Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer

Shin, S.J.,Kim, N.K.,Keum, K.C.,Kim, H.G.,Im, J.S.,Choi, H.J.,Baik, S.H.,Choen, J.H.,Jeung, H.C.,Rha, S.Y.,Roh, J.K.,Chung, H.C.,Ahn, J.B. Elsevier Science Publishers 2010 Radiotherapy and oncology Vol.95 No.3

Background and purpose: The aim of this study is to evaluate the efficacy and safety of preoperative radiation therapy combined with S-1 and irinotecan (SI) in LARC. Materials and methods: Patients were considered LARC if they had a T3/T4 lesion or node positive. Weekly doses of 40mg/m<SUP>2</SUP> irinotecan were intravenously administered once per week during weeks 1-5 of radiotherapy. S-1 (70mg/m<SUP>2</SUP>) was given from Monday to Friday in all weeks of radiotherapy. 3-D conformal radiotherapy was given at daily fractions of 1.8Gy for 5days for a total dose of 50.4 (45+5.4)Gy. Surgery was performed 4-6weeks following the completion of chemoradiation. Results: Between June 2006 and November 2007, 43 pts were enrolled. The stage was: cT3 24 patients, cT4 6 patients; 28 patients were cN+. Forty-one patients completed the chemoradiation and 42 patients underwent operation: a low anterior resection was performed in 36 patients, a total colectomy in 1 patient, and an abdominal perineal resection in 5 patients. T downstaging was observed in 50%; 23 N+ patients became N- (55%). The complete pathological response was observed in 9 patients (21%). The 3-year locoregional failure rate, distant failure rate, disease-free survival, and overall survival were 9.5%, 18.6%, 72.1%, and 94.3%, respectively. Only three patients experienced G3 diarrhea; one had G3 sepsis and two had septic shock. Hematological toxicity (G3-G4) was observed in five patients. Conclusions: This study demonstrated the efficacy of preoperative CRT with S-1 and irinotecan with 21% of complete response. However, prompt recognition and management of infection is needed to use it in patients with locally advanced rectal cancer.

A phase II study of S-1 monotherapy administered for 2 weeks of a 3-week cycle in advanced gastric cancer patients with poor performance status

Jeung, H-C,Rha, S Y,Shin, S J,Ahn, J B,Noh, S H,Roh, J K,Chung, H C Nature Publishing Group 2007 The British journal of cancer Vol.97 No.4

<P>Systemic chemotherapy for gastric cancer is often associated with treatment-related toxicity, which is particularly severe in patients with a poor performance status. In this paper, we describe the first study to evaluate S-1 monotherapy as an option for advanced gastric cancer patients who are not candidates for combination chemotherapy due to poor clinical condition. Fifty-two patients with Eastern Cooperative Oncology Group (ECOG) performance scale 2–3, whose general condition had made use of combination chemotherapy impossible, were enrolled. S-1 was administered to 30 patients as second- or third-line therapy. The initial dose of S-1 was 35 mg m<SUP>−2</SUP>, administered b.i.d for 14 days every 3 weeks. With a median follow-up period of 33 weeks, the median progression-free survival, and overall survival were 11 weeks (95% CI, 8–14) and 33 weeks (95% CI, 19–47), respectively. The overall 1-year survival rate was 29% by intent-to-treat analysis. The overall response rate was 12% (95% CI, 3–21), and the percentage of stable disease was 35%, resulting in the disease control rate of 47% (95% CI, 32–60). Significant drug-related toxicity included grade 3 diarrhoea (14%), anorexia (14%), fatigue (10%), neutropenia (10%), and leucopenia (6%). In conclusion, this study indicated the modest activity of S-1 in gastric cancer patients with poor performance status.</P>

한국의 정보통신 인프라 고도화 정책분석

이영로,김병초,나성욱,허정회 한국정보사회진흥원 2007 정보화정책 Vol.14 No.4

우리나라는 2002년 초고속인터넷 보급 1천만 가구 달성 이후, 현재까지 ITU, OECD 등 국제기구에서 우리나라를 세계 최고의 Broadband 강국으로 인정하고 있다. 한 국가의 발전에 있어서 인프라의 중요성은 매우 크며, 세계 최고를 기록한 사례는 우리나라 역사상 정보통신 인프라가 처음이다. 이는 지난 20년간 꾸준히 추진한 정보화 정책의 연장선상에서 이루어진 결과이며, 특히, 1994년 정보통신부 설립이후 1995년부터 2005년까지 지속적으로 추진된 초고속정보통신망 기반구축사업에 따른 결과이다. 정부의 일관되고 강력한 정책추진, 우리나라 고유의 사업모델, ADSL 방식의 기술선택, 학교와 농어촌 등 정보화 취약지역에 대한 우선투자, 정부의 선도적 투자로 인한 투자 선순환 구조 확립, 문화적∙환경적 특성 등이 주요 성공요인으로 꼽힌다. 현재의 초고속인프라는 완성단계이나, IPTV 등 통신∙방송 융합(Convergence), Giga 인터넷 서비스 등을 수용하기 위한 한 단계 높은 수준의 인프라 고도화가 요구되고 있어 계속적으로 세계적인 리더쉽을 갖추기 위한 새로운 전략 수립을 필요로 한다. With subscription to broadband Internet services reaching 10 million households in 2002, Korea has been dubbed the top broadband nation by international organizations such as ITU and OECD. National infrastructure plays a very important role in the industrial development of a nation. In particular, IT infrastructure has made Korea the world’s No. 1 for the first time in history. This is attributed to the informatization policy that has been constantly pursued for the last 20 years. In keeping with such informatization policy, the project on building the infra for high-speed communication network had been continuously carried out from 1995 to 2005 since the newly established Ministry of Information and Communications (MIC) in 1994. The government’s aggressive and relentless efforts to implement such policy, Korea's unique business model, selection of ADSL techniques for initial Infra deployment, high priority investment to isolated and vulnerable areas from IT distribution such as schools and rural districts, establishment of a pro-cyclical investment structure led by the government, and the country’s cultural and environmental characteristics are cited as the key success factors. Today, the construction of the high-speed infrastructure over the whole nation is nearly complete. The next step is upgrading the infrastructure by one notch to provide telecommunications and broadcasting convergence services such as IPTV, giga internet services. A new strategy that will enable Korea to sustain its global leadership in the IT field is also required.

