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Characterization of Ag-Doped p-Type SnO Thin Films Prepared by DC Magnetron Sputtering
Pham, Hoai Phuong,Thuy, Thanh Giang Le,Tran, Quang Trung,Nguyen, Hoang Hung,My Hoa, Huynh Tran,Thi Thu, Hoang,Cuong, Tran Viet Hindawi Limited 2017 Journal of nanomaterials Vol.2017 No.-
<P>Crystalline structure and optoelectrical properties of silver-doped tin monoxide thin films with different dopant concentrations prepared by DC magnetron sputtering are investigated. The X-ray diffraction patterns reveal that the tetragonal SnO phase exhibits preferred orientations along (101) and (110) planes. Our results indicate that replacing Sn<SUP>2+</SUP> in the SnO lattice with Ag<SUP>+</SUP> ions produces smaller-sized crystallites, which may lead to enhanced carrier scattering at grain boundaries. This causes a deterioration in the carrier mobility, even though the carrier concentration improves by two orders of magnitude due to doping. In addition, the Ag-doped SnO thin films show a p-type semiconductor behavior, with a direct optical gap and decreasing transmittance with increasing Ag dopant concentration.</P>
Biomedical and Environmental Applications of Chitosan-based Nanomaterials
( Jae Kweon Park ),( Lam Dai Tran ),( Hoang Vinh Tran ),( Trang Thu Mai ),( Thu Phuong Ha ),( Binh Hai Nguyen ),( Hoang Thai ),( Hoang Dinh Vu ),( Dien Gia Pham ),( Phuc Xuan Nguyen ) 한국키틴키토산학회 2011 한국키틴키토산학회지 Vol.16 No.1
Being naturally abundant resources and having many interesting physicochemical and biological properties, chitin/chitosan have been found useful in many fields. This paper describes the strategy to design a multifunctional, chitosan based nanomaterials and their biomedical and environmental applications. Different physicochemical methods including FESEM/TEM, PPMS were used to characterize the obtained nanomaterials. For each application, a series of specific characterizing methods were used for evaluating the applicability/capacity of materials.
Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
Phuong Dinh Tam,Nguyen Luong Hoang,Hoang Lan,Pham Hung Vuong,Ta Thi Nhat Anh,Tran Quang Huy,Nguyen Thanh Thuy 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.10
In this work, we evaluated the effects of different antibody immobilization strategies on the response of a CeO2-nanowires (NWs)-based immunosensor for V ibrio cholerae O1 detection. Accordingly, the changes in the electron-transfer resistance (Ret) from before to after cells bind to an antibody-modified electrode prepared by using three different methods of antibody immobilization were determined. The values were 16.2%, 8.3%, and 6.65% for the method that utilized protein A, antibodies activated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/Nhydroxysuccinimide (NHS), and absorption, respectively. Cyclic voltammetry confirmed that the change in the current was highest for the immunosensors prepared using protein A (11%), followed by those prepared with EDC/NHS-activated antibodies (9%), and finally, those prepared through absorption (7.5%). The order of the antibody immobilization strategies in terms of resulting immunosensor detection limit and sensitivity was as follows order: absorption (3.2 × 103 CFU/mL; 45.1 /CFU·mL−1) < EDC/NHS-activated antibody (1.0 × 103 CFU/mL; 50.6 /CFU·mL−1) < protein A (1.0 × 102 CFU/mL; 65.8 /CFU·mL−1). Thus, we confirmed that the protein A - mediated method showed significantly high cell binding efficiencies compared to the random immobilization method.
Factors Affecting the Internal Control System: A Case Study of Chemical Enterprises in Vietnam
Hoang Thanh NGO,Tung Dao NGUYEN,Nga Thuy Thi NGUYEN,Ha Ngoc DAO,Anh Phuong Tran VU 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12
The article analyzes the impact of factors affecting the internal control system of chemical enterprises in Vietnam, providing more empirical evidence on factors affecting the system of internal control. Research data is collected in the form of face-to-face interviews and email interviews with managers and employees working in different positions, managers at all levels, chief accountants, and accountants of 52 chemical enterprises in Vietnam. The survey results collected 310 questionnaires. After eliminating the invalid questionnaires due to many blank cells, the authors chose to use 297 questionnaires. Quantitative research was carried out with SPSS 25 software. Research results show that Business Strategy, Organizational Structure, Organization’s perception of the instability of the external environment, and Organizational culture are the factors that positively affect the internal control system of chemical enterprises. This can be explained that, for chemical enterprises, Business strategy, Organizational structure, Organization’s perception of the instability of the external environment, and Good organizational culture will positively impact the internal control system of chemical enterprises. Based on the research results, the authors have proposed recommendations to enhance the effectiveness of the internal control system of chemical enterprises in Vietnam, thereby contributing to improving the performance of enterprises in the chemical Vietnamese.
