심장수술 2,450예와 심장이식

조광현,황윤호,이양행,류지윤 인제대학교 1999 仁濟醫學 Vol.20 No.1S

인제대학교 부산백병원에서는 1985년 10원 개심술이 처음 시행된 이후 1998년 말까지 2,450예의 개심및 비개심 심장수술이 이루어졌는데 이중 개심술이 2,290예, 비개심술은 160예 였다. 개심술 중 선천성이 1,697예(74.1%), 후천성이 573예(25.9%)였으며, 선천성 중에는 비청색증군이 1,548예(91.2%), 청색증군이 149예(8.8%)이었다. 후천성 중에는 심장판막질환이 471예(79.6%)로 가장 많았고, 관상동맥우회수술이 73예(12.1%), 대동맥류수술이 28예(4.7%), 심장종양절제술이 15예(2.5%) 및 심장이식수술이 2예, 기타 4예 등이었다. 특히 1993년부터 심장이식술을 위한 기초 및 동물실험 을 계속하다가 1997년 9월 말기심부전증환자에게 심장이식이 성공적으로 이루어져 개심술의 새로운 장을 열게 되었다. 술후 조기 사망은 선천성 비청색증군에서 30예(1.9%), 청색증군에서는 27예(16.7%), 후천성질환군에서는 26예(4.4%)였고, 전체 수술성공률은 96.5% 로 비교적 좋은 성적을 거두었다. From Sep. 1985 to Dec. 1998, 2,450 cases of heart operation including 2 cases of orthotopic heart transplantaion were performed in the Department of Cardiothoracic Surgery, Inje Universty, Pusan Paik Hospital The results of retrospective clinical review of them were obtained as follows. 1.Open heart surgery cases and non-open heart surgery cases were 2.290 and 160, respectively. Among the open heart cases, congenital cases and acquired cases were 1,697(74.1%) and 593 (25.9%), respectively. 2.Among the congenital cases, acyanotic cases and cyanotic cases were 1,548(91.2%) and 149(8.8%), respectively. The postoperative hospital mortality was 1.9% (30 cases) in the acynotic group and 16.6% (25 cases) in the cyanotic group. 3.Among the acquired cases, valvular heart disease, coronary artery disease, aortic aneurysm, cardiac tumor, heart transplantation and others were 471 (79.6%), 73(12.1%), 28(4.7%), 15(2.5%), 2(0.3%) and 4(0.7%) cases, respectively. 4.Prosthetic valve replacement (457 case, 97.0%) and valve reconstructive surgery(14 cases, 3.0%) were performed for the valvular diseases. Postoperative hospital mortality of valve surgery and coronary artery bypass surgery was 2.8% (13 cases) and 28.6% (6 cases), respectively. 5.28 cases of aortic aneurysm (ascending or arch aneurysm) were operated under cardiopulmonary bypass. The causes of aneurysm were annuloaortic ectasia(9), dissecting aortic aneurysm(16), and non-dissecting chronic aneurysm(8). The early postoperative hospital mortality was 8 cases(28.6%). 6.Two cases of heart transplantation were performed successfully using Shumway method .The total ischemic time of donor heart was 80 minutes and 50 minutes respectively. 7.Minimally invasive surgery (using lower sternal incision) was performed successfully in the cases of mitral and tricuspid valve diseases(10) and congenital septal defects (20). In conclusion, the over all postoperative hospital mortality was not so high as 3.5 %, whereas more proper management for congenital cyanotic group was seemed to be necessary.

심장수술 2,450예와 심장이식

조광현,황윤호,이양행,류지윤 인제대학교 1999 仁濟醫學 Vol.20 No.1

구급일지를 통한 병원 전 환잔 분류 및 처치의 적절성 평가 연구

민순식,김재광,이근,박철완,양혁준,류일,현성열,이훈규,정환모,김윤 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Recently, patients' demands for emergency medicine are increasing, and most of prehospital medical care, including basic life support, cardiopulmonary resuscitation and triage, are provided by paramedics or emergency medical technicians. Evaluation of the adequacy of prehospital management and triage has become important for improving the quality and the effectiveness of the emergency medical system. Methods: The 202 patients who were transferred by ambulance with paramedics, nurses, or emergency medical technicians to the Emergency Department in Gil Medical Center from July 1, 1999, to September 31, 1999, were enrolled. This study was conducted prospectively by using the emergency physician,s log and newly devised protocols recorded by paramedics or nurses. Results: 1) Male to female ratio was 1: 0.8, and the peak age of the patients were the 4th(18.8%) and 6th decade(15.3%). 2) Of the 202 patients, 84 patients were transferred for trauma and 118 for medical problems. The mean transfer time was 6±1.73 minutes. 3) The validities of prehospital triage and decisions using the trauma severity measure and the disease severity measure, were 33.3% in trauma patients and 57.6% in medical patients.4) The results for the adequacy rate in prehospital management analyzed by using the rate of necessity of treatment. performance of treatment, and adequate treatment were as follows: oxygen supply.38.1/41.6/93.8 ; wound dressing. 19.3/71.8/92.9 ; immobilization of the cervical spine, 15.8/56.3/92.9 ; application of a spinal board. 12.9/42.3/72.7 ; application of a splint, 9.9/50.0/60.0 ; manual maintenance of an airway. 9.9/55.0/63.6 ; and CPR, 4.5/66.7/0. 5) Kind of ALS(Advanced Life Support) were not conducted(peripheral IV, EKG. intubation, medical administration. defibrillation, pacing). The rates of necessity of treatment were as follows: peripheral IV, 40.6%; ECG monitoring, 23.3% ; endotracheal intubation, 8.9% ; medical administration, 8.9% ; defibrillation. 3.5%; and pacing. 1.5% Conclusion: The adequacy of prehospital triage and decisions using trauma and disease severity measures was relatively low. To improve the adequacy of BLS(Basic Life Support) and to increase the performance of ALS(Advanced Life Support), we must create challenges to develop new protocols and to supplement new equipment.