A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer

Kang, Y-K,Rha, S Y,Tassone, P,Barriuso, J,Yu, R,Szado, T,Garg, A,Bang, Y-J Nature Publishing Group 2014 The British journal of cancer Vol.111 No.4

<P><B>Background:</B></P><P>Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab alone. Therefore, we conducted a phase IIa study of the pharmacokinetics and safety of pertuzumab plus trastuzumab and chemotherapy in advanced gastric cancer (aGC).</P><P><B>Methods:</B></P><P>Patients received pertuzumab 840 mg for cycle 1 and 420 mg q3w for cycles 2–6 (Arm A) or pertuzumab 840 mg q3w for six cycles (Arm B). Trastuzumab, cisplatin and capecitabine were also given for six cycles, then trastuzumab q3w until disease progression or unmanageable toxicity. The co-primary endpoints were day 43 pertuzumab serum trough concentration (<I>C</I><SUB>min</SUB>) and safety.</P><P><B>Results:</B></P><P>Thirty patients were randomised. Mean pertuzumab <I>C</I><SUB>min</SUB> at day 43 was 40.0 <I>μ</I>g ml<SUP>−1</SUP> (s.d.: 17.3) in Arm A and 62.7 <I>μ</I>g ml<SUP>−1</SUP> (29.1) in Arm B. Mean day 43 <I>C</I><SUB>min</SUB> in Arm A was ∼37% lower than that seen in metastatic breast cancer. The safety profiles were similar between arms and treatment was well tolerated. Partial responses were achieved by 86% and 55% of patients in Arms A and B, respectively.</P><P><B>Conclusions:</B></P><P>On the basis of the pharmacokinetic and safety data, the 840 mg q3w pertuzumab dose has been selected for a phase III study of pertuzumab, trastuzumab and chemotherapy in HER2-positive aGC.</P>

골반동통의 복강경 소견

정혁,이성동,나윤정,장하종,한세준,오세량 대한산부인과내시경학회 1991 대한산부인과내시경학회잡지 Vol.3 No.1

"Neurovascular Island Graft을 이용한 무지 재건술 -1예 보고-"

나수균,김연일,장세영,이병일,최창욱 순천향대학교 1988 논문집 Vol.11 No.1

The neurovascular island graft is an accepted method of restoring sensation to a localized tactile area on the hand. The procedure has been used to provide sensation to the volar surface of pedicle flaps on the thumb and to replace pulp tissue avulsed from the thumb or index finger. The patient had injured on right thumb by trauma and treated with autogenous bone graft and pedicle flap at local clinic, transferred at out department. We performed neurovascular island graft for defective sensibility of right thumb from the ulnar side of the right ring finger. In follow up for one year, recovery of protective sensation was good but reorientation of sensation was good but reorientation of sensation was poor.

10代에 發生한 胃癌의 1例

羅東錫,姜英俊,李武元,李泰熙 최신의학사 1966 最新醫學 Vol.9 No.2

巨大顆粒膜細胞腫의 1例

羅泰均,申慶子,張潤錫,李尙國,梁文浩,安亘煥 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.1

동측 하지에 병발한 다발성 골절

최완석,전병천,김연일,나수균,윤치순,최창욱,김학현 순천향대학교 1980 논문집 Vol.3 No.2

Twenty cases of simultaneous multiple fractures were managed from May 1975 to Dec. 1979. The management of fractures were divided into three groups: Group Ⅰ was treated with rigid internal or pin fixation (7 cases); Group Ⅱ treated with combination of conservative and surgical methods (9 cases) and Group Ⅲ treated with only conservative methods (4 cases). The results were as follows: 1. Male was affected more than female (M:F=1.5 : 1) and age range was between 14 to 72 years old. 2. There was a case of bilateral involvement. 3. The average time for fracture union in Group Ⅰ was shorter than other groups. 4. Complications in this series were 5 e.g., a case of joint stiffness in Group Ⅰ, one infection in Group Ⅱ and three cases (a delayed union, a malunion and an amputation) in Group Ⅲ.

동측 하지에 병발한 다발성 골절

최완석,전병천,김연일,나수균,윤치순,최창욱,김학현 순천향대학교 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2