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배성범(Seongbeom Bae),이병욱(Byung-Ook Lee),김영기(Youngki Kim),박상진(Sangjin Park) 한국중독정신의학회 2008 중독정신의학 Vol.12 No.2
알코올 의존 환자에 대한 기존의 국내 연구에서 사회인구 학적 변인이 치료 경과에 미치는 영향에 대한 보고가 거의 없었으나 본 연구에서는 결혼 상태가 재입원 즉 재발에 상당 한 영향을 주고 있어 단주 및 지속적인 외래 치료를 유지하는데 배우자의 역할이 중요함을 생각해 볼 수 있었다. 가장 주목할 만한 본 연구의 결과로는 입원 기간 중 절대적인 단주 프로그램의 수행 횟수 및 입원 기간에 비해 단주 프로그램에 얼마나 열심히 참여했는지가 향후 치료 경과에 중요함을 알 수 있었고 이는 제독 치료만을 마치고 퇴원을 원하는 환자들에게 단주 프로그램 참여를 권하는 데 있어 객관적인 근거로 사용될 수 있을 것으로 기대된다. 또한 동반된 신체 질환이 많을수록 재입원을 많이 하는 것으로 나타난 결과를 통해 임상 각 과와의 긴밀한 치료 협력 체계 구축을 통해 타 과적 처치가 끝난 후 단주 치료로 연계함으로써 단주 치료의 기회를 더욱 늘릴 수 있을 것으로 생각되었다. Objectives:The purpose of this study was to evaluate the effect of abstinence programs on the prognosis of alcoholic patients. Other factors that might also influence the prognosis of alcohol dependence were identified. Methods:A retrospective study was done by reviewing medical records of patients diagnosed as alcohol dependent between January 1, 2001 and December 31, 2005 at the National Health Insurance Medical Center, Ilsan Hospital, and data from the records of 207 patients who have been followed up on for more than 1 year were analyzed. The data included sociodemographic information. Results:Married patients were found to have a lower readmission rate com-pared to those who were single, divorced, bereaved, and separated, and those with alcoholic liver disease were more likely to relapse. Patients who had been re-admitted had statistically lower abstinence program participation numbers and participations (rates=participation number divided by admission day). Even in the re-admission group, the abstinence period was found to be longer in patients who had participated in more abstinence pro-grams during admission. Conclusion:Participation in inpatient abstinence programs was found to be a major factor of the patients’ prognosis. The role of spouses of alcoholic patients was also found to be important in preventing their re-admission.
Chung, Hyunjung,Kim, Seongbeom,Kim, Ki‐,Tae,Hwang, Bae‐,Geun,Kim, Hye‐,Jeong,Lee, Sang‐,Joon,Lee, Yong‐,Hwan BLACKWELL SCIENCE 2019 ENVIRONMENTAL MICROBIOLOGY Vol.21 No.3
<P><B>Summary</B></P><P>Because molecular oxygen functions as the final acceptor of electrons during aerobic respiration and a substrate for diverse enzymatic reactions, eukaryotes employ various mechanisms to maintain cellular homeostasis under varying oxygen concentration. Human fungal pathogens change the expression of genes involved in virulence and oxygen‐required metabolisms such as ergosterol (ERG) synthesis when they encounter oxygen limitation (hypoxia) during infection. The oxygen level in plant tissues also fluctuates, potentially creating hypoxic stress to pathogens during infection. However, little is known about how <I>in planta</I> oxygen dynamics impact pathogenesis. In this study, we investigated oxygen dynamics in rice during infection by <I>Magnaporthe oryzae</I> via two approaches. First, rice leaves infected by <I>M. oryzae</I> were noninvasively probed using a microscopic oxygen sensor. Second, an immunofluorescence assay based on a chemical probe, pimonidazole, was used. Both methods showed that oxygen concentration in rice decreased after fungal penetration. We also functionally characterized five hypoxia‐responsive genes participating in ERG biosynthesis for their role in pathogenesis. Resulting insights and tools will help study the nature of <I>in planta</I> oxygen dynamics in other pathosystems.</P>
이후승(Hu-Seung Lee),배한성(Han-Sung Bae),김성범(Seongbeom Kim),주윤재(Yun-Jae Joo),김정오(Jung-Oh Kim),노지환(Ji-Hwan Noh) 한국생산제조학회 2016 한국생산제조학회지 Vol.25 No.5
Recently, wireless charging systems have expanded their applications from household electrical appliances to outdoor activity devices. In wireless charging systems, solar cells have versatile advantages, such as abundant raw materials within the earth, reasonable prices of products, and highest power conversion efficiency. In this study, the photovoltaic effect between a silicon solar cell and a photon of infrared wavelength was simulated using a Shockley diode equation. A solar cell power charging system was then set up to: 1) clarify mechanisms of the charging interaction based on the photovoltaic effect with a laser source, and 2) verify interdependency of the parameters: laser settings and geometrical position between a solar cell and the laser. As was observed, the solar cell generates more power when the photon was irradiated uniformly, intensively, and vertically on the surface of the solar cell.
