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Current issues of pediatric inflammatory bowel disease in Korea
Oh, Seak Hee,Kim, Kyung Mo The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.11
Inflammatory bowel disease (IBD) is a chronic relapsing disorder of unknown etiology, which is believed to be multifactorial. Recently, the incidence of pediatric IBD has steeply increased in Korea since 2000. Poorly controlled disease activity can result in complications such as intestinal fistulae, abscess, and stricture, as well as growth retardation and delayed puberty in children. Because of a lack of confirmative tests, various diagnostic modalities must be used to diagnose IBD. Onset age, location, behavior, and activity are important in selecting treatments. Monogenic IBD must be excluded among infantile and refractory very-early-onset IBD. Early aggressive therapy using biologics has recently been proposed for peripubertal children to prevent growth failure and malnutrition.
Sedation in Pediatric Esophagogastroduodenoscopy
Seak Hee Oh 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.2
Pediatric esophagogastroduodenoscopy (EGD) has become an established diagnostic and therapeutic modality in pediatric gastroenterology. Effective sedation strategies have been adopted to improve patient tolerance during pediatric EGD. For children, safety is a fundamentalconsideration during this procedure as they are at a higher risk of severe adverse events from procedural sedation compared toadults. Therefore, a detailed risk evaluation is required prior to the procedure, and practitioners should be aware of the benefits and risksassociated with sedation regimens during pediatric EGD. In addition, pediatric advanced life support by endoscopists or immediate interventionby anesthesiologists should be available in the event that severe adverse events occur during pediatric EGD.
Is Whole Exome Sequencing Clinically Practical in the Management of Pediatric Crohn’s Disease?
( Seak Hee Oh ),( Jiwon Baek ),( Kyung Mo Kim ),( Eun-ju Lee ),( Yusun Jung ),( Yeoun Joo Lee ),( Hyun-seung Jin ),( Byong Duk Ye ),( Suk-kyun Yang ),( Jong-keuk Lee ),( Eul-ju Seo ),( Hyun Taek Lim ) 대한소화기학회 2015 Gut and Liver Vol.9 No.6
Background/Aims: The aim of this study was to identify the profile of rare variants associated with Crohn’s disease (CD) using whole exome sequencing (WES) analysis of Korean children with CD and to evaluate whether genetic profiles could provide information during medical decision making. Methods: DNA samples from 18 control individuals and 22 patients with infantile, very-early and early onset CD of severe phenotype were used for WES. Genes were filtered using panels of inflammatory bowel disease (IBD)-associated genes and genes of primary immunodeficiency (PID) and monogenic IBD. Results: Eighty-one IBD-associated variants and 35 variants in PID genes were revealed by WES. The most frequently occurring variants were carried by nine (41%) and four (18.2%) CD probands and were ATG16L2 (rs11235604) and IL17REL (rs142430606), respectively. Twenty-four IBD-associated variants and 10 PID variants were predicted to be deleterious and were identified in the heterozygous state. However, their functions were unknown with the exception of a novel p.Q111X variant in XIAP (X chromosome)of a male proband. Conclusions: The presence of many rare variants of unknown significance limits the clinical applicability of WES for individual CD patients. However, WES in children may be beneficial for distinguishing CD secondary to PID. (Gut Liver 2015,9:767-775)
MICRO WAVE OVEN용 마그네트론 구동을 위한 전원장치개발에 관한 연구
오덕진(Duck-Jin Oh),김희준(Hee-Jun Kim),오원석(Won-Seak Oh),정진홍(Jin-Hong Jung),김석기(Seak-Gi Kim),송종화(Jung-Hwa Song) 전력전자학회 1999 전력전자학술대회 논문집 Vol.- No.-
HVT<High Voltage Transformer) have been used to drive a magnetron in a microwave oven, but they have some problems such as heavy weight and low efficiency. To solve such problems of microwave oven power source, voltage resonant ZVS-PFM inverters have been developed. This paper presents a high-frequency high-voltage AC-DC converter incorporating high-frequency transformer resonant ZVS-PFM inverter with three-wmdmg transformer and voltage doubler type rectifier for drive high power magnetron. The new power supply makes it possible to realize light weight and high efficiency
