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Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’
Yamasaki, Satoshi,Yagishita, Naoko,Sasaki, Takeshi,Nakazawa, Minako,Kato, Yukihiro,Yamadera, Tadayuki,Bae, Eunkyung,Toriyama, Sayumi,Ikeda, Rie,Zhang, Lei,Fujitani, Kazuko,Yoo, Eunkyung,Tsuchimochi, K Wiley (John WileySons) 2007 The EMBO journal Vol.26 No.1
<P>Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of arthropathy. However, little is known about the molecular mechanisms of Synoviolin in these actions. To clarify these issues, we analyzed the profile of protein expression in synoviolin-null cells. Here, we report that Synoviolin targets tumor suppressor gene p53 for ubiquitination. Synoviolin sequestrated and metabolized p53 in the cytoplasm and negatively regulated its cellular level and biological functions, including transcription, cell cycle regulation and apoptosis. Furthermore, these p53 regulatory functions of Synoviolin were irrelevant to other E3 ubiquitin ligases for p53, such as MDM2, Pirh2 and Cop1, which form autoregulatory feedback loops. Our results provide novel insights into p53 signaling mediated by Synoviolin.</P>
Takahashi, Kazuo,Wu, Mincharn,Nakazawa, Satoshi Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.8
Vibration, buckling and dynamic stability of a cantilever rectangular plate subjected to an in-plane sinusoidally varying load applied along the free end are analyzed. The thin plate small deflection theory is used. The Rayleigh-Ritz method is employed to solve vibration and buckling of the plate. The dynamic stability problem is solved by using the Hamilton principle to drive time variables. The resulting time variables are solved by the harmonic balance method. Buckling properties and natural frequencies of the plate are shown at first. Unstable regions are presented for various loading conditions. Simple parametric resonances and combination resonances with sum type are obtained for various loading conditions, static load and damping.
Study of Trehalase during Autolysis of the Fruit-body in Pleurotus sp.
Alireza Arastoo,Masami Nakazawa,Tatsuji Sakamoto,Mizuho Kusuda,Hitoshi Kobayashi,Kenji Ouchi,Satoshi Inatomi,Mitsuhiro Ueda 한국버섯학회 2017 버섯 Vol.21 No.2
Fruiting bodies were degraded themselves by the several glycoside hydrolases after spore releasing from mature fruiting bodies or harvesting. The enzymes involved in autolysis such as glucanase and chitinase have been studied. However, there are almost no information about the relationship between several glycoside hydrolases and autolysis. In this study, we studied to obtain the enzymatic properties of trehalase, and also to get the new information on the relationship between trehalase and autolysis. Crude enzymes were prepared from each fruiting body of Pleurotus sp. (from the immature stage to the autolysis stage) and the trehalase activities were measured at each growth stage. Trehalase activities sharply increased in autolysis stage. Trehalase was partially purified from fruiting bodies of the autolysis stage using various column chromatography and its properties were examined. The optimum temperature was 50 °C and the optimum pH was 4.5. In order to elucidate the localization of trehalase, fruit bodies of the autolysis stage were divided into the stipes and the pileuses, and the each trehalase activity was measured. High trehalase activities were found in the pileuses. Furthermore, in order to elucidate trehalase activities in autolysis more detail, the each fruiting body of autolysis progressing stages was finely divided into the stipes and the pileuses, and their activities were measured. The activities in the outer part of the pileuses were highest at the initial stage of autolysis and the activities shifted from the outer side to the inner side of the pileuses according to the progress of autolysis.
Yusuke Okuda,Tomonori Yamada,Yoshikazu Hirata,Takaya Shimura,Ryuzo Yamaguchi,Eiji Sakamoto,Satoshi Sobue,Takahiro Nakazawa,Hiromi Kataoka,Takashi Joh 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Since oncological outcomes of transanal colorectal tube (TCT) placement, an endoscopic treatment for colorectal cancer (CRC) with acute colorectal obstruction (ACO), remain unknown, this study analyzed long-term outcomes of TCT placement for stage II/III CRC with ACO. Materials and Methods Data were retrospectively reviewed from consecutive patients with distal stage II/III CRC who underwent surgery between January 2007 and December 2011 at two Japanese hospitals. One hospital conducted emergency surgery and the other performed TCT placement as the standard treatment for all CRCs with ACO. Propensity score (PS) matching was used to adjust baseline characteristics between two groups. Results Among 754 patients with distal stage II/III CRC, 680 did not have ACO (non-ACO group) and 74 had ACO (ACO group). The PS matching between both hospitals identified 234 pairs in the non-ACO group and 23 pairs in the ACO group. In the non-ACO group, the surgical quality was equivalent between the two institutions, with no significant differences in overall survival (OS) and disease-free survival (DFS). In the ACO group, the rate of primary resection/anastomosis was higher in the TCT group than in the surgery group (87.0% vs. 26.1%, p < 0.001). No significant differences were noted between the surgery and the TCT groups in OS (5-year OS, 61.9% vs. 51.5%; p=0.490) and DFS (5-year DFS, 45.9% vs. 38.3%; p=0.658). Conclusion TCT placement can achieve similar long-term outcomes to emergency surgery, with a high rate of primary resection/anastomosis for distal stage II/III colon cancer with ACO.
Polymer electrolyte membrane based on polyacrylate with phosphonic acidvia long alkyl side chains
Higashihara, Tomoya,Fukuzaki, Namiko,Tamura, Youko,Rho, Yecheol,Nakabayashi, Kazuhiro,Nakazawa, Satoshi,Murata, Shigeaki,Ree, Moonhor,Ueda, Mitsuru The Royal Society of Chemistry 2013 Journal of Materials Chemistry A Vol.1 No.4