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Erythromycin 내성 포도알균의 유도형 Macrolide-Lincosamide-Streptogramin B (MLS_(B)) 내성 표현형 빈도
김경희,박순호,박필환,안정열,서일혜 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Background: Inducible MLS_(B) (macrolide-lincosamide-streptogramin B) resistance in staphylococci is not detected by standard susceptibility test methods. Failure to identify inducible MLS_(B) resistance may lead to clinical failure during clindamycin therapy. We determined the prevalence of inducible MLS_(B) resistance in erythromycin-resistant staphylococcal isolates. Materials and Methods: We evaluated all 2,792 non-duplicate staphylococcal strains: 1,402 Staphylococcus aureus and 1,390 coagulase-negative staphylococci (CoNS) isolated from May 2008-June 2009 at one-unoversity hospital. Testing for inducible MLS_(B) was accomplished by the disk approximation test (D-test) in accordance with the recommendations of the Clinical and Laboratory Standards Institute (CLSI). Results: Of the 2,792 staphylococcal isolates, 892 S. aureus isolates and 740 CoNS isolates were resistant to erythromycin. Among the 892 erythromycin-resistant S. aureus isolates, the overall prevalence of inducible MLS_(B) was 21.3% (16.2% of MRSA and 76.3% of methicillin-susceptible S. aureus). Among the 740 erythromycinresistant CoNS isolates, the overall prevalence of inducible MLS_(B) was 16.5% (16.0% of methicillin-resistant CoNS and 18.7% of methicillin-susceptible CoNS). The D-test was positive in 88.8% of S. aureus and 28.4% of CoNS isolates, which were erythromycin-resistant and clindamycin-susceptible. Conclusions: There are some variations in the prevalence of inducible MLS_(B) resistance in clinical staphylococcal isolates. It is important that clinical laboratories report inducible MLS_(B) resistance for erythromycin-resistant and clindamycinsusceptible staphylococcal isolates.
Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association
Pil Whan Park,Jeong Yeal Ahn,Dongki Yang 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Inositol-1,4,5-triphosphate [IP<sub>3</sub>] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly homologous to IRBIT (88%) and heteromerizes with IRBIT. The two important domains in the N-terminus of AHCYL2 are a PEST domain and a coiled-coil domain which are highly comparable to those in IRBIT. Therefore, in this study, we tried to identify the role of those domains in mouse AHCYL2 (Ahcyl2), and we succeeded in identifying PEST domain of Ahcyl2 as a regulation region for NBCe1-B activity. Site directed mutagenesis and coimmunoprecipitation assay showed that NBCe1-B binds to the N-terminal Ahcyl2-PEST domain, and its binding is determined by the phosphorylation of 4 critical serine residues (Ser151, Ser154, Ser157, and Ser160) in Ahcyl2 PEST domain. Also we revealed that 4 critical serine residues in Ahcyl2 PEST domain are indispensable for the activation of NBCe1-B using measurement of intracellular pH experiment. Thus, these results suggested that the NBCe1-B is interacted with 4 critical serine residues in Ahcyl2 PEST domain, which play an important role in intracellular pH regulation through NBCe1-B.
Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association
Park, Pil Whan,Ahn, Jeong Yeal,Yang, Dongki The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Inositol-1,4,5-triphosphate [$IP_3$] receptors binding protein released with $IP_3$ (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly homologous to IRBIT (88%) and heteromerizes with IRBIT. The two important domains in the N-terminus of AHCYL2 are a PEST domain and a coiled-coil domain which are highly comparable to those in IRBIT. Therefore, in this study, we tried to identify the role of those domains in mouse AHCYL2 (Ahcyl2), and we succeeded in identifying PEST domain of Ahcyl2 as a regulation region for NBCe1-B activity. Site directed mutagenesis and coimmunoprecipitation assay showed that NBCe1-B binds to the N-terminal Ahcyl2-PEST domain, and its binding is determined by the phosphorylation of 4 critical serine residues (Ser151, Ser154, Ser157, and Ser160) in Ahcyl2 PEST domain. Also we revealed that 4 critical serine residues in Ahcyl2 PEST domain are indispensable for the activation of NBCe1-B using measurement of intracellular pH experiment. Thus, these results suggested that the NBCe1-B is interacted with 4 critical serine residues in Ahcyl2 PEST domain, which play an important role in intracellular pH regulation through NBCe1-B.