치과용 타니타늄 임플란트의 최근 연구 개발 동향

이광민 ( Kwang Min Lee ),박상원 ( Sang Won Park ),임현필 ( Hyun Pil Lim ),고정태 ( Jeong Tae Koh ),강성수 ( Seong Soo Kang ),김현승 ( Hyun Seong Kim ),박광범 ( Kwang Bum Park ),류경호 ( Gyeong Ho Ryoo ),이경구 ( Kyung Ku Lee ) 대한금속·재료학회 2009 재료마당 Vol.22 No.4

Preparation of Three Different Style Packed Capillary Frits

Ryoo, Jae-Jeong,Song, Young-Ae,Lee, Kwang-Pill,Park, Ji-Yeon,Choi, Seong-Ho,Hyun, Myung-Ho,Ohta, Kazutoku,Fujimoto, Chuzo,Jin, Ji-Ye,Takeuchi, Toyohide,Lee, Jung-Whan Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.4

Three different style capillary columns, a packed capillary with temporary quartz wool frit, a packed capillary with immobilized frit, and an immobilized packed-capillary, were easily prepared with a commercially available (S)-N-(3,5-dinitro-benzoyl)leucine-N-phenyl-N-alkylamide derived chiral stationary phase. Liquid chromatographic chiral separations of some racemic amino acid derivatives on these columns were performed and the results were compared to each other. The packed capillary with immobilized frit showed some merits in chiral chromatography.

Clinical outcomes of surgical management for recurrent rectal prolapse: a multicenter retrospective study

Kwang Dae Hong,Keehoon Hyun,Seo-Gue Yoon,Jun Won Um,Do Yeon Hwang,Jaewon Shin,Dooseok Lee,Se-Jin Baek,Sanghee Kang,Byung Wook Min,Kyu Joo Park,Seung-Bum Ryoo,오흥권,Min Hyun Kim,Choon Sik Chung,Yong Geul 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.4

Purpose: There are few reports on outcomes following surgical repair of recurrent rectal prolapse. The purpose of this study was to examine surgical outcomes for recurrent rectal prolapse. Methods: We conducted a multicenter retrospective study of patients who underwent surgery for recurrent rectal prolapse. This study used data collected by the Korean Anorectal Physiology and Pelvic Floor Disorder Study Group. Results: A total of 166 patients who underwent surgery for recurrent rectal prolapse were registered retrospectively between 2011 and 2016 in 8 referral hospitals. Among them, 153 patients were finally enrolled, excluding 13 patients who were not followed up postoperatively. Median follow-up duration was 40 months (range, 0.2??29.3 months). Methods of surgical repair for recurrent rectal prolapse included perineal approach (n = 96) and abdominal approach (n = 57). Postoperative complications occurred in 16 patients (10.5%). There was no significant difference in complication rate between perineal and abdominal approach groups. While patients who underwent the perineal approach were older and more fragile, patients who underwent the abdominal approach had longer operation time and admission days (P < 0.05). Overall, 29 patients (19.0%) showed re-recurrence after surgery. Among variables, none affected the re-recurrence. Conclusion: For the recurrent rectal prolapse, the perineal approach is used for the old and fragile patients. The postoperative complications and re-recurrence rate between perineal and abdominal approach were not different significantly. No factor including surgical method affected re-recurrence for recurrent rectal prolapse.

Synthesis of Terphenyls and Quaterphenyls via the Nickel N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Neopentyl Arenesulfonates with Aryl Grignard Reagents

Jo, Hyun-Jong,Kim, Chul-Bae,Ryoo, Tae-Yong,Ahn, Bo-Kyoung,Park, Kwang-Yong Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.12

Various terphenyl and quaterphenyl derivatives were prepared by the Ni-NHC catalyzed cross coupling of the corresponding biphenyl- and terphenyl-sulfonates with arylmagnesium bromides. The reactions proceeded rapidly via a nucleophilic aromatic substitution of the alkoxysulfonyl moieties by the aryl nucleophiles to afford high yields within just 1.5 h at room temperature in spite of the low reactivity of the sulfur electrophiles.

