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An Evaluation of Assessing the Functional Movement Screen™ from Video Playback
Matthew D Portas,Daniel Meek,Warren Gregson,Barry Drust 한국코칭능력개발원 2015 International Journal of Coaching Science Vol.9 No.2
The study aimed to evaluate the method comparison and intra-rater test-retest reliability of the Functional Movement Screen when assessed by real-time and video playback. Eighteen participants (Age: 22 ± 2 years, Height: 1.77 m ± 0.10 m, Weight: 78.2 ± 11.5 kg, 15 males and 3 females), participated. Participants were scored during the screen in real-time by an experienced coach. Each screen was also video recorded in the frontal and sagittal plane. The coach then scored each FMS via video, in a randomised order, 3 days (video-1) and 7 days later (video-2). Median and interquartile range were calculated for the group score in each assessment. The weighted kappa statistic, percentage of agreement and bias were then calculated for each FMS test.. The median (interquartile ranges) for the group FMS score was 16.0 (15.0 and 17.0) for the live assessment; 16 (14.0 and 17.0) for video-1 and 16 (13.8 and 17.0) for video-2. The mean (SD) agreement across all tests live compared to video was 87.4% (11.1) with a weighted kappa statistic of 0.9 (0.1) (almost perfect). These results provide guidance for the interchangeably of these techniques in practice and confirm the legitimacy of the approach for the previous work that used video to assess reliability of measurement.
Soft biometrics through hand gestures driven by visual stimuli
Nahumi Nugrahaningsih,Marco Porta 한국통신학회 2019 ICT Express Vol.5 No.2
We present a novel biometric solution which exploits hand gestures, tracked by the Microsoft Kinect sensor, performed in response to a circle randomly appearing in five predefined screen positions. Features of both hand and screen pointer are used for classification purposes, considering both the whole 20-path trajectory and shorter routes. In particular, we search for the “optimal” trajectory length which assures a good trade-off between precision and user effort. For identification, the approach achieves classification accuracies ranging from 0.748 to 0.942. For verification, accuracy is still satisfactory (always higher than 0.962), despite moderate specificity values.
Neurotoxic chemicals in adipose tissue : A role in puzzling findings on obesity and dementia
Lee, Duk-Hee,Porta, Miquel,Lind, Lars,Lind, P. Monica,Jacobs Jr., David R. Ovid Technologies (Wolters Kluwer) - American Acad 2018 Neurology Vol.90 No.4
<P>Midlife obesity is associated with increased risk of dementia, whereas late-life obesity is commonly associated with a lower risk of dementia. Although methodologic issues are often discussed in this apparent risk reversal, chronic exposure to low-dose organochlorine pesticides (OCPs), an emerging risk factor for dementia in general populations, may contribute to a direct explanation for these differences. OCPs are strong lipophilic chemicals with very long half-lives (several years), primarily stored in adipose tissue and very slowly released and metabolized over years. As serum concentrations of neurotoxic OCPs strongly correlate with brain OCPs (<I>r</I> = 0.95), any condition enhancing the release of OCPs from the adipose tissue into circulation would increase the risk of dementia. Increased release of OCPs from adipose tissue typically occurs in (1) dysfunctional adipocytes accompanied by uncontrolled lipolysis and (2) weight loss. Weight gain may help sequester circulating OCPs in adipose tissue. As obesity is the most common reason that adipocytes become dysfunctional, midlife obesity can increase dementia risk through the chronic release of OCPs into circulation. However, late-life obesity potentially decreases dementia risk because weight loss after midlife will increase the release of OCPs while weight gain may actually decrease the release. These countervailing forces may underlie paradoxical associations with dementia of obesity in midlife vs late life which is influenced by weight change after midlife. This hypothesis should be tested in future experimental and human studies on obesity and dementia.</P>
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Ding, Li,Bailey, Matthew H.,Porta-Pardo, Eduard,Thorsson, Vesteinn,Colaprico, Antonio,Bertrand, Denis,Gibbs, David L.,Weerasinghe, Amila,Huang, Kuan-lin,Tokheim, Collin,Corté,s-Ciriano, Isidro,J Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An overview of PanCancer Atlas analyses on oncogenic molecular processes </LI> <LI> Germline genome affects somatic genomic landscape in a pathway-dependent fashion </LI> <LI> Genome mutations impact expression, signaling, and multi-omic profiles </LI> <LI> Mutation burdens and drivers influence immune-cell composition in microenvironment </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Vitamin D: molecular mechanism of action.
