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Will Molecular Optical Imaging Have Clinically Important Roles in Stroke Management, and How?
이동근,Matthias Nahrendorf,Dawid Schellingerhout,김동억 대한신경과학회 2010 Journal of Clinical Neurology Vol.6 No.1
Molecular imaging is a novel technology to visualize biological processes at the cellular and molecular levels, which is reshaping both biomedical research and clinical practice. By providing molecular information to supplement and augment conventional anatomy-based imaging, molecular imaging is expected to allow 1) the earlier detection of diseases, 2) precise evaluation of disease stages, and 3) both diagnostic and therapeutic monitoring of disease progression in a quantitative manner. In this brief review, we present our view on the prospects of molecular optical imaging in the field of stroke practice, focusing on the imaging vulnerability of atherosclerotic plaques, thrombolytic resistance, real-time cerebral perfusion, and penumbra.
Direct Thrombus Imaging in Stroke
김종성,박정이,Matthias Nahrendorf,김동억 대한뇌졸중학회 2016 Journal of stroke Vol.18 No.3
There is an emergent need for imaging methods to better triage patients with acute stroke for tissue-plasminogen activator (tPA)-mediated thrombolysis or endovascular clot retrieval by directly visualizing the size and distribution of cerebral thromboemboli. Currently, magnetic resonance (MR) or computed tomography (CT) angiography visualizes the obstruction of blood flow within the vessel lumen rather than the thrombus itself. The present visualization method, which relies on observation of the dense artery sign (the appearance of cerebral thrombi on a non-enhanced CT), suffers from low sensitivity. When translated into the clinical setting, direct thrombus imaging is likely to enable individualized acute stroke therapy by allowing clinicians to detect the thrombus with high sensitivity, assess the size and nature of the thrombus more precisely, serially monitor the therapeutic effects of thrombolysis, and detect post-treatment recurrence. This review is intended to provide recent updates on stroke-related direct thrombus imaging using MR imaging, positron emission tomography, or CT
Kim, Dong-Eog,Kim, Jeong-Yeon,Nahrendorf, Matthias,Lee, Su-Kyoung,Ryu, Ju Hee,Kim, Kwangmeyung,Kwon, Ick Chan,Schellingerhout, Dawid Ovid Technologies Wolters Kluwer -American Heart A 2011 Stroke Vol.42 No.12
<P>High experimental variability in mouse embolic stroke models could mask the effects of experimental treatments. We hypothesized that imaging thrombus directly would allow this variability to be controlled.</P>
Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque
Shon, S.M.,Park, J.H.,Nahrendorf, M.,Schellingerhout, D.,Kim, J.Y.,Kang, B.T.,Jeong, S.W.,Kim, E.J.,Ryu, J.H.,Kim, K.,Kwon, I.C.,Lee, D.K.,Lee, M.M.,Kim, D.E. Elsevier Scientific Publ. Co 2011 Atherosclerosis Vol.216 No.1
Objective: Few studies have investigated if exercise by itself has anti-atherosclerotic effects, without combining interventions with a low-fat diet. We studied the effects of exercise as a stand-alone intervention on preexisting atheromata by measuring not only plaque size but also the levels of plaque-destabilizing matrix-metalloproteinase (MMP) activity in vivo. Methods and results: We used near-infrared fluorescent (NIRF) molecular imaging with an MMP-2/9 activatable NIRF probe to visualize the inflammatory protease activity within preexisting atheromata of 17-week-old ApoE<SUP>-/-</SUP> mice on: (a) normal chow diet (NCD), (b) Western diet (WD), and (c) WD with treadmill exercise for 10 weeks. We also measured tissue levels of aortic lipid peroxidation (LPO) and plasma levels of glucose/lipid/cytokine profiles. Exercise did not attenuate growth of preexisting atheromatous plaques. However, exercise strongly decreased proteolytic activity in plaques for animals on WD, with levels decreasing almost to NCD levels. Exercise was associated with decreased aortic LPO levels and increased blood adiponectin/leptin levels; however, exercise did not affect WD-consumption/weight-gain or improve blood glucose/lipid profiles. Conclusions: Exercise training reduced aortic MMP activity in mice with preexisting atheromata, even though they remained on a high fat diet and plaque-growth was not attenuated.
Kim, Dong-Eog,Kim, Jeong-Yeon,Schellingerhout, Dawid,Ryu, Ju Hee,Lee, Su-Kyoung,Jeon, Sangmin,Lee, Ji Sung,Kim, Jiwon,Jang, Hee Jeong,Park, Jung E.,Kim, Eo Jin,Kwon, Ick Chan,Ahn, Cheol-Hee,Nahrendorf American Heart Association 2017 Stroke Vol. No.
<P>Conclusions-Thromboembolic burden and the efficacy of tPA therapy can be assessed serially, noninvasively, and quantitatively using high-resolution microcomputed tomography and a fibrin-binding nanoparticle imaging agent.</P>