유아 그림책 「강아지 똥」에 나타난 주인공의 자아형성 과정 분석

박찬옥(Park Chan-Ok),신혜선(Shin hye-sun) 한국열린유아교육학회 2005 열린유아교육연구 Vol.10 No.3

본 연구는 Berne의 교류 분석(Transactional Analysis)의 주요개념인 구조분석(Structural Analysis) 교류패턴(Transactional pattern), 게임(game), 각본(script)의 네 가지 측면에서 「강아지 똥」을 분석함으로써 주인공의 자아형성 과정을 알아보았다. 연구 결과 주인공 ‘강아지 똥’은 주변 등장인물과 교차교류(Crossed Transaction) 이면교류(Ulterior Transaction)를 통해 자신은 아무 짝에도 쓸모없다는 자아정체감을 형성한다. 자신이 무가치하다고 생각한 ‘강아지 똥’은 타인에게 도움을 주지 못해 착하게 살수 없다는 패자 각본(Script)을 형성한다. 그러나 ‘자신도 옳고 타인도 옳다’는 심리적 자세를 가진 민들레와의 교류를 통해 긍정적인 자아정체감을 형성하게 되고 자신도 타인에게 도움을 줄 수 있다는 승자의 각본을 가지게 된다. 이것은 주인공의 긍정적인 자아정체감 형성에 상보적 교류(Complementary Transaction)가 중요함을 시시한다. This research for "Gang-A-Ji, Dong" is basically analyzed with the 4 major notions of Berne's Transactional Analysis that are 'Structural Analysis', 'Transactional Pattern', 'Game' and 'Script'. The main character of "Gang-A-Ji, Dong" is explored through these Berne's concept. As a result of study, it is noticeable that the experiences of crossed and ulterior Transaction with others affect Dong to form himself as a dirty and needless dog. He thinks himself as a worthless existence and is not capable to help others. This idea builds up a vanquished-script for Dong's life. After the Transaction with Min-Dle-Le, Dong and Min-Dle-Le exchange many thoughts. Min-Dle-Le is the character whose mental behaviour is influenced by the idea of 'I am OK. You are OK'. Their Transaction provokes Dong to have positive mind and encourage helping others. Dong's life becomes to have a victor-script. The Complementary Transaction with Min-Dle-Le is the most important part of his life for Dong, the main character to mold himself positively.

LT, Others : PE-133 ; A case of hepatic hemangioma appearing atypical finding confirmed by dynamic MRI in patients with high risk of hepatocellular carcinoma

( Dong Won Park1 ),( Soo Hyung Ryu1 ),( Myung Ki Oh ),( Seong Yeon Jeong ),( Kyeong Sam Ok ),( Jae Chan Shim ),( Jin Nam Kim ),( You Sun Kim ),( Jeong Seop Moon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Hemangioma is the most common benign hepatic tumor. Many hepatic hemangiomas tend to be found incidentally, but should be differentiated from malignant tumors. We report an interesting case of hepatic hemangioma in patient who has high risks of hepatocellular carcinoma. Case: A 52-year-old woman, who was a chronic alcoholic abuser and hepatitis C virus carrier with no treatment experience, was admitted due to diarrhea. The patient had suffered from intermittent abdominal pain in the right subcostal area for recent 3 months. Also the patient had easy bruising and frequent epistaxis. She had used oral contraceptives for almost 20 years. Systolic blood pressure was 160 mmHg and diastolic blood pressure was 80 mmHg. Body temperature was normal. Physical examination revealed icteric sclerae and tenderness in right upper quadrant of the abdomen. Laboratory study showed platelet count of 31,000/ul, AST/ALT of 302/127 IU/L, and total bilirubin of 2.7 mg/dl. 3-phased contrast-enhanced abdominal computed tomography (CT) revealed a 4 cm × 4 cm sized hepatic mass involving both segment 5 and 6. Abdominal CT finding suggested hepatic hemangioma, however, typical finding of hemagioma was unclear, therefore, could not rule out the malignancy. Since she had risk factors for hepatocellular carcinoma, abdominal ultrasonography was performed for further evaluation. But abdominal ultrasonography also showed atypical finding. The confirmative diagnosis could be done by dynamic magnetic resonance imaging (MRI) using primovist®, which is an innovative liver cell-specific contrast medium. Dynamic MRI presented peripheral globular enhancement and a centripetal fill-in pattern, confirmatory findings of hepatic hemangioma, on the delayed image. The patient got relief from abdominal pain and diarrhea during admission, now is being followed-up at a general out-patient clinics. Conclusions: Hemangiomas with atypical abdominal CT and ultrasonographic findings in patients with high risks of hepatocellular carcinoma can be easily characterized with primovist-enhanced dynamic MRI.

