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Expression of Sara2 Human Gene in Erythroid Progenitors
Jardim, Denis Leonardo Fontes,Cunha, Anderson Ferreira Da,Duarte, Adriana Da Silva Santos,Santos, Camila Oresco Dos,Saad, Sara Terezinha Olalla,Costa, Fernando Ferreira Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.3
A human homologue of Sar1, named Sara2, was shown to be preferentially expressed during erythropoiesis in a culture stimulated by EPO. Previous studies, in yeast, have shown that secretion-associated and Ras-related protein (Sar1p) plays an essential role in protein transport from the endoplasmic reticulum to the Golgi apparatus. Here, we report the molecular analysis of Sara2 in erythroid cell culture. A 1250 bp long cDNA, encoding a 198 amino-acid protein very similar to Sar1 proteins from other organisms, was obtained. Furthermore, we also report a functional study of Sara2 with Real-time quantitative PCR analysis, demonstrating that expression of Sara2 mRNA increases during the initial stages of erythroid differentiation with EPO and that a two-fold increase in expression occurs following the addition of hydroxyurea (HU). In K562 cells, Sara2 mRNA was observed to have a constant expression and the addition of HU also up-regulated the expression in these cells. Our results suggest that Sara2 is an important gene in processes involving proliferation and differentiation and could be valuable for understanding the vesicular transport system during erythropoiesis.
Özge Saraçlı,Ayşe Semra Demir Akca,Nuray Atasoy,Özde Önder,Ömer Şenormanc,İsmet Kaygisız,Levent Atik 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2
Objective: Older people seek not only a longer life, but also a better quality of life (QOL). Our aim was to find out the relationship between QOL and socio-demographic factors, social activities, cognitive status, depression and anxiety symptoms among medically ill and hospitalized elderly people in Turkey. Methods: Two hundred forty three patients age 65 years or older were examined. The Socio-demographic Data Survey, the Mini Mental State Examination (MMSE), the Geriatric Depression Scale-short form (GDS-15), the Beck Anxiety Inventory (BAI) and the World Health Organization Quality of Life Instrument-Older Adults Module (WHOQOL-OLD) were applied to participants. The independent samples t-test and analysis of variance (ANOVA) were used to analyze quantitative data. Pearson’s correlation and linear regression analysis were performed. Results: The total score for QOL was significantly higher for those who saw their family members and relatives frequently rather than rarely (p=0.002), who were always busy with social activities rather than rarely or never (p<0.001), who had more years of education (p=0.003), and who were frequently exercising (p=0.023). According to linear regression analysis, the WHOQOL-OLD total score increased by 0.295 and −0.936 units, while MMSE and GDS-15 scale scores increased one unit respectively (β=0.295, t=1.979, p=0.04; β=−0.936, t=−4.881, p<0.001). Conclusion: Cognitive disabilities, depression, and other psychiatric problems along with medical disease negatively affect the QOL of elderly patients. While performing medical assessment regarding elders, detecting and treating cognitive disabilities and depression is very valuable in improving the QOL of elderly patients.
