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Deubiquitination and Stabilization of PD-L1 by CSN5
Lim, Seung-Oe,Li, Chia-Wei,Xia, Weiya,Cha, Jong-Ho,Chan, Li-Chuan,Wu, Yun,Chang, Shih-Shin,Lin, Wan-Chi,Hsu, Jung-Mao,Hsu, Yi-Hsin,Kim, Taewan,Chang, Wei-Chao,Hsu, Jennifer L.,Yamaguchi, Hirohito,Ding Elsevier 2016 Cancer cell Vol.30 No.6
<P><B>Summary</B></P> <P>Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation </LI> <LI> Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization </LI> <LI> CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination </LI> <LI> Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
The genetically healthy terrestrial orchid Liparis krameri on southern Korean Peninsula
정미윤,정재민,손성원,Kangshan Mao,Jordi LÓPEZ-PUJOL,정명기 한국식물분류학회 2019 식물 분류학회지 Vol.49 No.4
Neutral genetic diversity found in plant species usually leaves an indelible footprint of historical events. Korea’s main mountain range (referred to as the Baekdudaegan [BDDG]), is known to have served as a glacial refugium primarily for the boreal and temperate flora of northeastern Asia. In addition, life-history traits (life forms, geographic range, and breeding systems) influence the within- and among-population genetic diversity of seed plant species. For example, selfing species harbor significantly less within-population genetic variation compared to predominantly outcrossers. A previous study of two Liparis species (L. makinoana and L. kumokiri) emphasizes the role of the abovementioned factors shaping the levels of genetic diversity. Liparis makinoana, mainly occurring on the BDDG and self-incompatible, harbors high levels of within-population genetic diversity (expected heterozygosity, HeP = 0.319), whereas there is no allozyme variation (HeP = 0.000) in L. kumokiri, which is self-compatible and mainly occurs in lowland hilly areas. To determine if this trend is also found in other congeners, we sampled five populations of L. krameri from the southern part of the Korean Peninsula and investigated the allozyme-based genetic diversity at 15 putative loci. The somewhat intermediate levels of within-population genetic variation (HeP = 0.145) found in L. krameri are most likely due to its occurrence in mountainous areas that, despite being outside of the main BDDG, still served as refugia, and a self-incompatible breeding system. Management strategies are suggested for L. krameri and L. makinoana based on the levels and distribution of genetic diversity and inbreeding.
Seed collection strategies for plant restoration with the aid from neutral genetic diversity
정미윤,손성원,Kangshan Mao,Jordi LÓPEZ-PUJOL,정명기 한국식물분류학회 2019 식물 분류학회지 Vol.49 No.4
One key step in the plant restoration process is the collection of seeds from the field. For the selection of source populations of target plant species for translocation purposes (reintroduction or reinforcements), several approaches are possible. A practical method involves the use of data from reciprocal transplant studies. If no direct data are available, knowledge of population genetics and the phylogeography of the target species can serve as an alternative. In this short review, we briefly propose guidelines for those collecting seeds for plant species restoration based on population genetics theory, focusing on two main questions: Where does the plant material come from and how are sources designated, and how are seeds efficiently collected from local populations? While genetic data on a larger scale (phylogeography and population genetics) are needed to form a reply to the first question, similar data on a smaller scale (fine-scale genetic structures within populations) are necessary to shed light on the second issue.
Mao, H.L.,Wang, J.K.,Lin, J.,Liu, J.X. Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.5
This study was conducted to determine the effects of dietary addition of tea saponins (TS) and soybean oil (SO) on fatty acid profile and gene expression of stearoyl-CoA desaturase (SCD) in longissimus dorsi (LD) muscle of growing lambs. Thirty-two Huzhou lambs were assigned to four dietary treatments in a $2{\times}2$ factorial arrangement with main effects of TS (0 or 3 g/d) and SO (0 or 30 g/kg of diet DM). The diet without additives was considered as NTNS (no TS or SO). After a feeding trial for 60 d, four lambs of each treatment were slaughtered to collect the samples of LD muscle. Percentage of trans-11 vaccenic acid was enhanced (p<0.05) in muscle of lambs fed TS and SO. The proportion of total conjugated linoleic acid (CLA) was increased (p<0.05) by SO, but decreased (p<0.05) by TS in LD muscle. The percentage of total saturated fatty acids in muscle was decreased (p<0.05) by addition of TS and SO, while addition of SO increased (p<0.05) the percentage of total polyunsaturated fatty acids. The ratio of cis-9, trans-11 CLA to tran-11 vaccenic acid was decreased (p<0.05) by TS, but increased (p<0.05) by SO. The same effects were observed in SCD mRNA expression. From these results it is indicated that including TS and SO in the diet of growing lambs affect the fatty acid profiles of LD muscle and that the proportion of cis-9, trans-11 CLA in the muscle influenced by TS and SO may be related to the SCD gene expression.
