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노수경,Ji Yeong Yoon1,최철훈,Ui Nam Ryoo,Chang Ohk Sung,김태중,배덕수,김병기 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.4
Multiple primary cancer is defined as the multiple occurrence of malignant neoplasms in the same individual. Due to the development of new diagnostic techniques and the rise in long-term survival of cancer, reports of multiple primary cancers have gradually increased. Herein, we describe the case of a 68-year-old female patient with quadruple primary cancer of the breast, rectum, ovary, and endometrium. For its great rarity, we report this case with a review of the literature. Multiple primary cancer is defined as the multiple occurrence of malignant neoplasms in the same individual. Due to the development of new diagnostic techniques and the rise in long-term survival of cancer, reports of multiple primary cancers have gradually increased. Herein, we describe the case of a 68-year-old female patient with quadruple primary cancer of the breast, rectum, ovary, and endometrium. For its great rarity, we report this case with a review of the literature.
Nam, Soo Jeong,Kim, Sehui,Kwon, Dohee,Kim, Hannah,Kim, Soyeon,Lee, Eunyoung,Kim, Tae Min,Heo, Dae Seog,Park, Sung Hye,Lim, Megan S.,Kim, Chul Woo,Jeon, Yoon Kyung TaylorFrancis 2018 Oncoimmunology Vol.7 No.7
<P><B>ABSTRACT</B></P><P>Primary diffuse large B-cell lymphoma of the central nervous system (CNS-DLBCL) is an aggressive disease with a poor prognosis. The status of the tumor immune microenvironment in CNS-DLBCL remains unclear. We investigated the prognostic implications of tumor-associated macrophages (TAMs), regulatory T-cells (Tregs), and indoleamine 2,3-dioxygenase (IDO)<SUP>+</SUP> cells in primary CNS-DLBCL (n = 114) by immunohistochemical analysis. The numbers of tumor-infiltrating immune cells, including CD68<SUP>+</SUP> TAMs, CD163<SUP>+</SUP> or CD204<SUP>+</SUP> M2 macrophages, FOXP3<SUP>+</SUP> Tregs, and IDO<SUP>+</SUP> cells were all significantly lower in CNS-DLBCL versus systemic DLBCL (n = 165; all P < 0.001), but with little difference in the ratio of CD163<SUP>+</SUP>/CD68<SUP>+</SUP> or CD204<SUP>+</SUP>/CD68<SUP>+</SUP> cells. An increase in CD68<SUP>+</SUP> cell numbers was significantly associated with prolonged progression-free survival (PFS) and overall survival in patients with CNS-DLBCL (P = 0.004 and 0.021, respectively). In contrast, an increase in CD204<SUP>+</SUP> cell numbers or a higher ratio of CD204<SUP>+</SUP>/CD68<SUP>+</SUP> cells was related to a shorter PFS (P = 0.020 and 0.063, respectively). An increase in IDO<SUP>+</SUP> cell numbers was associated with a significantly longer PFS (P = 0.019). In combination, the status of low IDO<SUP>+</SUP> cell numbers combined with low CD68<SUP>+</SUP> cell numbers, high CD204<SUP>+</SUP> cell numbers, or a high CD204<SUP>+</SUP>/CD68<SUP>+</SUP> cell ratio all predicted poor PFS in multivariate analyses. This study showed that an increase in CD204<SUP>+</SUP> cell numbers, suggestive of M2 macrophages, was associated with poor clinical outcome in CNS-DLBCL, whereas increased CD68<SUP>+</SUP> or IDO<SUP>+</SUP> cell numbers were related to a favorable prognosis. The analysis of tumor-infiltrating immune cells could help in predicting the prognosis of CNS-DLBCL patients and determining therapeutic strategies targeting tumor microenvironment.</P>
Treatment of Cryptogenic Stroke with Active Cancer with a New Oral Anticoagulant
Nam, Ki-Woong,Kim, Chi Kyung,Kim, Tae Jung,An, Sang Joon,Oh, Kyungmi,Ko, Sang-Bae,Yoon, Byung-Woo Elsevier 2017 Journal of stroke and cerebrovascular diseases Vol.26 No.12
<P><B>Background</B></P> <P>Low-molecular weight heparin (LMWH) was shown to be effective and safe in treating venous thromboembolism, and generally used for stroke in cancer patients, but its effects on stroke are unclear. We compared clinical outcomes between LMWH and new oral anticoagulant (NOAC) in patients with cancer-related stroke.</P> <P><B>Methods</B></P> <P>We enrolled patients with cryptogenic ischemic stroke with active cancer who were treated with LMWH or NOAC between May 2012 and June 2015. The clinical outcomes, including early neurologic deterioration, early radiologic recurrence, 3-month modified Rankin scale score, 90-day mortality, cardio-cerebrovascular recurrence, and bleeding complications, were compared.</P> <P><B>Results</B></P> <P>Among 48 patients, 7 patients were treated with NOAC, and the remaining 41 patients with LMWH. Overall, the participants presented poor outcomes, including 20 (42%) early neurologic deteriorations, 28 (58%) early radiologic recurrences, 34 (71%) poor modified Rankin scale scores, 27 (56%) 90-day mortality events, 24 (50%) cardio-cerebrovascular recurrences, and 18 (38%) bleeding complications, that led to a change or temporary hold in medication in 12 cases. No statistical differences were found between the 2 groups in terms of demographic, clinical, or cardiovascular risk factors and clinical outcomes.</P> <P><B>Conclusions</B></P> <P>NOAC showed the similar clinical outcomes and safety compared with LMWH in the treatment of cryptogenic ischemic stroke in active cancer patients.</P>
