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Kwon, Yo Han,Woo, Sang‐,Wook,Jung, Hye‐,Ran,Yu, Hyung Kyun,Kim, Kitae,Oh, Byung Hun,Ahn, Soonho,Lee, Sang‐,Young,Song, Seung‐,Wan,Cho, Jaephil,Shin, Heon‐,Cheol,Kim, Je Y WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.38
<P>The first ever demonstration of a cable‐type lithium ion battery architecture with outstanding omni‐directional flexibility is described by Je Young Kim, Heon‐Cheol Shin, and co‐workers on page 5192. The Front Cover image illustrates the unique battery architecture comprising a skeleton frame surrounding an empty space, that is, a hollow‐spiral anode with a multi‐helical structure. This design enables the battery to reliably power an LED screen or an MP3 player even under severe mechanical twisting and bending. </P>
Biological Activity of Bamboo Salt
Shin, Hye-Young,Na, Ho-Jeong,Moon, Phil-Dong,Seo, Sang-Wan,Shin, Tae-Yong,Hong, Seoung-Heon,Lee, Ki-Nam,Park, Rae-Kil,Kim, Hyung-Min The Korean Society of Food Science and Nutrition 2004 식품산업과 영양 Vol.9 No.1
Bamboo salt has been used for the purpose of prevention and treatment of various diseases in Korea. Present study was carried out to ascertain the effects of purple bamboo salt upon anti-allergic effect, anti-inflammatory activity and immune-enhance effect as well. Purple bamboo salt significantly inhibited the ear swelling response and histamine release induced by compound 48/80 in mice and rat peritoneal mast cells. Purple bamboo salt (0.01 ∼ lg/kg) also dose-dependently inhibited the passive cutaneous anaphylaxis by oral administration. Purple bamboo salt (1 mg/mL) in hibited phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-1${\beta}$ and IL-6 secretion, by 67.04${\pm}$0.08%, 68.01${\pm}$1.85%, 69.48${\pm}$0.54%, respectively. In addition, purple bamboo salt inhibited the expression of TNF-${\alpha}$ mRNA in HMC-1 cells. Finally, we investigated the effect of purple bamboo salt in the forced swimming test (FST) and the change of purple bamboo salt-mediated cytokine production from MOLT-4 cells. At the 7th, immobility time was significantly decreased in the purple bamboo salt-administration group (35.4 ${\pm}$5.9 s for 1 g/kg) in comparison with the control group (93.2 ${\pm}$ 15.45). After FST, the content of glucose in the blood serum was increased and the levels of blood urea nitrogen, lactic dehydrogenase was decreased in purple bamboo salt-administration group. However, it had no effect on the elevation of CK and TP level. Purple bamboo salt (1 mg/mL) significantly increased the interferon (IFN)-${\gamma}$ and IL-2 level compared with media control (about 3.7-fold for IFN-${\gamma}$, about 3.5-fold for IL-2, p〈0.05) but did not affect the IL-4.
Single Crossover-Mediated Markerless Genome Engineering in Clostridium acetobutylicum
( Sang-hyun Lee ),( Hyun Ju Kim ),( Yong-an Shin ),( Kyoung Heon Kim ),( Sang Jun Lee ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.4
A novel genome-engineering tool in Clostridium acetobutylicum was developed based on singlecrossover homologous recombination. A small-sized non-replicable plasmid, pHKO1, was designed for efficient integration into the C. acetobutylicum genome. The integrated pHKO1 plasmid backbone, which included an antibiotic resistance gene, can be excised in vivo by Flp recombinase, leaving a single flippase recognition target sequence in the middle of the targeted gene. Since the pSHL-FLP plasmid, the carrier of the Flp recombinase gene, employed the segregationally unstable pAMβ1 replicon, the plasmid was rapidly cured from the mutant C. acetobutylicum. Consequently, our method makes it easier to engineer C. acetobutylicum.
Hyaluronic acid filler stimulates collagen neogenesis: case series of hand rejuvenation
( Sang Hyung Lee ),( Myoung Shin Kim ),( Hong Il Cho ),( Ki Young Park ),( Ji Hyun Lee ),( Jae Kyung Kim ),( Jong Heon Baek ),( Chong Hyun Won ),( Choon Shik Youn ),( Dong Hyun Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
The aging hands characterized by volume loss and changes in skin texture, resulting in thinning of skin and more visible wrinkles and vessels. This study was designed to estimate the clinical and biophysiologic effect of cross-linked hyaluronic acid (HA) filler on aging hand. Furthermore, we investigated whether this effect depends on the particle size of HA filler. 8 Korean patients (age 34-74) with signs of photoaging on both hands were recruited in this study. We injected two kinds of cross-linked HA fillers, 400um and 900um sized particle, intradermally in the dorsum of both hands and obtained biopsies after 4 and 12 weeks. No serious adverse events were reported during the 12-week follow up. We observed that injected materials remained in place in treated sites. All patients showed clinical improvement in wrinkles and volume loss on treated area. RT-PCR results showed increases at 4 weeks in relative expression of the procollagen I, collagen III and tissue inhibitors (TIMP-1) at the sites treated by filler (900 um particle size) compared with untreated sites. This effect was sustained for at least 12 weeks. Interestingly, there was no significant difference in the expression of the transcriptional markers for collagen neogenesis between particle size of 400 um and 900 um HA fillers injections, at 4-week in this study.
Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility
Sung, Hui-Jin,Ok, Seong-Ho,Sohn, Jin-Young,Son, Yong Hyeok,Kim, Jun Kyu,Lee, Soo Hee,Han, Jeong Yeol,Lim, Dong Hoon,Shin, Il-Woo,Lee, Heon-Keun,Chung, Young-Kyun,Choi, Mun-Jeoung,Sohn, Ju-Tae Hindawi Publishing Corporation 2012 Journal of biomedicine & biotechnology Vol.2012 No.-
<P>Aminoamide local anesthetics induce vasoconstriction <I>in vivo</I> and <I>in vitro</I>. The goals of this <I>in vitro</I> study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta. Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED<SUB>50</SUB>) of the local anesthetic-induced maximum vasoconstriction. We determined the order of potency (ED<SUB>50</SUB>) of vasoconstriction among local anesthetics to be levobupivacaine > ropivacaine > lidocaine > mepivacaine. The relative importance of the independent variables that affect the vasoconstriction potency is octanol/buffer partition coefficient > potency > pKa > molecular weight. The ED<SUB>50</SUB> in endothelium-denuded aorta negatively correlated with the octanol/buffer partition coefficient of local anesthetics (<I>r</I><SUP>2</SUP> = 0.9563; <I>P</I> < 0.001). The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa.</P>
( Sang Heon Nam ),( Yu Shin Ha ),( Tae Wook Kim ) 한국농업기계학회 2014 바이오시스템공학 Vol.39 No.2
Purpose: The purpose of this study is to develop a system to optimize drying potential energy of the exhausted hot air bychanging relative humidity of the air. This study modified the conventional drying method into a drying method changingexhaust cycle and time in order to control the relative humidity of the exhausted hot air during drying process. Method: Avalve on the vent was controlled according to a preset time to change the exhaust cycle and time. This study analyzed theinfluence of the two different types of drying method on the drying characteristics, required energy, and quality of the driedpeppers: conventional drying method exhausting hot air continuously and new drying method controlling exhaust cycle andtime. Results: Drying characteristics based on exhaust time showed that drying time increased with exhaust time, andspecific energy consumption was reduced by 28% from 18.39 MJ/kg (conventional method) to 13.24 MJ/kg when exhausttime was set to one minute. Drying characteristics based on heating time showed that drying time increased with heatingtime and specific energy consumption was reduced by 30% from 18.39 MJ/kg (conventional method) to 12.87 MJ/kg whenexhaust time was set to 22 minutes. Drying characteristics based on exhaust cycle showed that drying time increased withexhaust cycle, and specific energy consumption was reduced by 31% from 18.39 MJ/kg (conventional method) to 12.69MJ/kg when exhaust time was set to one minute and exhaust cycle was set to 22 minutes before drying and 40 minutes afterdrying. The quality of the dried red peppers showed that capsaicin, color, and sugar content were high as 34.87 mg/100g,66.33, and 11.87%, respectively, when exhaust time was set to one minute and exhaust cycle was set to 22 minutes beforedrying and 40 minutes after drying. Conclusions: In order to utilize the drying potential energy of the exhausted air duringdrying process, the conventional drying method was modified into the drying method controlling exhaust cycle and time. The results showed that drying with exhaust cycle of one minute was more efficient in terms of drying time, requiredenergy, and quality of the dried peppers than the one with exhaust cycle of 20~40 minutes.
Sung, Hui-Jin,Choi, Mun-Jeoung,Ok, Seong-Ho,Lee, Soo Hee,Hwang, Il Jeong,Kim, Hee Sook,Chang, Ki Churl,Shin, Il-Woo,Lee, Heon-Keun,Park, Kyeong-Eon,Chung, Young-Kyun,Sohn, Ju-Tae Canadian Science Publishing 2012 Canadian journal of physiology and pharmacology Vol.90 No.7
<P> Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and to determine the associated cellular mechanism with a particular focus on endothelium-derived vasodilators, which modulate vascular tone. In the aortic rings with or without endothelium, cumulative mepivacaine concentration-response curves were generated in the presence or absence of the following antagonists: N<SUP>ω</SUP>-nitro-l-arginine methyl ester [l-NAME], indomethacin, fluconazole, methylene blue, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ], verapamil, and calcium-free Krebs solution. Mepivacaine produced vasoconstriction at low concentrations (1 × 10<SUP>−3</SUP> and 3 × 10<SUP>−3</SUP> mol/L) followed by vasodilation at a high concentration (1 × 10<SUP>−2</SUP> mol/L). The mepivacaine-induced contraction was higher in endothelium-denuded aortae than in endothelium-intact aortae. Pretreatment with l-NAME, ODQ, and methylene blue enhanced mepivacaine-induced contraction in the endothelium-intact rings, whereas fluconazole had no effect. Indomethacin slightly attenuated mepivacaine-induced contraction, whereas verapamil and calcium-free Krebs solution more strongly attenuated this contraction. The vasoconstriction induced by mepivacaine is attenuated mainly by the endothelial nitric oxide - cyclic guanosine monophosphate pathway. In addition, mepivacaine-induced contraction involves cyclooxygenase pathway activation and extracellular calcium influx via voltage-operated calcium channels. </P>