A Study on the Current Situation of English Education for Military Aviation Personnel
Pil-Whan Park 한국응용언어학회 2013 응용 언어학 Vol.29 No.1
The purpose of this study is to present the current English education programs available in the Republic of Korea Air Force, identify any potential problems, and suggest improvements to develop a customized ESP aviation English course. A total of 39 students (15 pilots and 24 air traffic controllers) and three English teachers of the school participated in the study. The data sources in this study included two classobservations, a survey questionnaire, and personal interviews with three English teachers. The questionnaire given to the students composed of 14 items, and four interview questions were given to the three English teachers. The findings were discussed in the following categories: general perceptions of the course, specific job-related needs, and suggestions for the program’s improvement. The study identified some challenges for implementing an appropriate aviation English program related with their jobs and suggests learners’ job-related needs should be emphasized and accommodated in the military aviation English course’s curriculum development.
Lee, Pil Hyung,Cho, Min Soo,Lee, Seung-Whan,Ahn, Jung-Min,Park, Duk-Woo,Kang, Soo-Jin,Kim, Young-Hak,Lee, Cheol Whan,Park, Seong-Wook,Park, Seung-Jung Elsevier 2017 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.241 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Although studies have demonstrated comparable efficacy and safety profiles of everolimus- and zotarolimus-eluting stents (EES and ZES, respectively) for a broad spectrum of coronary artery diseases, there is paucity of data concerning their safety and efficacy for coronary chronic total occlusions (CTOs). This study compared the clinical performance of EES and ZES following successful percutaneous coronary intervention for CTOs.</P> <P><B>Methods</B></P> <P>The cohort included 539 consecutive CTO patients who underwent successful PCI using EES (n=313) and ZES (n=226) between September 2006 and August 2014. The primary outcome was defined as the composite of death, myocardial infarction, and target vessel revascularization.</P> <P><B>Results</B></P> <P>During a median follow-up of 3.3years, in both groups, the primary outcome occurred in 12.2% of patients. After multivariable adjustment, no significant difference was observed between the two groups in the risk of primary outcome [hazard ratio (HR) 1.03, 95% confidence interval (CI) 0.59–1.79, <I>P</I> =0.930 for ZES compared with EES]. Similarly, there were no significant differences in the risk of death (adjusted HR 0.96, 95% CI 0.43–2.15, <I>P</I> =925), death or myocardial infarction (adjusted HR 0.93, 95% CI 0.46–1.88, <I>P</I> =0.829), and target vessel failure (adjusted HR 0.96, 95% CI 0.51–1.82, <I>P</I> =0.902). The incidence of definite/probable stent thrombosis was relatively low [0% (ZES) vs. 1.0% (EES), <I>P</I> =0.19].</P> <P><B>Conclusion</B></P> <P>No significant differences were observed between EES and ZES in terms of clinical outcomes for coronary CTOs at 3.3years.</P>
박필환 ( Pil Whan Park ),김신규 ( Thin Kyou Kim ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.4
Objective: This study set out to determine the antinuclear antibody (ANA) frequency and fluorescence pattern, as well as the incidence of drug-induced lupus (DIL) in patients on long term medications with anticonvulsants. Methods: Sera from 200 patients on medications with anticonvulsants for at least 6 months and from 105 healthy controls were tested by indirect immunofluorescence on immunotype (IT)-1 cells, and the medical records were retrospectively reviewed. The patients included 72 on valproic acid, 24 on phenytoin, 75 on carbamazepine, and 29 patients on two or more anticonvulsants. Results: ANA were positive in 3 of the 105 normal controls (3%). Twenty nine percent of patients on valproic acid, 26% on phenytoin, 8% on carbamazepine, and 34% on two or more different anticonvulsants were positive for ANA. The cytoskeletal pattern was prominent in patients on valproic acid and the speckled pattern in phenytoin. Most were of low titers. Conclusion: Long-term ingestion of valproic acid and phenytoin were shown to influence ANA, while carbamazepine was not. No definite relationship was observed between ANA positivity and DIL. However, positive ANA indicates effects of anticonvulsants on the immune system, and therefore progression to DIL cannot be ruled out. Therefore, patients on long-term medications with anticonvulsants should be regularly tested for ANA.
A case of Zollinger-Ellison syndrome associated with neurofibromatosis type 1
( Wan Sik Lee ),( Pil Jin Jung ),( Min Ho Park ),( Im Kwan Ju ),( Sang Wook Park ),( Kun Soo Park ),( Nam Hoon Lee ),( Chang Whan Park ),( Young Eun Joo ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun 대한내과학회 2004 대한내과학회 추계학술발표논문집 Vol.2004 No.1