P>
Serological study of swine influenza A viruses in pig population in 2016 - 2017, Korea
Seyeon Park(Seyeon Park),In-Ohk Ouh(In-Ohk Ouh),Ju-Yeon Lee(Ju-Yeon Lee),Min-Su Cho(Min-Su Cho),Byeong Sul Kang(Byeong Sul Kang),Soo dong Cho(Soo dong Cho),Eun-Ju Kim(Eun-Ju Kim),Yeun-Kyung Shin(Yeun- 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Kim, Hyemin,Bae, Seyeon,Kim, Yejin,Cho, Chung-Hyun,Kim, Sung Joon,Kim, Yong-Jin,Lee, Seung-Pyo,Kim, Hang-Rae,Hwang, Young-il,Kang, Jae Seung,Lee, Wang Jae Elsevier 2013 FREE RADICAL BIOLOGY AND MEDICINE Vol.65 No.-
<P><B>Abstract</B></P> <P>It is thought that vitamin C has protective roles on stress-induced heart damage and the development of cardiovascular diseases, but its precise role and mechanisms are unclear. In the present study, we investigated the specific mechanisms by which vitamin C leads to protecting the heart from stress-induced damage in the <I>Gulo(</I>−/−<I>)</I> mice which cannot synthesize vitamin C like humans. By exposure to stress (1h/day), the heartbeat and cardiac output in vitamin C-insufficient <I>Gulo(</I>−/−<I>)</I> mice were definitely decreased, despite a significant increase of adrenaline (ADR) and noradrenaline (NA) production. A change of cardiac structure caused by the death of cardiomyocytes and an increased expression of matrix metalloprotease (MMP)-2 and -9 were also found. Moreover, lipid peroxidation and the production of tumor necrosis factor-alpha (TNF-α) in the heart were increased. Finally, all vitamin C-insufficient <I>Gulo(</I>−/−<I>)</I> mice were expired within 2 weeks. Interestingly, all of the findings in vitamin C-insufficient <I>Gulo(</I>−/−<I>)</I> mice were completely prevented by the supplementation of a sufficient amount of vitamin C. Taken together, vitamin C insufficiency increases the risk of stress-induced cardiac damage with structural and functional changes arising from the apoptosis of cardiomyocytes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Vitamin C insufficiency accelerates the stress-induced death of <I>Gulo(</I>−/−<I>)</I> mice. </LI> <LI> Oxidative stress in the heart is increased by stress and vitamin C insufficiency. </LI> <LI> TNF-α, ADR, and NA are excessively produced by stress and vitamin C insufficiency. </LI> <LI> Structural/functional cardiac changes are induced by stress and vitamin C insufficiency. </LI> <LI> Vitamin C supplementation prevents cardiac changes and death of <I>Gulo(</I>−/−<I>)</I> mice. </LI> </UL> </P>
Isolation and phylogenetic analysis of swine influenza A viruses (H1N2) in Korea in 2016 - 2017
Seyeon Park(Seyeon Park),In-Ohk Ouh(In-Ohk Ouh),Ju-Yeon Lee(Ju-Yeon Lee),Min-Su Cho(Min-Su Cho),Byeong Sul Kang(Byeong Sul Kang),Soo dong Cho(Soo dong Cho),Eun-Ju Kim(Eun-Ju Kim),Yeun-Kyung Shin(Yeun- 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-
Ovarian reserve as a predicting factor for successful pregnancy after adenomyomectomy
( Sohyun Kim ),( Seyeon Won ),( Ji Young Hwang ),( Nara Lee ),( Miseon Kim ),( Mikyoung Kim ),( Mi-la Kim ),( Bo Sung Yun ),( Seok Ju Seong ),( Yong Wook Jung ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: To compile the fertility outcomes of adenomyomectomy and to evaluate which demographic factors predict a successful pregnancy in patients who have undergone adenomyomectomy. Methods: We retrospectively reviewed the patient data between January 2017 and April 2020. Possible causes for infertility were excluded by hysterosalpingography, blood tests, karyotyping, hormonal assay, and semen analysis before the surgery. Candidates were selected for surgery based on the following criteria: 1) patients aged ≤45 years, 2) patients who consented to proceed with the surgery after being informed about the possibility of recurrence of the disease and operative blood loss, and 3) patients desiring pregnancy in the future. Patients were followed up monthly for 3 months. The subsequent follow-ups were conducted every 3-6 months. Patients who wanted to get pregnant could try for pregnancy 3 months after the surgery. We defined pregnancy success as the presence of fetal heartbeat at 6-7 weeks of gestation. The number of pregnancy trials was defined as the number of embryos transferred. Results: Forty-three patients were divided into two groups: the pregnancy failure group (n=28) and the pregnancy success group (n=15). The age of patients was higher (39.0 [32.046.0] vs. 37.0 [33.042.0] years, P=0.006) and the level of anti-Mllerian hormone (AMH) (0.54 [0.018.54] vs. 2.91 [0.347.92] ng/mL, P=0.002) was lower in the pregnancy failure group than in the pregnancy success group. The operative time was longer (220.0 [68.0440.0] vs. 175.0 [65.0305.0] minutes, P=0.048) and the estimated blood loss was higher (750 [1002500] vs. 500 [502000] ml, P=0.016) in the pregnancy failure group than in the pregnancy success group. No significant difference was observed in body mass index, symptoms, cancer antigen 125, preoperative uterine volume, and type of adenomyosis. In the multivariate analysis, age and AMH were significant predictive factors for successful pregnancy. Conclusion: Ovarian reserve (age and AMH) and disease severity might be predictive factors for successful pregnancy in patients who have undergone adenomyomectomy. Adenomyomectomy should be positively considered for women desiring pregnancy and having appropriate ovarian reserve. This information will be beneficial for patients and clinicians before the decision about adenomyomectomy. Larger prospective studies are needed to confirm our findings.