Hoang, Van-Hai,Tran, Phuong-Thao,Cui, Minghua,Ngo, Van T. H.,Ann, Jihyae,Park, Jongmi,Lee, Jiyoun,Choi, Kwanghyun,Cho, Hanyang,Kim, Hee,Ha, Hee-Jin,Hong, Hyun-Seok,Choi, Sun,Kim, Young-Ho,Lee, Jeewoo American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.6
<P>Glutaminyl cyclase (QC) has been implicated in the formation of toxic amyloid plaques by generating the N-terminal pyroglutamate of beta-amyloid peptides (pGlu-A beta) and thus may participate in the pathogenesis of Alzheimer's disease (AD). We designed a library of glutamyl cyclase (QC) inhibitors based on the proposed binding mode of the preferred substrate, A beta 3E-42. An in vitro structure-activity relationship study identified several excellent QC inhibitors demonstrating 5- to 40-fold increases in potency compared to a known QC inhibitor. When tested in mouse models of AD, compound 212 significantly reduced the brain concentrations of pyroform A beta and total A beta and restored cognitive functions. This potent A beta-lowering effect was achieved by incorporating an additional binding region into our previously established pharmacophoric model, resulting in strong-interactions with the carboxylate group of Glu327 in the QC binding site. Our study offers useful insights in designing novel QC inhibitors as a potential treatment option for AD.</P>
Tran, Dung Thi,Cho, Seungchan,Hoang, Phuong Mai,Kim, Jaedeok,Kil, Eui-Joon,Lee, Taek-Kyun,Rhee, Yong,Lee, Sukchan Springer-Verlag 2016 Plant molecular biology reporter Vol.34 No.1
<P>Chrysanthemum stunt viroid (CSVd), the smallest plant pathogen known to infect chrysanthemums, is a single-stranded circular RNA viroid that induces stunting that results in an overall height reduction of 30-50 % in mature plants. A catalytic single-chain variable antibody, 3D8 scFv, which exhibits intrinsic DNase and RNase activities, was expressed in chrysanthemums to generate transgenic plant resistance to CSVd infection. Moreover, a codon-optimized version of the 3D8 scFv gene for chrysanthemums was also transformed into plants; these codon-optimized transgenic chrysanthemums expressed twice as much 3D8 scFv and displayed 60 % more resistance to CSVd infection, compared with transgenic chrysanthemums harboring the original 3D8 scFv gene. CSVd challenge experiments with codon-optimized and original 3D8 scFv-transgenic chrysanthemums showed that CSVd in newly produced leaves of both codon-optimized and original 3D8 scFv-transgenic plants was not detected by RT-PCR. This is the first report describing the development of a CSVd-resistant chrysanthemum harboring a catalytic single-chain antibody, 3D8 scFv, which has intrinsic RNase activity.</P>
Novel antibiotic delivery using graphene oxide immobilized surfaces
( Tran Dieu Linh ),( Thai Thanh Hoang Thi ),( Phuong Le Thi ),박기동 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Implant-related infection is a noteworthy issue because of their negative effect to the success of implantation, and the cost of treatment. To solve this problem, the development of antimicrobial surface has been considered as an urgent mission. Herein, we demonstrated that graphene oxide (GO)-immobilized TiO<sub>2</sub> surface is an efficient carrier for the local delivery of antibiotic. The phenol-functionalized GO deriva-tive was synthesized and immobilized on TiO<sub>2</sub> under the catalysis of tyrosinase, following by the loading of doxycycline hyclate (Dox). The modified surface was able to carry 36 μg of Dox and ensured the release for a month. These surfaces also showed good antibacterial activity against both E. coli and S. aureus, without the cytotoxic effect on hDFBs. It is expected that the release of Dox from GO-immobilized surfaces can solve the pressing need for enhanced infection control