http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Qian Dang (검색결과 10 건)
- 무료
- 기관 내 무료
- 유료
-
Reactivity of poly(dimethylsiloxane) toward acidic permanganate
Dang, T.D.,Cheney, M.A.,Qian, S.,Joo, S.W.,Min, B.K. Korean Society of Industrial and Engineering Chemi 2013 Journal of industrial and engineering chemistry Vol.19 No.6
Poly(dimethylsiloxane) (PDMS) has been widely used in various microfluidic devices because it is considered to be one of the most inert materials available. A PDMS-based microfluidic system for the synthesis of manganese oxide (MO) nanoparticles is developed and tested. However, synthesis of MO nanoparticles in the PDMS-based microfluidic system is unsuccessful due to an unexpected reaction between acidic permanganate and PDMS. PDMS is pitted and coated with MnO<SUB>2</SUB> and opalized silica, which are confirmed by SEM and EDX. The products of the reaction between PDMS and acidic permanganate are mainly MnO<SUB>2</SUB>, Cl<SUB>2</SUB>, SiO<SUB>2</SUB> and CO<SUB>2</SUB>, respectively. Here we report for the first time the reactivity of PDMS toward acidic permangante resulting in a new process to coat the channel walls with MnO<SUB>2</SUB>.
-
Dang, Trung-Dung,Cheney, Marcos A.,Qian, Shizhi,Joo, Sang Woo,Min, Bong-Ki American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.7
<P>We report for the first time a novel rapid synthesis method for manganese oxide (MO) nanoparticles by a reaction between acidic permanganate and poly(dimethylsiloxane) (PDMS). In contrast to the existing traditional methods for synthesis of MO nanoparticles, the new method has the advantage of shorter reaction time (∼2 h) at room temperature (∼25 °C). The produced MO nanoparticles are characterized with X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM, HRTEM). The material produced is semicrystalline silicon-doped MnO<SUB>2</SUB> with homogeneous size and morphology with an average particle size around 300 nm. Other products of the reactions include Cl<SUB>2</SUB>, silicon dioxide sheets on PDMS, and CO<SUB>2</SUB>. A mechanism for this reaction is proposed. The prepared MO was successfully used as a catalyst for the rapid and highly efficient degradation of a water pollutantRhodamine B (RhB).</P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ie302971g'>ACS Electronic Supporting Info</A></P>
-
Ionic Liquids as Selectors for Controlling the Crystallization Nucleation of Hen Egg White Lysozyme
Zhanzhong Wang,Qian Wang,Leping Dang 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.5
Ionic liquids (ILs) have biomaterial applications and are used for protein crystallization. The effect of two imidazolium-based ILs, 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) and 1,3-dimethylimidazolium iodide ([dmim]I),on the nucleation kinetics of lysozyme was investigated by determining the nucleation induction time, and nucleation parameters were evaluated. The values of interfacial tension calculated for solutions with added 30 g/L ILs [C4mim]Cl and [dmim]I, and without added ILs were 99.03, 109.7, and 107.3 mJ/m2, respectively. Compared with solutions without IL addition, the critical free energy change, size, and molecular number of critical nuclei decreased and the nucleation rate increased after the addition of [C4mim]Cl. In contrast, the critical free energy change, size, and molecular number of critical nuclei increased and the nucleation rate decreased after the addition of [dmim]I. These new findings provide insights into controlling lysozyme crystallization separation, and present ILs as potentially useful additives for controlling the crystallization of macromolecules.
-
Chen, Xun,Zhang, Wentao,Zhang, Qian,Song, Tao,Yu, Zirui,Li, Zhong,Duan, Ning,Dang, Xiaoqian Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.6
Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.
-
Xinyu Hu,Shijie Li,Xiaoqing Dang,Yufei Zhang,Qian Zhang,Huachun Zheng 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
DBD-catalytic system has been widely studied for volatile organic compounds abatement, whereas howto obtain high mineralization rate and low zone emission synchronously remains a challenge. In view ofthis, a new type of multi-stage DBD-catalytic system (MS1) was established to abatement toluene in thisstudy. The mineralization rates of reactors IPC (63.81%) and MS1 (61.14%) were much higher than MS2,PPC1 and PPC2 reactors, which were 48.36%, 46.84%, and 5.8% at 33.8 (Vp-p) kV, respectively. For exportozone concentration, IPC reactor had the highest concentration of 160 ppm, and the values of reactorsMS1, MS2, PPC1, and PPC2 were 79, 34.2, 34.25 and 29 ppm, respectively. The catalyst filled in zone IIcan be utilized to further decompose the residual toluene and intermediates and also promote thedecomposition of ozone, which lead to the superior performance of the MS1 reactor. The influence ofapplied voltage, adsorbed amount, and discharge time on the toluene removal performance was investigatedto optimize the operation parameters of MS1 reactor, their appropriate values were 28.3–31.1 (Vpp)kV, 0.179–0.223 mmol, 1 h, respectively. Lastly, the contribution of disparate zones in multi-stageDBD-catalytic system to the toluene degradation were elucidated on the basis of the GC–MS results.
