일본의 연령주의 : 현황과 사회적 대응 (Ageism in Japan)

Okuyama Shoji 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술

Dr. Shoji Okuyama is currently President of Committee for Long-Term Care (LTC) insurance in Higashi-kurume-shi, Tokyo since 2000, and Professor Emeritus at Tokyo Keizai University from April of 2017. He graduated from Chuo University (B.A.), from Seijo University (MA and Ph.D. in Literature) and from Hitotsubashi University in Tokyo, Japan (Ph.D. in Sociology)(Ph.D., social welfare). Since 1972 until 1995, he had been researcher and senior researcher of Tokyo Metropolitan Institute of Gerontology (TMIG, now Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology). This during, he had been as visiting senior researcher at Center for the Study of Aging and Human Development in Duke University(USA). Since 1995 until May 2017, he had been Professor of social gerontology at Tokyo Keizai University and since 1995 until now, president and inspectors of Japan Socio-Erotological Society, Editorial Committee Member in Japanese Society for the Study of Social Welfare and Japan Society of Family Sociology. He also has worked many governmental committees and NGOs in Japan. He also has worked as part-time lecturer at many universities (Ochanomizu Women’s University, Waseda University, Nihon University, Dokkyo University, Toyo University and others). His publications include 30 books (including chapters) and 100 and over papers.

Mangiferin Induces Apoptosis by Suppressing Bcl-xL and XIAP Expressions and Nuclear Entry of NF-κB in HL-60 Cells

Kaori Shoji,Kaori Shoji,Masanobu Tsubaki,Yuzuru Yamazoe,Takao Satou,Tatsuki Itoh,Yasuhiro Kidera,Yoshihiro Tanimori,Masashi Yanae,Hideaki Matsuda,Atsushi Taga,Haruyuki Nakamura,Shozo Nishida 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated. In the present study, we attempt to clarify the mechanism of mangiferininduced apoptosis in the human acute myeloid leukemia cell line HL-60; mangiferin was found to induce apoptosis. We also observed a concurrent increase in caspase-3 activity and DNA fragmentation. Furthermore, on examining the survival signals expressed during apoptotic induction, we observed that mangiferin caused a remarkable decrease in the nuclear entry of NF-κB p65. However, there were no changes in the expression of other survival signals,such as extracellular signal-regulated kinase 1/2, protein kinase B, and p38 mitogenactivated protein kinase. In addition, mangiferin suppressed the expressions of Bcl-xL and XIAP; however, we did not note any changes in the levels of Bcl-2, Bax, and Bim. These results indicate that mangiferin induces apoptosis by suppressing NF-κB activation and expressions of Bcl-xL and XAIP. These findings suggest that mangiferin may be useful as an anticancer agent and can be used in combination therapy with other anticancer drugs for the treatment of acute myeloid leukemia.

MRI Update for New Millennium in Neurological Field

Shoji Naruse 가톨릭의과학연구원 2000 가톨릭 의과학연구원 국제학술대회 Vol.4 No.-

Magnetic resonance imaging (MRI) is used widely in neurological field as a powerful diagnostic imaging method which can clearly delineate the anatomical and pathological conditions in the brain. Moreover, the recent development of technology makes it possible to use analytical abilities of various NMR techniques on clinical MRI scanner, Consequently important information required in the neurological fled, such as brain function, metabolism and blood flow, becomes to be measured by using clinical MRI scanners. For last 20 years, we have developed several analytical techniques of NMR on clinical MR scanners, e.g. (a) Chemical shift imaging (CSI) method, which can visualize the distribution of intrinsic metabolites in the brain by obtaining magnetic resonance spectrum (MRS) from multiple, small areas simultaneously; (b) Diffusion weighted imaging (DWI), which can disclose water molecular diffusion in the brain; (c) Perfusion weighted imaging (PWE), which can demonstrate the hemodynamics relating to perfusion in the brain; (d) Functional MH which can visualize the brain function using intrinsic substance. In this seminar, I would like to demonstrate the usefulness of some of those techniques for analyzing the brain function and metabolism in expectation of the further development of those techniques to the New Millennium.