Yoon, Taeshik,Kim, Jae-Han,Choi, Jun Hyung,Jung, Dae Yool,Park, Ick-Joon,Choi, Sung-Yool,Cho, Nam Sung,Lee, Jeong-Ik,Kwon, Young-Duck,Cho, Seungmin,Kim, Taek-Soo American Chemical Society 2016 ACS NANO Vol.10 No.1
<P>Graphene produced by chemical-vapor-deposition inevitably has defects such as grain boundaries, pinholes, wrinkles, and cracks, which are the most significant obstacles for the realization of superior properties of pristine graphene. Despite efforts to reduce these defects during synthesis, significant damages are further induced during integration and operation of flexible and stretchable applications. Therefore, defect healing is required in order to recover the ideal properties of graphene. Here, the electrical and mechanical properties of graphene are healed on the basis of selective electrochemical deposition on graphene defects. By exploiting the high current density on the defects during the electrodeposition, metal ions such as silver and gold can be selectively reduced. The process is universally applicable to conductive and insulating substrates because graphene can serve as a conducting channel of electrons. The physically filled metal on the defects improves the electrical conductivity and mechanical stretchability by means of reducing contact resistance and crack density. The healing of graphene defects is enabled by the solution-based room temperature electrodeposition process, which 'broadens the use of graphene as an engineering material.</P>
Yoon, Hyunsik,Kim, Soaram,Park, Hyunggil,Nam, Giwoong,Kim, Yangsoo,Leem, Jae-Young,Kim, Min Su,Kim, Byunggu,Kim, Younggyu,Ji, Iksoo,Park, Youngbin,Kim, Ikhyun,Lee, Sang-heon,Jung, Jae Hak,Kim, Jin Soo Korean Physical Society 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.1
Undoped ZnO and Ga-doped ZnO (GZO) thin films with different Ga concentrations were prepared by using the sol-gel spin-coating method. The surface morphologies and the growth orientations of the films were measured by using scanning electron microscopy and X-ray diffraction, respectively. The electrical properties were measured by using the Hall effect. The optical transmittances and reflectances of the films were measured as functions of the wavelength by UV-vis spectroscopy. The undoped ZnO thin films exhibited rough surfaces with particle-like structures. When Ga was incorporated, the particle sizes dramatically decreased without changes in the surface morphologies, and the c-axis growth orientations of the GZO thin films were significantly decreased. The optical transmittances clearly exhibited shifts in the band edge, and those in the visible range gradually increased with increasing Ga concentration. The absorption coefficients, refractive indices, extinction constants, dielectric constants, and optical conductivities of the films gradually decreased with increasing Ga concentration.
Structure and Properties of Borophosphate Glasses
( Nam Jin Kim ),( Sang Hyeok Im ),( Dong Hwan Kim ),( Duck Ki Yoon ),( Bong Ki Ryu ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 ELECTRONIC MATERIALS LETTERS Vol.6 No.3
Glasses in the system xB2O3-(60-x)P2O5-40Na2O (x = 0 mol. %, 10 mol. %, 20 mol. %, 30 mol. %, 40 mol. %) were prepared and characterized by measuring their density (ρ), molar volume (VM), glass transition/ softening temperature (Tg/Td), thermal expansion coefficient (α) and chemical durability (DR). All of these values were found to vary with the B2O3 content of the glasses. The results were interpreted on the basis of the structural data. The Raman and infrared spectra confirmed these structural changes.
Nam, Sung Min,Choi, Jung Hoon,Yoo, Dae Young,Kim, Woosuk,Jung, Hyo Young,Kim, Jong Whi,Yoo, Miyoung,Lee, Sanghee,Kim, Chul Jung,Yoon, Yeo Sung,Hwang, In Koo The Korean Society of Food Science and Nutrition 2014 Journal of medicinal food Vol.17 No.6
Aging is a progressive process, and it may lead to the initiation of neurological diseases. In this study, we investigated the effects of wild Indian Curcuma longa using a Morris water maze paradigm on learning and spatial memory in adult and D-galactose-induced aged mice. In addition, the effects on cell proliferation and neuroblast differentiation were assessed by immunohistochemistry for Ki67 and doublecortin (DCX) respectively. The aging model in mice was induced through the subcutaneous administration of D-galactose (100 mg/kg) for 10 weeks. C. longa (300 mg/kg) or its vehicle (physiological saline) was administered orally to adult and D-galactose-treated mice for the last three weeks before sacrifice. The administration of C. longa significantly shortened the escape latency in both adult and D-galactose-induced aged mice and significantly ameliorated D-galactose-induced reduction of cell proliferation and neuroblast differentiation in the subgranular zone of hippocampal dentate gyrus. In addition, the administration of C. longa significantly increased the levels of phosphorylated CREB and brain-derived neurotrophic factor in the subgranular zone of dentate gyrus. These results indicate that C. longa mitigates D-galactose-induced cognitive impairment, associated with decreased cell proliferation and neuroblast differentiation, by activating CREB signaling in the hippocampal dentate gyrus.