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Takeshi Nakahara,Chikage Mitoma,Akiko Hashimoto-Hachiya,Masakazu Takahara,Gaku Tsuji,Hiroshi Uchi,Xianghong Yan,Junichi Hachisuka,Takahito Chiba,Hitokazu Esaki,Makiko Kido-Nakahara,Masutaka Furue 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.10
Opuntia ficus-indica (OFI) is a cactus species widely used as an anti-inflammatory, antilipidemic, and hypoglycemic agent. It has been shown that OFI extract (OFIE) inhibits oxidative stress in animal models of diabetes and hepatic disease; however, its antioxidant mechanism remains largely unknown. In this study, we demonstrated that OFIE exhibited potent antioxidant activity through the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the downstream antioxidant enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), which inhibited the generation of reactive oxygen species in keratinocytes challenged with tumor necrosis factor α or benzo[α]pyrene. The antioxidant capacity of OFIE was canceled in NRF2 knockdown keratinocytes. OFIE exerted this NRF2-NQO1 upregulation through activation of the aryl hydrocarbon receptor (AHR). Moreover, the ligation of AHR by OFIE upregulated the expression of epidermal barrier proteins: filaggrin and loricrin. OFIE also prevented TH2 cytokine-mediated downregulation of filaggrin and loricrin expression in an AHRdependent manner because it was canceled in AHR knockdown keratinocytes. Antioxidant OFIE is a potent activator of AHRNRF2-NQO1 signaling and may be beneficial in treating barrier-disrupted skin disorders.
Nakahara Takayuki,Okamoto Yoshihisa,Nagae Masahiro,Yoshio Tetsuo,Kurishita Hiroaki,Takada Jun,Hiraoka Yutaka,Takida Tomohiro 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
In order to overcome the recrystallization embrittlement and irradiation embrittlement of Mo, which are major problems for its fusion applications, internally nitrided Mo alloys were prepared by a novel multi-step internal nitriding. Neutron irradiation was performed in the Japan Material Testing Reactor (JMTR). After irradiation, nitrided Mo alloys exhibited ower ductile-brittle transition temperature than irradiated TZM. These results suggested that multi-step internal nitriding was effective to the improvement in the embrittlement by irradiation. Transmission electron microscope observation revealed that TiN particles precipitated by nitriding acted as a sink for irradiation-induced defects.
Effect of C/Ti Atomic Ratio of TiCx Raw Powder on the Properties of Ti-Mo-W-TiC Sintered Hard Alloy
Nakahara Kenji,Sakaguchi Shigeya 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
We have studied the effect of C/Ti atomic ratio of TiCx (x=0.5, 0.75 and 1.0) raw powder on the properties of the Ti-Mo-WTiC sintered hard alloy. The decrease of C/Ti atomic ratio accelerated the densification in the sintering process. The hardness was remarkably improved up to 1350HV with decreasing the C/Ti atomic ratio because of increase of TiCx phase volume content and its fine dispersion. From the results of electro-chemical tests in acid and 3% NaCl solutions, it was obvious that every alloy had excellent corrosion resistance, which meant about 200 times better than that of WC-Co cemented carbide.
ON THE SOLUTIONS FOR NET SHOPPING IN EXTREMELY AGING SOCIETY: CASE OF JAPAN
Ryuki Nakahara 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
The aging of society is speeding up in Japan. Although over 30 millions of aged persons in Japan are not good at using up-to-date tools like the internet for their daily life, they are well-off and have attractive purchasing power than younger generation. It is very import task how to approach them to sell goods, provide services through the internet. The issue seems to Japan just now, but will be the large and urgent task to Korea, to China in near future. We discuss the measures on the view of partnership marketing.
Partnership marketing for prevention
Ryuki Nakahara 한국마케팅과학회 2014 마케팅과학연구 Vol.24 No.2
There is no place in the world that has never suffered a disaster. We cannot escape fromdisaster in our daily life because we exist in a global setting. Disaster can happen to anindividual or an organization on any day and anywhere, at any time. Thus, what we do isconsider not how to escape disaster, but how to make an effort to overcome it. We usually consider how to reduce the losses caused by damage, how to reducethe degree of damage, and/or how to increase the speed of recovery after a disaster. Thisarticle will not discuss the constitution, the factors, or the causes of disaster. It willdiscuss the efficiency and effectiveness of avoiding disaster and recovering fromdisasters as quickly as possible through cases close to us in daily life in the view ofpartnership marketing. And we will argue the possibility and importance of preventingthe occurrence of disaster finally. We believe the best way to overcome disasters is tocreate a multidimensional partnership network with strategic planning to fundamentallyprevent the occurrence of disaster.