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In vitro Free Radical Scavenging and Hepatoprotective Compound from Sanguisorbae Radix
Ren-Bo An,Yu-Hua Tian,Hyuncheol Oh,Youn-Chul Kim 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
In the course of searching for hepatoprotective agents from natural products, four compounds wereisolated from the MeOH extract of Sanguisorbae Radix, as guided by their DPPH free radical scavenging activity.The structures were determined as 4,5-dimethoxy-3-hydroxybenzoic acid methyl ester (1), (+)-gallocatechin (2),methyl 6-O-galloyl-β-D-glucopyranoside (3), and pomolic acid 3-O-[α O-[β-D-gluco-pyranosyl] ester (ziyu-glycoside I) (4). Compounds 2 and 3 showed significant DPPH fre radical scavengingefects, exhibiting IC50 values of 1.4 and 13.0M, respectively. L-Ascorbic acid was used as a positive controland exhibited the IC50 value of 50.3M. In evaluation of the hepatoprotective activity of the isolated compoundson drug-induced cytotoxicity, compound 2 50 value of91.84 ± 11.0M on tacrine-induced cytotoxicity in Hep G2 cells, while silybin, a positive control, exhibited EC50value of 122.4 ± 12.5M.
Coumarins and Chromones from Angelica genuflexa
Ren Bo An,Bo-Young Park,Jung-Hee Kim,Ok-Kyoung Kwon,Joongku Lee,Byung-Sun Min,Kyung-Seop Ahn,Sei-Ryang Oh,Hyeong-Kyu Lee 한국생약학회 2005 Natural Product Sciences Vol.11 No.2
Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gelcolumn chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin(4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and fourchromones, hamaudol (6 10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), wereidentified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 wereisolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examinedfor their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an IC50value of 390M.
Anti-complement Activity of Triterpenoids from the Whole Plant of Patrinia saniculaefolia
Ren-Bo An,나민균,이형규,배기환,민병선 한국생약학회 2008 Natural Product Sciences Vol.14 No.4
Two oleanane-type triterpenes (1, 2) and their glycosides (4 - 6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O-α-L-arabinopyranosyl-oleanolic acid (4), 3- O-β-D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[α-D-xylopyranosyl-(1→ 3)-β-D-glucuronopyranoside- 6-O-butyl-ester] (6) on the basis of their MS, ¹H-, and 13C-NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with IC50 values of 470.1, 212.2, and 121.0 μM, respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/ or ursane-triterpenes are important for the anti-complement activity against the classical pathway.
A New Monoterpene Glycoside and Antibacterial Monoterpene Glycosides from Paeonia suffruticosa
Ren-Bo An,Hyun-Chul Kim,이성희,정길생,Dong-Hwan Sohn,Hyun Park,권동렬,John Hwa Lee,김윤철 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.10
Antibacterial activity-guided fractionation of the CHCl3-MeOH (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to 500 μg/mL against eighteen pathogenic microorganisms of concern for public health or zoonosis.
Chromone Glycosides and Hepatoprotective Constituents of Hypericum erectum
Ren Bo An,Jin-Seon Beom,손동환,Youn Chul Kim,Gil Saeng Jeong 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
Two chromone glycosides, hyperimone A [7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(β-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC50 values of 160.2 ± 0.6 μM and 217.7 ± 1.3 μM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
In Vitro Hepatoprotective Compounds from Suaeda glauca
Ren-Bo An,Dong-Hwan Sohn,Gil-Saeng Jeong,Youn-Chul Kim 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-β-D-galactoside (3), and quercetin 3-O-β-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC50 values of 72.7±6.2 and 117.2±10.5 μM, respectively. Silybin as a positive control showed an EC50 value of 82.4±4.1 μM.
Anti-Inflammatory Activity of Compounds from the Whole Plant of Patrinia saniculaefolia
Ren Bo An,나민균,민병선,장현욱,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the whole plant of Patrinia saniculaefolia (Valerianaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin D2 (PGD2) and leukotriene C4 (LTC4) in mouse bone marrow-derived mast cells (BMMCs). Phytochemical study of the MeOH extract of this plant led to the isolation of twelve compounds; b-farnesene (1), squalene (2), nardostachin (3), patridoid I (4), patridoid II (5), patridoid II-A (6), oleanolic acid (7), oleanonic acid (8), 23-hydroxyursolic acid (9), oleanolic acid 3-O-a-L-arabinopyranoside (10), oleanolic acid 3-O-b-D-glucopyranoside (11), oleanolic acid 3-O-[b-D-xylopyranosyl-(1 → 3)-b-D-(6-O-butyl)glucuronopyranoside] (12). Among the compounds, 4 and 5 strongly inhibited both the COX-2-dependent PGD2 generation with IC50 values of 8.7 and 13.6 mM, respectively, and the generation of LTC4 in the 5-LOX dependent phase with IC50 values of 41.7 and 46.9 mM, respectively, which suggest that the anti-inflammatory activity of P. saniculaefolia might occur in part via the inhibition of both PGD2 and LTC4 generation by 4 and 5.
Free Radical Scavenging and Hepatoprotective Constituents from the Leaves of Juglans sinensis
Ren-Bo An,Hyun-Chul Kim,Yu-Hua Tian,Youn-Chul Kim 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.5
In the course of searching for hepatoprotective agents from natural products, six compounds were isolated from the MeOH extract of the leaves of Juglans sinensis, as guided by their DPPH free radical scavenging activity. The structures were determined as juglanoside B (1), quercetin 3-O-α-L-arabinofuranoside (avicularin, 2), quercetin 3-O-α-L-arabinopyranoside (guaijaverin, 3), quercetin 3-O-α-L-rhamnopyranoside (quercitrin, 4), (+)-catechin (5) and quercetin 3-O-β-D-galactopyranoside (hyperin, 6). Compounds 2-6 showed significant DPPH free radical scavenging effects. An evaluation for the hepatoprotective activity of the isolated compounds on drug-induced cytotoxicity was conducted, and compounds 1, 2, and 5 showed protective effects against nitrofurantoin-induced cytotoxicity, and compound 5 also exhibited a moderate protective effect on amiodarone-induced cytotoxicity in Hep G2 cells.