Elena Saraí Baena-Santillán,Javier Piloni-Martini,Eva María Santos-López,Carlos Alberto Gómez-Aldapa,Esmeralda Rangel-Vargas,Javier Castro-Rosas 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
To determine and compare the antimicrobial effect of Hibiscus sabdariffa calyx extracts, six types of commercial mouthwashes, and chlorhexidine on Streptococcus mutans, Streptococcus sanguinis, Capnocytophaga gingivalis, and Staphylococcus aureus. Two varieties of H. sabdariffa cultivated in Mexico were used. Aqueous, methanolic, ethanolic, acetonic, and ethyl acetate extracts were obtained from H. sabdariffa calyces. Six different types of mouthwash (Astringosol®, Colgate plax-ice-infinity®, Crest pro-health®, Dental max®, Equate®, and Listerine zero®) and chlorhexidine (0.12%) were purchased at a pharmacy. The antimicrobial activity of the H. sabdariffa calyx extracts, mouthwashes, and chlorhexidine was determined by the agar disc diffusion technique. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of all solutions were determined by the broth dilution method and the pour plate technique, respectively. Also, the effect of H. sabdariffa extracts and chlorhexidine on permeability of the bacterial membrane was determined by the violet crystal assay. All H. sabdariffa calyx extracts and chlorhexidine showed antibacterial activity against all oral pathogenic bacteria. The mouthwashes showed lower antibacterial effect than H. sabdariffa extracts and chlorhexidine. Dental max showed no antibacterial effect. The MICs and MBCs, respectively, for H. sabdariffa extracts were between 5–20 and 10–20 mg/mL; and for chlorhexidine, between 3–4 and 3–5 mg/mL. For the Listerine®, the MIC and MBC values were between 20–25 and 25–33 mg/mL, respectively. The results of the crystal violet test indicate that H. sabdariffa calyx extracts and chlorhexidine alter the permeability of the bacterial membrane. All H. sabdariffa extracts and chlorhexidine showed significantly greater antimicrobial effect than mouthwashes. This is the first report in which the antimicrobial effect of the H. sabdariffa calyx extracts, mouthwashes, and chlorhexidine is compared.
Sari Ahmet,Ekinci Osman,Saraçoğlu Kemal Tolga,Balık Recep,Aslan Mesut,Balık Yelda,Önal Ceren,Aslan Murat,Cevher Semra,Parmaksız Aylin,Vatansever Şule,Çicek Münire Canan,Ayan Özge Sayın,Şensöz Çelik Ga 대한의학회 2023 Journal of Korean medical science Vol.38 No.29
Background: Coronavirus disease 2019 (COVID-19) is often a mild disease, usually manifesting with respiratory complaints, and is sometimes mortal due to multiple organ failure. Hyperinflammation is a known COVID-19 component and is associated with organ dysfunction, disease severity and mortality. Controlling hyperinflammatory response is crucial in determining treatment direction. An important agent in providing this control is corticosteroids. This study aimed to determine whether dexamethasone and methylprednisolone, doses, administration time and duration in COVID-19 treatment are associated with improved treatment outcomes. Methods: This retrospective multicenter study was conducted with participation of 6 healthcare centers which collected data by retrospectively examining files of 1,340 patients admitted to intensive care unit due to COVID-19 between March 2020 and September 2021, diagnosed with polymerase chain reaction (+) and/or clinically and radiologically. Results: Mortality in the pulse methylprednisolone group was statistically significantly higher than that in the other 3 groups. Mortality was higher in older patients with comorbidities such as hypertension, diabetes mellitus, chronic kidney failure, coronary artery disease, and dementia. Pulse and mini-pulse steroid doses were less effective than standard methylprednisolone and dexamethasone doses, pulse steroid doses being associated with high mortality. Standard-dose methylprednisolone and dexamethasone led to similar effects, but standard dose methylprednisolone was more effective in severe patients who required mechanical ventilation (MV). Infection development was related to steroid treatment duration, not cumulative steroid dose. Conclusion: Corticosteroids are shown to be beneficial in critical COVID-19, but the role of early corticosteroids in mild COVID-19 patients remains unclear. The anti-inflammatory effects of corticosteroids may have a positive effect by reducing mortality in severe COVID-19 patients. Although dexamethasone was first used for this purpose, methylprednisolone was found to be as effective at standard doses. Methylprednisolone administered at standard doses was associated with greater PaO2/FiO2 ratios than dexamethasone, especially in the severe group requiring MV. High dose pulse steroid doses are closely associated with mortality and standard methylprednisolone dose is recommended.
On primary decompositions and radicals of submodules
M. Alkan,B. Saraç 장전수학회 2007 Proceedings of the Jangjeon mathematical society Vol.10 No.1
In this paper, we give some characterizations for prime and primary submodules of a nitely generated free modules over PIDs and determine the height of prime submodules. We also char- acterize the minimal primary decompositions and radicals of submodules of any nitely generated free module over a PID.