-
A Source Code Cross-site Scripting Vulnerability Detection Method
Mu Chen,Lu Chen,Zhipeng Shao,Zaojian Dai,Nige Li,Xingjie Huang,Qian Dang,Xinjian Zhao 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.6
To deal with the potential XSS vulnerabilities in the source code of the power communication network, an XSS vulnerability detection method combining the static analysis method with the dynamic testing method is proposed. The static analysis method aims to analyze the structure and content of the source code. We construct a set of feature expressions to match malignant content and set a "variable conversion" method to analyze the data flow of the code that implements interactive functions. The static analysis method explores the vulnerabilities existing in the source code structure and code content. Dynamic testing aims to simulate network attacks to reflect whether there are vulnerabilities in web pages. We construct many attack vectors and implemented the test in the Selenium tool. Due to the combination of the two analysis methods, XSS vulnerability discovery research could be conducted from two aspects: “white-box testing” and “black-box testing”. Tests show that this method can effectively detect XSS vulnerabilities in the source code of the power communication network.
-
Xue‑Lian Song,Fei‑Fei Zhang,Wen‑Jing Wang,Xin‑Ning Li,Yi Dang,Ying‑Xiao Li,Qian Yang,Mei‑Jing Shi,Xiao‑Yong Qi 한국유전학회 2020 Genes & Genomics Vol.42 No.12
Background: Myocardial ischemia and reperfusion injury (MI/RI) is a complex pathophysiological process, which can lead to severe myocardial injury. The long noncoding RNA alpha-2-macroglobulin antisense RNA 1 (A2M-AS1) has been revealed to be abnormally expressed in MI, However, its function in MI and the potential mechanism are still unclear. Objective: To evaluate the functional role of A2M-AS1 in hypoxia/reoxygenation (H/R)-induced neonatal cardiomyocytes and its potential molecular mechanism. Methods: Dataset GSE66360 was obtained from GEO database for analyzing the RNA expression of A2M-AS1 and interleukin 1 receptor type 2 (IL1R2). KEGG pathway enrichment analysis of the genes that co-expressed with A2M-AS1 was performed. Human neonatal cardiomyocytes were subjected to H/R to construct in vitro models. QRT-PCR and Western blot were adopted to test the levels of mRNA and protein. The viability and apoptosis of cardiomyocytes were tested by CCK-8 and flow cytometry assays, respectively. Results: The expression of A2M-AS1 was notably downregulated in H/R-treated cardiomyocytes. Overexpression of A2M-AS1 can notably enhance the cell viability of H/R-damaged cardiomyocytes, whereas knockdown of A2M-AS1 showed the opposite outcomes. Besides, a negative correlation was showed between A2M-AS1 and IL1R2 expression. In H/R-treated cardiomyocytes, overexpression of IL1R2 weakened the promoting proliferation and anti-apoptosis effects caused by overexpressing A2M-AS1, however, IL1R2-knockdown abolished the anti-proliferation and pro-apoptosis effects caused by silencing A2M-AS1. Conclusion: This study demonstrates the potential regulatory role of A2M-AS1/ IL1R2 axis in cardiomyocytes suffered from H/R, and provides insight into the protection of MI/RI.
-
Nomogram for predicting overall survival in children with neuroblastoma based on SEER database
Song-Wu Liang,Gang Chen,Yi-Ge Luo,Peng Chen,Jin-Han Gu,Qiong-Qian Xu,Yi-Wu Dang,Li-Ting Qin,Hui-Ping Lu,Wen-Ting Huang,Zhi-Guang Huang,Li Gao,Jia-Bo Chen 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.2
Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma. Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram. Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves. Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.
-
Diabetes Promotes Myocardial Fibrosis via AMPK/EZH2/PPAR-γ Signaling Pathway
Shan-Shan Li,Lu Pan,Zhen-Ye Zhang,Meng-Dan Zhou,Xu-Fei Chen,Ling-Ling Qian,Min Dai,Juan Lu,Zhi-Ming Yu,Shipeng Dang,Ru-Xing Wang 대한당뇨병학회 2024 Diabetes and Metabolism Journal Vol.48 No.4
Background: Diabetes-induced cardiac fibrosis is one of the main mechanisms of diabetic cardiomyopathy. As a common histone methyltransferase, enhancer of zeste homolog 2 (EZH2) has been implicated in fibrosis progression in multiple organs. However, the mechanism of EZH2 in diabetic myocardial fibrosis has not been clarified.Methods: In the current study, rat and mouse diabetic model were established, the left ventricular function of rat and mouse were evaluated by echocardiography and the fibrosis of rat ventricle was evaluated by Masson staining. Primary rat ventricular fibroblasts were cultured and stimulated with high glucose (HG) <i>in vitro</i>. The expression of histone H3 lysine 27 (H3K27) trimethylation, EZH2, and myocardial fibrosis proteins were assayed.Results: In STZ-induced diabetic ventricular tissues and HG-induced primary ventricular fibroblasts in vitro, H3K27 trimethylation was increased and the phosphorylation of EZH2 was reduced. Inhibition of EZH2 with GSK126 suppressed the activation, differentiation, and migration of cardiac fibroblasts as well as the overexpression of the fibrotic proteins induced by HG. Mechanical study demonstrated that HG reduced phosphorylation of EZH2 on Thr311 by inactivating AMP-activated protein kinase (AMPK), which transcriptionally inhibited peroxisome proliferator-activated receptor γ (PPAR-γ) expression to promote the fibroblasts activation and differentiation.Conclusion: Our data revealed an AMPK/EZH2/PPAR-γ signal pathway is involved in HG-induced cardiac fibrosis.
-
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
