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배일헌,한기석,차상훈,김성진,박길선,한설희,김동호 충북대학교 의학연구소 2002 忠北醫大學術誌 Vol.12 No.2
연구목적: 본 연구의 목적은 초음파 유도 하에 갑상선 결절을 경피적 흡인 생검 할 때 검체 획득률을 알아 보고, 검체 획득률에 영향을 주는 요소들을 알아보고자 하였다. 대상 및 방법: 갑상선 결절이 있어 초음파 유도하 경피적 흡인 생검을 하였던 132명 (12-71; 평균 42세) 환자의 결절 215예를 대상으로 전향적 연구를 시행하였다. 2000년 9월부터 2001년 2월까지 62명의 환자의 결절 111예에서 21-gauge 세침을 이용하였고, 2001년 3월부터 9월까지 70명의 환자의 결절 104예에서 20-gauge 절단침을 이용하였다. 초음파 유도하 경피적 흡인 생검의 검체 획득률을 구하였고, 결절 단경이 1 ㎝ 이하와 1 ㎝ 초과, 결절의 성상, 촉지여부에 따라 검체 확득률에 차이가 있는지 비교 분석하였다. 통계적 분석은 Chisquare test로 검증하였다 (p<0.05). 결과: 총 215예 중 188예에서 적절한 검체가 얻어져 전체 검체 획득률은 87.4%이었다. 낭성 결절 (78.8%)보다 고형 결절 (90.2%)에서 더 높은 검체 획득율을 보였으나, 결절의 크기(≤1 ㎝:85.7% vs. >1 ㎝:88.7%)와 촉지 여부 (촉지되는 결절: 87.5% vs. 촉지되지 않는 결절:87.4%)에 따라서는 유의한 차이를 보이지 않았다. 결론: 갑상선 결절의 초음파 유도하 경피적 흡인 생검은 높은 검체 획득율을 보이며, 결절의 크기, 촉지 여부에 따른 차이는 없으나, 고형 결절에서 낭성 결절보다 높은 검체 획득율을 보인다. Purpose: The purpose of this study is to evaluate the acquisition rate of adequate specimen in ultrasound-guided percutaneous needle aspiration biopsy (US-PCNB) of thyroid nodules and to find the factors influencing the acquisition rate. Materials and Methods: We conducted a prospective study in 132 patients (mean age 47 years: range 12-71) who had 215 nodules. Aspiration biopsy was performed with 21-gauge fine needles for 111 nodules (62 patients) and with 20-gauge cutting needles for 104 nodules (70 patients). We calculated overall acquisition rate of adequate specimen of US-PCNB and compared acquisition rates according to nodule size, nature and palpability. Results: Total acquisition rate of adequate specimen was 87.4%. The acquisition rate of adequate specimen of solid nodules (90.2%) was higher than that of cystic nodules (78.8%). The size of nodules did not affect the acquisition rate of specimen (≤1 ㎝:85.7% vs. >1 ㎝:88.7%). The palpability of nodules also cause no difference the acquisition rate (palpable: 87.5% vs. non-palpable:87.4%). Conclusion: US-guided PCNB of thyroid nodules was high acquisition rate of adequate specimen. There was no statistically significant difference according to size and palpability of nodules but was according to nature of nodules in the acquisition rate of adequate specimen.
가상건설기법을 활용한 철도시설물의 시공시뮬레이션 기능 개발
강인석(Kang Leen-Seok),문진석(Moon Jin-Seok),김슬기(Kim Seol-Gi),권중희(Kwon Jung-Hui),지상복(Ji Sang-Bok) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-
This study suggests a virtual construction technology for railway project using virtual reality and attempts to develop a virtual construction system. For the study, the final system include the layout review function that can rearrange designed element for optimal placement and the earthwork simulation function that can visualize filling and cutting work using central line of earthwork section. Those functions can improve applicability of 3D and 4D object in the design and construction phases of railway project.
설국환 ( Kuk Hwan Seol ),장운기 ( Oun Ki Chang ),김민경 ( Min Kyung Kim ),한기성 ( Gi Sung Han ),정석근 ( Seok Geun Jeong ),박범영 ( Beom Young Park ),함준상 ( Jun Sang Ham ) 한국유가공기술과학회 2012 Journal of Dairy Science and Biotechnology (JMSB) Vol.30 No.1
Milk-derived bioactive peptides have been found to exhibit various physiological activities such as angiotensin-converting enzyme (ACE) inhibitory, antibacterial, and antioxidative effects. Bioactive peptides can be used in the formulation of functional foods, nutraceuticals, and natural drugs because of their beneficial effects. However, the degree of variability in the composition, functionality, and sensory properties of such peptides has greatly limited their use in the food industry. In this review, we discuss the main peptides obtained from milk proteins and summarize findings from previous studies on the production and biological activities of these peptides. In addition, we compare the methods used to separate and identify the structure of the bioactive peptides and highlight current investigations into engineering and implementation of technologies that would allow more efficient isolation of bioactive peptides for functional food production. To improve human health, further molecular biology studies will also be required to elucidate the complex network of interactions between food microorganisms and the digestive system.
