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노치권(외 6명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-
To study fauna of Silla University located in Mt. Baek-yang, we conducted six surveys from 29 May 2011 to 28 April 2012. We found five phyla 41 orders 197 species of animals inhabiting in this area: four phyla 27 orders 163 species of invertebrates and in vertebrates one order six species of fishes, three orders nine species of amphibians and reptiles, six orders 14 species of aves, and four orders five species of mammals. Of these species, some Korean endemic species were included: a fish of Rhodeus uyekii in a pond near main gate of this university, a frog of Rana coreana in a creek near a dormitory, and a rabbit of Lepus coreanus and a water deer of Hydropotes inermis in a grass region near a main stadium. A kind of hawk, Falco tinnunculus as a natural monument (animal) of no. 323-8, was observed on a building of medical and life science. A blue frog of Hyla japonica as a variation was found near a spring resort. Therefore, this area is considered an ecologically important area having a high animal diversity.
( Seung Hyun Yong ),( Seung Up Kim ),( Ah Young Leem ),( Young Sam Kim ),( Joon Chang ),( Ji Ye Jung ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Various comorbidities influence the prognosis of patient with chronic obstructive pulmonary disease (COPD). We investigated whether liver fibrosis burden is associated with acute exacerbation and all-cause mortality in patients with COPD. Methods: We included 756 COPD patients between 2006 and 2010 in Severance Hospital, South Korea. Medical records of enrolled patients were retrospectively reviewed until 2018. Patients were categorized into survival and deceased groups. Liver fibrosis was assessed using the fibrosis-4 index (FIB-4) [age (years)*aspartate aminotransferase level (IU/L)/platelet count (109/L)/√alanine aminotransferase (IU/ L)]. Results: Of 756 patients, 582 (76.9%) and 174 (23.1%) patients were categorized into survival and deceased groups, respectively. Deceased group showed older age, higher proportion of male and ever smoker, and lower FEV1/FVC ratio than survival group. Various comorbidities were more frequently observed in deceased group than in survival group. FIB-4 score was higher in deceased group (1.8 vs. 1.4, P < 0.001). According to multivariate Cox hazard model for all-cause mortality, age at diagnosis of COPD (HR=1.05), body mass index (HR=0.95), underlying malignancy (HR=2.94), and coronary artery occlusive disease (HR=1.58), FEV1 (HR=1.15) and FIB- 4 score (HR=1.15) at initial diagnosis were significant factors. To find out correlation between FIB score and mortality, we divided FIB-4 score into 3 groups, lower than 25% (Low group), 25% to 75% (intermediate group), above 75% (High group). Kaplan-Meier analysis of all-cause mortality showed high FIB-4 score group had lower cumulative survival than low FIB-4 score group (Figure 1, P=0.031). In multivariate regression analysis for acute exacerbation, higher FIB-4 score was significant risk factor (OR=1.08). Conclusion: FIB-4 score showed usefulness as noninvasive prognostic marker for acute exacerbation and all-cause mortality in COPD patients.
Ye Byong Duk,Hong Sung Noh,Seo Seung In,Kim Ye-Jee,Cha Jae Myung,Rhee Kyoung Hoon,Yoon Hyuk,Kim Young-Ho,Kim Kyung Ho,Kim Kyung Ho,Jeong Seung Kyu,Lee Ji Hyun,Park Hyunju,Kim Joo Sung,Im Jong Pil,Kim 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.2
Background/Aims: The long-term course of Crohn’s disease (CD) has never been evaluated in non-Caucasian population-based cohorts. The aim of the present study was to evaluate the longterm prognosis of Korean CD patients in the well-defined population-based Songpa-Kangdong inflammatory bowel disease cohort. Methods: Outcomes of disease and their predictors were evaluated for 418 patients diagnosed with CD between 1986 and 2015. Results: During a median of 123 months, systemic corticosteroids, thiopurines, and anti-tumor necrosis factor (TNF) agents were administered to 58.6%, 81.3%, and 37.1% of patients, respectively. Over time, the cumulative probability of starting corticosteroids significantly decreased (p=0.001), whereas that of starting thiopurines and anti-TNFs significantly increased (both p<0.001). The cumulative probability of behavioral progression was 54.5% at 20 years, and it significantly decreased during the anti-TNF era. Intestinal resection was required for 113 patients (27.0%). The cumulative probabilities of intestinal resection at 1, 5, 10, 20, and 25 years after CD diagnosis were 12.7%, 16.5%, 23.8%, 45.1%, and 51.2%, respectively. Multivariable Cox regression analysis identified stricturing behavior at diagnosis (adjusted hazard ratio [aHR], 2.70; 95% confidence interval [CI], 1.55 to 4.71), penetrating behavior at diagnosis (aHR, 11.15; 95% CI, 6.91 to 17.97), and diagnosis of CD during the anti-TNF era (aHR, 0.51; 95% CI, 0.35 to 0.76) as independently associated with intestinal resection. The standardized mortality ratio among CD patients was 1.36 (95% CI, 0.59 to 2.68). Conclusions: The long-term prognosis of Korean patients with CD is at least as good as that of Western CD patients, as indicated by the low intestinal resection rate. Moreover, behavioral progression and intestinal resection rates have decreased over the past 3 decades.
