Intracerebral Microdialysis Technique and its Application on Brain Pharmacokinetic- Pharmacodynamic Study

Yue-fang Pan,Jian Feng,Qiao-yuan Cheng,Fan-zhu Li 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

Intracerebral microdialysis (IC-MD) has been developed as a well-validated and powerful technique for decades. As a practical sampling tool, it can gain the continuous dialysates of endogenous and exogenous substances in extracellular fluid (ECF) of awake freely moving animals. Also, variform IC-MD probes (IC-MDPs) have grown more exquisite. The implantation of the IC-MDP in certain tissue of brain allows monitor drug distribution and measure drug and corresponding neurotransmitters levels in brain ECF after administration for brain pharmacokineticpharmacodynamic (B-PK-PD) study. So it is suitable for IC-MD to B-PK-PD study (IC-MD/BPK- PD). The performance of IC-MD/B-PK-PD can not only elevate the degree of precision and accuracy of experimental data, minimize the individual difference by reduced number of animals, but also give important information for the prediction and optimization of drug effective dose in preclinical study. In this review, we have discussed various IC-MD/B-PK-PD studies of analgesic, antiepileptic and antidepressant drug. The role of IC-MD/B-PK-PD in confirming and assessing the drug effect before clinic trials is highlighted.

Anatomical Study of the Accessory Tendon of the Extensor Hallucis Longus Muscle and Its Clinical Application

Yue Li,Jing-Ying Zhang,Xin-Yue Zhao,Li-Ya Pan,De-Hao Jin,He-Xing Xu,Hu-Zhe Cui,Yan-Qun Liu,Xiang-Zheng Qin,Qingyuan Li 대한정형외과학회 2021 Clinics in Orthopedic Surgery Vol.13 No.2

Background: The accessory tendon of the extensor hallucis longus (ATEHL) muscle is a common abnormal structure, and its clinical significance remains debatable. In this study, we provide the incidence of the ATEHL and characterize its morphological types in Asian cadavers and investigate its clinical applications. Methods: The tendons from 50 adult cadaveric feet, fixed in 10% formalin, were analyzed. We measured the length and width of both the ATEHL and the extensor hallucis brevis (EHB). Results: All dissected specimens had an ATEHL. The first metatarsophalangeal joint was surrounded by an accessory tendon that inserted onto the joint capsule and the dorsal base of the proximal phalanx. We classified the ATEHL into 3 types based on their directions. Differences in ATEHL type based on sex were not statistically significant. Conclusions: We found an ATEHL in all cadaveric specimens in this study. We surmise that the ATEHL acts as an antagonist with the EHB when the toe is extending, which might help prevent the occurrence of hallux valgus deformity.

Vibration Analysis and Experiments on Electrochemical Micro-Machining Using Cathode Vibration Feed System

Yue Pan,Lizhong Xu 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

Based on mechanics of vibration and electrochemical principle, an electrochemical micro-machining method using cathode vibrationfeed was proposed. The electrochemical micro-machining system using cathode vibration feed was designed and manufactured. Thedynamics model of vibration excitation mechanism was given. The vibration modes and natural frequencies were discussed. Theelectrochemical micro-machining test using cathode vibration feed was completed. The test results were compared withelectrochemical micro-machining test ones using DC and pulse power. The experimental results show that electrochemical micromachiningusing cathode vibration feed can improve the accuracy of electrochemical micro-machining. Machining accuracy of themicro holes is close to one of the electrochemical micro-machining using high-frequency pulse power. The micro-machining techniqueis simple, without using high-frequency pulse power.

Intracerebral Microdialysis Technique and its Application on Brain Pharmacokinetic-Pharmacodynamic Study

Pan, Yue-Fang,Feng, Jian,Cheng, Qiao-Yuan,Li, Fan-Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

Intracerebral microdialysis (IC-MD) has been developed as a well-validated and powerful technique for decades. As a practical sampling tool, it can gain the continuous dialysates of endogenous and exogenous substances in extracellular fluid (ECF) of awake freely moving animals. Also, variform IC-MD probes (IC-MDPs) have grown more exquisite. The implantation of the IC-MDP in certain tissue of brain allows monitor drug distribution and measure drug and corresponding neurotransmitters levels in brain ECF a after administration for brain pharmacokinetic-pharmacodynamic (B-PK-PD) study. So it is suitable for IC-MD to B-PK-PD study (IC-MD/B-PK-PD). The performance of IC-MD/B-PK-PD can not only elevate the degree of precision and accuracy of experimental data, minimize the individual difference by reduced number of animals, but also give important information for the prediction and optimization of drug effective dose in preclinical study. In this review, we have discussed various IC-MD/B-PK-PD studies of analgesic, antiepileptic and antidepressant drug. The role of IC-MD/B-PK-PD in confirming and assessing the drug effect before clinic trials is highlighted.

Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Pan, Feng,Tian, Jing,Ji, Chu-Shu,He, Yi-Fu,Han, Xing-Hua,Wang, Yong,Du, Jian-Ping,Jiang, Feng-Shou,Zhang, Ying,Pan, Yue-Yin,Hu, Bing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Published data on the associations between tumor necrosis factor-alpha (TNF-${\alpha}$) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-${\alpha}$-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in Caucasian population (A vs. G: OR = 1.43, 95% CI = 1.00-2.03; AA vs. GG: OR = 2.09, 95% CI = 1.34-3.25; Recessive model: OR = 2.09, 95% CI = 1.35-3.25) and African population (GA vs. GG: OR = 1.53, 95% CI = 1.02-2.30). An association of TNF-${\alpha}$-238G>A polymorphism with cervical cancer was found (A vs. G: OR = 0.61, 95% CI = 0.47-0.78; GA vs. GG: OR = 0.59, 95% CI = 0.45-0.77; Dominant model: OR = 0.59, 95% CI = 0.46-0.77). When stratified by ethnicity, similar association was observed in Caucasian population (A vs. G: OR = 0.62, 95% CI = 0.46-0.84; GA vs. GG: OR = 0.59, 95% CI = 0.43-0.82; Dominant model: OR = 0.60, 95% CI = 0.44-0.83). In summary, this meta-analysis suggests that TNF-${\alpha}$-238A allele significantly decreased the cervical cancer risk, and the TNF-${\alpha}$-308G>A polymorphism is associated with the susceptibility to cervical cancer in Caucasian and African population.

중국 여행 플랫폼의 지속적 사용의도에 관한 연구: 확장된 기술수용모델의 적용

Ming-Yue Pan,최판호,전재균 사단법인 한국융합기술연구학회 2023 아시아태평양융합연구교류논문지 Vol.9 No.8

Recently, travel platform companies are growing by combining advanced ICT technology with the travel industry. The growth of these companies reflects consumers’ high interest in the platform. It will be necessary to understand the consumer’s acceptance process for new technologies such as platform. This study aimed to study variables that affect consumers' continuous intention to use Xiaohongshu, a Chinese travel platform company. To this end, the ETAM(extended technology acceptance model) was applied to identify the structural relationship between variables that affect the intention to continue use. The survey method was collected through a convenience sampling method through a Chinese online survey company in consideration of the COVID-19 situation. An online survey was conducted on Chinese consumers who had experience using the Xiaohongshu service, and a total of 334 questionnaires were collected. As a result of empirical analysis, first, the user's personal innovation had a significant positive effect on perceived ease of use, perceived usefulness, and perceived enjoyment. Second, perceived ease of use had a significant positive effect on perceived usefulness and perceived enjoyment. Third, perceived ease of use, perceived usefulness, and perceived enjoyment were all found to have a positive effect on continuous use intention. Finally, based on the analysis results, this study aims to present implications that can improve the intention to use of travel platforms. 오늘날 첨단 ICT 기술이 관광산업과 접목하여 여행 플랫폼 기업들이 성장하고 있다. 이러한 기업의 성장에는 플랫폼에 대한 소비자의 높은 관심을 반영한다. 플랫폼과 같은 신기술에 대한 소비자의 수용과정을 이해하는 것이 필요할 것이다. 이를 위해 중국판 인스타그램인 샤오홍슈를 대상으로 소비자의 지속적인 사용의도에 영향을 미치는 변인들을 연구하고자 한다. 이를 위해 확장된 기술수용모델을 적용하여 지속적 사용의도에 영향을 주는 변인들 간의 영향관계를 파악하였다. 자료수집은 COVID-19 상황을 감안하여 중국 온라인 설문 업체를 통해서 2022년 9월 1일부터 9월 12일까지 진행되었다. 다만 연구목적에 맞게 샤오홍슈 서비스 사용한 경험이 있는 중국 소비자들을 대상으로 연구자가 임의로 선정한 편의표본추출법으로 총 334부의 설문지를 수집하였다. 실증분석 결과, 첫째, 사용자의 개인 혁신성은 지각된 용이성, 지각된 유용성, 지각된 즐거움에 유의한 정(+)의 영향을 미쳤다. 둘째, 지각된 용이성은 지각된 유용성과 지각된 즐거움에 유의한 정(+)의 영향을 미쳤다. 셋째, 지각된 용이성, 지각된 유용성, 지각된 즐거움은 지속적 사용의도에 유의한 정(+)의 영향을 미쳤다. 마지막으로 분석결과를 기초로 여행 플랫폼의 지속적 사용의도를 향상할 수 있는 시사점을 제시하고자 한다.

Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.

