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( Chul Ju Hwang ),( Dong Young Choi ),( Yu Yeon Jung ),( Young Jung Lee ),( Jae Suk Yun ),( Ki Wan Oh ),( Sang Bae Han ),( Seikwan Oh ),( Mi Hee Park ),( Jin Tae Hong ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Approximately, 7-10 million people in the world suffer from Parkinson``s disease (PO), Recently, increasing evi-dence has suggested the protective effect of estrogens against nigrostriatal dopaminergic damage in PD. In this study, we investigated whether estrogen affects l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-induced behavioral impairment in estrogen receptor alpha (ERa)-deficient mice. MPTP (15 mg/kg, four times with l.5-h interval)-induced dopaminergic neurodegeneration was evaluated in ERα wild-type (WT) and knockout (KO) mice. Larger dopamine depletion, behavioral impairments (Rotarod test, Pole test, and Gait test), activation of mi-croglia and astrocytes, and neurointlammation after MPTP injection were observed in ERα KO mice compared to those in WT mice.Immunostaining for tyrosine hydroxylase (TH) after MPTP injection showed fewerTH-positive neurons in ERα KO mice than WT mice. Levels of dopamine and 3,4-<lihydroxyphenylacetic acid (OOPAC, metab-olite of dopamine) were also lowered in ERα KO mice after MPTP injection. Interestingly, a higher immunoreac-tivity for monoamine oxidase (MAO) B was found in the substantia nigra and striatum of ERα KO mice after MPTP injection. We also found an increased activation of p38 kinase (which positively regulates MAO B expression) in ERα KO mice. In vitro estrogen treatment inhibited neuroinflammation in l-methyl-4-phenyl pyridium (MPP +)-treated cultured astrocyte cells; however, these inhibitory effects were removed by p38 inhibitor. These results indicate that ERα might be important for dopaminergic neuronal survival through inhibition of p38 pathway.
연구논문 : 과학영재교육원 학생들의 과학 통합 탐구 능력
정은영 ( Eun Young Jeong ),권이영 ( Yi Young Kwon ),양주성 ( Joo Sung Yang ),고유미 ( Yu Mi Ko ) 경북대학교 과학교육연구소 2013 科學敎育硏究誌 Vol.37 No.3
과학영재교육원 학생들이 성공적으로 과학 탐구를 수행하기 위해서는 문제 인식, 가설 설정, 탐구 설계, 결론 도출 등의 과학 통합 탐구 능력이 요구된다. 이 연구에서는 김유향(2013)이 개발한 ‘과학 탐구 사고력 측정을 위한 서술형 평가도구’를 사용하여 과학영재교육원 학생들의 과학 통합 탐구 능력을 평가 요소별, 성별, 이수 과정별, 전공 분야별로 비교하였다. 이 평가도구는 탐구 사고력의 주요 요소들인 탐구 문제 도출, 변인 추출, 가설 설정, 실험 설계, 자료 변환, 자료 해석, 결론 도출, 일반화, 평가에 관한 문항이 각 2개씩 총 18문항으로 구성되어 있다. 이 평가도구를 2013년 현재 C 대학교 부설 과학영재교육원에 다니고 있는 학생들 중 102명 학생들(초등과학반 15명, 중등과학심화Ⅰ반 58명, 중등과학심화Ⅱ반 29명)을 대상으로 시행하였다. 그 결과, 과학 통합 탐구 능력의 요소 중 가설 설정, 변인 추출의 점수는 상대적으로 높았고, 자료 변환, 자료 해석, 평가의 점수는 상대적으로 낮았다. ‘자료 변환’에 해당하는 선 그래프 그리기 문항과 ‘평가’에 해당하는 실험 설계의 개선점 찾기 문항의 정답률은 약 40 %로 상대적으로 낮게 나타 났다. 영재교육을 받은 단계별로 비교하면 과학 통합 탐구 능력의 요소들 중 일반화의 경우 유의미한 차이가 있었다. 남학생과 여학생의 점수 차이는 유의미하지 않았다. 이 연구에서 사용한 평가도구가 생물 분야의 소재를 다루고 있어 생물 분야의 영재 학생들과 다른 분야(물리, 화학, 지구과학)의 영재 학생들과 비교한 결과, 유의미한 차이가 없었다. 과학영재교육원 학생들의 과학 통합 탐구 능력 향상을 위하여 자료 변환, 자료 해석, 평가에 관한 교수·학습을 강화하고, 과학 탐구와 관련된 구체적인 교수·학습 자료를 개발할 필요가 있다. The purpose of this study was to investigate science integrated process skill of the students in science education center for the gifted. In order to do this, ``free-response test for the assessment of science process skills`` developed by Yu-Hyang Kim(2013) was administered to 102 students(15 in elementary school science class, 58 in middle school science classⅠ, and 29 in middle school science classⅡ) who attend the program of science education center for the gifted in C university. The assessment tool measured 9 skills ; formulating inquiry questions, recognizing variables, formulating hypotheses, designing