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- 저자 : Sang-Hyeok CHO (검색결과 369 건)
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( Sang-hyeok Cho ),( Yujin Jeong ),( Eunju Lee ),( So-ra Ko ),( Chi-yong Ahn ),( Hee-mock Oh ),( Byung-kwan Cho ),( Suhyung Cho ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4
Erythrobacter species are extensively studied marine bacteria that produce various carotenoids. Due to their photoheterotrophic ability, it has been suggested that they play a crucial role in marine ecosystems. It is essential to identify the genome sequence and the genes of the species to predict their role in the marine ecosystem. In this study, we report the complete genome sequence of the marine bacterium Erythrobacter sp. 3-20A1M. The genome size was 3.1 Mbp and its GC content was 64.8%. In total, 2998 genetic features were annotated, of which 2882 were annotated as functional coding genes. Using the genetic information of Erythrobacter sp. 3-20A1M, we performed pangenome analysis with other Erythrobacter species. This revealed highly conserved secondary metabolite biosynthesis-related COG functions across Erythrobacter species. Through subsequent secondary metabolite biosynthetic gene cluster prediction and KEGG analysis, the carotenoid biosynthetic pathway was proven conserved in all Erythrobacter species, except for the spheroidene and spirilloxanthin pathways, which are only found in photosynthetic Erythrobacter species. The presence of virulence genes, especially the plant-algae cell wall degrading genes, revealed that Erythrobacter sp. 3-20A1M is a potential marine plant-algae scavenger.
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( Sung-bin Chon ),( Sang Do Shin ),( Sang Hoon Na ),( Youngsuk Cho ),( Hwan Suk Jung ),( Jun Hyeok Choi ),( Gyu Chong Cho ),( Kap Su Han ),( Taehwan Cho ),( Sung-woo Lee ),( Yong Joo Park ) 대한응급의학회 2017 대한응급의학회지 Vol.28 No.1
Purpose: Sudden cardiac arrest (SCA) accounts for approximately 15% of all-cause mortality in the US and 50% of all cardiovascular mortalities in developed countries; 10% of cases have an underlying structural cardiac abnormality. An echocardiography has widely been used to evaluate cardiac abnormality, but it needs to be performed by emergency physicians available in the emergency department immediately after death, rather than by cardiologists. We aimed to determine whether post-mortem echocardiography (PME) performed in the emergency department may reveal such abnormalities. Methods: We evaluated the reliability and validity of PME performed by emergency physicians in the emergency department. Measurement by a cardiologist was used as reference. Results: Two emergency physicians performed PME on 3 out of the 4 included patients who died after unsuccessful cardiopulmonary resuscitation. PME was started within 10 minutes of death, and it took 10 minutes to complete. Parasternal views in either supine or left decubitus position were most helpful. The adequacy of the image was rated good to fair, and that of measurements was acceptable to borderline. Regarding the chamber size and left ventricular wall thickness, intraclass correlation coefficients for reliability and validity were 0.97 (n=15) and 0.95 (n=35), respectively (p<0.001). Evaluation of presence/absence of left ventricular wall thinning, valve calcification, and pericardial effusion was incomplete (3/7-5/7), precluding further analysis. Conclusion: Emergency physicians could perform reliable and valid PME to assess the chamber size and left ventricular wall thickness. A large prospective study with collaboration between emergency physicians and cardiologists would reveal the feasibility and usefulness of PME in diagnosing structural causes of sudden cardiac arrest.