무등산국립공원 군부대 주둔지역 복원 종합계획^a

최윤호 ( Yeon-ho Choi ),오구균 ( Koo Kyun Oh ),나경태 ( Kyong Tae Na ),이영주 ( Young Ju Lee ),조우 ( Woo Cho ),오현경 ( Hyun Kyung Oh ),박석곤 ( Seok Gon Park ),김영선 ( Young Sun Kim ),최옥곤 ( Ok Gon Choi ),윤주옥 ( Ju Og Yun 한국환경생태학회 2017 한국환경생태학회 학술대회지 Vol.2017 No.1

Evaluation of the Diagnostic and Therapeutic Effects on Tumor Cells by Using Anti - AFP Monoclonal Abs

Park, Tae Kyu,Kang, Shin Sung,Bang, Ok Sun,Cho, Dong Tek 한국유전학회 1988 Genes & Genomics Vol.10 No.4

By non-competitive enzyme-linked immunosorbent assay using anti-alpha-fetoprotein (AFP) monoclonal antibodies (MAbs), it was confirmed that screening of serum AFP level is essential in diagnosis of the hepatocellular carcinoma. By indirect immunofluorescence technique, anti-AFP MAbs were found to react with the surface of hepatoma cells (70%) and MCF-7 breast carcinoma cells (45%), but not with ME-180 cervic carcinoma cells. The purified anti-AFP MAbs were coupled with ricin toxin A-chain to form immunotoxin, whose effectiveness in in vitro killing of target cells was evaluated by cytotoxic assay. The results showed that this immunotoxin was specifically cytotoxic to hepatocellular carcinoma cells.

SOME CRETACEOUS CONCHOSTRACANS OF KYONGSANG BASIN

Sun-Ok PARK(朴順玉),Ki-Hong CHANG(章基弘) 한국고생물학회 1998 고생물학회지 Vol.14 No.2

Bacterial communities in Antarctic lichens

Park, Chae Haeng,Kim, Kyung Mo,Kim, Ok-Sun,Jeong, Gajin,Hong, Soon Gyu Cambridge University Press 2016 Antarctic science Vol.28 No.6

<B>Abstract</B><P>To date, many studies surveying the bacterial communities in lichen thalli from diverse geographical areas have shown that Alphaproteobacteria is the predominant bacterial class in most lichens. In this study, bacterial communities in several Antarctic lichens with different growth form and substrates were analysed. The bacterial community composition in fruticose and foliose lichens, <I>Cladonia</I>, <I>Umbilicaria</I> and <I>Usnea</I>, and crustose lichens, <I>Buelia granulosa</I>, <I>Amandinea coniops</I> and <I>Ochrolechia parella</I>, from King George Island was analysed by pyrosequencing of bacterial 16S rRNA genes. Results showed that Proteobacteria, Acidobacteria, Actinobacteria and Bacteroidetes were predominant phyla. The predominant bacterial class in most of the samples was Alphaproteobacteria. <I>Acetobacteriaceae</I> of the order <I>Rhodospiralles</I> in Alphaproteobacteria was the most abundant bacterial family in Antarctic lichens. The LAR1 lineage of the order <I>Rhizobiales</I>, a putative N-fixer which has been frequently observed in lichens from temperate areas, was detected only from a few samples at low frequency. It is expected that other bacterial taxa are working as N-fixers in Antarctic lichens. From the PCoA analysis of the Fast UniFrac distance matrix, it was proposed that the microbial community structures in Antarctic lichens were affected by host species, growth form and substrates.</P>

A Comparative Genome-Wide Analysis of GATA Transcription Factors in Fungi

Park, Jong-Sun,Kim, Hyo-Jeong,Kim, Soon-Ok,Kong, Sung-Hyung,Park, Jae-Jin,Kim, Se-Ryun,Han, Hyea-Young,Park, Bong-Soo,Jung, Kyong-Yong,Lee, Yong-Hwan Korea Genome Organization 2006 Genomics & informatics Vol.4 No.4