experiment, transforming data, interpreting data, drawing conclusions, formulating generalizations, and evaluating the designed experiments. As a result, the students in science education center for the gifted had relatively high scores in the area of ``formulating hypotheses`` and ``recognizing variables``, but they had relatively low scores in the area of ``transforming data``, ``interpreting data``, and ``evaluating the designed experiments``. The 2 items` percentage of correct answers were below 40% ; one is about a drawing a line graph in ``transforming data``, and the other requires finding improvements of the experimental design in ``evaluation``. There was no significant difference between boys`` scores and girls`s one, and between the scores of students in the field of biology and those of students in the other fields(physics, chemistry, and earth science) in science integrated process skills. And there was significant difference according to the periods receiving the gifted education in ``formulating generalizations``. The teaching and learning has to focus on improving science integrated process skills in the program of science education center for the gifted and teaching and learning materials needs to be developed.
Yu, Shi Nae,Jung, Jiwon,Kim, Yong-Kyun,Lee, Ju Young,Kim, Sun-Mi,Park, Su Jin,Lee, Sang-Oh,Choi, Sang-Ho,Kim, Yang Soo,Woo, Jun Hee,Kim, Sung-Han Williams & Wilkins Co 2015 Medicine Vol.94 No.28
<P><B>Abstract</B></P><P>IFN-gamma releasing assays (IGRAs) such as T-SPOT.<I>TB</I> assay and QuantiFERON-TB In-Tube (QFT-GIT) have yielded promising results for the diagnosis of tuberculosis (TB). However, little is known about the usefulness of these assays for diagnosing disseminated TB. We therefore compared their usefulness with traditional tests in patients with disseminated TB. All adult patients with suspected disseminated TB were prospectively enrolled at a tertiary hospital in an intermediate TB-burden country during a 6-year period. Disseminated TB was defined as involvement of the bone marrow or ≥2 noncontiguous organs, or presence of miliary lung lesions. A total of 101 patients with confirmed and probable disseminated TB were finally analyzed. Of these 101 patients, 52 (52%) had miliary TB and the remaining 49 (48%) had nonmiliary disseminated TB. In addition, 63 (62%) had no underlying disease. Chronic granuloma with/without necrosis, acid-fast bacillus staining, <I>Mycobacterium tuberculosis</I> PCR, and culture for <I>M tuberculosis</I> were positive in 77% (41/53), 43% (43/101), 70% (67/96), and 72% (73/101), of the patients, respectively. The T-SPOT.<I>TB</I> assay was positive in 90% (91/101) of them. The sensitivity of the T-SPOT.<I>TB</I> assay in patients with miliary TB (90%) was similar to that in patients with nonmiliary TB (90%) (<I>P</I> > 0.99). In a subgroup analysis of the 58 patients in whom both QFT-GIT and the T-SPOT.<I>TB</I> results were available, the sensitivity of QFT-GIT (67%) was lower than that of T-SPOT.<I>TB</I> (95%) (<I>P</I> < 0.001).</P><P>In conclusion, T-SPOT.TB assay may be a helpful adjunct test for disseminated TB.</P>
Sung Hwan Kim,Yu Mi Kim,김재녕 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.8
Various dienamide derivatives were synthesized in reasonable yields from benzonitriles having an amide moiety at the ortho-position, via the sequential (i) In-mediated allylation of nitrile moiety to form an imine intermediate, (ii)intramolecular quenching of an acyl group by the imine intermediate, and (iii) a proton transfer to dienamide.