황견을 이용한 심장이식술 및 심장관류 용액의 심보존 효과 비교

조광현,황윤호,이양행,류지윤,최영균 인제대학교 1996 仁濟醫學 Vol.17 No.4

한국산 황견을 이용한 심장이식 수술을 11회 시행하여 수술 전후의 혈역학적인 변화를 관찰하고 수술 수기의 숙달 및 준비과정의 문제점을 파악하는데 도움이 되고자 하였다. 심장관류 용액의 심보존 효과를 비교 관찰하기 위하여 각기 다른 2 종류의 심장 정지액 주입으로 황견의 심장을 정지시킨 후 심장을 절제하여 0℃에서 24시간 보존하면서 좌심실 근육조직 절편을 채취하여 고속 액체 크로마토그라피를 이용한 방법으로 ATP, ADP, AMP를 측정하였다. University of Wisconsin(이하 UW) 용액은 상온 단순 심정지 방법으로, St. Thomas 용액은 인공 심폐기를 이용한 전신 저체온법을 함께 사용하였다. ATP 농도는 UW 용액에서 St. Thoms 용액보다 2, 4, 8, 12 시간대에서 높게 유지되었으며 ADP 농도도 역시 UW 용액이 4시간대 이후에 높은 수치를 보였다. AMP 농도는 두용액 사이에 의미있는 차이를 보이지 않았다. Eleven cases of orthotopic cardiac transplantations were performed using 33 mongrel dogs. The main causes of death were pulmonary edema and bleeding at anastomotic site. To compare the efficacy of cardiac preservation, purine metabolites(ATP, ADP, AMP) were examed during 24 hours of cold storage(0℃) of the mongrel dog hearts after using two different types of cardioplegic solutions. The hypothermic arrest with total cardiopulmonary bypass method was employed in St. Thomas solution preservation cases. Left ventricular myocardial specimens were obtained after 0.5, 2, 4, 8, 12, and 24 hours at 0℃, and stored at -75℃ deep freezer until analysis. Specimens were analyzed for levels of adenine nucleotides by high performance liquid chromatography. The ATP content in the UWS (University of Wisconsin solution) group tends to be higher than that of the combined hypothermic arrest STS(St. Thomas solution) group after 2, 4, 8, and 12 hours of preservation respectively. The ADP content in the UWS group was higher than that of the STS group at 4, 8, 12, and 24 hours. The AMP contents did not change significantly in the two groups. These results strongly suggests that although UW solution did not provide satisfactory long-term preservation of heart, UWS group is better than STS group with hypothermic arrest method.

Selection and Analysis of Genomic Sequence-Derived RNA Motifs Binding to C5 Protein

Kim, Kwang-sun,Ryoo, Hye-jin,Lee, June-Hyung,Kim, Mee-hyun,Kim, Tae-yeon,Kim, Yool,Han, Kook,Lee, Seol-Hoon,Lee, Young-hoon Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.5

Escherichia coli RNase P is a ribonucleoprotein composed of M1 RNA and C5 protein. Previously, analysis of RNA aptamers selected for C5 protein from a synthetic RNA library showed that C5 protein could bind various RNA molecules as an RNA binding protein. In this study, we searched cellular RNA motifs that could be recognized by C5 protein by a genomic SELEX approach. We found various C5 protein-binding RNA motifs derived from E. coli genomic sequences. Our results suggest that C5 protein interacts with various cellular RNA species in addition to M1 RNA.

HEVC 영상 코덱을 위한 SAO 부호기의 ASIC 설계

조현표(Hyun-Pyo Cho),박승용(Seung-Yong Park),류광기(Kwang-Ki Ryoo) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-

본 논문에서는 HEVC(High Efficiency Video Coding) 영상 코덱을 위한 SAO(Sample Adaptive Offset) 부호기의 ASIC(Application Specific Integrated Circuit) 설계 구조를 제안한다. SAO는 HEVC 표준에서 새롭게 채택된 루프 내 필터 기술 중 하나이다. 기존 SAO 수행 방법은 화소 단위 연산을 수행하여 초고해상도 영상을 처리하기 위해 많은 연산시간과 연산량이 소요된다. 본 논문에서 제안하는 SAO 부호기의 ASIC 설계 구조는 SAO의 연산시간 및 연산량을 줄이기 위해 4개의 화소들을 병렬적으로 처리하며, 화소를 분류하고 율-왜곡 최적화를 통하여 최적의 SAO 파라메터를 결정하는 작업과 SAO 파라메터를 통해 복원 영상을 보상하는 작업을 2단계 파이프라인 구조로 구현하였다. 또한 메모리 접근 사이클을 최소화하고 입력 화소를 효율적으로 처리하기 위해 three-layered buffer 구조를 사용하고, 하드웨어 면적을 최소화하기 위해 SAO 수행 시 영상의 휘도 성분과 색차 성분에 대하여 단일 경로 구조를 갖는다. 제안하는 SAO 부호기 구조는 Verilog HDL로 설계하였으며, TSMC 0.13μ m CMOS 표준 셀 라이브러리를 사용하여 합성한 결과 약 190K개의 게이트로 구현되었다. 제안하는 SAO 부호기는 200MHz의 동작주파수에서 4K UHD@60fps 영상을 실시간으로 처리 가능하며, 최대 250MHz까지 동작 가능하다.