염증성 관절염 마우스 모델에서 Sauchinone의 치료 효과
정승민 ( Seung Min Jung ),이재선 ( Jae Seon Lee ),이주현 ( Ju Hyun Lee ),백승예 ( Seung Ye Baek ),박성환 ( Sung Hwan Park ),곽승기 ( Seung Ki Kwok ) 대한류마티스학회 2016 대한류마티스학회지 Vol.23 No.3
Objective. Rheumatoid arthritis (RA) is a chronic inflammatory disease, mainly involving joints and bones. Sauchinone is an anti-inflammatory agent isolated from Saururus chinensis, which was used in oriental medicine. The aim of this study was to evaluate the therapeutic effect of sauchinone on inflammatory arthritis and underlying mechanism of anti-arthritic effect. Methods. Mice with collagen induced arthritis (CIA) was intraperitoneally injected with sauchinone (20 mg/kg) or vehicle. The clinical and histological evaluations were performed with arthritis scoring and hematoxylin-eosin staining, respectively. CD4+ interleukin (IL) 17+ T cells were determined under Th17 skewing condition treated with sauchinone. To evaluate the effect of sauchinone on osteoclastogenesis, mice bone marrow macrophages (BMMs) and human peripheral blood mononuclear cells (PBMCs) were cultured with macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand in the absence or presence of sauchinone. Results. Sauchinone significantly attenuated the inflammatory arthritis in CIA mice both clinically and histologically. The proportion of Th17 cells were decreased with treatment with sauchinone in vivo and in vitro. The expressions of Th17 cell markers (IL-17 and retinoic acid receptor-related orphan receptor gamma t) and B cell markers (activation-induced cytidine deaminase) were downregulated in the presence of sauchinone. Sauchinone also suppressed the formation of tartrate-resistant acid phosphatase positive cells from mice BMMs and human PBMCs, and the expression of osteoclastogenic markers. Conclusion. Sauchinone alleviates inflammatory arthritis in mice through inhibition of Th17 differentiation and osteoclastogenesis. Sauchinone, one of traditional herbal medicine, could be a therapeutic candidate for the treatment of RA. (J Rheum Dis 2016;23:161-173)
윤승현 ( Seung-hyun Yoon ),남유리 ( Yu Ri Nam ),강현수 ( Hyun-su Kang ),정다운 ( Da Un Jeong ),유예담 ( Ye Dam Yoo ),임기무 ( Ki-moo Lim ),박성준 ( Seong-jun Park ),김배환 ( Bae-hwan Kim ),김기석 ( Ki-suk Kim ) 한국동물실험대체법학회 2021 동물실험대체법학회지 Vol.15 No.1
For the assessment of cardiotoxicity and Torsade de Pointes (TdP), a fatal arrhythmic symptom, ICH S7B and E14 guidelines were presented. However, focusing on hERG block, which are essential determinants of arrhythmic risk, may unexpectedly limit drug development by increasing the risk of drugs that are actually non-toxic. To compensate for these problems, the Comprehensive in vitro Proarrhythmic Assay (CiPA) project was proposed. In this study, based on the CiPA project and previous studies, the nine drugs were tested using in vitro multiple ion channel screening on both temperature conditions (room temperature and 37℃). Using the in vitro results, in silico computer simulation was performed based on the O'Hara-Rudy human ventricular myocyte model, and same as the CiPA project obtained a new biomarker, qNet. The in silico computer simulation was performed using 2000 samples of IC<sub>50</sub> values extracted by R code. The nine test drugs were associated with cardiotoxicity and TdP, and were selected by the CiPA project and previous studies. Furthermore, as in previous studies, Torsade Metic Score (TMS), the mean qNet value averaged across 1-4 × Cmax, and the threshold was calculated. As a result, the nine tested drugs using the TMS were well plotted by the risk categories and the threshold was able to well classify the risk categories by grade on both temperature conditions. In particular, the threshold 2 value confirmed to significant difference depending on the temperature conditions. The range of threshold narrowed at 37℃, which can be considered as having the ability to distinguish more finely. It shows the correlation with the CiPA project’s validity that a study should be tested at a physiological temperature of 3 7℃. In this study, using the method proposed by the CiPA project, it was possible to predict the risk groups of drugs more accurately, which could be presented as a new paradigm in the cardiotoxicity assessment.
