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Yoo, Heon Jong,Lim, Myong Cheol,Lim, Soyi,Park, Jeong-Yeol,Kang, Sokbom,Park, Sang-Yoon,Seo, Sang-Soo Springer International 2012 Archives of gynecology and obstetrics Vol.286 No.6
<P>To evaluate the efficacy and toxicity of combined paclitaxel and carboplatin treatment for persistent or recurrent uterine sarcoma.</P>
Yoo-Sun Park,Yun-Sang Choi,Ko-Eun Hwang,Tae-Kyung Kim,Cheol-Won Lee,Dong-Min Shin,Sung Gu Han 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.3
This study was conducted to investigate the physicochemical properties of meat batters prepared with fresh pork meat, back fat, water, and salt and formulated with three different amounts (5%, 10%, and 15%) of silkworm pupae (Bombyx mori) powder and transglutaminase (TG). Meat batters formulated with silkworm pupae powder showed significantly higher contents of protein and ash than control batter. Addition of silkworm pupae to batter also showed significantly lower cooking loss than the control. Moreover, meat batter containing 15% silkworm pupae showed no significant difference in redness value compared to the control. In addition, pH, viscosity, hardness, gumminess, and chewiness were improved after the addition of silkworm pupae. Furthermore, meat batter formulated with TG and silkworm pupae showed improved hardness, gumminess, chewiness and viscosity compared to control batter. Addition of 1% TG with 15% silkworm pupae to meat batter resulted in significantly higher pH, textures, and viscosity. Our data suggest that both silkworm pupae and TG can be added to meat batter to improve its physicochemical properties. Therefore, combination of silkworm pupae and TG could be a new nutritional and functional source for meat products.
Neuroprotective Effects of Carpinus tschonoskii MAX on 6-Hydroxydopamine-Induced Death of PC12 Cells
( Sang Cheol Kim ),( Hee Kyoung Kang ),( Min Kyoung Kim ),( Ji Hoon Kang ),( Jin Won Hyun ),( Eun Sook Yoo ),( Jung Il Kang ),( Deok Bae Park ),( Hye Jin Boo ),( Young Sang Koh ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4
The present study investigated the neuroprotective effect of Carpinus tschonoskii MAX and its intracellular protective mechanism on 6-hydroxydopamine (6-OHDA)-induced oxidative damage in PC12 cells. We found that pretreatment of PC12 cells with C. tschonoskii extract significantly inhibited the cell death induced by 6-OHDA in a dose dependent manner. C. tschonoskii extract decreased 6-OHDA-induced apoptotic events such as chromatin condensation, DNA fragmentation, the decrease of Bcl-2/Bax ratio, caspase-3 activation and PARP cleavage. C. tschonoskii extract also reduced generation of 6-OHDA-induced reactive oxygen species and nitric oxide. Furthermore, C. tschonoskii extract up-regulated the myocyte enhancer factor 2 D (MEF2D), a critical transcription factor for neuronal survival, and Akt activity, whereas it inhibited the activity of ERK1/2 and JNK. The results suggest that C. tschonoskii extract decreases 6-OHDA-induced oxidative stress and could prevent PC12 cell apoptosis induced by 6-OHDA via the up-regulation of MEF2D and Akt activity, and thus may have application in developing therapeutic agents for Parkinson`s disease.
Compression Behavior of Confined Columns with High-Volume Fly Ash Concrete
Yoo, Sung-Won,Choi, Young Cheol,Choi, Wonchang Hindawi Publishing Corporation 2017 Advances In Materials Science And Engineering Vol.2017 No.1
<P>The use of fly ash in ordinary concrete provides practical benefits to concrete structures, such as a gain in long-term strength, reduced hydration heat, improved resistance to chloride, and enhanced workability. However, few studies with high-volume fly ash (HVFA) concrete have been conducted that focus on the structural applications such as a column. Thus, there is a need to promote field applications of HVFA concrete as a sustainable construction material. To this end, this study investigated the compressive behavior of reinforced concrete columns that contain HVFA with a 50 percent replacement rate. Six columns were fabricated for this study. The study variables were the HVFA replacement rate, tied steel ratio, and tie steel spacing. The computed ultimate strength by the American Concrete Institute (ACI) code conservatively predicted the measured values, and, thus, the existing equation in the ACI code is feasible for confined RC columns that contain HVFA. In addition, an analysis model was calibrated based on the experimental results and is recommended for predicting the stress-strain relationship of confined reinforced concrete columns that contain HVFA.</P>
Yoo, Sijung,Yoo, Chanyoung,Park, Eui-Sang,Kim, Woohyun,Lee, Yoon Kyeung,Hwang, Cheol Seong The Royal Society of Chemistry 2018 Journal of Materials Chemistry C Vol.6 No.18