First Report of Smut Caused by Urocystis eranthidis on Anemone flaccida in Korea
Avalos-Ruiz Diane,Seol Gi-Seok,Lim Seong-Keun,Kang In-Kyu,Lee Seung-Yeol,Jung Hee- Young 한국균학회 2022 韓國菌學會誌 Vol.50 No.1
Abnormal symptoms were observed on Anemone flaccida in Korea, indicating an infection caused by smut fungi. Morphological and molecular analyses of the strain KNUF-UB were consistent with previous reports of Urocystis eranthidis. Therefore, this is the first report of smut caused by U. eranthidis on A. flaccida in Korea.
개방성 치조골 골절의 고정법: 응급실에서 간편하게 적용할 수 있는 방법
설승환 ( Seung Hwan Seol ),차수현 ( Soo Hyun Cha ),최상천 ( Sang Cheon Choi ),안정환 ( Jung Hwan Ahn ),김기운 ( Gi Woon Kim ),최혜경 ( Hea Kyung Choi ),조준필 ( Joon Pil Cho ),정윤석 ( Yoon Seok Jung ) 대한외상학회 2007 大韓外傷學會誌 Vol.20 No.2
Purpose: The purpose of this clinical trial was to evaluate the fixation method for treating alveolar fractures in an emergency department. Methods: The efficiency of using the fixation method was judged on the basis of clinical criteria. Stability, occlusion state, bleeding amount after fixation, operation time, and difficulties during procedural operation were recorded. Results: Eight patients were enrolled in this study. In all instances, the fixation method was effective in bleeding control. Each patient had a noticeable decrement in bleeding. A wire was used for four of the eight patients, and nylon strings was used for the others. The average operation time was 6.3 minutes for the wire patients and 2.8 minutes for the Nylon string patients. No specific problem was identified during the procedural operation. However, the difference in the fixation material influenced the effectiveness of the procedure, the operation time, and the satisfaction of the doctor. Conclusion: In the emergency department, the fixation method using wire or nylon string in the treatment of alveolar fractures is effective in bleeding control (J Korean Soc Traumatol 2007;20:72-76)
Temozolomide Salvage Chemotherapy for Recurrent Anaplastic Oligodendroglioma and Oligo-Astrocytoma
Gwak, Ho-Shin,Yee, Gi Taek,Park, Chul-Kee,Kim, Jin Wook,Hong, Yong-Kil,Kang, Seok-Gu,Kim, Jeong Hoon,Seol, Ho Jun,Jung, Tae-Young,Chang, Jong Hee,Yoo, Heon,Hwang, Jeong-Hyun,Kim, Se-Hyuk,Park, Bong Ji The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.6
Objective : To evaluate the efficacy of temozolomide (TMZ) chemotherapy for recurrent anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA). Methods : A multi-center retrospective trial enrolled seventy-two patients with histologically proven AO/AOA who underwent TMZ chemotherapy for their recurrent tumors from 2006 to 2010. TMZ was administered orally (150 to 200 $mg/m^2/day$) for 5 days per 28 days until unacceptable toxicity occurred or tumor progression was observed. Results : TMZ chemotherapy cycles administered was median 5.3 (range, 1-41). The objective response rate was 24% including 8 cases (11%) of complete response and another 23 patients (32%) were remained as stable disease. Severe side effects (${\geq}$grade 3) occurred only in 9 patients (13%). Progression-free survival (PFS) of all patients was a median 8.0 months (95% confidence interval, 6.0-10.0). The time to recurrence of a year or after was a favorable prognostic factor for PFS (p<0.05). Overall survival (OS) was apparently differed by the patient's histology, as AOA patients survived a median OS of 18.0 months while AO patients did not reach median OS at median follow-up of 11.5 months (range 2.7-65 months). Good performance status of Eastern Cooperative Oncology Group 0 and 1 showed prolonged OS (p<0.01). Conclusion : For recurrent AO/AOA after surgery followed by radiation therapy, TMZ could be recommended as a salvage therapy at the estimated efficacy equal to procarbazine, lomustine, and vincristine (PCV) chemotherapy at first relapse. For patients previously treated with PCV, TMZ is a favorable therapeutic option as 2nd line salvage chemotherapy with an acceptable toxicity rate.
장운기 ( Oun Ki Chang ),설국환 ( Kuk Hwan Seol ),김민경 ( Min Kyung Kim ),한기성 ( Gi Sung Han ),정석근 ( Seok Geun Jeong ),오미화 ( Mi Hwa Oh ),박범영 ( Beom Young Park ),함준상 ( Jun Sang Ham ) 한국유가공기술과학회 2012 한국유가공기술과학회지 Vol.30 No.2
Lactic acid bacteria (LAB) have been used as starter cultures in the manufacturing processes of fermented dairy products such as cheese and yogurt. LAB have a proteolytic system to use the nitrogen source from milk for their growth. The proteolytic system involved in casein utilization provides cells with essential amino acids during growth in milk and is also of industrial importance, because of its contribution to the development of the organoleptic properties such as flavor of fermented milk products. In the most extensively studied LAB, Lactococcus lactis, the main features of the proteolytic system comprise 3 groups. The first is proteinase, which initially cleaves the milk protein to peptides. The second group consists of transport systems for the internalization of oligopeptides, which are involved in the cellular uptake of small peptides and amino acids. The third group, peptidases in the cell, cleaves peptides into smaller peptides and amino acids. This review is to provide the information about the proteolytic system of LAB.