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Nirala, Satendra Kumar,Bhadauria, Monika 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
The present study has been conducted to evaluate the curative effect of propolis extract, a honey bee-hive product, against acetaminophen (APAP) induced oxidative stress and dysfunction in liver and kidney. Animals were challenged with APAP (2 g/kg, p.o.) followed by treatment of propolis extract (100 and 200 mg/kg, p.o.) once only after 24 h. Release of transaminases, alkaline phosphatase, lactate dehydrogenase, and serum bilirubin were increased, whereas hemoglobin and blood sugar were decreased after APAP administration. Antioxidant status in both the liver and kidney tissues were estimated by determining the glutathione, malondialdehyde content and activities of the CYP enzymes, which showed significant alterations after APAP intoxication. In addition, activities of adenosine triphosphatase, acid phosphatase, alkaline phosphatase, and major cell contents (total protein, glycogen and cholesterol) were also altered due to APAP poisoning. Propolis extract successfully reversed the alterations of these biochemical variables at higher dose. Improvements in hepatorenal histoarchitecture were also consistent with biochemical observations. The results indicated that ethanolic extract of propolis has ability to reverse APAP-induced hepatorenal biochemical and histopathological alterations probably by increasing the antioxidative defense activities due to various phenolic compounds present in it.
Application of genetics and genomics towards Capsicum translational research
Nirala Ramchi,Mechuselie Kehie,Vijaya Brahma,Suman Kumaria,Pramod Tandon 한국식물생명공학회 2014 Plant biotechnology reports Vol.8 No.2
Capsicum species commonly known as Chilipeppers are economically important group of plantsbelonging to the Solanaceae family. Of the 38 speciesreported, only six species namely, Capsicum annuum, C. assamicum, C. baccatum, C. frutescence, C. chinense andC. pubescens are cultivated. They are very importantcomponent of the human being as peppers are used asvegetables, spices, and a coloring agent and for medicinalpurposes. Based on pungency trait which is due to thepresence of a group of compounds known as capsaicinoids,cultivated capsicums are classified into sweet peppers andhot peppers. Although conventional breeding and classicalgenetic analysis were successful in estimating the numberof genes for economically important traits governed by fewmajor genes and their incorporation in the breeding programme,the advent of molecular markers and recentlydeveloped next generation sequencing technologies supplementedgreatly in dissecting the genetic and molecularbasis of economically important traits in the capsicumgenome for applied research. Here in this review, we triedto highlight the use of molecular markers, comparativemapping and advanced genomics technologies and theirintegrated use in the translational research of cultivatedCapsicums.
Ramchiary, Nirala,Nguyen, Van Dan,Li, Xiaonan,Hong, Chang Pyo,Dhandapani, Vignesh,Choi, Su Ryun,Yu, Ge,Piao, Zhong Yun,Lim, Yong Pyo Oxford University Press 2011 DNA research Vol.18 No.5
<P>Genic microsatellite markers, also known as functional markers, are preferred over anonymous markers as they reveal the variation in transcribed genes among individuals. In this study, we developed a total of 707 expressed sequence tag-derived simple sequence repeat markers (EST-SSRs) and used for development of a high-density integrated map using four individual mapping populations of <I>B. rapa</I>. This map contains a total of 1426 markers, consisting of 306 EST-SSRs, 153 intron polymorphic markers, 395 bacterial artificial chromosome-derived SSRs (BAC-SSRs), and 572 public SSRs and other markers covering a total distance of 1245.9 cM of the <I>B. rapa</I> genome. Analysis of allelic diversity in 24 <I>B. rapa</I> germplasm using 234 mapped EST-SSR markers showed amplification of 2 alleles by majority of EST-SSRs, although amplification of alleles ranging from 2 to 8 was found. Transferability analysis of 167 EST-SSRs in 35 species belonging to cultivated and wild <I>brassica</I> relatives showed 42.51% (<I>Sysimprium leteum</I>) to 100% (<I>B. carinata, B. juncea</I>, and <I>B. napus</I>) amplification. Our newly developed EST-SSRs and high-density linkage map based on highly transferable genic markers would facilitate the molecular mapping of quantitative trait loci and the positional cloning of specific genes, in addition to marker-assisted selection and comparative genomic studies of <I>B. rapa</I> with other related species.</P>
Harish Kumar Nirala,Prashant K. Jain,J. J. Roy,M. K. Samal,Puneet Tandon 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
Incremental sheet forming (ISF) is a recently developed manufacturing technique. In ISF, forming is done by applying deformation force through the motion of Numerically controlled (NC) single point forming tool on the clamped sheet metal blank. Single Point Incremental sheet forming (SPISF) is also known as a die-less forming process because no die is required to fabricate any component by using this process. Now a day it is widely accepted for rapid manufacturing of sheet metal components. The formability of SPISF process improves by adding some intermediate stages into it, which is known as Multi-stage SPISF (MSPISF) process. However during forming in MSPISF process because of intermediate stages stepped features are generated. This paper investigates the generation of stepped features with simulation and experimental results. An effective MSPISF strategy is proposed to remove or eliminate this generated undesirable stepped features.
