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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
Rodgers, Mary A.,Bowman, James W.,Fujita, Hiroaki,Orazio, Nicole,Shi, Mude,Liang, Qiming,Amatya, Rina,Kelly, Thomas J.,Iwai, Kazuhiro,Ting, Jenny,Jung, Jae U. The Rockefeller University Press 2014 The Journal of experimental medicine Vol.211 No.7
<P>Linear ubiquitination is a newly discovered posttranslational modification that is currently restricted to a small number of known protein substrates. The linear ubiquitination assembly complex (LUBAC), consisting of HOIL-1L, HOIP, and Sharpin, has been reported to activate NF-κB–mediated transcription in response to receptor signaling by ligating linear ubiquitin chains to Nemo and Rip1. Despite recent advances, the detailed roles of LUBAC in immune cells remain elusive. We demonstrate a novel HOIL-1L function as an essential regulator of the activation of the NLRP3/ASC inflammasome in primary bone marrow–derived macrophages (BMDMs) independently of NF-κB activation. Mechanistically, HOIL-1L is required for assembly of the NLRP3/ASC inflammasome and the linear ubiquitination of ASC, which we identify as a novel LUBAC substrate. Consequently, we find that HOIL-1L<SUP>−/−</SUP> mice have reduced IL-1β secretion in response to in vivo NLRP3 stimulation and survive lethal challenge with LPS. Together, these data demonstrate that linear ubiquitination is required for NLRP3 inflammasome activation, defining the molecular events of NLRP3 inflammasome activation and expanding the role of LUBAC as an innate immune regulator. Furthermore, our observation is clinically relevant because patients lacking HOIL-1L expression suffer from pyogenic bacterial immunodeficiency, providing a potential new therapeutic target for enhancing inflammation in immunodeficient patients.</P>
Janise E. Rodgers,Stephen A. Mahin 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.1
In the years since the 1994 Northridge earthquake, the profession has paid significant attention to the potential effects of various forms of deterioration in connection strength and stiffness that steel moment-resisting frames can experience during severe seismic excitations. The brittle connection fractures that a number of welded steel moment-resisting frame structures experienced during recent earthquakes have been the most extensively studied to date. However, cyclic testing of post-Northridge beam-column connections demonstrates that ductile connections may suffer other forms of deterioration. Negative post-yield tangent stiffness or capping, hereafter referred to as deformation softening, is a behavior of particular interest because it may have significant adverse effects on frame system behavior. The effects of deformation softening on frames subjected to pulse excitations were examined as part of an integrated experimental and analytical investigation of the effect of various forms of hysteretic deterioration on the overall system behavior of moment resisting steel frames. Pulse excitations, and the near-field ground motions they represent, can be highly damaging to structures and are therefore the primary focus of the results presented in this paper. The experimental portion of this study consisted of a series of thirty-two shaking table tests, which were performed on a one-third scale, two-story, one bay, steel moment frame with idealized, mechanical connections. These tests and subsequent analytical studies show that, in general, significant loss of connection strength capacity, whether from deformation softening or other types of deterioration, leads to large residual drifts and, for large pulse excitations with durations longer than the fundamental period of the structure, to collapse. In particular, frames with connections exhibiting negative post-yield stiffness tend to have substantially increased peak and residual displacements when subjected to pulse excitations.
Analog active valve control design for non-linear semi-active resetable devices
Geoffrey W. Rodgers,J. Geoffrey Chase,Sylvain Corman 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.5
Semi-active devices use the building\'s own motion to produce resistive forces and are thus strictly dissipative and require little power. Devices that independently control the binary open/closed valve state can enable novel device hysteresis loops that were not previously possible. However, some device hysteresis loops cannot be obtained without active analog valve control allowing slower, controlled release of stored energy, and is presents an ongoing limitation in obtaining the full range of possibilities offered by these devices. This in silico study develops a proportional-derivative feedback control law using a validated nonlinear device model to track an ideal diamond-shaped force-displacement response profile using active analog valve control. It is validated by comparison to the ideal shape for both sinusoidal and random seismic input motions. Structural application specific spectral analysis compares the performance for the non-linear, actively controlled case to those obtained with an ideal, linear model to validate that the potential performance will be retained when considering realistic nonlinear behaviour and the designed valve control approach. Results show tracking of the device force-displacement loop to within 3-5% of the desired ideal curve. Valve delay, rather than control law design, is the primary limiting factor, and analysis indicates a ratio of valve delay to structural period must be 1/10 or smaller to ensure adequate tracking, relating valve performance to structural period and overall device performance under control. Overall, the results show that active analog feedback control of energy release in these devices can significantly increase the range of resetable, valve-controlled semi-active device performance and hysteresis loops, in turn increasing their performance envelop and application space.
Estimation of the Impact of Devaluation on Indonesian Aggregate Trade Performance
( Yana Van Der Meulen Rodgers ) 세종대학교 경제통합연구소 1995 Journal of Economic Integration Vol.10 No.4
This study evaluates the relationship between the real exchange rate and Indonesia`s aggregate trade performance between 1975 and 1990. I estimate structural import and export functions that are consistent with traditional empirical trade models, in which a rupiah devaluation leads rupiah import and export prices to increase relative to domestic prices. The study provides the first Indonesian import demand elasticity estimates, and it offers more precisely estimated non-oil export supply elasticities than previous work. Results add to the body of evidence that supports devaluation`s use in dampening imports and stimulating exports.
Automated electrospray ionization FT-ICR mass spectrometry for petroleum analysis
Kim, Sunghwan,Rodgers, Ryan P.,Blakney, Greg T.,Hendrickson, Christopher L.,Marshall, Alan G. Springer-Verlag 2009 Journal of the American Society for Mass Spectrome Vol.20 No.2
<P>Analysis of petroleum samples at the molecular level by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) typically requires a prolonged accumulation of ions and/or summing up a large number of scans. Here, a chip-based micro-ESI system (Advion NanoMate, Ithaca, NY) has been successfully automated in combination with FT-ICR MS analysis of petroleum samples. A foil-sealed 96-well glass plate prevents solvent evaporation, with no visible loss of sample after 20 h of continuous operation. Mass spectra obtained from the same sample but taken from different wells after various time delays were very similar. Data from replicate samples in different wells could be combined to enhance mass spectral signal-to-noise ratio and dynamic range. Furthermore, the automated data acquisition eliminates sample carryover, and produces heteroatom class distribution, double-bond equivalents (DBE), and carbon number very similar to those from the conventional (manual) micro-ESI experiments.</P>