J.L. Cui,L.D. Mao,D.Y. Chen,X. Qian,X.L. Liu,W. Yang 한국물리학회 2009 Current Applied Physics Vol.9 No.3
Zn–Sb based alloys with Cu2Sb addition were prepared using spark plasma sintering technique and the effects of a Cu-contained intermetallic phase on the microstructures and thermoelectric properties were examined. Rietveld refinement reveals that there are many phases in the alloys, which involve β-Zn4Sb3, a major phase ZnSb, a small amount of an intermetallic compound Cu5Zn8 and unidentified impurity phases, the quantities of ZnSb and Cu5Zn8 increase from 67.3 wt.% to 91.8 wt.% and 0–4.3 wt.% with Cu2Sb additive increasing, respectively. The ZnSb plays a fundamental role in controlling the thermoelectric properties, and Cu5Zn8 is of great significance to optimize the transport properties. The maximum thermoelectric figure of merit ZT of 0.72 is obtained for the alloy (Cu2Sb)0.05–(Zn4Sb3)0.95 at 654 K, which is 0.25 higher than that of undoped β-Zn4Sb3 at the same conditions. Therefore, we conclude that a proper addition of Cu2Sb can contribute to the improvement of thermoelectric properties of Zn–Sb based alloys.
Liu L.N.,Zheng W.M.,Zhang X.J.,Yang H.,Yuan S.,Mao Y.Z.,Zhang W.,Zhu G.H.,Wang L.,Qin C.M.,Zhao Y.P.,Cheng Y.,Zhang K. 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1
Ion cyclotron range of frequency (ICRF) heating system is an important auxiliary heating method in the experimental Advanced Superconducting Tokamak (EAST). In EAST, several megawatts of power are transmitted with coaxial transmission lines and coupled to the plasma. For the long pulse and high power operation of the ICRF waves heating system, it is very important to effectively control the power and initial phase of the ICRF signals. In this paper, a power and phase feedback control system is described based on field programmable gate array (FPGA) devices, which can realize complicated algorithms with the advantages of fast running and high reliability. The transmitted power and antenna phase are measured by a power and phase detector and digitized. The power and phase feedback control algorithms is designed to achieve the target power and antenna phase. The power feedback control system was tested on a dummy load and during plasma experiments. Test results confirm that the feedback control system can precisely control ICRF power and antenna phase and is robust during plasma variations.
Liu L.N.,Liang Q.C.,Yang H.,Zhang X.J.,Yuan S.,Mao Y.Z.,Zhang W.,Zhu G.H.,Wang L.,Qin C.M.,Zhao Y.P.,Cheng Y.,Zhang K. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.10
To operate the ion cyclotron resonance heating (ICRH) antennas in a better heating state and produce relatively low impurities, it is necessary to control the antenna spectrum by changing the antenna phasing. As the electrical length of the antenna feeding transmission lines is changing as a matter of the standing wave pattern at the ceramic supports, 90 elbows, T-connectors and antenna loops, we chose to measure the current at the grounding points of the antenna loops by antenna strap probe. The voltage drops along a small, several millimeter-long paths at the end of the antenna loops give a signal that is proportional to the current in the antenna loop. Through the simulation of the antenna strap probe and the actual measurement of the antenna phasing under vacuum conditions, the reliability of the antenna strap probe based diagnostic system have been successfully proved. Moreover, this system was successfully applied to the ICRH daily experiments in the spring of 2021. In the near future, the active realtime feedback control of the antenna phasing system will be developed based on this diagnostic system in the EAST tokamak.