Satendra Kumar Nirala,Monika Bhadauria 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
The present study has been conducted to evaluate the curative effect of propolis extract, a honey bee-hive product, against acetaminophen (APAP) induced oxidative stress and dysfunction in liver and kidney. Animals were challenged with APAP (2 g/kg, p.o.) followed by treatment of propolis extract (100 and 200 mg/kg, p.o.) once only after 24 h. Release of transaminases, alkaline phosphatase, lactate dehydrogenase, and serum bilirubin were increased, whereas hemoglobin and blood sugar were decreased after APAP administration. Antioxidant status in both the liver and kidney tissues were estimated by determining the glutathione, malondialdehyde content and activities of the CYP enzymes, which showed significant alterations after APAP intoxication. In addition, activities of adenosine triphosphatase, acid phosphatase, alkaline phosphatase, and major cell contents (total protein, glycogen and cholesterol) were also altered due to APAP poisoning. Propolis extract successfully reversed the alterations of these biochemical variables at higher dose. Improvements in hepatorenal histoarchitecture were also consistent with biochemical observations. The results indicated that ethanolic extract of propolis has ability to reverse APAP-induced hepatorenal biochemical and histopathological alterations probably by increasing the antioxidative defense activities due to various phenolic compounds present in it.
Development Of SNP Markers And Genome-wide Association Study In Chinese Cabbage
Wenxing Pang,Nirala Ramchiary,Su Ryun Choi,Yong Pyo Lim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Genome-wide association study (GWAS) is a very powerful method to identify the natural allelic variation present in crop plants causing variation to economically important traits. The recent advances in high throughput genotyping and sequencing technology supplemented greatly to GWAS. Taking this advantage, we selected a total of 382 Chinese cabbage inbred lines for GWAS study. The selected inbred lines are being sequenced using next generation sequencing technology to develop genome wide gene specific single nucleotide polymorphism markers. The morphological and quality traits data were taken from field grown inbred lines. The phenotype and genotype association study will be done with more environmental grown data’s and developed SNP. At the end of this project, gene specific SNP markers will be developed for Chinese cabbage breeding for morphological and quality traits.
Yu Ge,Nirala Ramchiary,Tao Wang,Cui Liang,Na Wang,Zhe Wang,최수련,임용표,Zhong Yun Piao 한국원예학회 2011 Horticulture, Environment, and Biotechnology Vol.52 No.5
The inheritance of leaf and heading-related traits in Chinese cabbage (Brassica rapa ssp. pekinensis) are poorly understood since only a handful of studies of these traits are available till date. In this study, QTL mapping was done for seven leaf and heading related traits that includes gross weight, number of non-wrapper leaves, head weight, head length, head width,head length/head width ratio, and the number of head-forming leaves in 139 F3 families derived from a cross between two diverse Chinese cabbage lines, ‘501’ with small head and ‘601’ with large head. A total of 27 QTL spread over the nine linkage groups were identified for seven leaf and head-related traits, many of which showed major effects clustered in A2, A4,A6, and A8. The results provided a better understanding of the genetic factors controlling leaf and head-related traits in Chinese cabbage.
Identification of Potential microRNAs and Their Targets in Brassica rapa L.
Vignesh Dhandapani,Nirala Ramchiary,Parameswari Paul,김준기,최선희,Jeongyeo Lee,Yoonkang Hur,임용표 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1
MicroRNAs (miRNAs) are recently discovered, noncoding, small regulatory RNA molecules that negatively regulate gene expression. Although many miRNAs are identified and validated in many plant species, they remain largely unknown in Brassica rapa (AA 2n =, 20). B. rapa is an important Brassica crop with wide genetic and morphological diversity resulting in several subspecies that are largely grown for vegetables, oilseeds, and fodder crop production. In this study, we identified 186 miRNAs belonging to 55 families in B. rapa by using comparative genomics. The lengths of identified mature and pre-miRNAs ranged from 18 to 22 and 66 to 305 nucleotides, respectively. Comparison of 4 nucleotides revealed that uracil is the predominant base in the first position of B. rapa miRNA, suggesting that it plays an important role in miRNA- mediated gene regulation. Overall, adenine and guanine were predominant in mature miRNAs, while adenine and uracil were predominant in pre-miRNA sequences. One DNA sequence producing both sense and antisense mature miRNAs belonging to the BrMiR 399 family, which differs by 1 nucleotide at the, 20th position, was identified. In silico analyses, using previously established methods, predicted 66 miRNA target mRNAs for 33 miRNA families. The majority of the target genes were transcription factors that regulate plant growth and development, followed by a few target genes that are involved in fatty acid metabolism, glycolysis, biotic and abiotic stresses, and other cellular processes. Northern blot and qRT-PCR analyses of RNA samples prepared from different B. rapa tissues for 17 miRNA families revealed that miRNAs are differentially expressed both quantitatively and qualita-tively in different tissues of B. rapa.