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Basic, HCC basic : PO-21 ; Increased apolipoprotein E in hepatocellular carcinoma
( Hyeok Choon Kwon ),( Seung Woo Nam ),( Jae Youn Cheong ),( Soon Sun Kim ),( Marie Yeo ),( Dong Kyu Kim ),( Sung Won Cho ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide. The goal of our study was to identify new biomarkers for HCC for early detection and for gaining an improved understanding of hepatocarcinogenesis by performing a comparative proteomic analysis of HCC and adjacent non-tumor tissue. Methods: Pairs of tumor and adjacent non-tumor tissue were obtained from 167 HCC patients after surgical resection at Ajou University Hospital, Korea. We assessed the histopathological features and additional clinical data. Proteomic analysis of tumor and non-tumor tissue revealing differential expression using 2D electrophoresis and MALDI-TOF MS analysis reveals some xenobiotic enzymes and apo E was selected. The associations between the expression of apoE and the clinical and pathological parameters were analyzed using SPSS. Results: One of the xenobiotic enzymes, apoE was significantly increased in tumor tissue compared with surrounding nontumor tissue. Paired T-test showed significant high level of apoE in tumor compared with non-tumor (209.91 vs 87.59, p < .01). Oneway ANOVA revealed that levels of apoE were elevated independently among different Child classes, etiologies, sex and consumption of alcohol. Conclusions: We compared the protein profiles between tumor and non-tumor tissue in HCC patients. This study revealed that apoE was significantly higher in HCC than in non-tumor tissue. The multivariate analysis confirmed apoE was higher in regardless of Child class, etiology, sex and alcohol consumption. ApoE has long been known as plasma lipoproteins responsible for cholesterol transport and metabolism. Plasma apoE is produced mainly in the liver but also in the brain, adrenal glands, kidney, and macrophage and not increased in gene expression and serum level in patients with HCC. Some proteomic studies reports a strong relationship between other cancers and apoE. We suppose that this report add a clue to understand hepatocarcinogenesis from hepatic steatosis to consequently hepatic carcinoma.
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Sang-Ho Park,Seung-Jin Lee,Jae Yun Kim,Min Jeong Kim,Ji Yeon Lee,A-Ra Cho,Hyeok-Gyu Lee,Se-Whan Lee,Won-Yong Shin,Dong-Kyu Jin 순천향대학교 순천향의학연구소 2011 Journal of Soonchunhyang Medical Science Vol.17 No.2
Objective: The importance of central blood pressure evaluation for cardiovascular risk stratification has been emphasized. The aim of this study is to evaluate whether brachial blood pressure obtained by the oscillometric method accurately reflects central blood pressure. Methods: The subjects consisted of 84 consecutive patients with suspected coronary artery disease who underwent cardiac catheterization. Central blood pressure was invasively measured in the origin of the left subclavian artery by using the fluid-filled system, and at the same time, brachial blood pressure in the left upper arm was measured by the oscillometric method. Results: No significant difference was found between central systolic pressure and brachial systolic pressure (144.49±18.84 mmHg vs. 142.44±14.96 mmHg, P=0.063). Bland-Altman analysis accounted for only a small bias of +2.25 mmHg, and the limits of agreement were 24.15 mmHg and -19.65 mmHg. Central diastolic pressure was significantly lower than brachial diastolic pressure (75.80± 8.74 mmHg vs. 86.70±10.48 mmHg, P<0.001). Bland-Altman analysis showed a significant bias of -5.45 mmHg, and the limits of agreement were 2.83 mmHg and -13.73 mmHg. Conclusion: These results indicate that central systolic pressure can be directly estimated from brachial systolic pressure using the noninvasive oscillometric method and observed biases seem to remain within the practical range. However, use of the brachial diastolic pressure and pulse pressure measured by the noninvasive oscillometric method is doubtful in clinical practice because of their large biases.
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Sang-Beom Kim,Jin-Hyeok Lee,Jae-Ouk Ahn,Jae-Hwan Cho 한국자기학회 2015 Journal of Magnetics Vol.20 No.3
The purpose of the study was to identify how isotope and magnetic resonance imaging (MRI) contrast media impact on noise to computed tomography (CT) examination. For the study, divide the phantoms to two groups: 1) saline, saline + different kinds of contrast agent without <SUP>99m</SUP>Tc administration; 2) <SUP>99m</SUP>Tc administration: saline, saline + different kinds of contrast agent with <SUP>99m</SUP>Tc administration. CT contrast agent was used for Iopamidol<SUP>®</SUP> and Dotarem. And MRI contrast agent was used for Primovist<SUP>®</SUP> and Gadovist<SUP>®</SUP>. To obtain an image, we used CT scanner. With an obtained image, we set the 1 cm² region of interest in the middle of bottle to measure the noise and CT number. As a result, there was no difference in CT number before and after inserting <SUP>99m</SUP>Tc into all contrast media including Normal Saline. However, when it comes to Noise, there was a difference before and after inserting <SUP>99m</SUP>Tc into every contrast media except MRI contrast media such as Primovist<SUP>®</SUP> and Gadovist<SUP>®</SUP>.