A Case of Folliculosebaceous Cystic Hamartoma
( Yu Sung Choi ),( Doo Rak Lee ),( Chung Eui You ),( Mi Youn Park ),( Sook Ja Son ) 대한피부과학회 2007 Annals of Dermatology Vol.19 No.1
Folliculosebaceous cystic hamartoma (FSCH) is a recently-recognized cutaneous hamartoma composed of follicular, sebaceous and mesenchymal elements. We describe an unusual case of FSCH in a 61-year-old male, who had a relatively large, 3×2.5cm sized, smooth subcutaneous nodule on the occipital area of the scalp, an uncommon location for FSCH. (Ann Dermatol (Seoul) 19(1) 13~15, 2007)
TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis
Yu-Mi Yang,Hwi-Hoon Jung,Sung Jun Lee,Hyung-Jun Choi,Min Seuk Kim*,Dong Min Shin* 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non- selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg<sup>2+</sup> homeostasis in mammals. However, the roles of TRPM7 during osteoclastogenesis in RAW264.7 cells and bone marrow-derived monocyte/macrophage precursor cells (BMMs) are not clear. In the present study, we investigate the roles of TRPM7 in osteoclastogenesis using methods of small interfering RNA (siRNA), RT-PCR, patch-clamp, and calcium imaging. RANKL (receptor activator of NF-ՊB ligand) stimulation did not affect the TRPM7 expression and TRPM7-mediated current was activated in HEK293, RAW264.7, and BMM cells by the regulation of Mg<sup>2+</sup>. Knock-down of TRPM7 by siTRPM7 reduced intracellular Ca<sup>2+ </sup>concentration ([Ca<sup>2+</sup>]<sub>i</sub>) increases by 0 mM [Mg<sup>2+</sup>]<sub>e </sub>in HEK293 cells and inhibited the generation of RANKL-induced Ca<sup>2+ </sup>oscillations in RAW264.7 cells. Finally, knock-down of TRPM7 suppressed RANKL-mediated osteoclastogenesis such as activation and translocation of NFATc1, formation of multinucleated cells, and the bone resorptive activity, sequentially. These results suggest that TRPM7 plays an essential role in the RANKL-induced [Ca<sup>2+</sup>]<sub>i</sub> oscillations that triggers the late stages of osteoclastogenesis.
Yu-mi Lee,Tae-Yon Sung,Jong Ho Yoon,Ki-Wook Chung,Suck Joon Hong 대한갑상선-내분비외과학회 2018 The Koreran journal of Endocrine Surgery Vol.18 No.3
Purpose: This study evaluated the risk factors for distant metastasis in patients with minimally invasive follicular thyroid carcinoma (MIFTC) and compared distant metastasis-free survival (DMFS) rates between the groups divided based on the number of involved risk factors. Methods: Patients were divided into 4 groups based on the number of involved risk factors; group 0 with no risk factor, group 1 with any one risk factor, group 2 with any 2 risk factors, and group 3 with all risk factors. Results: The 195 patients were enrolled in this study. Distant metastasis was detected in 15 patients (7.7%). In the multivariate analysis, age ≥ 45 years (hazard ratio [HR]=5.95; 95% confidence interval [CI]=1.44–24.55; P=0.014), primary tumor size >4.0 cm (HR=4.79; 95% CI=1.18–19.33; P=0.028), and extensive vascular invasion with ≥4 foci (HR=19.63; 95% CI=5.18–74.39; P<0.001) were identified as independent risk factors for distant metastasis. Group 1 tended to have poorer DMFS rates as compared with group 0, but there was no significant difference (P=0.069). DMFS rates of group 2 and 3 were significantly poorer than those of group 1 (P<0.001 and <0.001, respectively). DMFS rates of group 3 were also significantly poorer than those of group 2 (P=0.004). Conclusion: MIFTC patients with no or only one distant metastasis-related risk factor may become candidates for close observation without additional treatments with respect to DMFS rates.