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Ri-Young Goh,김성현,한진영 대한혈액학회 2011 Blood Research Vol.46 No.1
Background :Chimerism analysis is an important tool for assessing the origin of hematopoietic cells after allogeneic stem cell transplantation (allo-SCT) and can be used to detect impending graft rejection and the recurrence of underlying malignant or nonmalignant diseases. Methods :This study included 24 patients who underwent myeloablative allo-SCT. DNA was extracted from nucleated cells (NCs), T cells, and natural killer (NK) cells, and the chimerism status of these cell fractions was determined by STR-PCR performed using an automated fluorescent DNA analyzer. Results :Twenty-three out of the 24 patients achieved engraftment. Mixed chimerism (MC) in NCs, but not in T cells and NK cells, was significantly correlated with disease relapse. MC in all cell fractions was correlated with mortality. Ten patients (41.6%) developed extensive chronic GVHD. Six patients had MC in T cells, and 3 of them had chronic GVHD. Four patients with MC and relapse received donor lymphocyte infusion (DLI), and among them, 3 had secondary relapse. Further, the chimerism status differed among different cell lineages in 6 patients with myeloid malignancies. Conclusion :The implications of MC in lymphocyte subsets are an important area for future research. Chimerism analysis in lineage-specific cells permits detection of relapse and facilitates the monitoring of therapeutic interventions. These results can provide the basic data for chimerism analysis after myeloablative SCT.
Kim, Boram,Quan, Mei-Lian,Goh, Ri-Young,Kim, Ji-Eun,Woo, Kwang-Sook,Kim, Moo-Hyun,Han, Jin-Yeong American Society for Clinical Pathology 2013 Laboratory medicine Vol.44 No.4
<P><B>Objective:</B></P><P>The aim of this study was to investigate the performance and feasibility of the rotational thromboelastometry (ROTEM) profile by comparing prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) results with ROTEM parameters.</P><P><B>Methods:</B></P><P>We tested external TEM (EXTEM)– and internal TEM (INTEM)–activated determinations, mainly focusing on 5 basic parameters: Clotting time (CT), clot formation time (CFT), α angle, clot formation rate (CFR), and maximum clot firmness (MCF). We then compared PT and APTT results with ROTEM parameters.</P><P><B>Results:</B></P><P>We observed no significant correlations between any of the ROTEM EXTEM or INTEM parameters and PT results. Similarly, only 1 parameter, the INTEM CT value, was significantly correlated with APTT results (<I>r</I><SUP>2</SUP> = 0.165, <I>P</I> <.05).</P><P><B>Conclusion:</B></P><P>Much work is still needed to further evaluate ROTEM assay results stemming from clinical scenarios and standard laboratory testing.</P>
Shuhua Li,최재임,Long Zhe Guo,Ri-Young Goh,김보람,우광숙,김무현,한진영 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.1
Background: An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200 System; Siemens Healthcare, Germany) P2Y test. Methods: Polymorphisms of CYP2C19*2, *3, *17 and the degree of inhibition of platelet function were determined in 83 patients. Three different platelet function tests were used to evaluate the degree of platelet inhibition and to check the association with genotype. Results: The post-procedure PFA-200 values of extensive metabolizers (EM) patients (285.3±38.8) were higher than those of intermediate metabolizers (IM) and poor metabolizers (PM) patients (227.7±98.3 and 133.7±99.2, respectively; P=0.024). Light transmittance aggregometry (LTA) and the VerifyNow system showed that the post-procedure values for EM patients were lower than those of IM and PM patients (LTA: 24.4±15.7, 34.1±17.6, and 42.2±16.9, respectively, P<0.001; VerifyNow: 133.2±60.5, 171.5±42.6, and 218.7±59.3, respectively, P<0.001). The high residual platelet reactivity (HPR) rates were significantly different among the EM, IM, and PM groups using PFA-200 (PM:IM:EM=82.4:40.6:11.8, P<0.001). Conclusions: Approximately, 59.0% of Korean patients with cardiovascular disease receiving clopidogrel had CYP2C19 loss-of-function genotypes classified as IM or PM, and the frequency was similar to the data from Asian people. The PFA-200, LTA, and VerifyNow platelet function tests revealed evidence of a significant association between the efficacy of clopidogrel and CYP2C19 genotypes.
Platelet Activation: The Mechanisms and Potential Biomarkers
Yun, Seong-Hoon,Sim, Eun-Hye,Goh, Ri-Young,Park, Joo-In,Han, Jin-Yeong Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this review, we discuss recent advances in the pathways of platelet activation and potential application of platelet activation biomarkers to diagnosis and prediction of disease states.</P>
베체트씨병에 동반된 복부 대동맥 동맥류의 스텐트 삽입술 1 예 : Treatment with Endovascular Stent Graft
허웅,안정수,황지영,김현지,강보리,나현희,이건주,변영섭,고충원,이병권 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1
Behcet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcer, genital ulcers, ocular manifestations, and skin lesions. Large-vessel involvement of both arterial and venous system appears in 7-29% of patients, and it is major cause of morbidity and mortality. Venous involvement, including superficial thrombophlebitis and deep vein thrombosis, is more frequent. Arterial manifestations occurs infrequently and presents with aortitis or arterial aneurysm and arterial thrombosis. Arterial aneurysms or occlusions which occur in the systemic or the pulmonary arterial bed are present in approximately 2 to 3% of patients with Behcet's disease and accounts for only 12% of vascular complication. Aneurysms are more frequent than occlusions and are mostly present in the pulmonary arteries and abdominal aorta. They have poor prognosis because of rupture with fatal outcome and surgical treatment is necessary. But, Surgical treatment often difficult and may lead to formation of further false aneurysms at the site of vascular anastomosis. Endovascular stent graft placement emerged as an alternative treatment that is less invasive with a lower risk. We experienced a case of abdominal aortic aneurysm in 36-year-old man with Behcet's disease. The patient was diagnosed by CT scan and treated with percutaneous endovascular stent graft.