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Lim, Seong-in,Choe, SeEun,Kim, Ki-Sun,Jeoung, Hye-Young,Cha, Ra Mi,Park, Gil-Soon,Shin, Jihye,Park, Gyu-Nam,Cho, In-Soo,Song, Jae-Young,Hyun, Bang-Hun,Park, Bong-Kyun,An, Dong-Jun Elsevier Ltd. 2019 Vaccine Vol.37 No.27
<P><B>Abstract</B></P> <P>Here, we constructed an attenuated live marker classical swine fever (CSF) vaccine (Flc-LOM-BE<SUP>rns</SUP>) to eradicate CSF. This was done by taking infectious clone Flc-LOM, which is based on an attenuated live CSF vaccine virus (LOM strain), and removing the full-length classical swine fever virus (CSFV) E<SUP>rns</SUP> sequences and the 3′ end (52 base pairs) of the CSFV capsid. These regions were substituted with the full-length bovine viral diarrhoea virus (BVDV) E<SUP>rns</SUP> gene sequence and the 3′ end (52 base pairs) of the BVDV capsid gene. Sows were vaccinated with the Flc-LOM-BE<SUP>rns</SUP> vaccine 3 weeks before insemination and then challenged with virulent CSFV at the early, mid- or late stages of pregnancy. We then examined transplacental transmission to the foetuses. Piglets born to sows vaccinated with Flc-LOM-BE<SUP>rns</SUP> did not show vertical infection, regardless of challenge time. In addition, CSFV challenge did not affect the delivery date, weight or length of the foetus. Pregnant sows inoculated with the Flc-LOM-BE<SUP>rns</SUP> vaccine were anti-CSF E<SUP>rns</SUP> antibody-negative and anti-BVDV E<SUP>rns</SUP> antibody-positive. Challenge of pregnant sows with virulent CSFV resulted in anti-CSF E<SUP>rns</SUP> antibody positivity. These results strongly indicate that differential diagnosis can be conducted between the Flc-LOM-BE<SUP>rns</SUP> vaccinated animal and virulent CSFV affected animal by detecting antibody against BVDV E<SUP>rns</SUP> or CSF E<SUP>rns</SUP> gene. Therefore, the Flc-LOM-BE<SUP>rns</SUP> vaccine may fulfil the function of differential diagnosis which required for DIVA vaccine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Flc-LOM-BE<SUP>rns</SUP> is live attenuated DIVA vaccine for CSFV. </LI> <LI> The Flc-LOM-BE<SUP>rns</SUP> vaccine protected foetuses from vertical transmission. </LI> <LI> The Flc-LOM-BE<SUP>rns</SUP> vaccine enables differential identification of serum antibodies. </LI> </UL> </P>
Kang, Seong-Ho,Jin, Bo-Ra,Kim, Hyeon-Jin,Seo, Goo-Young,Jang, Young-Saeng,Kim, Sun-Jin,An, Sun-Jin,Park, Seok-Rae,Kim, Woan-Sub,Kim, Pyeung-Hyeun The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.1
It is well established that TGF-${\beta}1$ and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching in spleen B cells. The present study explored the effect of LF on the Ig production by mouse peritoneal B cells. LF, like TGF-${\beta}1$, substantially increased IgA production in peritoneal B1 cells but little in peritoneal B2 cells. In contrast, LF increased IgG2b production in peritoneal B2 cells much more strongly than in peritoneal B1 cells. LF in combination with RA further enhanced the IgA production and, interestingly, this enhancement was restricted to IgA isotype and B1 cells. Similarly, the combination of the two molecules also led to expression of gut homing molecules ${\alpha}4{\beta}7$ and CCR9 on peritoneal B1 cells, but not on peritoneal B2 cells. Thus, these results indicate that LF and RA can contribute to gut IgA response through stimulating IgA isotype switching and expression of gut-homing molecules in peritoneal B1 cells.
Evolutionary dynamics of classical swine fever virus in South Korea: 1987–2017
An, Dong-Jun,Lim, Seong-in,Choe, SeEun,Kim, Ki-Sun,Cha, Ra Mi,Cho, In-Soo,Song, Jae-Young,Hyun, Bang-Hun,Park, Bong-Kyun Elsevier 2018 Veterinary microbiology Vol.225 No.-
<P><B>Abstract</B></P> <P>The 5′ UTR (n=102) and full-length E2 (n=37) genes of classical swine fever viruses (CSFVs) circulating in South Korea over the past 30 years (1987–2017) were examined to determine the evolutionary rate and estimated time of the most recent common ancestor (tMRCA). From 2000, the Korean classical swine fever (CSF) antigen changed from genotype 3 to 2, which comprises subgenotypes 2.1b (2002–2013) and 2.1d (2011–2017). There are genotypic variations in the full-length E2 gene of Korean CSFV genotypes 2.1b and 2.1d (seven separate amino acid substitutions); these are useful distinguishing markers. The mean substitution rate (×10<SUP>3</SUP> substitutions/site/year) for Korean CSFV was estimated to be 2.2088 (95% highest posterior density (HPD): lower, 1.7045; upper, 2.7574) and the mean tMRCA was estimated to be 1901 (95% HPD: lower, 1865; upper, 1933). The effective population size of Korean CSFV genotype 2 increased rapidly from 2002 to 2003, after which it remained constant. The occurrence of CSF in Korea is expected to decline in the future; however, it will likely be more prevalent in wild boar than in domestic pigs. Thus, there is a risk of transmission from wild boar to breeding pigs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> From 2000, Korean CSFV changed from genotype 3 to 2 (subgenotypes 2.1b and 2.1d). </LI> <LI> Subgenotype 2.1d(prevalent in Korea) was detected in wild boar and breeding pigs. </LI> <LI> The mean substitution rate for circulating Korean CSFVs is 2.2114(×10<SUP>−3</SUP> s/s/y). </LI> </UL> </P>
이유라(You-Ra Lee),신정호(Jong-Ho Shin),민성호(Seong-Ho Min),김태희(Tae-Hui Kim),김민혁(Min-Hyuck Kim),장형민(Hyung-Min Chang),박기창(Ki-Chang Park),안정숙(Joung-Sook Ah),전영안(Yong-An Jeon),장지숙(Jee-Sook Jang) 한국중독정신의학회 2005 중독정신의학 Vol.9 No.1
Objectives:This study was designed to find out the changes of alcohol use behavior and it’s attributing factors through two surveys conducted in 1998 and 2004 in a rural community. Methods:We selected 116 problem drinkers and 116 matched non-problem drinkers among 480 men of the first survey. We surveyed basic epidemiologic data and alcohol use behavior with several questionnaires. Results:The results were as follows : 1) Drinking amount and frequency decreased with increasing age. 2) More than half among previous problem drinkers did not show any significant change in their alcohol use behavior. 3) Most of previous non-problem drinkers maintained their past alcohol use behavior. 4) Continuous problem drinkers had larger amount of past alcohol drinking than no more problem drinkers. They had lower scores on awareness of negative consequence, higher scores on drinking for coping strategy of Alcohol Effects Questionnaire (AEQ) and higher scores on drinking urge to relieve hangover of the Severity of Alcohol Dependence Questionnaire (SADQ) than no more problem drinkers. 5) Continuous problem drinkers showed more smoking and earlier drinking than continuous non-problem drinkers. 6) Continuous problem drinkers became poorer than no more problem drinkers. Conclusions: Continuous problem drinking pattern was associated with larger amount of past alcohol drinking, higher drinking frequency, higher drinking urge to relieve hangover, higher use of drinking for coping strategy and less awareness of negative consequence.