Kim, Dae-Seung,Lee, Hyun-Ja,Jeon, Yong-Deok,Han, Yo-Han,Kee, Ji-Ye,Kim, Hyun-Jeong,Shin, Hyun-Ji,Kang, JongWook,Lee, Beom Su,Kim, Sung-Hoon,Kim, Su-Jin,Park, Sang-Hyun,Choi, Byung-Min,Park, Sung-Joo,U Institute for Advanced Research in Asian Science a 2015 The American journal of Chinese medicine Vol.43 No.4
<P>In this study, we found that alpha-pinene (α-pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-κB) pathway in mouse peritoneal macrophages. α-Pinene is found in the oils of many coniferous trees and rosemary. We investigated the inhibitory effects of α-Pinene on inflammatory responses induced by lipopolysaccharide (LPS) using mouse peritoneal macrophages. α-Pinene significantly decreased the LPS-induced production of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nitric oxide (NO). α-Pinene also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in LPS-stimulated macrophages. Additionally, the activations of MAPKs and NF-κB were attenuated by means of α-pinene treatment. These results indicate that α-pinene has an anti-inflammatory effect and that it is a potential candidate as a new drug to treat various inflammatory diseases.</P>
항결핵제 투여 후 C-reactive Protein 측정을 통한 크론병과 장결핵의 감별진단
박상현 ( Sang Hyun Park ),양석균 ( Suk-kyun Yang ),명승재 ( Seung-jae Myung ),변정식 ( Jeong-sik Byeon ),예병덕 ( Byong Duk Ye ),권승현 ( Seung Hyun Kwon ),김병규 ( Benjamin Kim ),윤순만 ( Soon Man Yoon ),도미영 ( Mi Young Do ) 대한장연구학회 2007 Intestinal Research Vol.5 No.1
Background/Aims: Crohn’s disease (CD) and intestinal tuberculosis (TB) are chronic inflammatory bowel disorders that are difficult to differentiate. Therefore, a therapeutic trial of antimycobacterial drugs is often used to differentiate CD from TB. This study aimed to evaluate the usefulness of C-reactive protein (CRP) level before or during antimycobacterial therapy to differentiate CD from TB. Methods: A total of 26 CD patients and 52 TB patients who received antimycobacterial therapy at the Asan Medical Center were included. CRP levels before or during antimycobacterial therapy were compared between CD and TB patients. A positive response to antimycobacterial therapy was defined as the decrease of CRP level below 50% of its baseline value. Results: The baseline CRP level was normal in only 1 of 26 CD patients (3.8%), while it was in 26 of 52 TB patients (50%). The rate of positive response to antimycobacterial therapy was significantly different between CD and TB patients whose baseline CRP level was abnormal: 28.0% (7/25) vs 88.5% (23/26) in 2 weeks, 34.8% (8/23) vs 84.6% (22/26) in 4 weeks, and 43.5% (10/23) vs 92.3% (24/26) in 8 weeks of antimycobacterial therapy. The rate of normalization in CRP level was also significantly different between the two groups: 0% (0/25) vs 73.1% (19/26) in 2 weeks, 13.0% (3/23) vs 69.2% (18/26) in 4 weeks, and 8.7% (2/23) vs 80.8% (21/26) in 8 weeks of antimycobacterial therapy. Conclusions: The CRP level before and during antimycobacterial therapy may be used as a supplementary tool in the differential diagnosis between CD and TB patients. (Intest Res 2007;5:19-25)