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Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors
김원진,Yoon Jung Chung,Se Hwa Kim,Sehee Park1,Jae Hyun Bae,Gyuri Kim1,Su Jin Lee1,Jo Eun Kim1,박병우,임승길,이유미 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.1
Background: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. Methods: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 μg calcitriol (n=46), or placebo (n=44) for 6 months. Results: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8±13.6 pmol/L vs. 23.1±4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%±10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%±10.2% vs. 55.9%±9.13%, P>0.05). Conclusion: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.
Antiviral Agents Against Influenza Viruses
Park, Sehee,Kim, Jin Il,Park, Man-Seong 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.4
In annual epidemics and occasional pandemics, influenza viruses cause acute respiratory illnesses in infected humans. Vaccines and antiviral drugs are two main arsenals available for a fight against influenza viruses. However, vaccines often exhibit a limited efficacy in high risk populations, and antiviral drugs are always concerned for mutations, which confer viral resistance. Here we review current advances and knowledge in relation to the usage of antiviral drugs as a prophylactic or therapeutic and the mechanism of resistant variants mainly against the neuraminidase inhibitors. Comprehensive understanding of the resistant mechanism will pave a road for developing new antivirals and/or finding medical or natural alternatives inducing less frequent resistance, and application of combination therapy using two or three different kinds of antivirals can suggest a useful medical intervention against both of seasonal and highly pathogenic influenza viruses including resistant variants. In this review, we provide insights of antiviral drugs for the control and prevention of influenza viruses.
MicroRNA clustering on the biogenesis of suboptimal microRNAs
Park Sehee,Kang Igojo,Shin Chanseok 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.S
Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed by Microprocessor that is composed of RNase III enzyme Drosha and DGCR8, and the second by another RNase III enzyme Dicer. There are many examples of miRNAs that are poor substrates for Drosha and Dicer, owing to their suboptimal structures. However, a number of these suboptimal miRNAs are known to be expressed at the same or higher level as their neighboring structurally-optimal miRNAs. Recent studies suggest that the clustered orientation of these suboptimal miRNAs is the explanation for this phenomenon. It has been observed that the biogenesis of these suboptimal miRNAs can be affected by the expression of their neighboring optimal miRNAs. This principle is expected to apply more broadly, as it has been shown that a large percentage of suboptimal miRNAs reside within operons.
Towards the Application of Human Defensins as Antivirals
Park, Mee Sook,Kim, Jin Il,Lee, Ilseob,Park, Sehee,Bae, Joon-Yong,Park, Man-Seong The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express ${\alpha}$- and ${\beta}$-defensins, which are known for their antiviral and antibacterial activities. This review describes the application of human defensins. We discuss the extant experimental results, limited though they are, to consider the potential applicability of human defensins as antiviral agents. Given their antiviral effects, we propose that basic research be conducted on human defensins that focuses on RNA viruses, such as human immunodeficiency virus (HIV), influenza A virus (IAV), respiratory syncytial virus (RSV), and dengue virus (DENV), which are considered serious human pathogens but have posed huge challenges for vaccine development for different reasons. Concerning the prophylactic and therapeutic applications of defensins, we then discuss the applicability of human defensins as antivirals that has been demonstrated in reports using animal models. Finally, we discuss the potential adjuvant-like activity of human defensins and propose an exploration of the 'defensin vaccine' concept to prime the body with a controlled supply of human defensins. In sum, we suggest a conceptual framework to achieve the practical application of human defensins to combat viral infections.
Park, Sehee,Song, Wooseok,Kim, Seong Ku,Han, Jin Kyu,Chae, Heeyeop,Myung, Sung,Lee, Sun Sook,Lim, Jongsun,An, Ki-Seok American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.8
<P>Diverse carbon nanotubes (CNTs) with controlled structures and graphene hybrid nanostructures were synthesized for supercapacitor electrode applications. Three-dimensional multilayer graphene foams were synthesized via thermal chemical vapor deposition (TCVD). The diameter and density of the synthesized CNTs were controlled through the use of two different CVD systems in addition to adjusting the thickness of the Fe catalyst used in the production of these nanomaterials. We thereby fabricated single-walled CNTs/graphene, multi-walled CNTs/graphene, and vertically aligned CNTs/graphene hybrid nanostructures, which was confirmed via scanning electron microscopy and resonant Raman spectroscopy. Additionally, the electrochemical properties of the CNTs/graphene hybrid nanostructures were studied by cyclic voltammetry.</P>
Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
Park, Sehee,Kim, Jin Il,Bae, Joon-Yong,Yoo, Kirim,Kim, Hyunung,Kim, In-Ho,Park, Man-Seong,Lee, Ilseob MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.2
The potential use of dietary measures to treat influenza can be an important alternative for those who lack access to influenza vaccines or antiviral drugs. Lactobacillus plantarum (Lp) is one of many lactic acid bacteria that grow in 'kimchi', an essential part of Korean meal, and several strains of Lp reportedly show protective effects against influenza. Using heat-killed Lp (nF1) isolated from kimchi, which is known for its immunomodulatory effects, we investigated whether regular oral intake of nF1 could influence the outcome of influenza virus infection in a mouse model. In a lethal challenge with influenza A (H1N1 and H3N2 subtypes) and influenza B (Yamagata lineage) viruses, daily oral administration of nF1 delayed the mean number of days to death of the infected mice and resulted in increased survival rates compared with those of the non-treated mice. Consistent with these observations, nF1 treatment also significantly reduced viral replication in the lungs of the infected mice. Taken together, our results might suggest the remedial potential of heat-killed Lactobacillus probiotics against influenza.
Ahn, Sehee,Choe, Ayoung,Park, Jonghwa,Kim, Heesuk,Son, Jeong Gon,Lee, Sang-Soo,Park, Min,Ko, Hyunhyub The Royal Society of Chemistry 2015 Journal of materials chemistry. C, Materials for o Vol.3 No.10
<P>The development of a transparent and stretchable electrode is critical to the realization of stretchable optoelectronic devices. In this study, a template-guided self-assembly is demonstrated for the integration of carbon nanotubes into 2D rhombic nanomesh films, where the deformation of the rhombic structure accommodates the strain, greatly improving the stretchability. In addition, the regular 2D nanomesh patterns greatly reduce the contact resistance and light scattering. Our rhombic carbon nanotube nanomesh films exhibited significantly lower sheet resistance (∼10 times) at a similar optical transmittance (78%), greater stretchability (∼8 times less resistance increase at 30% strain), and better mechanical durability (∼42 times less resistance increase after 500 stretching cycles at a strain of 30%) than those of random-network carbon nanotube films.</P>