http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sanjay Marwah,Shouvik Das,Abhishek Mandal,Ritesh Kumar,Sandeep Chauhan,Krishna Rekha Mantry,Sandeep Kumar Malik 대한외상중환자외과학회 2023 Journal of Acute Care Surgery Vol.13 No.2
Fine needle aspiration (FNA) of the thyroid is a well-tolerated minimally invasive procedure. Thyroid abscess, as a complication of FNA in an immune-competent adult, is extremely rare. Diagnosis requires a high index of suspicion, for which treatment is intravenous antibiotics, drainage, and sometimes surgery. Here we present a case of thyroid abscess in an otherwise healthy man who presented with neck pain, rapidly increasing neck swelling, difficulty in swallowing, and hoarseness of the voice that developed two weeks after diagnostic FNA of a thyroid nodule which had been present for ten months. Despite antibiotic treatment, the abscess ruptured into the trachea, requiring surgical intervention. This highlights the importance of maintaining asepsis during FNA of the thyroid. Timely diagnosis of a thyroid abscess is essential to avoid life-threatening airway complications.
Mathematical Model to Analyze Coiling Feasibility at Downcoiler in Hot Strip Mill
Manoj Krishna Majumder,Potnuru Venkata Dilip,Pawan Kumar Singh,Gaurav Singh,Saurabh Gaur,Rashmi Ranjan Samantaray,Sanjay Chandra 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.10
The coiling of a steel strip in a Downcoiler is an integrated part of the hot-rolled steel production line. Failure to coiling results damage to finished rolled strip along with mill downtime due to cobble. Thus, coiling success in Downcoiler is a critical concern for production of hot rolled steel strip. A mathematical model has been developed to analyze coiling feasibility for new grade of high strength steel to be rolled for the first time in the mill and to thereby identify a safe operating window for the coiling-process parameters. This has significant benefit in reducing the risk of coiling failure during plant trial and thus product development cycle time. The model is based on the estimation of coiler tension for a new grade with reference to mill-based physical data of coiling compactness as defined by a wrapper angle from known grades, coiled in the mill. This is followed by computation and comparison of coiling torque vis-à-vis the capacity of the Downcoiler allows a decision to be taken about the coiling feasibility of the new grade. It is believed that it is for the first time that a coiling feasibility algorithm has been developed and discussed. The model has been widely used within Tata Steel to carry out plant trails for the development of new grade as well as rolling of new section in existing grades at its Hot Strip Mill in Indian plant at Kalinganagar.
Pandey Neha,Rai Krishna Kumar,Rai Sanjay Kumar,Pandey-Rai Shashi 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.3
The present study provides the frst report of heterologous expression of phytochelatin synthase from Anabaena PCC 7120 (anaPCS) into the hairy roots of Artemisia annua. Transformed hairy roots of A. annua expressing anaPCS gene showed better tolerance to heavy metals, viz., arsenic (As) and cadmium (Cd) owing to 143 and 191% more As- and Cd-accumulation, respectively, as compared to normal roots with a bioconcentration factor (BCF) of 9.7 and 21.1 for As and Cd, respectively. Under As and Cd stresses, transformed hairy roots possessed signifcantly higher amounts of phytochelatins and thiols probably due to the presence of both AaPCS (Artemisia annua PCS) and anaPCS. In addition, artemisinin synthesis was also induced in transformed hairy roots under heavy metals stresses. In-silico analysis revealed the presence of conserved motifs in both AaPCS and anaPCS sequences as well as structural modelling of PCS functional domain was conducted. Interaction of AaPCS and anaPCS proteins with CdCl2 and sodium arsenate gene ontology analysis gave insights to anaPCS functioning in transformed hairy roots of A. annua. The study provides transformed hairy roots of A. annua as an efcient tool for efective phytoremediation with added advantages of artemisinin extraction from hairy roots used for phytoremediation. The present study provides the frst report of heterologous expression of phytochelatin synthase from Anabaena PCC 7120 (anaPCS) into the hairy roots of Artemisia annua. Transformed hairy roots of A. annua expressing anaPCS gene showed better tolerance to heavy metals, viz., arsenic (As) and cadmium (Cd) owing to 143 and 191% more As- and Cd-accumulation, respectively, as compared to normal roots with a bioconcentration factor (BCF) of 9.7 and 21.1 for As and Cd, respectively. Under As and Cd stresses, transformed hairy roots possessed signifcantly higher amounts of phytochelatins and thiols probably due to the presence of both AaPCS (Artemisia annua PCS) and anaPCS. In addition, artemisinin synthesis was also induced in transformed hairy roots under heavy metals stresses. In-silico analysis revealed the presence of conserved motifs in both AaPCS and anaPCS sequences as well as structural modelling of PCS functional domain was conducted. Interaction of AaPCS and anaPCS proteins with CdCl2 and sodium arsenate gene ontology analysis gave insights to anaPCS function ing in transformed hairy roots of A. annua. The study provides transformed hairy roots of A. annua as an efcient tool for efective phytoremediation with added advantages of artemisinin extraction from hairy roots used for phytoremediation.
