http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
소학교령기(1895-1905) 관·공립소학교교육의 성격에 대한 고찰
이성은,김정효,정희숙,이해지,허선영 한국초등교육학회 2004 초등교육연구 Vol.17 No.1
본 연구의 목적은 국가 주도의 기초 공교육의 효시가 된 소학교령기(1895-1905) 관, 공립소학교교육의 성격을 탐구함으로써, 우리나라 초등교육기원에서 보여지는 특성을 재조명하려는 데에 있다. 이를 위해 소학교령기의 사회적 상황과 교육적 요구, 초등학교의 교육목적, 교육내용 및 방법, 학습자계층과 교원양성과 처우에 대해 알아봄으로써, 당시 초등학교교육의 성격이 어떠했는지 규명하였다. 연구결과, 이 당시 관, 공립소학교는 사회 통합적이라기보다는 구국적 국민계몽교육의 성격을 띠었으며, 보편적 아동교육 이라기보다는 혁신적 근대교육을 상징하였고, 현실안주적 보통교육 이라기보다는 미래지향적 교육의 성격을 띠었다. 결론적으로 다양한 시대상황적 한계에도 불구하고 교육개혁의 의지는 대단하였던 것으로 평가되어졌다. The purpose of this study was to search for the nature of public primary school education in beginning period Enlightenment in Korea(1895-1905) in terms of the aims, the educational contents and methods, and the learner and teacher. For the purpose, the contemporary governmental documents, the newspapers, and other historic materials were collected and analyzed and the school sites were visited. The nature of public primary school education in beginning period of Enlightenment, was revealed as follows: First, it was not for the social consensus, but for the enlightenment of the people against nationalism. Second, it was not universal child education, but innovational elite education, Third, it did reflect not the present need, but the future need. In conclusion, it can be said that their intention of establishment of modem primary school has been underestimated and that their effort for educational reform should be reevaluated. But the research result suggests that public primary school education needs the balance not only between national needs and individual needs, but also between present needs and the future need.
Seon Yeong Ji,Min Yeong Kim,So Yung Kim,Hyun Hwangbo,Hyesook Lee,Suhkmann Kim,Yung Hyun Choi 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Previous studies have suggested that 5-aminolevulinic acid (ALA), a heme precursor, may be a potential treatment for inflammatory responses and oxidative stress. In this study, we investigated the inhibitory effect of ALA on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages and zebrafish models. Our results indicated that ALA treatment significantly attenuated the LPS-induced release of pro-inflammatory mediators including nitric oxide (NO) and prostaglandin E2, which was associated with decreased inducible NO synthase and cyclooxygenase-2 expression. ALA also inhibited the LPS-induced expression of pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, reducing their extracellular secretion. Additionally, ALA abolished reactive oxygen species (ROS) generation, improved the mitochondrial mass, and enhanced the expression of heme oxygenase-1 (HO-1) and the activation of nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in LPS-stimulated RAW 264.7 macrophages. However, zinc protoporphyrin, a specific inhibitor of HO-1, reversed the ALA-mediated inhibition of pro-inflammatory cytokines production and activation of mitochondrial function in LPS-treated RAW 264.7 macrophages. Furthermore, ALA significantly abolished the expression of LPS-induced pro-inflammatory mediators and cytokines, and showed strong protective effects against NO and ROS production in zebrafish larvae. In conclusion, our findings suggest that ALA exerts LPS-induced anti-inflammatory and antioxidant effects by upregulating the Nrf2/HO-1 signaling pathway, and that ALA can be a potential functional agent to prevent inflammatory and oxidative damage.
Seon Yeong Ji,Min Yeong Kim,So Yung Kim,Hyun Hwangbo,Da Hye Kim,Hyesook Lee,Joung-Hyun Park,Bae-Jin Lee,Yung Hyun Choi 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Numerous studies have been reported that excessive salt intake is associated with increased risk of hypertension, renal failure and cardiovascular events. Recently, several gamma-aminobutyric acid (GABA) supplements have been shown to reduced high salt-induced diseases. Although there is suggested that GABA salt (GS), a fermented salt by Lactobacillus brevis BJ20 containing GABA, attenuated high salt-induced hypertension, the effect of GS on the organs is unclear. The aim of this study was to elucidate the effect of oral administration of GS, GS containing live lactic acid bacteria (LGS) and GS containing post-biotics (PGS) on organ weight, hematology and clinical parameters in high salt-fed C57BL/6 Mice. Normal group was orally administered with 0.3% NaCl, and high salt groups were fed with salt, GS, LGS and PGS containing 4% NaCl for 8 weeks. High salt intake had no effect on the body weight and hematological profiles. However, the weights of spleen and heart were markedly decreased in high salt groups, while liver, lung and pancreas were not altered. In kidney, the expressions of T-cell immunoglobulin mucin domain-1 and inflammatory cytokines were greatly increased in high salt mice, but attenuated by GS administration, suggesting GS have biological safety and prevent high salt intake-mediated disease.