Color vision diversity and significance in primates inferred from genetic and field studies

Shoji Kawamura 한국유전학회 2016 Genes & Genomics Vol.38 No.9

Color provides a reliable cue for object detection and identification during various behaviors such as foraging, mate choice, predator avoidance and navigation. The total number of colors that a visual system can discriminate is largely dependent on the number of different spectral types of cone opsins present in the retina and the spectral separations among them. Thus, opsins provide an excellent model system to study evolutionary interconnections at the genetic, phenotypic and behavioral levels. Primates have evolved a unique ability for three-dimensional color vision (trichromacy) from the two-dimensional color vision (dichromacy) present in the majority of other mammals. This was accomplished via allelic differentiation (e.g. most New World monkeys) or gene duplication (e.g. Old World primates) of the middle to long-wavelength sensitive (M/ LWS, or red–green) opsin gene. However, questions remain regarding the behavioral adaptations of primate trichromacy. Allelic differentiation of the M/LWS opsins results in extensive color vision variability in New World monkeys, where trichromats and dichromats are found in the same breeding population, enabling us to directly compare visual performances among different color vision phenotypes. Thus, New World monkeys can serve as an excellent model to understand and evaluate the adaptive significance of primate trichromacy in a behavioral context. I shall summarize recent findings on color vision evolution in primates and introduce our genetic and behavioral study of vision-behavior interrelationships in free-ranging sympatric capuchin and spider monkey populations in Costa Rica.

Comparable three dimensional rollover characteristics of typical prosthetic feet measured on the gait simulating test device

Shoji Morimoto,Haruyuki Yoshida 한국재활복지공학회 2016 한국재활복지공학회 학술대회논문집 Vol.2016 No.11

Circumferential Spinal Cord Decompression through a Single Posterior Approach with Microendoscopy for Thoracic and Thoracolumbar Ossification of the Posterior Longitudinal Ligament

Shoji Seki,Hayato Mine,Yoshiharu Kawaguchi,Hiroto Makino,Tomoatsu Kimura 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.4

Thoracic and thoracolumbar ossification of the posterior longitudinal ligament (OPLL) can be difficult to treat due to the anatomical position. The purpose of this study was to report the significance of a novel surgical technique that represented two cases of thoracic or thoracolumbar OPLL. The first patient was a 72-year-old woman who had a beak-type OPLL at the T11/12. The second was a 45-yearold woman who had a beak-type OPLL at the T12/L1. We performed circumferential spinal cord decompression through a single posterior approach with microendoscopy in both cases. The postoperative computed tomography revealed the complete removal of the OPLL, and the magnetic resonance imaging confirmed adequate decompression of the spinal cord. Preoperative symptoms were substantially improved in both patients. To date, we have used this novel technique to treat five patients with thoracic or thoracolumbar OPLL. This new surgical technique is likely to be useful in patients with a beak-type OPLL of the thoracic or thoracolumbar spine.

Present Situation and Problems of Inclusive Education in Japan

Shoji Higo KOREA INSTITUTE FOR SPECIAL EDUCATION 2005 The Asia-Pacific Journal of Inclusive Education Vol.2 No.-

The purpose of this paper was to discuss the inevitability and the difficulties of introducing inclusive education in Japan by analyzing the present special education situation. Attaining the purpose, three directions were discussed. The first was analyzing present tendencies of statistics about special education and outcomes of investigation studies on realities of special or regular school settings. The second was discussing cultural factors against introducing inclusive education to Japan. And the last was reconsidering the meaning of two reports on special education reform. After these discussions, some important points were suggested. Many problems which affected present system arose and preparedness for transition from the present system to inclusive education was proceeding. And solving cultural problems was an important condition if we introduced inclusive education in Japan. In these circumstances, the government has been tried to reform special education system. Achieving this reform, we had to pay attention to cultural factors more intensively and to slough off the remedial education paradigm for reorganize education system effectively.

Change of East Asia Monsoon in global warming projection by an atmospheric general circulation model with a 20-㎞ grid size

Shoji KUSUNOKI 한국기상학회 2006 한국기상학회 학술대회 논문집 Vol.2006 No.-

Deployment Scenario for Fiber-Optic Subscriber Networks by a CT / RT System

Shoji Hashiba,Shingo Yagi,Katsumi Murakami,Toshikazu Doi 한국통신학회 1993 Asia-Pacific Conference on Communications Vol.2 No.2

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens

Shoji Fukushima,Min Gi,Masaki Fujioka,Anna Kakehashi,Hideki Wanibuchi,Michiharu Matsumoto 한국독성학회 2018 Toxicological Research Vol.34 No.4

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ≪ Mutations ≪ GST-positive foci (preneoplasia) ≪ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.