Christakos, Sylvia,Dhawan, Puneet,Benn, Bryan,Porta, Angela,Hediger, Matthias,Oh, Goo T,Jeung, Eui-Bae,Zhong, Yan,Ajibade, Dare,Dhawan, Kopal,Joshi, Sneha New York Academy of Sciences 2007 Annals of the New York Academy of Sciences Vol.1116 No.1
<P>Vitamin D maintains calcium homeostasis and is required for bone development and maintenance. Recent evidence has indicated an interrelationship between vitamin D and health beyond bone, including effects on cell proliferation and on the immune system. New developments in our lab related to the function and regulation of target proteins have provided novel insights into the mechanisms of vitamin D action. Studies in our lab have shown that the calcium-binding protein, calbindin, which has been reported to be a facilitator of calcium diffusion, also has an important role in protecting against apoptotic cell death in different tissues including protection against cytokine destruction of osteoblastic and pancreatic beta cells. These findings have important implications for the therapeutic intervention of many disorders including diabetes and osteoporosis. Recent studies in our laboratory of intestinal calcium absorption using calbindin-D(9k) null mutant mice as well as mice lacking the 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inducible epithelial calcium channel, TRPV6, provide evidence for the first time of calbindin-D(9k) and TRPV6 independent regulation of active calcium absorption. Besides calbindin, the other major target of 1,25(OH)(2)D(3) in intestine and kidney is 25(OH)D(3) 24 hydroxylase (24(OH)ase), which is involved in the catabolism of 1,25(OH)(2)D(3). In our laboratory we have identified various factors that cooperate with the vitamin D receptor in regulating 24(OH)ase expression including C/EBP beta, SWI/SNF (complexes that remodel chromatin using the energy of ATP hydrolysis) and the methyltransferases, CARM1 and G9a. Evidence is also presented for C/EBP beta as a nuclear coupling factor that coordinates regulation of osteopontin by 1,25(OH)(2)D(3) and PTH. Our findings define novel mechanisms that may be of fundamental importance in understanding how 1,25(OH)(2)D(3) mediates its multiple biological effects.</P>
Effect of Annurca Apple Polyphenols on Human HaCaT Keratinocytes Proliferation
Stefania D’Angelo,Raffaele La Porta,Maria Napolitano,Patrizia Galletti,Lucio Quagliuolo,Mariarosaria Boccellino 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.11
Polyphenols have been demonstrated to have clear antioxidant activities in vitro. However, in complex biological systems, they exhibit additional properties, which are yet poorly understood. The apple is among the most consumed fruits worldwide, and several studies suggest that apple polyphenols could play a role in the prevention of degenerative diseases. The present study aimed at evaluating the Annurca apple polyphenol extract (APE) effects both proliferation and apoptosis on HaCaT cells. The data indicate that apple polyphenolic compounds had significant antiproliferative action on HaCaT cells. The fluorescence-activated cell-sorting analysis showed that APE induced cell apoptosis in a dose-dependent manner. Moreover, apple polyphenols induced apoptosis in epithelial cells by triggering a death receptor-associated extrinsic pathway p53-independent. APE was also capable of inducing morphological changes as evidenced by nuclear condensation. The cellular, morphological, and molecular data unequivocally demonstrated that induction of cellular apoptosis was mainly responsible for the previously observed antiproliferation-induced APE on HaCaT keratinocytes. Our experimental results suggest that apple polyphenols are a promising source from which a natural-based topical agent could be developed for skin diseases treatment.