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Multi-Layer SnSe Nanoflake Field-Effect Transistors with Low-Resistance Au Ohmic Contacts
Cho, Sang-Hyeok,Cho, Kwanghee,Park, No-Won,Park, Soonyong,Koh, Jung-Hyuk,Lee, Sang-Kwon SPRINGER SCIENCE + BUSINESS MEDIA 2017 NANOSCALE RESEARCH LETTERS Vol.12 No.1
<P>We report p-type tin monoselenide (SnSe) single crystals, grown in double-sealed quartz ampoules using a modified Bridgman technique at 920 °C. X-ray powder diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX) measurements clearly confirm that the grown SnSe consists of single-crystal SnSe. Electrical transport of multi-layer SnSe nanoflakes, which were prepared by exfoliation from bulk single crystals, was conducted using back-gated field-effect transistor (FET) structures with Au and Ti contacts on SiO<SUB>2</SUB>/Si substrates, revealing that multi-layer SnSe nanoflakes exhibit p-type semiconductor characteristics owing to the Sn vacancies on the surfaces of SnSe nanoflakes. In addition, a strong carrier screening effect was observed in 70−90-nm-thick SnSe nanoflake FETs. Furthermore, the effect of the metal contacts to multi-layer SnSe nanoflake-based FETs is also discussed with two different metals, such as Ti/Au and Au contacts.</P>
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Perirenal Fat and Kidney Function Deterioration in Patients With Acute Decompensated Heart Failure
Cho In-Jeong,Wi Jin,Lee Sang Eun,Kim Dong-Hyeok,Pyun Wook Bum 대한심부전학회 2023 International Journal of Heart Failure Vol.5 No.1
Background and Objectives The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association of perirenal fat thickness with kidney dysfunction in patients with acute decompensated heart failure (ADHF). Methods Data from 266 patients hospitalized with ADHF were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (preserved kidney function [GFR ≥60 mL/min/1.73 m2] and reduced kidney function [GFR <60 mL/min/1.73 m2] groups). Right and left posterior perirenal fat thicknesses were measured using computed tomography, and their average values were calculated. Associated factors with reduced kidney function was assessed by logistic regression model, presenting with odds ratio (OR) and confidence interval (CI). Results Increasing age (OR, 1.08; 95% CI, 1.04–1.12; p<0.001), diabetes mellitus (OR, 2.46; 95% CI, 1.18–5.12; p<0.017), increased log N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR, 1.82; 95% CI, 1.32–2.52; p<0.001), and increased average perirenal fat thickness (OR, 1.11; 95% CI, 1.06–1.16; p<0.001) were independently associated with reduced kidney function. In the subgroup analyses, patients over 70 years old, the ratio of mitral-to-mitral annular velocity >15, elevated log NT-proBNP had a significantly higher association with increased perirenal fat thickness with reduced kidney function. Conclusions Thick perirenal fat pads were independently associated with kidney function deterioration in patients hospitalized with ADHF. Background and Objectives The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association of perirenal fat thickness with kidney dysfunction in patients with acute decompensated heart failure (ADHF). Methods Data from 266 patients hospitalized with ADHF were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (preserved kidney function [GFR ≥60 mL/min/1.73 m2] and reduced kidney function [GFR <60 mL/min/1.73 m2] groups). Right and left posterior perirenal fat thicknesses were measured using computed tomography, and their average values were calculated. Associated factors with reduced kidney function was assessed by logistic regression model, presenting with odds ratio (OR) and confidence interval (CI). Results Increasing age (OR, 1.08; 95% CI, 1.04–1.12; p<0.001), diabetes mellitus (OR, 2.46; 95% CI, 1.18–5.12; p<0.017), increased log N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR, 1.82; 95% CI, 1.32–2.52; p<0.001), and increased average perirenal fat thickness (OR, 1.11; 95% CI, 1.06–1.16; p<0.001) were independently associated with reduced kidney function. In the subgroup analyses, patients over 70 years old, the ratio of mitral-to-mitral annular velocity >15, elevated log NT-proBNP had a significantly higher association with increased perirenal fat thickness with reduced kidney function. Conclusions Thick perirenal fat pads were independently associated with kidney function deterioration in patients hospitalized with ADHF.
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