Deng, Pan-Yue,Xiao, Zhaoyang,Jha, Archana,Ramonet, David,Matsui, Toshimitsu,Leitges, Michael,Shin, Hee-Sup,Porter, James E,Geiger, Jonathan D,Lei, Saobo The Society 2010 The Journal of neuroscience Vol.30 No.15

<P>Cholecystokinin (CCK), a neuropeptide originally discovered in the gastrointestinal tract, is abundantly distributed in the mammalian brains including the hippocampus. Whereas CCK has been shown to increase glutamate concentration in the perfusate of hippocampal slices and in purified rat hippocampal synaptosomes, the cellular and molecular mechanisms whereby CCK modulates glutamatergic function remain unexplored. Here, we examined the effects of CCK on glutamatergic transmission in the hippocampus using whole-cell recordings from hippocampal slices. Application of CCK increased AMPA receptor-mediated EPSCs at perforant path-dentate gyrus granule cell, CA3-CA3 and Schaffer collateral-CA1 synapses without effects at mossy fiber-CA3 synapses. CCK-induced increases in AMPA EPSCs were mediated by CCK-2 receptors and were not modulated developmentally and transcriptionally. CCK reduced the coefficient of variation and paired-pulse ratio of AMPA EPSCs suggesting that CCK facilitates presynaptic glutamate release. CCK increased the release probability and the number of readily releasable vesicles with no effects on the rate of recovery from vesicle depletion. CCK-mediated increases in glutamate release required the functions of phospholipase C, intracellular Ca(2+) release and protein kinase Cgamma. CCK released endogenously from hippocampal interneurons facilitated glutamatergic transmission. Our results provide a cellular and molecular mechanism to explain the roles of CCK in the brain.</P>

中国托育服务发展的政策支持与完善路径研究

潘栎(Yue Pan) YIXIN 출판사 2024 Journal of China Studies Vol.2 No.3

我国托育服务刚刚起步,面临着很多问题和挑战。目前,我国托育服务发展存在一些亟待解决的问题,如托育服务供给与需求矛盾依然存在、托育服务政策落实存在地区差异、国家与地方财政的投入与补贴不足、管理部门责任不明确以及托育服务质量良莠不齐等问题。为解决市场化托育服务的负面影响,政府将托育服务纳入建立健全社会福利体系的战略规划之中。在托育服务发展的路径上,可以通过倡导新办和改办托育机构、打破传统托育二元类型体系、实施托育价格管制以及完善托育服务综合监管体系等来推动托育服务发展的政策意图,旨在促进我国托育服务的健康、快速发展,满足社会和家庭的需求。 The childcare service in our country has just started and is faced with many problems and challenges. At present, there are some urgent problems to be solved in the development of childcare services in China, such as the contradiction between supply and demand of childcare services, regional differences in the implementation of childcare service policies, insufficient national and local financial investment and subsidies, unclear responsibilities of management departments, and uneven quality of childcare services. In order to address the negative impact of market-oriented childcare services, the government has included childcare services in the strategic planning of establishing a sound social welfare system. In the path of the development of childcare services, the policy intention of promoting the development of childcare services can be promoted by advocating new and changing childcare institutions, breaking the traditional dual type system of childcare services, implementing price control of childcare services and improving the comprehensive supervision system of childcare services, so as to promote the healthy and rapid development of childcare services in China and meet the needs of society and families.

高质量发展背景下普惠性幼儿园面临的挑战及其发展策略

潘栎(Yue Pan) YIXIN 출판사 2024 教育教学研究论丛 Vol.2 No.1

在高质量发展的背景下,普惠性幼儿园的建设和发展显得尤为重要。这不仅关乎教育公平,也是社会进步和人口政策的重要体现。普惠性幼儿园旨在缩小城乡、区域间的教育差距,提供均等的教育机会,特别是对中低收入家庭的儿童。面对的主要挑战包括城乡资源分配不均衡、财政投入的结构性失衡以及办园体制的显著差异。解决这些挑战的关键在于精细化资源配置、建立需求与供给的预警及协作机制、优化公平合理的资源分配机制,以及利用政策工具构建完善的激励机制。此外,强化质量评估和内涵发展、提升教育和保育服务水平也至关重要。 Under the background of high-quality development, the construction and development of inclusive kindergartens are particularly important. This is not only about educational equity, but also an important embodiment of social progress and population policy. Inclusive kindergartens aim to narrow the education gap between urban and rural areas and between regions and provide equal educational opportunities, especially for children from low- and middle-income families. The main challenges include the unbalanced distribution of resources between urban and rural areas, the structural imbalance of financial input, and the significant differences in the management system of parks. The key to solving these challenges lies in the fine allocation of resources, the establishment of early warning and cooperation mechanism between demand and supply, the optimization of fair and reasonable resource allocation mechanism, and the use of policy tools to build a sound incentive mechanism. In addition, it is essential to strengthen quality assessment and content development, and improve the level of education and childcare services.

Association Between the FAS/FASL Polymorphisms and Gastric Cancer Risk: A Meta-Analysis

Tian, Jing,Pan, Feng,Li, Jing,Ma, Yan,Cen, Han,Pan, Hai-Feng,Pan, Yue-Yin,Ye, Dong-Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed. Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models. Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, $I^2$ = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, $I^2$ = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041-1.646, Ph = 0.240, $I^2$ = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, $I^2$ = 0.0) polymorphisms. Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.