Kamlesh Rangari,Kuntal Kanti Das,Suyash Singh,Krishna G. Kumar,Kamlesh Singh Bhaisora,Jayesh Sardhara,Anant Mehrotra,Arun Kumar Srivastava,Awadhesh Kumar Jaiswal,Sanjay Behari 대한척추신경외과학회 2021 Neurospine Vol.18 No.1
Objective: Posterior fossa decompression is the treatment of choice in type 1 Chiari malformation (CM-1) without bony instability. Although surgical fixation has been recommended by a few authors recently, comparative studies to evaluate these treatment strategies using objective outcome tools are lacking. Methods: Seventy-three patients with pure CM-1 (posterior fossa bony decompression [PFBD], n=21; posterior fossa bony and dural decompression [PFBDD], n=40; and posterior fixation [PF], n=12) underwent a postoperative outcome assessment using Chicago Chiari Outcome Score (CCOS). Logistic regression analysis detected predictors of an unfavorable outcome. Results: Minimally symptomatic patients generally underwent a PFBD while most of the clinically severe patients underwent a PFBDD (p=0.049). The mean CCOS score at discharge was highest in the PF (12.0±1.41) and lowest in PFBDD group (10.98±1.73, p=0.087). Patients with minimal preoperative clinical disease severity (adjusted odds ratio [AOR], 4.58; 95% confidence interval [CI], 1.29–16.31) and PFBDD (AOR, 7.56; 95% CI, 1.70–33.68) represented risks for an unfavorable short-term postoperative outcome. Though long-term outcomes (CCOS) did not differ among the 3 groups (p=0.615), PFBD group showed the best long-term improvements (mean follow-up CCOS, 13.71±0.95), PFBDD group improved to a comparable degree despite a poorer short-term outcome while PF had the lowest scores. Late deteriorations (n=3, 4.1%) occurred in the PFBDD group. Conclusion: Minimally symptomatic patients and PFBDD predict a poor short-term postoperative outcome. PFBD appears to be a durable procedure while PFBDD group is marred by complications and late deteriorations. PF does not provide any better results than posterior fossa decompression alone in the long run.
Development of a Unique Mouse Intervertebral Disc Degeneration Model Using a Simple Novel Tool
Baldia Manish,Mani Sunithi,Walter Noel,Kumar Sanjay,Srivastava Alok,Prabhu Krishna 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.4
Study Design: Animal case control study.Purpose: To create a simple, reproducible disc degeneration model for mouse coccygeal vertebrae. Overview of Literature: Back pain due to disc degeneration is probably the most common problem encountered in neurosurgical practice. An easily reproducible animal model for disc degeneration will help in understanding its pathophysiology, and serve as a platform for examining various therapeutic options.Methods: A total of 18 mice were divided into injured (n=12) and non-injured (n=6) groups. The disc height index (DHI%) at coccygeal 4–5 level was measured by computed tomography (CT) scan for all mice. Coccygeal 4–5 discs of the injury group were injured using a 32G needle fixed to a novel tool and confirmed by CT. The non-injury group underwent no procedure. DHI% was measured by CT at 2-, 4-, and 6-week post-injury, and all mice tails were sectioned for histopathology grading of disc degeneration at the respective time intervals.Results: The injured group showed significant variation in DHI% at 2, 4, and 6 weeks, whereas there was no change in the noninjured group. Histopathologic evaluation with Safranin O stain showed a worsening of the disc degeneration score at 2, 4, and 6 weeks in the injured group, but in the non-injured group there was no change. Percutaneous needle injury technique with our novel tool provided 100% accuracy and uniform degeneration.Conclusions: A simple, easily reproducible mouse model for disc degeneration was created using a simple, cost-effective, novel tool and technique, its advantage being high precision and user friendly.