Effect of norgalanthamine on renal injury induced by carbon tetrachloride in mice
Nayeon Yang,Myungsoon Ko,Minhwa Jang,Eunjun Jang,Dowook Yu,Wootaek Hong,Seongbeom Bae,Jieun Ryoo,Taekyun Shin,Meejung Ahn 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Norgalanthamine is a major component of Crinum asiaticum var. japonicum that exhibits several biological activities. This study evaluated the anti-inflammatory and anti-oxidative properties of norgalanthamine in mice with carbon tetrachloride (CCl4)-induced renal injury. Norgalanthamine (1 and 10 mg/kg) was orally administered to mice for 7 or 14 days, after which renal injury was induced by CCl4 (1.5 ml/kg, i.p.). The vehicle and positive controls consisted of phosphate-buffered saline and silymarin (100 mg/kg), respectively. In CCl4-injured mice, norgalanthamine pretreatment significantly reversed the increases in serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels, and the decrease in the serum glucose level. The histopathological evaluation and Iba-1 immunoreactivity also supported the protective effects of norgalanthamine against CCl4-induced kidney injury. These results suggest that norgalanthamine ameliorates oxidative renal injury, possibly through reducing enhancing antioxidant enzymes, and suppressing infiltrated macrophages.
( Woo-hyun Kim ),( Jae-uk An ),( Junhyung Kim ),( Oun-kyong Moon ),( Sun Hak Bae ),( Jeffrey B. Bender ),( Seongbeom Cho ) 대한인수공통전염병학회 2018 창립총회 및 학술대회 초록집 Vol.2018 No.1
Introduction: Highly Pathogenic Avian Influenza (HPAI) subtype H5N8 outbreaks occurred in poultry farms in South Korea in 2014 resulting in significant damage to the poultry industry. Between 2014 and 2016, the pandemic disease caused significant economic loss and social disruption. To evaluate the risk factors of HPAI infection in broiler duck farms, we conducted a retrospective case-control study on broiler duck farms. Materials and Methods: Forty-three farms with confirmed laboratories on premises were selected as the case group and 43 HPAI-negative farms were designated as the control group. Control farms were matched based on farm location and were within a 3-km radius from the case premises. Spatial and environmental factors were characterized by site visit and plotted through a geographic information system (GIS). Univariable and multivariable logistic regression models were developed to assess possible risk factors associated with HPAI broiler duck farm infection. Results: Four final variables were identified as risk factors in a final multivariable logistic model: “Farms with ≥ seven flocks” (odds ratio [OR] = 6.99, 95% confidence interval [CI] 1.34-37.04), “Farm owner with ≥ 15 yrs. of raising poultry career” (OR = 7.91, 95% CI 1.69-37.14), “Presence of any poultry farms located within 500 m of the farm” (OR = 6.30, 95% CI 1.08-36.93), and “Not using a fecal removal service” (OR = 27.78, 95% CI 3.89-198.80). Conclusion: This highlights that the HPAI H5N8 outbreaks in South Korea were associated with farm owner education, number of flocks and facilities, and farm biosecurity. Awareness of these factors may help reduce the spread of HPAI H5N8 across broiler duck farms in Korea during epidemics. Greater understanding of the risk factors for H5N8 may improve farm vulnerability to HPAI and other subtypes and help establish policies to prevent re-occurrence. These findings are relevant to global prevention recommendations and intervention protocols. Acknowledgements: This research was supported by Animal Disease Management Technology Development, Ministry for Agriculture, Food and Rural Affairs, Republic of Korea. (314005-2)