Hee Gyung Lee,Kyung Mo Kim,Seak Hee Oh,Yeoun Joo Lee,Jae Seung Kim,Kyoung Hyo Choi,Young Ah Cho 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.3
Purpose: To compare the abilities of radionuclide salivagrams (RS) and videofluoroscopic swallow studies (VFSS) to diagnose aspiration in children with aspiration pneumonia. Methods: The records of children who were referred to the Asan Medical Center between April, 2006 and April, 2012 and who underwent both VFSS and RS to evaluate their recurrent aspiration pneumonia were reviewed (n=67). The aspiration positivity rates of the two tests were determined. The agreement between the tests was assessed by using the kappa statistic. Results: VFSS was more frequently positive (n=26, 39%) than RS (n=23, 34%) (p=0.68). In the 11 children who repeat two test, Repeated examination increased positive rate in each tests (n=11), repeated RS (54%, p=1) is more frequent positive than repeated VFSS (46%, p=0.37). If a cumulative positive test had been defined as at least one positive result, the positive rate of two test was 56% (p<0.05). There was a fair agreement between RS and VFSS (kappa=0.26). Conclusion: The RS and VFSS positivity rates in children with aspiration pneumonia were similar but there was fair agreement between the two tests. This result suggests that these investigations to demonstrate aspiration are not interchangeable but complementary.
Primary Sclerosing Cholangitis with Inflammatory Bowel Disease in Korean Children
Jisun Yoon,Seak Hee Oh,Hyun Jin Kim,Sang Hyoung Park,Byong Duk Ye,Suk-Kyun Yang,Kyung Mo Kim 대한소아소화기영양학회 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.4
Purpose: Primary sclerosing cholangitis (PSC) is a rare condition that can be associated with inflammatory bowel disease (IBD). The aim of this study was to evaluate PSC and its association with IBD in children.Methods: We retrospectively enrolled 13 pediatric patients (<18 years) with PSC treated at Asan Medical Center between June 1989 and December 2013. Clinical findings and long-term outcomes were investigated. During the same period, the incidence of PSC among IBD patients was evaluated among 600 Crohn disease (CD) and 210 ulcerative colitis (UC) patients.Results: All 13 study patients diagnosed with PSC also presented with IBD. Eleven boys and two girls with a median age of 15.0 years old (9.0-17.8 years) were included. The cumulative incidence of PSC for UC was 5.7% (12 of 210) and 0.2% for CD (1 of 600), respectively. PSC occurred during follow-up for IBD for five patients (38.5%) whereas, IBD developed during follow-up for PSC for two patients (15.4%), and was diagnosed during the initial work-up for PSC for 6 patients (46.2%). For the 77.3 month median follow-up period, 9/13 patients (69.2%), neither the clinical symptoms nor blood test results worsened. Two cases (15.4%) developed liver cirrhosis and underwent liver transplantation. Among 13 PSC patients with IBD, two (15.4%) developed colorectal cancer, and no one developed cholangiocarcinoma. Conclusion: All patients with PSC in this study had associated IBD. The incidence of PSC was not rare compared to reports in adults. PSC should be considered during the management of IBD and vice versa in children.
Jisun Hwang,Hee Mang Yoon,Pyeong Hwa Kim,Jung-Man Namgoong,Seak Hee Oh,Ah Young Jung,Jin Seong Lee,Young Ah Cho 대한영상의학회 2022 대한영상의학회지 Vol.83 No.5
The Kasai portoenterostomy is the first-line treatment for the restoration of the flow of bile to the small intestine in patients with biliary atresia. Various complications can occur after Kasai portoenterostomy, including ascending cholangitis, biliary cirrhosis, and portal hypertension. Of these potential complications, ascending cholangitis in the most common. In cases of patients having uncontrolled complications due to progressive liver cirrhosis, portal hypertension, or progressive hyperbilirubinemia, liver transplantation is the indicated as treatment plan. Lifelong follow-up, particularly involving imaging studies, is important for the identification of various complications arising from biliary atresia after Kasai portoenterostomy. Additionally, imaging studies play a crucial role in the evaluation of potential liver donors and recipients. US is a key imaging modality utilized in the management of patients who undergo Kasai portoenterostomy, while CT and MRI are imperative to obtaining an accurate diagnosis.