GATA transcription factors are widespread eukaryotic regulators whose DNA-binding domain is a class IV zinc finger motif in the form $CX_{2}CX_{17-20}CX_{2}C$followed by a basic region. In fungi, they act as transcriptional activators or repressors in several different processes, ranging from nitrogen source utilization to mating-type switching. Using an in-house bioinformatics portal system, we surveyed 50 fungal and 9 out-group genomes and identified 396 putative fungal GATA transcription factors. The proportion of GATA transcription factors within a genome varied among taxonomic lineages. Subsequent analyses of phylogenetic relationships among the fungal GATA transcription factors, as well as a study of their domain architecture and gene structure, demonstrated high degrees of conservation in type IVa and type IVb zinc finger motifs and the existence of distinctive clusters at least at the level of subphylum. The SFH1 subgroup with a 20-residue loop was newly identified, in addition to six well-defined subgroups in the subphylum Pezizomycotina. Furthermore, a novel GATA motif with a 2f-residue loop ($CX_{2}CX_{21}CX_{2}C$, designated 'zinc finger type IVc') was discovered within the phylum Basidiomycota. Our results suggest that fungal GATA factors might have undergone multiple distinct modes of evolution resulting in diversified cellular modulation in fungi.

BATF regulates collagen-induced arthritis by regulating T helper cell differentiation

Park, Sang-Heon,Rhee, Jinseol,Kim, Seul-Ki,Kang, Jung-Ah,Kwak, Ji-Sun,Son, Young-Ok,Choi, Wan-Su,Park, Sung-Gyoo,Chun, Jang-Soo BioMed Central 2018 Arthritis research & therapy Vol.20 No.-

<P><B>Background</B></P><P>We recently demonstrated that BATF, a member of the activator protein-1 (AP-1) family, regulates osteoarthritic cartilage destruction. Here, we explored the roles and regulatory mechanisms of BATF in collagen-induced arthritis (CIA) in mice.</P><P><B>Methods</B></P><P>CIA and K/BxN serum transfer were used to generate inflammatory arthritis models in wild-type (WT) and <I>Batf</I><SUP><I>−/−</I></SUP> mice. RA manifestations were determined by examining CIA incidence, clinical score, synovitis, synovial hyperplasia, angiogenesis in inflamed synovium, pannus formation, bone erosion, and cartilage destruction. Immune features in RA were analyzed by examining immune cell populations and cytokine production.</P><P><B>Results</B></P><P>BATF was upregulated in the synovial tissues of joints in which inflammatory arthritis had been caused by CIA or K/BxN serum transfer. The increases in CIA incidence, clinical score, and autoantibody production in CIA-induced WT mice were completely abrogated in the corresponding <I>Batf</I><SUP><I>−/−</I></SUP> DBA/1 J mice. Genetic ablation of <I>Batf</I> also inhibited CIA-induced synovitis, synovial hyperplasia, angiogenesis in synovial tissues, pannus formation, bone erosion, and cartilage destruction. <I>Batf</I> knockout inhibited the differentiation of T helper (Th)17 cells and the conversion of CD4<SUP>+</SUP>Foxp3<SUP>+</SUP> cells to CD4<SUP>+</SUP>IL-17<SUP>+</SUP> cells. However, BATF did not modulate the functions of fibroblast-like synoviocytes (FLS), including the expressions of chemokines, matrix-degrading enzymes, vascular endothelial growth factor, and receptor activator of NF-κB ligand (RANKL).</P><P><B>Conclusion</B></P><P>Our findings indicate that BATF crucially mediates CIA by regulating Th cell differentiation without directly affecting the functions of FLS.</P>

A Buddy-List Manipulation Mechanism on SIP-based IMPP System

Sun Ok Park,Jae Cheon Han,Wook Hyun,Mi-Young Huh,Shin Gak Kang 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.2

Transient Increase of Lipocortin 1 in Nuclei of the Hippocampal Pyramidal Neurons in Rats Induced by Immobilization Stress

Park, Hyoung-Sup,Jang, Yeon-Jin,Kim, Dong-Hou,Lee, Su-Ok,Na, Doe-Sun Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.2

Changes of lipocortin 1 (LC1) in the brain induced by immobilization stress were investigated in rats. Rats were immobilized for 0,1,2,3,4, and 5 h, and the brain slices were immunostained with anti-human LC1 antibodl (anti-LC1). Immunoreactivity of LCI (iLC1) was most prominent in neuronal cell bodies and processes of hippocampal CA regions and dentate gyrus. At rest without stress, most of the LC1 in the neuron located in the cytoplasm with the nuclei exhibiting relatively scarce immunoreactivity. Immobilization stress changed this intracellular distribution of LC1 by increasing nuclear LC1. The change was apparent in 1 h and reached the peak by 3 h. However, by 5 h of immobilization, the distribution pattern returned to that of the resting state. This transient nuclear translocation of LC1 was most prominent in $CA_1$ pyramidal neurons, and was not observed in areas other than the hippocampus. Adrenalectomy abolished this transient translocation of LC1. The roles of hippocampal LC1 as a mediator of glucocorticoid feedback signal and/or as an intracellar stress signaling protein could be suggested.