<P>Ge-Sb-Se-Te (GSST) quaternary films were prepared through atomic layer deposition (ALD) to ensure their amorphous stability for ovonic threshold switching (OTS) applications. Se, a typical phase-change material, was incorporated into Ge-Sb-Te (GST) films using Sb (OC2H5)3 and [(CH3)3Si]2Se precursors. The process produces highly conformal, uniform films consisting of stoichiometric binaries of GeTe2, Sb2Te3, and Sb2Se3. A detailed analysis of the atomic compositions revealed Te substitution for Se on the film surface through the ligand exchange reaction between the Te and Se precursors. Comparative experimental and simulation studies on the OTS behaviors showed that Ge and Se increase the optical bandgaps while Se decreases the density of the localized states. The amorphous stability of the Se-containing films enhances the cycling endurance of the OTS device up to 10<SUP>5</SUP> cycles. As conformality and atomic-level accuracy in terms of thickness and composition are prerequisites for three-dimensional crossbar-type passive arrays, the ALD process and the OTS performance presented in this work have a high potential utility for constructing a selector element in non-volatile high-density memories.</P>
FcγR 3b polymorphism and its association with clinical manifestations in Korean Lupus patients
( Cheol Ho Hong ),( Il Kim ),( Jin Sook Lee ),( Tae Young Kang ),( Hye Soon Lee ),( Wan Sik Uhm ),( Tae Hwan Kim ),( Jae Bum Jun ),( Sang Cheol Bae ),( Dae Hyun Yoo ) 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10
Yoo, Jung-Hwa,Yim, Sung-Vin,Lee, Byung-Cheol Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><B>Background</B></P><P> Bojungikki-tang (BJIKT) is a widely used traditional herbal formula in China, Japan, and Korea. There have been reports that several herbs among BJIKT have interactions with antiplatelet drugs, such as aspirin. This study aimed to assess whether BJIKT interacts with aspirin in terms of pharmacokinetics (PK) and pharmacodynamics (PD) in healthy subjects and ischemic stroke patients.</P><P><B> Methods</B></P><P> The phase I interaction trial was a randomized, open-label, crossover study of 10 healthy male subjects, and the phase III interaction trial was a randomized, placebo-controlled, parallel study of 43 ischemic stroke patients. Each participant randomly received aspirin + BJIKT or aspirin + placebo. For PK analysis, plasma acetyl salicylic acid (ASA) and salicylic acid (SA) were evaluated, and, for PD analysis, platelet aggregation and plasma thromboxane B<SUB>2</SUB> (TxB<SUB>2</SUB>) were measured.</P><P><B> Results</B></P><P> In the PK parameters, mean area under curve, maximum concertation, and peak concentration time of ASA and SA were not different between two groups in healthy subjects and ischemic stroke patients. In the PD profiles, TxB<SUB>2</SUB> concentrations and platelet aggregation were not affected by coadministration of BJIKT in healthy subjects and ischemic stroke patients.</P><P><B> Conclusions</B></P><P> These results suggest that coadministration of BJIKT with aspirin may not result in herb-drug interaction.</P>
( Cheol-kyu Park ),( Hyung-joo Oh ),( Jae-kyung Lee ),( Min-seok Kim ),( Bo-gun Koh ),( Ha-young Park ),( Tae-ok Kim ),( Hong-joon Shin ),( Yong-soo Kwon ),( Yoo-il Kim ),( Sung-chul Lim ),( Young-chu 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background This study aimed to investigate the feasibility of circulating tumor cells (CTCs) and peripheral blood cells (PBCs) as predictive markers for immunotherapy in advanced non-small cell lung cancer (NSCLC). Methods This study included patients with advanced NSCLC receiving pembrolizumab or atezolizumab from July 2019 to June 2020. Blood was collected in K2-EDTA tube before each administration from cycle 1 to 4 (C1-4), and PBC counts (absolute neutrophil count[ANC], neutrophil-to-lymphocyte ratio[NLR], derived NLR[dNLR], platelet-to-lymphocyte ratio[PLR]) were calculated at each cycle. CTCs were enriched by using CD-PRIMETM system, the antibody-independent size-based isolation Method, and identified by single positive cells (EpCAM/CK+CD45-) in Bioview CCBS system. Results Among 89 response-evaluable patients, objective response rate was 21% and durable clinical benefit (DCB) were 35%. Baseline (C1) CTC and PBC count did not show a significant difference according to best response and DCB. However, patients with lower NLR, dNLR and PLR at C1 showed significant benefit in progression-free survival (PFS) and overall survival (OS) (p<0.05 for all). Patients with decreased CTC at C2 compared to C1 showed benefit in median PFS (6.2 vs 2.3, p=0.078) and OS (not reached [NR] vs 6.8, p=0.021) than those with increased CTC count. Patients with decreased ANC and NLR at C3 compared to C1 showed benefit in median PFS (6.3 vs 1.9, p=0.001 and 6.3 vs 1.9, p=0.007) and OS (NR vs 5.1, p=0.014; NR vs 6.8, p=0.045) than those with increased ANC and NLR. Low dNLR (≤2.0) at C1, decreased CTC at C2 and decreased ANC at C3 compared to C1 were the independently significant factors for survival (Fig. 1). Conclusion The CTC and PBC count at baseline and their changes during treatment could be potential biomarkers to predict the survival benefit and may help risk-group stratification in patients with advanced NSCLC who received anti-PD-1/PD-L1 immunotherapy.