Çiğdem Yüksektepe,Hanife Saraçoğlu,Nezihe Çalışkan,Ibrahim Yilmaz,Alaaddin Cukurovali 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12
A new hydrazone derivative compound has been synthesized and characterized by IR, 1H-NMR, 13C-NMR and UV-vis. spectroscopy techniques, elemental analysis and single-crystal X-ray diffraction (XRD). The new compound crystallizes in monoclinic space group C2/c. In addition to the crystal structure from X-ray experiment, the molecular geometry, vibrational frequencies and frontier molecular orbitals analysis of the title compound in the ground state have been calculated by using the HF/6-31G(d, p), B3LYP/6-311G(d, p) and B3LYP/6-31G(d, p) methods. The computed vibrational frequencies are used to determine the types of molecular motions associated with each of the observed experimental bands.To determine conformational flexibility, molecular energy profile of (1) was obtained by semi-empirical (AM1) calculation with respect to a selected degree of torsional freedom, which was varied from ‒180o to +180o in steps of 10o. Molecular electrostatic potential of the compound was also performed by the theoretical method.
New Elastoplastic Analysis of Two-Dimensional Frames When Some Plastic Hinges Unload Elastically
Fethullah Uslu,Mehmet Tevfik Bayer,Mustafa Haluk Saraçoğlu 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.2
Two-dimensional frames are made of elastic and perfectly plastic materials. Frames are analized by using the step by step elastoplastic analysis method where the applied loads are gradually increased at each step until a plastic hinge is developed. Then an equivalent frame model is generated by placing a mechanical hinge at the location of the plastic hinge and the increased external loads and the reduced plastic moments acting at the plastic hinge sections are applied to this model and elastoplastic analysis is performed. This elastoplastic analysis is repeated by incrementally increasing the external loads and applying the new reduced plastic moments, until the next plastic hinge is developed. Then a new equivalent frame model is generated to search for the following plastic hinge. This step by step elastoplastic analysis continues until the frame partially or totally collapses. When a plastic hinge is developed, it means that the section is at a fully plastic stress state. In the following small load increment: if this fully plastic stress state moves to another fully plastic stress state then this movement is called plastic fl ow. But if this fully plastic stress state moves to an elastic–plastic stress state then this movement is called elastic unloading. During the search of the next plastic hinge if one of the plastic hinges begins to unload elastically then the current equivalent frame model must be revised. For this the frame member which contains the elastically unloading plastic hinge is replaced by the equivalent frame member carrying balancing loads.
True Collapse Mechanisms of Two Dimensional Frames Determined from True Nonlinear Yield Surfaces
Fethullah Uslu,Mehmet Tevfik Bayer,Mustafa Haluk Saraçoğlu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.1
In this work, collapse mechanisms and collapse load factors of two-dimensional frames which are subject to point loads and uniformly distributed loads are determined by employing new elastoplastic analysis method. In this new iterative method as the applied loads on frames are gradually increased, plastic hinges begin to develop at frame member sections and this continues until the partial or total collapse occurrence. If a plastic hinge develops at a section of a frame member, then a mechanical hinge is defined at this location and at each iteration reduced plastic moments are also applied as external loads. This is a new approach to search for the next plastic hinge where a series of linear elastoplastic analyses are executed. For each analysis the revised reduced plastic moments are used in the calculations. For elastoplastic calculations of two-dimensional frames, yield surface definitions of frame member sections are needed, and for I sections, yield surfaces are defined by two curves. In order to simplify collapse load factor calculations these yield surfaces are generally approximated by two lines. In this work the influences of the approximations on the elastoplastic behaviour of two-dimensional frames are examined by comparing the solutions of four example frames. When their solutions are compared, it is observed that almost equal collapse load factors are determined when true and approximate yield surfaces are used in the elastoplastic calculations but true collapse mechanisms are obtained only when true nonlinear yield surfaces are used.