( Seon Yeong Ji ),( Hee-Jae Cha ),( Ilandarage Menu Neelaka Molagoda ),( Min Yeong Kim ),( So Young Kim ),( Hyun Hwangbo ),( Hyesook Lee ),( Gi-Young Kim ),( Do-Hyung Kim ),( Jin Won Hyun ),( Heui-Soo 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.6
In this study, we investigated the inhibitory effect of 5-aminolevulinic acid (ALA), a heme precursor, on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages by estimating nitric oxide (NO), prostaglandin E2 (PGE2), cytokines, and reactive oxygen species (ROS). We also evaluated the molecular mechanisms through analysis of the expression of their regulatory genes, and further evaluated the anti-inflammatory and antioxidant efficacy of ALA against LPS in the zebrafish model. Our results indicated that ALA treatment significantly attenuated the LPS-induced release of pro-inflammatory mediators including NO and PGE2, which was associated with decreased inducible NO synthase and cyclooxygenase-2 expression. ALA also inhibited the LPS-induced expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, reducing their extracellular secretion. Additionally, ALA abolished ROS generation, improved the mitochondrial mass, and enhanced the expression of heme oxygenase-1 (HO-1) and the activation of nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in LPS-stimulated RAW 264.7 macrophages. However, zinc protoporphyrin, a specific inhibitor of HO-1, reversed the ALA-mediated inhibition of pro-inflammatory cytokines production and activation of mitochondrial function in LPS-treated RAW 264.7 macrophages. Furthermore, ALA significantly abolished the expression of LPS-induced pro-inflammatory mediators and cytokines, and showed strong protective effects against NO and ROS production in zebrafish larvae. In conclusion, our findings suggest that ALA exerts LPS-induced anti-inflammatory and antioxidant effects by upregulating the Nrf2/HO-1 signaling pathway, and that ALA can be a potential functional agent to prevent inflammatory and oxidative damage.
Change of Blood Cells' Number from Capillaries and Venous Blood of 20's Healthy Adults
Seon, Ji-Yeong,Lee, Jae Sik 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4
It was confirmed that we got somewhat different results even though we performed same items with same methods from capillaries and venous blood of healthy 72 cases. Items which capillaries blood has higher value than venous blood are the numbers of erythrocyte, lymphocyte, basophil, hematocrit, MCHC and RDW. Total numbers of RBC (p<0.035), lymphocyte and basophil are shown statistically significance. Items which venous blood has higher value than capillary blood are the numbers of platelet (p<0.00) and neutrophil (p<0.01). Fallible items in clinics can be shown the numbers of RBC, platelet, lymphocyte and neutrophil because we got somewhat different results even though we performed same items with same methods from capillaries and venous blood, respectively. It is necessary to choose the clear criteria and normal value depends on clinical specimen as the number of platelets are measured with an abnormal value shown over 40% down. As normal difference according to each item and method is currently acceptable and applicable in clinics, it is considered that a new normal value depends on clinical specimen should be established and is to be useful positively in clinics.
Change of Blood Cells` Number from Capillaries and Venous Blood of 20`s Healthy Adults
( Ji-yeong Seon ),( Jae Sik Lee ) 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.4
It was confirmed that we got somewhat different results even though we performed same items with same methods from capillaries and venous blood of healthy 72 cases. Items which capillaries blood has higher value than venous blood are the numbers of erythrocyte, lymphocyte, basophil, hematocrit, MCHC and RDW. Total numbers of RBC (p<0.035), lymphocyte and basophil are shown statistically significance. Items which venous blood has higher value than capillary blood are the numbers of platelet (p<0.00) and neutrophil (p<0.01). Fallible items in clinics can be shown the numbers of RBC, platelet, lymphocyte and neutrophil because we got somewhat different results even though we performed same items with same methods from capillaries and venous blood, respectively. It is necessary to choose the clear criteria and normal value depends on clinical specimen as the number of platelets are measured with an abnormal value shown over 40% down. As normal difference according to each item and method is currently acceptable and applicable in clinics, it is considered that a new normal value depends on clinical specimen should be established and is to be useful positively in clinics.